- Advancements in dengue vaccines: A historical overview and pro-spects for following next-generation candidates
-
Kai Yan, Lingjing Mao, Jiaming Lan, Zhongdang Xiao
-
J. Microbiol. 2025;63(2):e2410018. Published online February 27, 2025
-
DOI: https://doi.org/10.71150/jm.2410018
-
-
13,000
View
-
436
Download
-
5
Web of Science
-
7
Crossref
-
 Abstract
 PDF
-
Dengue, caused by four serotypes of dengue viruses (DENV-1 to DENV-4), is the most prevalent and widely mosquito-borne viral disease affecting humans. Dengue virus (DENV) infection has been reported in over 100 countries, and approximately half of the world's population is now at risk. The paucity of universally licensed DENV vaccines highlights the urgent need to address this public health concern. Action and attention to antibody-dependent enhancement increase the difficulty of vaccine development. With the worsening dengue fever epidemic, Dengvaxia® (CYD-TDV) and Qdenga® (TAK-003) have been approved for use in specific populations in affected areas. However, these vaccines do not provide a balanced immune response to all four DENV serotypes and the vaccination cannot cover all populations. There is still a need to develop a safe, broad-spectrum, and effective vaccine to address the increasing number of dengue cases worldwide. This review provides an overview of the existing DENV vaccines, as well as potential candidates for future studies on DENV vaccine development, and discusses the challenges and possible solutions in the field.
-
Citations
Citations to this article as recorded by  - Role of c-ABL in DENV-2 Infection and Actin Remodeling in Vero Cells
Grace Paola Carreño-Flórez, Alexandra Milena Cuartas-López, Ryan L. Boudreau, Miguel Vicente-Manzanares, Juan Carlos Gallego-Gómez
International Journal of Molecular Sciences.2025; 26(9): 4206. CrossRef - Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals
Manisha Saini, Jasmin C. Aschenbrenner, Francesc Xavier Ruiz, Ashima Chopra, Anu V. Chandran, Peter G. Marples, Blake H. Balcomb, Daren Fearon, Frank von Delft, Eddy Arnold
Journal of Medicinal Chemistry.2025; 68(17): 18356. CrossRef - Understanding the Diversity of Dengue Serotypes: Impacts on Public Health and Disease Control
Gopinath Ramalingam, Madhumitha Patchaiyappan, M. Arundadhi, Krishnapriya Subramani, A. Dhanasezhian, Sucila Thangam Ganesan
The Journal of Medical Research.2025; 11(4): 69. CrossRef - Dengue Fever Resurgence in Iran: An Integrative Review of Causative Factors and Control Strategies
Seyed Hassan Nikookar, Saeedeh Hoseini, Omid Dehghan, Mahmoud Fazelidinan, Ahmadali Enayati
Tropical Medicine and Infectious Disease.2025; 10(11): 309. CrossRef - Enhancement of viral infection by antibodies and consequences
Corentin Morvan, Magloire Pandoua Nekoua, Cyril Debuysschere, Enagnon Kazali Alidjinou, Didier Hober, Sebla Bulent Kutluay
Microbiology and Molecular Biology Reviews.2025;[Epub] CrossRef - Microbial Volatiles from Human Skin and Floral Nectar: Insufficiently Understood Adult Feeding Cues To Improve Odor-Based Traps for Aedes Vector Control
Simon Malassigné, Claire Valiente Moro, Patricia Luis
Journal of Chemical Ecology.2025;[Epub] CrossRef - An interpretable machine learning model for dengue detection with clinical hematological data
Izaz Ahmmed Tuhin, A.K.M.Fazlul Kobir Siam, Md Mahfuzur Rahman Shanto, Md Rajib Mia, Imran Mahmud, Apurba Ghosh
Healthcare Analytics.2025; 8: 100430. CrossRef
|
MSK
