- Ulmus macrocarpa Hance extract modulates intestinal microbiota in healthy adults: a randomized, placebo-controlled clinical trial
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Kwangmin Kim , Karpagam Veerappan , Nahyun Woo , Bohyeon Park , Sathishkumar Natarajan , Hoyong Chung , Cheolmin Kim , Junhyung Park
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J. Microbiol. 2021;59(12):1150-1156. Published online October 26, 2021
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DOI: https://doi.org/10.1007/s12275-021-1329-8
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 Abstract
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The stem and root bark of Ulmus macrocarpa Hance has been
used as traditional pharmacological agent against inflammation
related disorders. The objective of this study was to explore
the impact of Ulmus macrocarpa Hance extract (UME)
on human gut microbiota. A randomized placebo-controlled
clinical study was conducted in healthy adults. The study subjects
were given 500 mg/day of UME or placebo orally for 4
weeks. Eighty fecal samples were collected at baseline and 4
weeks of UME or placebo intervention. The gut microbiota
variation was evaluated by 16S rRNA profiling. The microbial
response was highly personalized, and no statistically significant
differences was observed in both species richness
and abundance. The number of bacterial species identified
in study subjects ranged from 86 to 182 species. The analysis
for taxonomical changes revealed an increase in Eubacterium
ventriosum, Blautia faecis, Ruminococcus gnavus in the UME
group. Functional enrichment of bacterial genes showed an
increase in primary and secondary bile acid biosynthesis in
UME group. Having known from previous studies Eubacterium
regulated bile acid homeostasis in protecting gut microbial
architecture and immunity, we suggest that UME supplementation
might enhance host immunity by modulating
gut microbiota. This is the first stage study and forthcoming
clinical studies with larger participants are needed to confirm
these findings.
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Citations
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