- Phytochemicals for the treatment of COVID-19
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Erica Españo , Jiyeon Kim , Kiho Lee , Jeong-Ki Kim
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J. Microbiol. 2021;59(11):959-977. Published online November 1, 2021
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DOI: https://doi.org/10.1007/s12275-021-1467-z
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The coronavirus disease 2019 (COVID-19) pandemic has
underscored the lack of approved drugs against acute viral
diseases. Plants are considered inexhaustible sources of drugs
for several diseases and clinical conditions, but plant-derived
compounds have seen little success in the field of antivirals.
Here, we present the case for the use of compounds from vascular
plants, including alkaloids, flavonoids, polyphenols,
and tannins, as antivirals, particularly for the treatment of
COVID-19. We review current evidence for the use of these
phytochemicals against SARS-CoV-2 infection and present
their potential targets in the SARS-CoV-2 replication cycle.
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Citations
Citations to this article as recorded by  - Key insights into recent advances and challenges in COVID-19 management
Prakash Monika, Anushka A. Poola, Prithvi S. Prabhu, K. Samrat, C. Likhitha
Discover Public Health.2025;[Epub] CrossRef - Comprehensive insights into the therapeutic effects of baicalein and baicalin against SARS-COV-2 infection
Cheng-Han Lin, Meng-Wei Lin, Hua-Hsin Chiang, Ting-Hsuan Wu, Chin-Hung Tsai, Chih-Sheng Lin
Phytomedicine Plus.2025; 5(3): 100851. CrossRef - A review of health benefits of selected South African indigenous fruits and vegetables
Thiambi R. Netshiluvhi, Jacobus N. Eloff
South African Journal of Botany.2025; 179: 358. CrossRef - Role of dietary supplements in the continuous battle against COVID‐19
Rahela Zaman, Vignesh Ravichandran, Chung Keat Tan
Phytotherapy Research.2024; 38(2): 1071. CrossRef - The Potential of Anti-coronavirus Plant Secondary Metabolites in COVID-19 Drug Discovery as an Alternative to Repurposed Drugs: A Review
Zahra Alipour, Somayeh Zarezadeh, Ali Akbar Ghotbi-Ravandi
Planta Medica.2024; 90(03): 172. CrossRef - In Silico Screening of Some Active Phytochemicals to Identify Promising
Inhibitors Against SARS-CoV-2 Targets
V. Alagarsamy, V. Raja Solomon, S. Murugesan, P. Shyam Sundar, MD. Muzaffar-Ur-Rehman, A. Chandu, A. Dharshini Aishwarya, B. Narendhar, M.T. Sulthana, V. Ravikumar
Current Drug Discovery Technologies.2024;[Epub] CrossRef - Screening Commercial Tea for Rapid Inactivation of Infectious SARS-CoV-2 in Saliva
Julianna N. Morris, Malak A. Esseili
Food and Environmental Virology.2024; 16(2): 159. CrossRef - Phytochemical-loaded Nanoparticles in COVID-19 Management
Suneetha Vuppu, Toshika Mishra, Shatakshi Mishra, Stany B, Anushka Das
Natural Resources for Human Health.2023; 4(1): 51. CrossRef - Nutritional deficiencies that may predispose to long COVID
John V. Schloss
Inflammopharmacology.2023; 31(2): 573. CrossRef - Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review
Lucas Fornari Laurindo, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Maria Eduardo Figueira, Rosa Direito, Ricardo de Alvares Goulart, Daiene Santos Buglio, Sandra Maria Barbalho
Pharmaceutics.2023; 15(1): 229. CrossRef - Changes in phytochemical compositions and antioxidant activity of Schisandra sphenathera fruit during ripening
Bohan Ma, Xinghua Zhao, Bin Dai, Mengge Zhao, Xingbin Yang, Langjun Cui, Hongjun Shao
Industrial Crops and Products.2023; 199: 116773. CrossRef - Role of nutrition in minimizing mental and health-related issues during COVID-19: a systematic literature review
Luxita Sharma, Dhananjay Sharma
Nutrition & Food Science.2023; 53(4): 659. CrossRef - Current Update of Phytotherapeutic Agents in the Treatment of COVID-19: In-Silico Based Virtual Screening Approach for the Development of Antiviral Drug
Veena Ramesh, Seema A. Kulkarni, Palaniyandi Velusamy, Velmurugan Devadasan, Panneer Devaraju, Kandathil Narayanan Rajnish, Thirumurthy Madhavan, Periasamy Anbu, Palaniappan Ramasamy, Rajamanikandan Sundarraj
Frontiers in Bioscience-Landmark.2022;[Epub] CrossRef - Promising natural products against SARS‐CoV‐2: Structure, function, and clinical trials
Yan Zhao, Shanshan Deng, Yujiao Bai, Jinlin Guo, Guoyin Kai, Xinhe Huang, Xu Jia
Phytotherapy Research.2022; 36(10): 3833. CrossRef - Effective food hygiene principles and dietary intakes to reinforce the immune system for prevention of COVID-19: a systematic review
Jalaledin Mirzay-Razaz, Majid Hassanghomi, Marjan Ajami, Glareh Koochakpoor, Firoozeh Hosseini-Esfahani, Parvin Mirmiran
BMC Nutrition.2022;[Epub] CrossRef - Beneficial effect of polyphenols in COVID‐19 and the ectopic F1FO‐ATP synthase: Is there a link?
Isabella Panfoli, Alfonso Esposito
Journal of Cellular Biochemistry.2022; 123(8): 1281. CrossRef - In vitro inhibition of SARS-CoV-2 Infection by dry algae powders
Daniel Garcia-Ruiz, Erendira Villalobos-Sánchez, David Alam-Escamilla, Darwin Elizondo-Quiroga
Scientific Reports.2022;[Epub] CrossRef - Schizophyllum commune Reduces Expression of the SARS-CoV-2 Receptors ACE2 and TMPRSS2
Te-Kai Sun, Wen-Chin Huang, Yu-Wen Sun, Jeng-Shyan Deng, Liang-Hsuan Chien, Ya-Ni Chou, Wen-Ping Jiang, Jaung-Geng Lin, Guan-Jhong Huang
International Journal of Molecular Sciences.2022; 23(23): 14766. CrossRef - An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations
Shiv Kumar Prajapati, Akanksha Malaiya, Gaurav Mishra, Dolly Jain, Payal Kesharwani, Nishi Mody, Amirhossein Ahmadi, Rishi Paliwal, Ankit Jain
Journal of Ethnopharmacology.2022; 296: 115420. CrossRef - Computational screening for investigating the synergistic regulatory potential of drugs and phytochemicals in combination with 2-deoxy-D-glucose against SARS-CoV-2
Anshika Gupta, Shweta Singh Chauhan, Anamika Singh Gaur, Ramakrishnan Parthasarathi
Structural Chemistry.2022; 33(6): 2179. CrossRef - BOTANICALS AS PROSPECTIVE AGENTS AGAINST SARS-COV-2 VIRUS
V. DUSHENKOV, A. DUSHENKOV
AVICENNA BULLETIN.2022; 24(1): 113. CrossRef
- Anti-MRSA agent discovery using Caenorhabditis elegans-based high-throughput screening
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Soo Min Kim , Iliana Escorbar , Kiho Lee , Beth Burgwyn Fuchs , Eleftherios Mylonakis , Wooseong Kim
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J. Microbiol. 2020;58(6):431-444. Published online May 27, 2020
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DOI: https://doi.org/10.1007/s12275-020-0163-8
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1,036
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10
Web of Science
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11
Crossref
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Abstract
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Staphylococcus aureus is a leading cause of hospital- and community-
acquired infections. Despite current advances in antimicrobial
chemotherapy, the infections caused by S. aureus
remain challenging due to their ability to readily develop resistance.
Indeed, antibiotic resistance, exemplified by methicillin-
resistant S. aureus (MRSA) is a top threat to global health
security. Furthermore, the current rate of antibiotic discovery
is much slower than the rate of antibiotic-resistance development.
It seems evident that the conventional in vitro bacterial
growth-based screening strategies can no longer effectively
supply new antibiotics at the rate needed to combat bacterial
antibiotic-resistance. To overcome this antibiotic resistance
crisis, screening assays based on host–pathogen interactions
have been developed. In particular, the free-living nematode
Caenorhabditis elegans has been used for drug screening
against MRSA. In this review, we will discuss the general
principles of the C. elegans-based screening platform and
will highlight its unique strengths by comparing it with conventional
antibiotic screening platforms. We will outline major
hits from high-throughput screens of more than 100,000
small molecules using the C. elegans–MRSA infection assay
and will review the mode-of-action of the identified hit compounds.
Lastly, we will discuss the potential of a C. elegansbased
screening strategy as a paradigm shift screening platform.
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Citations
Citations to this article as recorded by -
Advances in methicillin-resistant
Staphylococcus aureus
drug discovery: developments and challenges
Stephanos Vassilopoulos, Eleftherios Mylonakis
Expert Opinion on Drug Discovery.2026; 21(2): 231. CrossRef - Investigation of anti-aging and anti-infection properties of Jingfang Granules using the Caenorhabditis elegans model
Xin Yin, Yiwei Meng, Chenghong Sun, Yanqiu Zhao, Weitao Wang, Peipei Zhao, Mengmeng Wang, Jingli Ren, Jingchun Yao, Lixin Zhang, Xuekui Xia
Biogerontology.2024; 25(3): 433. CrossRef - PHPGAT: predicting phage hosts based on multimodal heterogeneous knowledge graph with graph attention network
Fu Liu, Zhimiao Zhao, Yun Liu
Briefings in Bioinformatics.2024;[Epub] CrossRef - Alternatives to animal models to study bacterial infections
Chengming Hu, Wenlong Yang
Folia Microbiologica.2023; 68(5): 703. CrossRef - Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice
Jaeyeong Park, Eunkyoung Shin, Ji-Hyun Yeom, Younkyung Choi, Minju Joo, Minho Lee, Je Hyeong Kim, Jeehyeon Bae, Kangseok Lee
Journal of Microbiology.2022; 60(1): 128. CrossRef - Antimicrobial activity of the membrane-active compound nTZDpa is enhanced at low pH
Soo Min Kim, Guijin Zou, Hyerim Kim, Minjeong Kang, Soyeon Ahn, Hee Young Heo, Jae-Seok Kim, Kyung-Min Lim, Frederick M. Ausubel, Eleftherios Mylonakis, Huajian Gao, Wooseong Kim
Biomedicine & Pharmacotherapy.2022; 150: 112977. CrossRef - Antibiotic resistant bacteria: current situation and treatment options to accelerate the development of a new antimicrobial arsenal
Antonio Tarín-Pelló, Beatriz Suay-García, María-Teresa Pérez-Gracia
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Ayodeji O. Falade, Kayode E. Adewole, Temitope C. Ekundayo
Egyptian Journal of Basic and Applied Sciences.2021; 8(1): 117. CrossRef -
Novel Immune Modulators Enhance
Caenorhabditis elegans
Resistance to Multiple Pathogens
Nicholas A. Hummell, Alexey V. Revtovich, Natalia V. Kirienko, Paul Dunman
mSphere.2021;[Epub] CrossRef - Caenorhabditis elegans, a Host to Investigate the Probiotic Properties of Beneficial Microorganisms
Cyril Poupet, Christophe Chassard, Adrien Nivoliez, Stéphanie Bornes
Frontiers in Nutrition.2020;[Epub] CrossRef - New Antimicrobial Bioactivity against Multidrug-Resistant Gram-Positive Bacteria of Kinase Inhibitor IMD0354
Iliana E Escobar, Alexis White, Wooseong Kim, Eleftherios Mylonakis
Antibiotics.2020; 9(10): 665. CrossRef
- TatC-dependent translocation of pyoverdine is responsible for the microbial growth suppression
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Yeji Lee , Yong-Jae Kim , Jung-Hoon Lee , Hyung Eun Yu , Kiho Lee , Shouguang Jin , Un-Hwan Ha
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J. Microbiol. 2016;54(2):122-130. Published online February 2, 2016
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DOI: https://doi.org/10.1007/s12275-016-5542-9
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916
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3
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Abstract
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Infections are often not caused by a colonization of Pseudomonas
aeruginosa alone but by a consortium of other bacteria.
Little is known about the impact of P. aeruginosa on
the growth of other bacteria upon coinfection. Here, cellree
culture supernatants obtained from P. aeruginosa suppressed
the growth of a number of bacterial strains such as
Corynebacterium glutamicum, Bacillus subtilis, Staphylococcus
aureus, and Agrobacterium tumefaciens, but had little effect
on the growth of Escherichia coli and Salmonella Typhimurium.
The growth suppression effect was obvious when P.
aeruginosa was cultivated in M9 minimal media, and the
suppression was not due to pyocyanin, a well-known antimicrobial
toxin secreted by P. aeruginosa. By performing
transposon mutagenesis, PA5070 encoding TatC was identified,
and the culture supernatant of its mutant did not suppress
the growth. HPLC analysis of supernatants showed
that pyoverdine was a secondary metabolite present in culture
supernatants of the wild-type strain, but not in those
of the PA5070 mutant. Supplementation of FeCl2 as a source
of iron compromised the growth suppression effect of supernatants
and also recovered biofilm formation of S. aureus,
indicating that pyoverdine-mediated iron acquisition is responsible
for the growth suppression. Thus, this study provides
the action of TatC-dependent pyoverdine translocation for
the growth suppression of other bacteria, and it might aid
understanding of the impact of P. aeruginosa in the complex
community of bacterial species upon coinfection.
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Citations
Citations to this article as recorded by - Characterization of the antagonistic potential of the glyphosate-tolerant Pseudomonas resinovorans SZMC 25872 strain against the plant pathogenic bacterium Agrobacterium tumefaciens
Anuar R. Zhumakayev, Mónika Varga, Mónika Vörös, Sándor Kocsubé, Pramod W. Ramteke, András Szekeres, Csaba Vágvölgyi, Lóránt Hatvani, Tamás Marik
Frontiers in Plant Science.2022;[Epub] CrossRef - Ecology drives the evolution of diverse social strategies in Pseudomonas aeruginosa
Alexandre R. T. Figueiredo, Andreas Wagner, Rolf Kümmerli
Molecular Ecology.2021; 30(20): 5214. CrossRef - Mycobacterium abscessus subsp. abscessus Is Capable of Degrading Pseudomonas aeruginosa Quinolone Signals
Franziska S. Birmes, Timo Wolf, Thomas A. Kohl, Kai Rüger, Franz Bange, Jörn Kalinowski, Susanne Fetzner
Frontiers in Microbiology.2017;[Epub] CrossRef
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