- T cell responses to SARS-CoV-2 in humans and animals
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Sameer-ul-Salam Mattoo , Jinjong Myoung
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J. Microbiol. 2022;60(3):276-289. Published online February 14, 2022
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DOI: https://doi.org/10.1007/s12275-022-1624-z
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SARS-CoV-2, the causative agent of COVID-19, first emerged
in 2019. Antibody responses against SARS-CoV-2 have been
given a lot of attention. However, the armamentarium of humoral
and T cells may have differing roles in different viral
infections. Though the exact role of T cells in COVID-19 remains
to be elucidated, prior experience with human coronavirus
has revealed an essential role of T cells in the outcomes
of viral infections. Moreover, an increasing body of evidence
suggests that T cells might be effective against SARS-CoV-2.
This review summarizes the role of T cells in mouse CoV,
human pathogenic respiratory CoV in general and SARSCoV-
2 in specific.
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Citations
Citations to this article as recorded by  - Vaccine Strategies Against RNA Viruses: Current Advances and Future Directions
Kuei-Ching Hsiung, Huan-Jung Chiang, Sebastian Reinig, Shin-Ru Shih
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Ratchanon Sophonmanee, Perawas Preampruchcha, Jomkwan Ongarj, Bunya Seeyankem, Porntip Intapiboon, Smonrapat Surasombatpattana, Supattra Uppanisakorn, Pasuree Sangsupawanich, Sarunyou Chusri, Nawamin Pinpathomrat
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Hongmei Deng, Yinpeng Jin, Minmin Sheng, Min Liu, Jie Shen, Wei Qian, Gang Zou, Yixin Liao, Tiefu Liu, Yun Ling, Xiaohong Fan
Frontiers in Immunology.2024;[Epub] CrossRef - Differential Impact of Spike Protein Mutations on SARS-CoV-2 Infectivity and Immune Evasion: Insights from Delta and Kappa Variants
Tae-Hun Kim, Sojung Bae, Jinjong Myoung
Journal of Microbiology and Biotechnology.2024; 34(12): 2506. CrossRef - Animal models for COVID-19 and tuberculosis
Björn Corleis, Max Bastian, Donata Hoffmann, Martin Beer, Anca Dorhoi
Frontiers in Immunology.2023;[Epub] CrossRef - A mathematical model and simulation scenarios for T and B cells immune response to severe acute respiratory syndrome-coronavirus-2
L Cuesta-Herrera, F Córdova-Lepe, L Pastenes, A D Arencibia, Y Baldera-Moreno, H A Torres-Mantilla
Journal of Physics: Conference Series.2023; 2516(1): 012007. CrossRef - Distinctive Combinations of RBD Mutations Contribute to Antibody Evasion in the Case of the SARS-CoV-2 Beta Variant
Tae-Hun Kim, Sojung Bae, Sunggeun Goo, Jinjong Myoung
Journal of Microbiology and Biotechnology.2023; 33(12): 1587. CrossRef - Two years of COVID-19 pandemic: where are we now?
Jinjong Myoung
Journal of Microbiology.2022; 60(3): 235. CrossRef - Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a Coin
Sameer-ul-Salam Mattoo, Seong-Jun Kim, Dae-Gyun Ahn, Jinjong Myoung
Viruses.2022; 14(3): 530. CrossRef - Development of a T Cell-Based COVID-19 Vaccine Using a Live Attenuated Influenza Vaccine Viral Vector
Irina Isakova-Sivak, Ekaterina Stepanova, Victoria Matyushenko, Sergei Niskanen, Daria Mezhenskaya, Ekaterina Bazhenova, Elena Krutikova, Tatiana Kotomina, Polina Prokopenko, Bogdan Neterebskii, Aleksandr Doronin, Elena Vinogradova, Kirill Yakovlev, Konst
Vaccines.2022; 10(7): 1142. CrossRef
- [SPECIAL ISSUE]Two years of COVID-19 pandemic: where are we now?
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Jinjong Myoung
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J. Microbiol. 2022;60(3):235-237.
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DOI: https://doi.org/10.1007/s12275-022-1679-x
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431
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Citations
Citations to this article as recorded by - Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2
Sojung Bae, Jinjong Myoung
Journal of Microbiology.2025; 63(7): e2504015. CrossRef - Real-time infectious disease endurance indicator system for scientific decisions using machine learning and rapid data processing
Shivendra Dubey, Dinesh Kumar Verma, Mahesh Kumar
PeerJ Computer Science.2024; 10: e2062. CrossRef - Differential Impact of Spike Protein Mutations on SARS-CoV-2 Infectivity and Immune Evasion: Insights from Delta and Kappa Variants
Tae-Hun Kim, Sojung Bae, Jinjong Myoung
Journal of Microbiology and Biotechnology.2024; 34(12): 2506. CrossRef - Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications
Isa Seida, Mahmoud Alrais, Ravend Seida, Abdulkarim Alwani, Zeynep Kiyak, Abdulrahman Elsalti, Sevval Nil Esirgun, Tunahan Abali, Naim Mahroum
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Tae-Hun Kim, Sojung Bae, Sunggeun Goo, Jinjong Myoung
Journal of Microbiology and Biotechnology.2023; 33(12): 1587. CrossRef - Paxlovid for Treating COVID-19 Patients: A Case-Control Study From Two Hospitals in the Eastern Province of Saudi Arabia
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- Methyltransferase of a cell culture-adapted hepatitis E inhibits the MDA5 receptor signaling pathway
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Jinjong Myoung , Jeong Yoon Lee , Kang Sang Min
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J. Microbiol. 2019;57(12):1126-1131. Published online November 22, 2019
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DOI: https://doi.org/10.1007/s12275-019-9478-8
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Hepatitis E virus (HEV) is a causative agent of acute hepatitis
and jaundice. The number of human infections is approximated
to be over 20 million cases per year. The transmission
is mainly via the fecal-oral route and contaminated water and
food are considered to be a major source of infection. As a
mouse model is not available, a recent development of a cell
culture-adapted HEV strain (47832c) is considered as a very
important tools for molecular analysis of HEV pathogenesis
in cells. Previously, we demonstrated that HEV-encoded methyltransferase
(MeT) encoded by the 47832c strain inhibits
MDA5- and RIG-I-mediated activation of interferon β (IFN-β)
promoter. Here, we report that MeT impairs the phosphorylation
and activation of interferon regulatory factor 3 and the
p65 subunit of NF-κB in a dose-dependent manner. In addition,
the MeT encoded by the 47832c, but not that of HEV
clinical or field isolates (SAR-55, Mex-14, KC-1, and ZJ-1),
displays the inhibitory effect. A deeper understanding of MeTmediated
suppression of IFN-β expression would provide
basis of the cell culture adaptation of HEV.
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Citations
Citations to this article as recorded by - Viral Hepatitis: Host Immune Interaction, Pathogenesis and New Therapeutic Strategies
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Frontiers in Microbiology.2021;[Epub] CrossRef - A Promising Vaccination Strategy against COVID-19 on the Horizon: Heterologous Immunization
Sameer-ul-Salam Mattoo, Jinjong Myoung
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Sojung Bae, Jeong Yoon Lee, Jinjong Myoung
Journal of Microbiology and Biotechnology.2020; 30(12): 1801. CrossRef - Zika Virus-Encoded NS2A and NS4A Strongly Downregulate NF-κB Promoter Activity
Jeong Yoon Lee, Thi Thuy Ngan Nguyen, Jinjong Myoung
Journal of Microbiology and Biotechnology.2020; 30(11): 1651. CrossRef
- Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine design
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Jeong Yoon Lee , Sojung Bae , Jinjong Myoung
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J. Microbiol. 2019;57(9):803-811. Published online August 27, 2019
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DOI: https://doi.org/10.1007/s12275-019-9272-7
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Middle East respiratory syndrome coronavirus (MERS-CoV)
is a causative agent of severe-to-fatal pneumonia especially
in patients with pre-existing conditions, such as smoking and
chronic obstructive pulmonary disease (COPD). MERS-CoV
transmission continues to be reported in the Saudi Arabian
Peninsula since its discovery in 2012. However, it has rarely
been epidemic outside the area except one large outbreak
in South Korea in May 2015. The genome of the epidemic
MERS-CoV isolated from a Korean patient revealed its homology
to previously reported strains. MERS-CoV encodes
5 accessory proteins and generally, they do not participate
in the genome transcription and replication but rather are involved
in viral evasion of the host innate immune responses.
Here we report that ORF8b, an accessory protein of MERSCoV,
strongly inhibits both MDA5- and RIG-I-mediated activation
of interferon beta promoter activity while downstream
signaling molecules were left largely unaffected. Of
note, MDA5 protein levels were significantly down-regulated
by ORF8b and co-expression of ORF4a and ORF4b. These
novel findings will facilitate elucidation of mechanisms of
virus-encoded evasion strategies, thus helping design rationale
antiviral countermeasures against deadly MERS-CoV
infection.
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- [Minireview] Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
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Sangmin Kang , Jinjong Myoung
-
J. Microbiol. 2017;55(5):319-329. Published online April 29, 2017
-
DOI: https://doi.org/10.1007/s12275-017-7075-2
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339
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Abstract
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Kaposi’s sarcoma-associated herpesvirus (KSHV) is the latest addition to the human herpesvirus family. Unlike alpha- and beta-herpesvirus subfamily members, gamma-herpesviruses, including Epstein-Barr virus (EBV) and KSHV, cause vari-ous tumors in humans. KSHV primarily infects endothelial and B cells in vivo, and is associated with at least three malig-nancies: Kaposi’s sarcoma and two B cell lymphomas, res-pectively. Although KSHV readily infects endothelial cells in vitro and thus its pathogenic mechanisms have been exten-sively studied, B cells had been refractory to KSHV infection. As such, functions of KSHV genes have mostly been eluci-dated in endothelial cells in the context of viral infection but not in B cells. Whether KSHV oncogenes, defined in endo-thelial cells, play the same roles in the tumorigenesis of B cells remains an open question. Only recently, through a few ground-breaking studies, B cell infection models have been established. In this review, those models will be compared and contrasted and putative mechanisms of KSHV-induced B cell transformation will be discussed.
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Citations
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Journal of Microbiology.2019; 57(9): 803. CrossRef - Methyltransferase of a cell culture-adapted hepatitis E inhibits the MDA5 receptor signaling pathway
Jinjong Myoung, Jeong Yoon Lee, Kang Sang Min
Journal of Microbiology.2019; 57(12): 1126. CrossRef - Cell Type-Specific Interferon-γ-mediated Antagonism of KSHV Lytic Replication
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herpesvirus pathogenesis
Lu Dai, Zhen Lin, Wei Jiang, Erik K. Flemington, Zhiqiang Qin
Virologica Sinica.2017; 32(5): 369. CrossRef - The Roles of Matricellular Proteins in Oncogenic Virus-Induced Cancers and Their Potential Utilities as Therapeutic Targets
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International Journal of Molecular Sciences.2017; 18(10): 2198. CrossRef
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