- Regulation and function of the Salmonella MgtC virulence protein
-
Jang-Woo Lee , Eun-Jin Lee
-
J. Microbiol. 2015;53(10):667-672. Published online August 1, 2015
-
DOI: https://doi.org/10.1007/s12275-015-5283-1
-
-
1,026
View
-
2
Download
-
26
Crossref
-
Abstract
PDF
-
Salmonella enterica serovar Typhimurium produces many
virulence proteins to cause diseases. The Salmonella MgtC
protein is one of such virulence proteins specially required
for intracellular proliferation inside macrophages and mouse
virulence. In this review, we will cover how the mgtC gene
is turned on or off and what the signals required for mgtC
expression are. Later in this review, we will discuss a recent
understanding of MgtC function in Salmonella pathogenesis
by identifying its target proteins.
-
Citations
Citations to this article as recorded by 
- Effect of phages and their pretreatment on reducing Salmonella biofilm on stainless steel surface with hypochlorous acid disinfectant
Xiaowen Sun, Xinyue Chi, Huaqiang Li, Lili Wang, Jianguang Li, Yongping Xu, Yanfen Liu, Xiaoyu Li LWT.2026; 239: 118936. CrossRef - Unraveling Mycobacterium abscessus: Pathogenesis and host immune dynamics
Daichen Ju, Peng Li, Duohua Su, Hua Chen, Pinru Chen, Yaoju Tan, Ning Su, Jialou Zhu, Jinxing Hu Microbial Pathogenesis.2026; 219: 108703. CrossRef -
Pseudomonas aeruginosa mgtC
gene is under the control of PhoP and CbrAB regulators, and its expression can be visualized in macrophages
Anne Bonhoure, Pauline Nogaret, Valérie Perez, Flore Nilly, Sylvaine Huc-Brandt, Malika Moussouni, Robert E. W. Hancock, Virginie Molle, Anne-Béatrice Blanc-Potard, Cezar M. Khursigara Microbiology Spectrum.2026;[Epub] CrossRef - PhoU interaction with the PhoR PAS domain is required for repression of the pho regulon and Salmonella virulence, but not for polyphosphate accumulation
Seungwoo Baek, Soomin Choi, Yoontak Han, Eunna Choi, Shinae Park, Jung-Shin Lee, Eun-Jin Lee Journal of Microbiology.2025; 63(9): e2505013. CrossRef - The peptidoglycan-associated lipoprotein gene mutant elicits robust immunological defense in mice against Salmonella enteritidis
Guixin Zhao, Wenlong Duan, Lu Zhang, Wenchao Sun, Wan Liu, Xiaoyu Zhang, Yanying Zhang, Qiumei Shi, Tonglei Wu Frontiers in Microbiology.2024;[Epub] CrossRef - Insights into the global genomic features of Salmonella enterica serovar Gallinarum biovars Gallinarum and Pullorum
Isabela C Campos, Felipe Pinheiro Vilela, Mauro de M S Saraiva, Angelo Berchieri Junior, Juliana Pfrimer Falcão Journal of Applied Microbiology.2024;[Epub] CrossRef - Salmonella Gallinarum mgtC mutant shows a delayed fowl typhoid progression in chicken
Lucas Bocchini Rodrigues Alves, Oliveiro Caetano de Freitas Neto, Mauro de Mesquita Souza Saraiva, Daniel Farias Marinho do Monte, Bruna Nestlehner de Lima, Julia Memrava Cabrera, Fernanda de Oliveira Barbosa, Valdinete Pereira Benevides, Túlio Spina de L Gene.2024; 892: 147827. CrossRef - CRISPR-Cas system positively regulates virulence of Salmonella enterica serovar Typhimurium
Nandita Sharma, Ankita Das, Abhilash Vijay Nair, Palash Sethi, Vidya Devi Negi, Dipshikha Chakravortty, Sandhya Amol Marathe Gut Pathogens.2024;[Epub] CrossRef - Contribution of intramacrophage stages to Pseudomonas aeruginosa infection outcome in zebrafish embryos: insights from mgtC and oprF mutants
Hélène Hajjar, Laurence Berry, Yongzheng Wu, Lhousseine Touqui, Annette C. Vergunst, Anne-Béatrice Blanc-Potard Scientific Reports.2024;[Epub] CrossRef - Impact of Arsenic Stress on the Antioxidant System and Photosystem of Arthrospira platensis
Jiawei Liu, Jie Du, Di Wu, Xiang Ji, Xiujuan Zhao Biology.2024; 13(12): 1049. CrossRef - Horizontal Gene Transfer and Drug Resistance Involving Mycobacterium tuberculosis
Xuhua Xia Antibiotics.2023; 12(9): 1367. CrossRef - Virulence genes identification in Salmonella enterica isolates from humans, crocodiles, and poultry farms from two regions in Colombia
Julieth Michel Petano-Duque, Valentina Rueda-García, Iang Schroniltgen Rondón-Barragán Veterinary World.2023; : 2096. CrossRef - Virulence and Antimicrobial Resistance Gene Profiling of Salmonella Isolated from Swine Meat Samples in Abattoirs and Wet Markets of Metro Manila, Philippines
Rance Derrick N. Pavon, Windell L. Rivera Microbiology and Biotechnology Letters.2023; 51(4): 390. CrossRef - Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design
Kia C. Ferrell, Matt D. Johansen, James A. Triccas, Claudio Counoupas Frontiers in Microbiology.2022;[Epub] CrossRef - Characterization of Salmonella spp. Isolates from Swine: Virulence and Antimicrobial Resistance
Hai Nguyen Thi, Thi-Thanh-Thao Pham, Barbara Turchi, Filippo Fratini, Valentina Virginia Ebani, Domenico Cerri, Fabrizio Bertelloni Animals.2020; 10(12): 2418. CrossRef - The mgtCBR mRNA Leader Secures Growth of Salmonella in Both Host and Non-host Environments
Myungseo Park, Hyunkeun Kim, Daesil Nam, Dae-Hyuk Kweon, Dongwoo Shin Frontiers in Microbiology.2019;[Epub] CrossRef - Synthetic hydrophobic peptides derived from MgtR weaken Salmonella pathogenicity and work with a different mode of action than endogenously produced peptides
Mariana Rosas Olvera, Preeti Garai, Grégoire Mongin, Eric Vivès, Laila Gannoun-Zaki, Anne-Béatrice Blanc-Potard Scientific Reports.2019;[Epub] CrossRef - The malS-5′UTR weakens the ability of Salmonella enterica serovar Typhi to survive in macrophages by increasing intracellular ATP levels
Fang Dong, Lin Xia, Renfei Lu, Xin Zhao, Yiquan Zhang, Ying Zhang, Xinxiang Huang Microbial Pathogenesis.2018; 115: 321. CrossRef - High‐level, constitutive expression of the mgtC gene confers increased thermotolerance on Salmonella enterica serovar Typhimurium
Aaron R. Gall, Annie E. Hegarty, Kirill A. Datsenko, Richard P. Westerman, Phillip SanMiguel, Laszlo N. Csonka Molecular Microbiology.2018; 109(3): 327. CrossRef - Regulatory RNAs in Virulence and Host-Microbe Interactions
Alexander J. Westermann, Gisela Storz, Kai Papenfort Microbiology Spectrum.2018;[Epub] CrossRef - Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus
Michael Rahe, Michael Murtaugh Viruses.2017; 9(6): 148. CrossRef - Regulating Bacterial Virulence with RNA
Juan J. Quereda, Pascale Cossart Annual Review of Microbiology.2017; 71(1): 263. CrossRef -
A
trans
-acting leader RNA from a
Salmonella
virulence gene
Eunna Choi, Yoontak Han, Yong-Joon Cho, Daesil Nam, Eun-Jin Lee Proceedings of the National Academy of Sciences.2017; 114(38): 10232. CrossRef - Elongation factor P restricts Salmonella’s growth by controlling translation of a Mg2+ transporter gene during infection
Eunna Choi, Soomin Choi, Daesil Nam, Shinae Park, Yoontak Han, Jung-Shin Lee, Eun-Jin Lee Scientific Reports.2017;[Epub] CrossRef - Intramacrophage Survival for Extracellular Bacterial Pathogens: MgtC As a Key Adaptive Factor
Claudine Belon, Anne-Béatrice Blanc-Potard Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef - Behavior variability of Salmonella enterica isolates from meat-related sources
Huhu Wang, Yun Jiang, Xuan Liu, Wenjuan Qian, Xinglian Xu, Guanghong Zhou LWT.2016; 73: 375. CrossRef
|