- Recombinant baculovirus-based vaccine expressing M2 protein induces protective CD8+ T-cell immunity against respiratory syncytial virus infection
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Jeong-Yoon Lee , Jun Chang
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J. Microbiol. 2017;55(11):900-908. Published online October 27, 2017
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DOI: https://doi.org/10.1007/s12275-017-7306-6
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 Abstract
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Respiratory syncytial virus (RSV) is an important cause of
acute lower respiratory tract disease in infants, young children,
immunocompromised individuals, and the elderly. However,
despite ongoing efforts to develop an RSV vaccine, there
is still no authorized RSV vaccine for humans. Baculovirus
has attracted attention as a vaccine vector because of its ability
to induce a high level of humoral and cellular immunity, low
cytotoxicity against various antigens, and biological safety
for humans. In this study, we constructed a recombinant baculovirus-
based vaccine expressing the M2 protein of RSV under
the control of cytomegalovirus promoter (Bac_RSVM2)
to induce CD8+ T-cell responses which play an important
role in viral clearance, and investigated its protective efficacy
against RSV infection. Immunization with Bac_RSVM2 via
intranasal or intramuscular route effectively elicited the specific
CD8+ T-cell responses. Most notably, immunization with
Bac_RSVM2 vaccine almost completely protected mice from
RSV challenge without vaccine-enhanced immunopathology.
In conclusion, these results suggest that Bac_RSVM2 vaccine
employing the baculovirus delivery platform has promising
potential to be developed as a safe and novel RSV vaccine
that provides protection against RSV infection.
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Citations
Citations to this article as recorded by  - Structural Advances in Respiratory Syncytial Virus: Implications for Vaccine and Antiviral Development
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Pesticide Biochemistry and Physiology.2023; 192: 105382. CrossRef - Cytokines and CD8 T cell immunity during respiratory syncytial virus infection
Megan E. Schmidt, Steven M. Varga
Cytokine.2020; 133: 154481. CrossRef - Induction of mucosal immunity against pathogens by using recombinant baculoviral vectors: Mechanisms, advantages, and limitations
Mario Fragoso-Saavedra, Marco A Vega-López
Journal of Leukocyte Biology.2020; 108(3): 835. CrossRef - Endogenous n-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8+ T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice
Kyung Won Kang, Seyoung Kim, Yong-Bin Cho, Seung Rok Ryu, Young-Jin Seo, Sang-Myeong Lee
International Journal of Molecular Sciences.2019; 20(18): 4510. CrossRef - Anti-viral activity of compounds from Agrimonia pilosa and Galla rhois extract mixture
Jeong Eun Kwon, Yeong-Geun Lee, Ji-Hun Kang, Yun-Feng Bai, Yong Joon Jeong, Nam-In Baek, Young-Jin Seo, Se Chan Kang
Bioorganic Chemistry.2019; 93: 103320. CrossRef - Vaccine containing G protein fragment and recombinant baculovirus expressing M2 protein induces protective immunity to respiratory syncytial virus
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Clinical and Experimental Vaccine Research.2019; 8(1): 43. CrossRef - Recombinant live attenuated influenza vaccine viruses carrying CD8 T-cell epitopes of respiratory syncytial virus protect mice against both pathogens without inflammatory disease
Tatiana Kotomina, Irina Isakova-Sivak, Victoria Matyushenko, Ki-Hye Kim, Youri Lee, Yu-Jin Jung, Sang-Moo Kang, Larisa Rudenko
Antiviral Research.2019; 168: 9. CrossRef - The CD8 T Cell Response to Respiratory Virus Infections
Megan E. Schmidt, Steven M. Varga
Frontiers in Immunology.2018;[Epub] CrossRef
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