- Helicobacter pylori outer membrane protein, HomC, shows geographic dependent polymorphism that is influenced by the Bab family
-
Aeryun Kim , Stephanie L. Servetas , Jieun Kang , Jinmoon Kim , Sungil Jang , Yun Hui Choi , Hanfu Su , Yeong-Eui Jeon , Youngmin A. Hong , Yun-Jung Yoo , D. Scott Merrell , Jeong-Heon Cha
-
J. Microbiol. 2016;54(12):846-852. Published online November 26, 2016
-
DOI: https://doi.org/10.1007/s12275-016-6434-8
-
-
1,010
View
-
0
Download
-
10
Crossref
-
 Abstract
 PDF
-
The array of outer membrane proteins (OMPs) found in
Helicobacter pylori provides a crucial component for persistent
colonization within the gastric niche. Not only does
H. pylori harbor a wide number of OMPs, but these OMPs
often vary across strains; this likely contributes to immune
evasion, adaptation during long term colonization, and potentially
differential disease progression. Previous work from
our group described OMP differences among the Bab family
(babA, babB, and babC) and Hom family (homA and homB)
from 80 American H. pylori clinical isolates (AH) and 80
South Korean H. pylori clinical isolates (KH). In the current
study, we expanded our investigation to include the less well
characterized Hom family member, HomC.
Overall, we identified and genotyped three homC variants:
homCS, homCL, and homCM, in both populations. Similar to
other polymorphic genes, the KH group showed less overall
diversity, with 97.5% of strains harboring homCL. In contrast,
a more heterogeneous profile was observed in strains
derived from an American population; we found nearly equal
distribution of homCS and homCL. Further analysis of the AH
group identified associations between homC polymorphism
and bab genotype; in AH strains, there was a significant association
between homCL and carriage of babA at locus A.
Since babA is an important virulence factor for the development
of severe gastric disease, these data may suggest that
homC polymorphism plays a role in H. pylori pathogenesis.
-
Citations
Citations to this article as recorded by  -
A unique
Helicobacter pylori
strain to study gastric cancer development
Jeannette M. Whitmire, Ian H. Windham, Morris O. Makobongo, Mandy D. Westland, Sirena C. Tran, Jaume Piñol, Yvonne Hui, Rasha Raheem Alkarkoushi, Oscar Q. Pich, David J. McGee, M. Blanca Piazuelo, Angela Melton-Celsa, Traci L. Testerman, Timothy L. Cover,
Microbiology Spectrum.2025;[Epub] CrossRef - Helicobacter pylori outer membrane protein families and related pathogenesis
Senlin You, Jiao Li, Eng Guan Chua, Alfred Tay, Mohammed Benghezal, Barry Marshall, Hong Tang, Hong Li
Microbial Pathogenesis.2025; 206: 107740. CrossRef - Infiltration to infection: key virulence players of Helicobacter pylori pathogenicity
Arghyadeep Bhattacharjee, Om Saswat Sahoo, Ahana Sarkar, Saurabh Bhattacharya, Rukhsana Chowdhury, Samarjit Kar, Oindrilla Mukherjee
Infection.2024; 52(2): 345. CrossRef - (Re)-definition of the holo- and apo-Fur direct regulons of Helicobacter pylori
Andrea Vannini, Eva Pinatel, Paolo Emidio Costantini, Simone Pelliciari, Davide Roncarati, Simone Puccio, Gianluca De Bellis, Vincenzo Scarlato, Clelia Peano, Alberto Danielli
Journal of Molecular Biology.2024; 436(10): 168573. CrossRef - Biofilm of Helicobacter pylori: Life Cycle, Features, and Treatment Options
Yasmine Elshenawi, Shuai Hu, Skander Hathroubi
Antibiotics.2023; 12(8): 1260. CrossRef -
Recent Progress in Biomarker-Based Diagnostics of
Helicobacter pylori
, Gastric Cancer-Causing Bacteria
Kirti Saxena, Akanksha Deshwal, Ramesh Namdeo Pudake, Utkarsh Jain, Ravi Mani Tripathi
Biomarkers in Medicine.2023; 17(16): 679. CrossRef -
Genomic diversity of
Helicobacter pylori
populations from different regions of the human stomach
Daniel James Wilkinson, Benjamin Dickins, Karen Robinson, Jody Anne Winter
Gut Microbes.2022;[Epub] CrossRef - Geographic diversity in Helicobacter pylori oipA genotype between Korean and United States isolates
Aeryun Kim, Jing Lai, D. Scott Merrell, Ji-Hye Kim, Hanfu Su, Jeong-Heon Cha
Journal of Microbiology.2021; 59(12): 1125. CrossRef - Virulence of Helicobacter pylori outer membrane proteins: an updated review
Chenjing Xu, Djaleel Muhammad Soyfoo, Yao Wu, Shunfu Xu
European Journal of Clinical Microbiology & Infectious Diseases.2020; 39(10): 1821. CrossRef - Comparative analysis of the Hom family of outer membrane proteins in isolates from two geographically distinct regions: The United States and South Korea
Stephanie L. Servetas, Aeryun Kim, Hanfu Su, Jeong‐Heon Cha, D. Scott Merrell
Helicobacter.2018;[Epub] CrossRef
|
MSK
