- Characterization of a Mutant Strain of a Filamentous Fungus Cladosporium phlei for the Mass Production of the Secondary Metabolite Phleichrome
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Min-Hee Yi , Jung-Ae Kim , Jung-Mi Kim , Jin-Ah Park , Beom-Tae Kim , Seung-Moon Park , Moon-Sik Yang , Ki-Jun Hwang , Dae-Hyuk Kim
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J. Microbiol. 2011;49(4):680-683. Published online September 2, 2011
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DOI: https://doi.org/10.1007/s12275-011-1022-4
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UV-mutagenesis was performed to obtain mutant strains that demonstrate altered production of phleichrome,
a secondary metabolite of Cladosporium phlei. Among fifty mutants selected, based on the increased area
and intensity of the purple pigment surrounding the colonies, the strain M0035 showed the highest production
of phleichrome, more than seven fold over wild type. Plate cultures of the M0035 strain resulted in a total
of 592 mg phleichrome consisting of 146 mg and 446 mg from the mycelia and agar media, respectively.
The M0035 strain displayed a growth rate and a mycelial mass comparable to the parental strain but
had significantly reduced asexual sporulation.
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Citations
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