- Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
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Junsoo Park , Rackhyun Park , Minsu Jang , Yea-In Park , Yeonjeong Park
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J. Microbiol. 2022;60(3):347-354. Published online January 28, 2022
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DOI: https://doi.org/10.1007/s12275-022-1499-z
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Coronavirus disease (COVID-19) can cause critical conditions
that require efficient therapeutics. Several medicines are derived
from plants, and researchers are seeking natural compounds
to ameliorate the symptoms of COVID-19. Viral enzymes
are popular targets of antiviral medicines; the genome
of coronaviruses encodes several enzymes, including RNAdependent
RNA polymerase and viral proteases. Various screening
systems have been developed to identify potential inhibitors.
In this review, we describe the natural compounds that
have been shown to exert inhibitory effects on coronavirus enzymes.
Although computer-aided molecular structural studies
have predicted several antiviral compound candidates, the current
review focuses on experimentally proven natural compounds.
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- Kaposi’s Sarcoma-Associated Herpesvirus Viral Protein Kinase Interacts with RNA Helicase A and Regulates Host Gene Expression
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Jae Eun Jong , Junsoo Park , Sunmi Kim , Taegun Seo
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J. Microbiol. 2010;48(2):206-212. Published online May 1, 2010
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DOI: https://doi.org/10.1007/s12275-010-0021-1
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688
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RNA helicase A (RHA) containing the DExH motif is a human homolog of maleless protein that regulates expression of genes located in the Drosophila X chromosome during dosage compensation. RHA exerts helicase activity that unwinds double-stranded RNA and DNA to a single-strand form. The protein acts as a bridging factor mediating interactions of CBP/p300 and RNA pol II, and consequently affects gene expression. Kaposi’s sarcoma-associated herpesvirus (KSHV) is a member of the γ-herpesvirus subfamily that causes several disorders. The majority of herpesviruses commonly encode predicted viral protein kinases. KSHV open reading frame 36 (ORF36) codes for protein kinase domains, and functions as a serine/threonine protein kinase. KSHV ORF36 is classified as a late gene, as it is expressed during lytic replication and localized in the nuclei of KSHV-infected cells. Recent studies show that viral protein kinase (vPK) interacts with cellular proteins. In this study, we determined the cellular localization of vPK in KSHVinfected BCBL-1 cells using confocal microscopy. Proteomic analysis indicates that cellular proteins interacted with vPK, and co-immunoprecipitation reactions further reveal interactions between vPK and RHA. Moreover, KSHV vPK appeared to regulate the transcriptional activation of Cre promoter, and plays an important role in cellular transcription of RHA.
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