- Pneumococcal wall teichoic acid is required for the pathogenesis of Streptococcus pneumoniae in murine models
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Hongmei Xu , Libin Wang , Jian Huang , Yanqing Zhang , Feng Ma , Jianmin Wang , Wenchun Xu , Xuemei Zhang , Yibing Yin , Kaifeng Wu
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J. Microbiol. 2015;53(2):147-154. Published online January 28, 2015
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DOI: https://doi.org/10.1007/s12275-015-4616-4
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 Abstract
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Pneumococcal asymptomatic colonization of the respiratory
tracts is a major risk for invasive pneumococcal disease.
We have previously shown that pneumococcal wall teichoic
acid (WTA) was involved in pneumococcal infection of sepsis
and adherence to epithelial and endothelial cells. In this
study, we investigated the contribution of pneumococcal
WTA to bacterial colonization and dissemination in murine
models. The result showed that nasopharynx colonizing D39
bacterial cells have a distinct phenotype showing an increased
exposure of teichoic acids relative to medium-grown bacteria.
The WTA-deficient mutants were impaired in their colonization
to the nasopharynx and lungs, and led to a mild inflammation
in the lungs at 36 h post-inoculation. Pretreatment
of the murine nares with WTA reduced the ability of
wild type D39 bacteria to colonize the nasopharynx. In addition,
the WTA-deficient strain was impaired in its ability
to invade the blood and brain following intranasal administration.
WTA-deficient D39 strain was reduced in C3 deposition
but was more susceptible to the killing by the neutrophils
as compared with its parent strain. Our results also
demonstrated that the WTA enhanced pneumococcal colonization
and dissemination independently of the host strains.
These results indicate that WTA plays an important role in
pneumococcal pathogenesis, both in colonization and dissemination
processes.
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Citations
Citations to this article as recorded by  - Insight into the structure, biosynthesis, isolation method and biological function of teichoic acid in different gram-positive microorganisms: A review
Jiarun Han, Xin Zhao, Xilian Zhao, Ping Li, Qing Gu
International Journal of Biological Macromolecules.2023; 253: 126825. CrossRef - spd1672, a novel in vivo-induced gene, affects inflammatory response in a murine model of Streptococcus pneumoniae infection
Lingling Gan, Xuemei Zhang, Xiuyu Xu, Wenchun Xu, Chang Lu, Jin Cui, Hong Wang
Canadian Journal of Microbiology.2018; 64(6): 401. CrossRef - Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
Nathalie Heß, Franziska Waldow, Thomas P. Kohler, Manfred Rohde, Bernd Kreikemeyer, Alejandro Gómez-Mejia, Torsten Hain, Dominik Schwudke, Waldemar Vollmer, Sven Hammerschmidt, Nicolas Gisch
Nature Communications.2017;[Epub] CrossRef - New chemical tools to probe cell wall biosynthesis in bacteria
Robert T Gale, Eric D Brown
Current Opinion in Microbiology.2015; 27: 69. CrossRef
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