Journal of Microbiology

Jayanta Kumar Patra

1 Article

Cure of tuberculosis using nanotechnology: An overview: Rout George Kerry , Sushanto Gouda , Bikram Sil , Gitishree Das , Han-Seung Shin , Gajanan Ghodake , Jayanta Kumar Patra; J. Microbiol. 2018;56(5):287-299. Published online May 2, 2018; DOI: https://doi.org/10.1007/s12275-018-7414-y

955 View
1 Download
13 Crossref

Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), a major health issue of the present era. The bacterium inhabits the host macrophage and other immune cells where it modulates the lysosome trafficking protein, hinders the formation of phagolysosome, and blocks the TNF receptor- dependent apoptosis of host macrophage/monocytes. Other limitations such as resistance to and low bioavailability and bio-distribution of conventional drugs aid to their high virulence and human mortality. This review highlights the use of nanotechnology-based approaches for drug formulation and delivery which could open new avenues to limit the pathogenicity of tuberculosis. Moreover phytochemicals, such as alkaloids, phenols, saponins, steroids, tannins, and terpenoids, extracted from terrestrial plants and mangroves seem promising against M. tuberculosis through different molecular mechanisms. Further understanding of the genomics and proteomics of this pathogenic microbe could also help overcome various research gaps in the path of developing a suitable therapy against tuberculosis.

Citations

Citations to this article as recorded by

Advancement of functional peptides: Promising candidates for antituberculosis therapeutics
Bojie Lin, Siqi Lin, Jiayi Yang, Xuanyu Yang, Shuhui Wang, Yuting Liu, Qianqian Zhang, Junfa Xu, Jiang Pi, Fen Yang
Science of Traditional Chinese Medicine.2026; 4(1): 24. CrossRef
Advances in nanomaterials-assisted drug delivery, diagnosis, and action towards drug-resistant Mycobacterium
Parikshana Mathur, Pinky Choudhary, Rajkuberan Chandrasekaran, Ragini Singh, Hemant Kumar Daima
Progress in Biophysics and Molecular Biology.2026; 199: 1. CrossRef
Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Ma
Medicinal Research Reviews.2026;[Epub] CrossRef
Nanomedicine-based drug delivery systems for tuberculosis: Overcoming resistance, dormancy, and translational barriers
Prashant Kumar Tiwari, Deepti Verma, Shivani, Manvi Singh, Divya Kushwaha, Ambuj Kumar Kushwaha
Next Nanotechnology.2026; 10: 100642. CrossRef
Mechanisms of Antibiotic Resistance and Novel Therapeutic Approaches for Mycobacterium tuberculosis: A Narrative Review With a Focus on Tuberculosis Mutations in Iran
Ali Bayat Bodaghi, Aref Shariati, Jebreil Shamseddin, Amir Bayat Bodaghi, Mina Rezaei, Abbas Farahani
Health Science Reports.2025;[Epub] CrossRef
Multi-purpose prototypes for extrapulmonary Mycobacterium tuberculosis targeting: A regenerative medicine perspective
Mashudu T. Mphaphuli, Mduduzi N. Sithole, Pradeep Kumar, Pierre P.D. Kondiah, Mostafa Mabrouk, Yahya E. Choonara
Journal of Drug Delivery Science and Technology.2023; 89: 105039. CrossRef
Clay minerals-based drug delivery systems for anti-tuberculosis drugs
Saeida Saadat, Deepak Rawtani, Garvita Parikh
Journal of Drug Delivery Science and Technology.2022; 76: 103755. CrossRef
A Systematic Review on Antituberculosis Drug Discovery and Antimycobacterial Potential of Biologically Synthesized Silver Nanoparticles: Overview and Future Perspectives
Christian K. Ezeh, Chibuzor N. Eze, Uju M. E. Dibua, Stephen C. Emencheta
Infectious Microbes and Diseases.2022; 4(4): 139. CrossRef
Treatment of Tuberculosis in Nano Era: Recent Avenues
Ritu Rathi, Manju Nagpal, Malkiet Kaur, Priyansh Ballouria, Redhima Dutta, Geeta Aggarwal, Sandeep Arora
Current Bioactive Compounds.2022;[Epub] CrossRef
Detection of Mycobacterium Tuberculosis by Magnetic Nanoparticle Capture-Polymerase Chain Reaction
Zhanying Li, Lei Zhao, Lili Diao, Pei Wang, Conglu Che, Yanqing Tian, Xiuzheng Wang
Science of Advanced Materials.2021; 13(11): 2116. CrossRef
Inhalable linezolid loaded PLGA nanoparticles for treatment of tuberculosis: Design, development and in vitro evaluation
Sunny Shah, Dhanya Cristopher, Shweta Sharma, Moinuddin Soniwala, Jayant Chavda
Journal of Drug Delivery Science and Technology.2020; 60: 102013. CrossRef
Enhancement of cell proliferation and motility of mammalian cells grown in co-culture with Pichia pastoris expressing recombinant human FGF-2
Henry Hieu M. Le, David Vang, Nadia Amer, Tou Vue, Colwin Yee, Hyam Kaou, Joseph S. Harrison, Nan Xiao, Joan Lin-Cereghino, Geoff P. Lin-Cereghino, Der Thor
Protein Expression and Purification.2020; 176: 105724. CrossRef
Silver Nanoparticles for the Therapy of Tuberculosis

Alexandru-Flaviu Tăbăran, Cristian Tudor Matea, Teodora Mocan, Alexandra Tăbăran, Marian Mihaiu, Cornel Iancu, Lucian Mocan
International Journal of Nanomedicine.2020; Volume 15: 2231. CrossRef

Author index