- Antiviral activity of Poncirus trifoliata seed extract against oseltamivirresistant influenza virus
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Yoonki Heo , Yeondong Cho , Kwon sung Ju , Hansam Cho , Ki Hoon Park , Hanul Choi , Jong Kwang Yoon , Chiung Moon , Young Bong Kim
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J. Microbiol. 2018;56(8):586-592. Published online July 25, 2018
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DOI: https://doi.org/10.1007/s12275-018-8222-0
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The emergence of oseltamivir-resistant variants of influenza
virus has highlighted the necessity for the development of
more effective novel antiviral drugs. To date, numerous researchers
have focused on developing antiviral drugs using
natural resources, such as traditional herbal medicines. Poncirus
trifoliata is widely used in oriental medicine as a remedy
for gastritis, dysentery, inflammation and digestive ulcers. In
this study, we investigated the potential antiviral effect of the
Poncirus trifoliata orange seed extract against influenza virus.
An ethanol extract of Poncirus trifoliata seeds (PTex) inhibited
the activity of influenza viruses, in particular, oseltamivir-
resistant strains, in Madin-Darby canine kidney cells. In
contrast to oseltamivir, PTex exerted a significant inhibitory
effect on the cellular penetration pathway of the virus rather
than HA receptor binding. The potent antiviral effect and novel
working mechanism of PTex support its further development
as an effective natural antiviral drug with a wide spectrum
of activity against influenza and oseltamivir-resistant
viruses.
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Citations
Citations to this article as recorded by  - A review-plant medicine and its extraction components inhibit influenza virus
Jiejie Lu, Zhenzhen Liu, Ziyan Li, Jiahui Su, Haojie Zhen, Ying Qu, Piet Herdewijn, Hongmin Liu, Ying Liu, Zhenya Wang
Bioorganic & Medicinal Chemistry Letters.2025; 120: 130151. CrossRef - A Comprehensive Study on Natural Products and their Bioactive Constituents
to Cure Respiratory Diseases
Avadh Biharee, Lokesh Chaudhari, Sudha Bhartiya, Shivam Kumar Kori, Anu Chaudhary, Dheeraj Dubey, Arpita Yadav
The Natural Products Journal.2024;[Epub] CrossRef - Seed extracts as an effective strategy in the control of plant pathogens: Scalable industry bioactive compounds for sustainable agriculture
Tamara Sánchez-Gómez, Óscar Santamaría, Jorge Martín-García, Jorge Poveda
Biocatalysis and Agricultural Biotechnology.2024; 60: 103332. CrossRef - Insights into identifying resistance genes for cold and disease stresses through chromosome-level reference genome analyses of Poncirus polyandra
Shanshan Zhang, Jian Chen, Chuanguang Zhang, Siqi Zhang, Xiaolei Zhang, Lanjing Gao, Wenzhong Yang
Genomics.2023; 115(3): 110617. CrossRef - Poncirus trifoliata (L.) Raf. Seed Extract Induces Cell Cycle Arrest and Apoptosis in the Androgen Receptor Positive LNCaP Prostate Cancer Cells
Francesca Giordano, Stefano Comità, Giulia Venneri, Vittoria Rago, Giuseppina Daniela Naimo, Francesca De Amicis, Anna De Bartolo, Rosa Tundis, Loredana Mauro, Maria Luisa Panno
International Journal of Molecular Sciences.2023; 24(22): 16351. CrossRef - Structural Bioinformatics Used to Predict the Protein Targets of
Remdesivir and Flavones in SARS-CoV-2 Infection
Avram Speranta, Laura Manoliu, Catalina Sogor, Maria Mernea, Corina Duda Seiman, Daniel Duda Seiman, Carmen Chifiriuc
Medicinal Chemistry.2022; 18(3): 382. CrossRef - Bioactive Chemical Constituents and Pharmacological Activities of Ponciri Fructus
Gopal Lamichhane, Jitendra Pandey, Hari Prasad Devkota
Molecules.2022; 28(1): 255. CrossRef - Plant-Based Natural Products and Extracts: Potential Source to Develop New Antiviral Drug Candidates
Eyana Thomas, Laura E. Stewart, Brien A. Darley, Ashley M. Pham, Isabella Esteban, Siva S. Panda
Molecules.2021; 26(20): 6197. CrossRef - COVID-19 Prophylaxis Efforts Based on Natural Antiviral Plant Extracts and Their Compounds
Oksana Sytar, Marian Brestic, Shokoofeh Hajihashemi, Milan Skalicky, Jan Kubeš, Laura Lamilla-Tamayo, Ulkar Ibrahimova, Sayyara Ibadullayeva, Marco Landi
Molecules.2021; 26(3): 727. CrossRef - KIF11 inhibition decreases cytopathogenesis and replication of influenza A virus
Dong-In Kim, Ji-Hun Kang, Eui-Ho Kim, Young-Jin Seo
Molecular & Cellular Toxicology.2021; 17(2): 201. CrossRef - Chios mastic gum inhibits influenza A virus replication and viral pathogenicity
Dong-In Kim, Yong-Bin Cho, Younghyun Lim, So-Hee Hong, Bumsuk Hahm, Sang-Myeong Lee, Se Chan Kang, Young-Jin Seo
Journal of General Virology
.2021;[Epub] CrossRef - Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection
Fang-Ju Cheng, Thanh-Kieu Huynh, Chia-Shin Yang, Dai-Wei Hu, Yi-Cheng Shen, Chih-Yen Tu, Yang-Chang Wu, Chih-Hsin Tang, Wei-Chien Huang, Yeh Chen, Chien-Yi Ho
Nutrients.2021; 13(8): 2800. CrossRef - Selective and ATP‐competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus
Yong‐Bin Cho, Sungguan Hong, Kyung‐Won Kang, Ji‐Hun Kang, Sang‐Myeong Lee, Young‐Jin Seo
Journal of Cellular and Molecular Medicine.2020; 24(10): 5463. CrossRef - Natural products against acute respiratory infections: Strategies and lessons learned
Julia Langeder, Ulrike Grienke, Ya Chen, Johannes Kirchmair, Michaela Schmidtke, Judith M. Rollinger
Journal of Ethnopharmacology.2020; 248: 112298. CrossRef - Retracted: Phytotherapeutic options for the treatment of COVID‐19: A concise viewpoint
Misbahud Din, Fawad Ali, Abdul Waris, Fatima Zia, Muhammad Ali
Phytotherapy Research.2020; 34(10): 2431. CrossRef - Chung Hun Wha Dam Tang attenuates atherosclerosis in apolipoprotein E-deficient mice via the NF-κB pathway
Yeonsoo Joe, Md Jamal Uddin, Jeongmin Park, Jinhyun Ryu, Gyeong Jae Cho, Jeong Woo Park, Hye-Seon Choi, Min Ho Cha, Stefan W. Ryter, Hun Taeg Chung
Biomedicine & Pharmacotherapy.2019; 120: 109524. CrossRef
- Therapeutic potential of an AcHERV-HPV L1 DNA vaccine
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Hee-Jung Lee , Jong Kwang Yoon , Yoonki Heo , Hansam Cho , Yeondong Cho , Yongdae Gwon , Kang Chang Kim , Jiwon Choi , Jae Sung Lee , Yu-Kyoung Oh , Young Bong Kim
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J. Microbiol. 2015;53(6):415-420. Published online May 30, 2015
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DOI: https://doi.org/10.1007/s12275-015-5150-0
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956
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0
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6
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Cervical cancer is strongly associated with chronic human
papillomavirus infections, among which HPV16 is the most
common. Two commercial HPV vaccines, Gardasil and
Cervarix are effective for preventing HPV infection, but cannot
be used to treat existing HPV infections. Previously, we
developed a human endogenous retrovirus (HERV)-enveloped
recombinant baculovirus capable of delivering the L1
genes of HPV types 16, 18, and 58 (AcHERV-HP16/18/58L1,
AcHERV-HPV). Intramuscular administration of AcHERVHPV
vaccines induced a strong cellular immune response
as well as a humoral immune response. In this study, to examine
the therapeutic effect of AcHERV-HPV in a mouse
model, we established an HPV16 L1 expressing tumor cell
line. Compared to Cervarix, immunization with AcHERVHPV
greatly enhanced HPV16 L1-specific cytotoxic T lymphocytes
(CTL) in C57BL/6 mice. Although vaccination
could not remove preexisting tumors, strong CTL activity
retarded the growth of inoculated tumor cells. These results
indicate that AcHERV-HPV could serve as a potential therapeutic
DNA vaccine against concurrent infection with HPV
16, 18, and 58.
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Citations
Citations to this article as recorded by - Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia
Chichao Xia, Sile Li, Teng Long, Zigui Chen, Paul K. S. Chan, Siaw Shi Boon
Cancers.2021; 13(11): 2691. CrossRef - In Silico Design and Immunological Studies of Two Novel Multiepitope DNA-Based Vaccine Candidates Against High-Risk Human Papillomaviruses
Matin Kayyal, Azam Bolhassani, Zahra Noormohammadi, Majid Sadeghizadeh
Molecular Biotechnology.2021; 63(12): 1192. CrossRef - Unraveling the Genome-Wide Impact of Recombinant Baculovirus Infection in Mammalian Cells for Gene Delivery
Ha Youn Shin, Hanul Choi, Nahyun Kim, Nayoung Park, Heesun Kim, Jaebum Kim, Young Bong Kim
Genes.2020; 11(11): 1306. CrossRef - Treatment with Radix Euphorbiae Ebracteolatae Significantly Decreases the Expression of E6 and L1, and Increases the Expression of p53 and Rb in HPV18-infected Human Foreskin Keratinocytes
Xiang He, Xufeng He, Ping Xu, Lili Yang, Xin Ma, Wen Li, Huimin Zhang
Current Molecular Medicine.2019; 19(1): 20. CrossRef - Trial watch: DNA-based vaccines for oncological indications
Stefano Pierini, Renzo Perales-Linares, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvogel, Guido Kroemer, Andrea Facciabene, Lorenzo Galluzzi
OncoImmunology.2017; 6(12): e1398878. CrossRef - Broad-spectrum antiviral properties of andrographolide
Swati Gupta, K. P. Mishra, Lilly Ganju
Archives of Virology.2017; 162(3): 611. CrossRef
- Identification of Porcine Endogenous Retrovirus (PERV) packaging sequence and development of PERV packaging viral vector system
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Jiwon Choi , Hoon-mi Kim , Jong Kwang Yoon , Yeondong Cho , Hee-Jung Lee , Kang Chang Kim , Chang-Kyu Kim , Gye-Woong Kim , Young Bong Kim
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J. Microbiol. 2015;53(5):348-353. Published online May 3, 2015
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DOI: https://doi.org/10.1007/s12275-015-5134-0
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940
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2
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Abstract
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Studies of the retroviruses have focused on the specific interaction
of the nucleocapsid protein with a packaging signal
in the viral RNA as important for this selectivity, but the
packaging signal in porcine endogenous retrovirus (PERV)
has not been defined. Herein, we identified and analyzed
this packaging signal in PERV and found hairpin structures
with conserved tetranucleotides in their loops and nucleocapsid
recognition sequences; both of which are key elements
in the viral packaging signal of MLV. We evaluated packaging
efficiency of sequence variants isolated from viral and
proviral integrated genomes. All viral packaging sequences
(Ψ) were identical, while five distinct packaging sequences
were identified from proviral sources. One proviral sequence
(Ψ1) was identical to that of the viral Ψ and had the highest
packaging efficiency. Three variants (Ψ2, Ψ3, Ψ4) maintained
key elements of the viral packaging signal, but had nucleotide
replacements and consequently demonstrated reduced
packaging efficiency. Despite of the same overall hairpin
structure, the proviral variant (Ψ5) had only one GACG sequence
in the hairpin loop and showed the lowest packaging
efficiency other than ΔΨ, in which the essential packaging
sequence was removed. This result, thus, defined the
packaging sequences in PERV and emphasized the importance
of nucleotide sequence and RNA structure in the determination
of packaging efficiency. In addition, we demonstrate
efficient infection and gene expression from the PERVbased
viral vector, which may serve as a novel alternative to
current retroviral expression systems.
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Citations
Citations to this article as recorded by - Characterization of porcine endogenous retrovirus insertion in Jeju native pigs and commercial breeds
Seungwon Yoon, Mrinmoy Ghosh, Myeongyeon Shin, Hyunyong Choi, Cheol-Ho Hyun, Dae Cheol Kim, Shin Ji Lee, Min Jee An, Young-Ok Son, Chang-Gi Hur
Animal Bioscience.2025; 38(12): 2741. CrossRef - Porcine Endogenous Retrovirus (PERV) – Molecular Structure and Replication Strategy in the Context of Retroviral Infection Risk of Human Cells
Krzysztof Łopata, Emilia Wojdas, Roman Nowak, Paweł Łopata, Urszula Mazurek
Frontiers in Microbiology.2018;[Epub] CrossRef
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