- Susceptibility of Human H3N2 Influenza Virus to Oseltamivir in South Korea, 2009–2011
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Sehee Park , Jin Il Kim , Ilseob Lee , Sangmoo Lee , Min-Woong Hwang , Joon-Yong Bae , Jun Heo , Eun-Joo Lim , Won-Seok Seok , Hee Jin Cheong , Joon Young Song , Woo Joo Kim , Man-Seong Park
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J. Microbiol. 2012;50(6):1067-1070. Published online December 30, 2012
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DOI: https://doi.org/10.1007/s12275-012-2541-3
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During the 2009–2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.
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Citations
Citations to this article as recorded by  - Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Hyejin Kim, Hee Jin Cheong, Jin-Won Song, Ki-Joon Song, Luck Ju Baek, Man-Seong Park, Balaji Manicassamy
PLoS ONE.2014; 9(7): e101325. CrossRef - Effects of a hemagglutinin D222G substitution on the pathogenicity of 2009 influenza A (H1N1) virus in mice
Jin Il Kim, Ilseob Lee, Sehee Park, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Jin-Won Song, Man-Seong Park
Archives of Virology.2014; 159(10): 2559. CrossRef - The anti-influenza virus effect of Phellinus igniarius extract
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Journal of Microbiology.2013; 51(5): 676. CrossRef - Strategy for Developing Medical Arsenals by Modulation of Membrane Fusion Activity of Influenza Virus Hemagglutinin
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Journal of Bacteriology and Virology.2013; 43(4): 337. CrossRef
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