- Characteristic alterations of gut microbiota in uncontrolled gout
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Asad ul-Haq , Kyung-Ann Lee , Hoonhee Seo , Sukyung Kim , Sujin Jo , Kyung Min Ko , Su-Jin Moon , Yun Sung Kim , Jung Ran Choi , Ho-Yeon Song , Hyun-Sook Kim
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J. Microbiol. 2022;60(12):1178-1190. Published online November 24, 2022
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DOI: https://doi.org/10.1007/s12275-022-2416-1
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Microbiome research has been on the rise recently for a more
in-depth understanding of gout. Meanwhile, there is a need to
understand the gut microbiome related to uric acid-lowering
drug resistance. In this study, 16S rRNA gene-based microbiota
analysis was performed for a total of 65 stool samples
from 17 healthy controls and 48 febuxostat-treated gout patients
(including 28 controlled subjects with decreased uric
acid levels and 20 uncontrolled subjects with non-reduced
uric acid levels). Alpha diversity of bacterial community decreased
in the healthy control, controlled, and uncontrolled
groups. In the case of beta diversity, the bacterial community
was significantly different among groups (healthy control, controlled,
and uncontrolled groups). Taxonomic biomarker analysis
revealed the increased population of g-Bifidobacterium
in healthy controls and g-Prevotella in uncontrolled patients.
PCR further confirmed this result at the species level. Additionally,
functional metagenomics predictions led to the exploration
of various functional biomarkers, including purine
metabolism. The results of this study can serve as a basis
for developing potential new strategies for diagnosing and
treating gout from microbiome prospects.
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Citations
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