- Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish against its Infection
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Santosh Pushpa Ramya Ranjan Nayak , Catharine Basty , Seenivasan Boopathi , Loganathan Sumathi Dhivya , Khaloud Mohammed Alarjani , Mohamed Ragab Abdel Gawwad , Raghda Hager , Muthu Kumaradoss Kathiravan , Jesu Arockiaraj
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J. Microbiol. 2024;62(2):75-89. Published online February 21, 2024
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DOI: https://doi.org/10.1007/s12275-024-00103-6
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The emergence of carbapenem-resistant Pseudomonas aeruginosa, a multi-drug-resistant bacteria, is becoming a serious
public health concern. This bacterium infects immunocompromised patients and has a high fatality rate. Both naturally and
synthetically produced chalcones are known to have a wide array of biological activities. The antibacterial properties of
synthetically produced chalcone were studied against P. aeruginosa. In vitro, study of the compound (chalcone derivative
named DKO1), also known as (2E)-1-(5-methylfuran-2-yl)-3-(4-nitrophenyl) prop-2-en-1-one, had substantial antibacterial
and biofilm disruptive action. DKO1 effectively shielded against P. aeruginosa-induced inflammation, oxidative stress, lipid
peroxidation, and apoptosis in zebrafish larvae. In adult zebrafish, the treatment enhanced the chances of survivability and
reduced the sickness-like behaviors. Gene expression, biochemical analysis, and histopathology studies found that proinflammatory
cytokines (TNF-α, IL-1β, IL-6, iNOS) were down regulated; antioxidant enzymes such as superoxide dismutase
(SOD) and catalase (CAT) levels increased, and histoarchitecture was restored in zebrafish. The data indicate that DKO1 is
an effective antibacterial agent against P. aeruginosa demonstrated both in vitro and in vivo.
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Citations
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S. Madesh, Mukil Srivasan, Karthikeyan Ramamurthy, Sanjay Gopi, B. Aswinanand, Santhanam Sanjai Dharshan, Bader O. Almutairi, Ki Choon Choi, Jesu Arockiaraj
Journal of Hazardous Materials.2026; 501: 140692. CrossRef - A multifunctional benzaimidazole-based quorum-sensing inhibitor and silver nanoparticle-loaded chitosan hydrogel for enhanced healing of MDR Pseudomonas aeruginosa infected wounds
S.P. Ramya Ranjan Nayak, Gokul Karthikeyan, Chitra V, Senthilkumar Palaniappan, Ponmurugan Karuppiah, Balamuralikrishnan Balasubramanian, Mariadhas Valan Arasu, Kathiravan Muthu Kumaradoss, Jesu Arockiaraj
Journal of Drug Delivery Science and Technology.2026; 125: 108702. CrossRef - Chalcone derivative enhance poultry meat preservation through quorum sensing inhibition against Salmonella (Salmonella enterica serovar Typhi) contamination
S.P. Ramya Ranjan Nayak, Pratik Pohokar, Anamika Das, L.S. Dhivya, Mukesh Pasupuleti, Ilavenil Soundharrajan, Bader O. Almutairi, Kathiravan Muthu Kumaradoss, Jesu Arockiaraj
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Current Microbiology.2025;[Epub] CrossRef - Targeted inhibition of PqsR in Pseudomonas aeruginosa PAO1 quorum-sensing network by chalcones as promising antibacterial compounds
Negin Arami, Amineh Sadat Tajani, Maryam Hashemi, Tahoura Rezaei, Razieh Ghodsi, Vahid Soheili, Bibi Sedigheh Fazly Bazzaz
Molecular Biology Reports.2025;[Epub] CrossRef - Exposure to bisphenol A and sodium nitrate found in processed meat induces endocrine disruption and dyslipidemia through PI3K/AKT/SREBP pathway in zebrafish larvae
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The Journal of Nutritional Biochemistry.2025; 140: 109887. CrossRef - Starch films with triethanolamine and chalcone derivative for improved durability and antimicrobial properties in poultry packaging
S.P. Ramya Ranjan Nayak, Pratik Pohokar, L.S. Dhivya, Aveeda Herold, V. Chitra, Mansour K. Gatasheh, Selvaraj Arokiyaraj, Kathiravan Muthu Kumaradoss, Jesu Arockiaraj
International Journal of Biological Macromolecules.2025; 316: 144627. CrossRef - Efficacy of 6-nitrobenzo[d]thiazol-2 Amine Derivative (N3) in Mitigating PTZ-Induced Epileptic Conditions Via Modulation of Inflammatory and Neuroprotective Pathways in-vivo Zebrafish
Karthikeyan Ramamurthy, S. P. Ramya Ranjan Nayak, S. Madesh, Siva Prasad Panda, K. Manikandan, Rajakrishnan Rajagopal, Ahmed Alfarhan, Senthilkumar Palaniappan, Ajay Guru, M. K. Kathiravan, Jesu Arockiaraj
Journal of Neuroimmune Pharmacology.2025;[Epub] CrossRef - Testing of Anti-EMT, Anti-Inflammatory and Antibacterial Activities of 2′,4′-Dimethoxychalcone
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Pharmaceuticals.2024; 17(5): 653. CrossRef - Furan-based chalcone protects β-cell damage and improves glucose uptake in alloxan-induced zebrafish diabetic model via influencing Peroxisome Proliferator-Activated Receptor agonists (PPAR-γ) signaling
S.P. Ramya Ranjan Nayak, B. Haridevamuthu, Raghul Murugan, L.S. Dhivya, S. Venkatesan, Mikhlid H. Almutairi, Bader O. Almutairi, M.K. Kathiravan, S. Karthick Raja Namasivayam, Jesu Arockiaraj
Process Biochemistry.2024; 142: 149. CrossRef - Protective role of 2-aminothiazole derivative against ethanol-induced teratogenic effects in-vivo zebrafish
S. Madesh, Gokul Sudhakaran, Karthikeyan Ramamurthy, Avra Sau, Kathiravan Muthu Kumaradoss, Mikhlid H. Almutairi, Bader O. Almutairi, Senthilkumar Palaniappan, Jesu Arockiaraj
Biochemical Pharmacology.2024; 230: 116601. CrossRef - Tissue damage alleviation and mucin inhibition by P5 in a respiratory infection mouse model with multidrug-resistant Acinetobacter baumannii
Jun Hee Oh, Jonggwan Park, Hee Kyoung Kang, Hee Joo Park, Yoonkyung Park
Biomedicine & Pharmacotherapy.2024; 181: 117724. CrossRef - Toxicity and therapeutic property of dioxopiperidin derivative SKT40 demonstrated in-vivo zebrafish model due to inflammatory bowel disease
B. Aswinanand, S.P. Ramya Ranjan Nayak, S. Madesh, Suthi Subbarayudu, S. Kaliraj, Rajakrishnan Rajagopal, Ahmed Alfarhan, Muthu Kumaradoss Kathiravan, Jesu Arockiaraj
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology.2024; 284: 109990. CrossRef
- Antimicrobial Efficacy of Allium cepa and Zingiber officinale Against the Milk‑Borne Pathogen Listeria monocytogenes
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Abirami Arasu , Nagaram Prabha , Durga Devi , Praveen Kumar Issac , Khaloud Mohammed Alarjani , Dunia A. Al Farraj , Reem A. Aljeidi , Dina S. Hussein , Magesh Mohan , Jehad Zuhair Tayyeb , Ajay Guru , Jesu Arockiaraj
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J. Microbiol. 2023;61(11):993-1011. Published online December 4, 2023
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DOI: https://doi.org/10.1007/s12275-023-00086-w
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Listeria monocytogenes is an important food-borne pathogen that causes listeriosis and has a high case fatality rate despite
its low incidence. Medicinal plants and their secondary metabolites have been identified as potential antibacterial substances,
serving as replacements for synthetic chemical compounds. The present studies emphasize two significant medicinal plants,
Allium cepa and Zingiber officinale, and their efficacy against L. monocytogenes. Firstly, a bacterial isolate was obtained
from milk and identified through morphology and biochemical reactions. The species of the isolate were further confirmed
through 16S rRNA analysis. Furthermore, polar solvents such as methanol and ethanol were used for the extraction of secondary
metabolites from A. cepa and Z. officinale. Crude phytochemical components were identified using phytochemical
tests, FTIR, and GC–MS. Moreover, the antibacterial activity of the crude extract and its various concentrations were tested
against L. monocytogenes. Among all, A. cepa in methanolic extracts showed significant inhibitory activity. Since, the A.
cepa for methanolic crude extract was used to perform autography to assess its bactericidal activity. Subsequently, molecular
docking was performed to determine the specific compound inhibition. The docking results revealed that four compounds
displayed strong binding affinity with the virulence factor Listeriolysin-O of L. monocytogenes. Based on the above results,
it can be concluded that the medicinal plant A. cepa has potential antibacterial effects against L. monocytogenes, particularly
targeting its virulence.
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Citations
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Amin Abbasi, Hadi Pourjafar, Mahdi Asghari Ozma, Mansoureh Taghizadeh, Hedayat Hosseini
Letters in Applied Microbiology.2025;[Epub] CrossRef - Cultural Perspectives on the Sustainable Use and Added Value of Plant-Based Food Dyes—A Case Study from Bulgaria
Mihail Chervenkov, Teodora Ivanova, Yulia Bosseva, Dessislava Dimitrova
Sustainability.2024; 16(20): 9049. CrossRef
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