- The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
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Yanxia Zhao , Mi-Kyung Lee , Jieyin Lim , Heungyun Moon , Hee-Soo Park , Weifa Zheng , Jae-Hyuk Yu
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J. Microbiol. 2021;59(8):746-752. Published online July 5, 2021
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DOI: https://doi.org/10.1007/s12275-021-1055-2
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7
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 Abstract
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The VosA-VelB heterocomplex governs expression of several
genes associated with fungal development and secondary
metabolism. In this study, we have investigated the functions
of one of the VosA-VelB-activated developmental genes vadJ
in development and production of the mycotoxin sterigmatocystin
in the model fungus Aspergillus nidulans. The vadJ
gene is predicted to encode a 957-amino acid length protein
containing a highly conserved sensor histidine kinase domain.
The deletion of vosA or velB resulted in decreased mRNA
levels of vadJ throughout the life cycle, suggesting that VosA
and VelB are necessary for proper expression of vadJ. Nullifying
vadJ led to highly restricted colony growth, lowered formation
of asexual spores, and about two-fold reduction in
conidial viability. Conversely, the deletion of vadJ resulted in
elevated production of sexual fruiting bodies and sterigmatocystin.
These suggest that VadJ is necessary for proper coordination
of asexual and sexual development, and sterigmatocystin
production. In accordance with this idea, the deletion
of vadJ led to elevated mRNA levels of the two key sexual
developmental activators esdC and nsdD. In summary, the
putative sensor histidine kinase VadJ represses sexual development
and sterigmatocystin production, but activates
asexual development in A. nidulans.
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Citations
Citations to this article as recorded by  - Velvet Family Protein FpVelB Affects Virulence in Association with Secondary Metabolism in Fusarium pseudograminearum
Yuxing Wu, Sen Han, Yajiao Wang, Qiusheng Li, Lingxiao Kong
Cells.2024; 13(11): 950. CrossRef - Involvement of LaeA and Velvet Proteins in Regulating the Production of Mycotoxins and Other Fungal Secondary Metabolites
Xuwen Hou, Liyao Liu, Dan Xu, Daowan Lai, Ligang Zhou
Journal of Fungi.2024; 10(8): 561. CrossRef - Adaptative responses of Neurospora crassa by histidine kinases upon the attack of the arthropod Sinella curviseta
Ting Lu, Xiao-meng Wang, Peng-xu Chen, Juan Xi, Han-bing Yang, Wei-fa Zheng, Yan-xia Zhao
Current Genetics.2024;[Epub] CrossRef - Implication of VelB in the development, pathogenicity, and secondary metabolism of Penicillium expansum
Nadia Tahtah, Chrystian Zetina-Serrano, Ophélie Rocher, Claire Naylies, Yannick Lippi, André El Khoury, Ali Atoui, Emilien L. Jamin, Isabelle P. Oswald, Sophie Lorber, Olivier Puel
Postharvest Biology and Technology.2023; 195: 112121. CrossRef - Regulators of the Asexual Life Cycle of Aspergillus nidulans
Ye-Eun Son, Jae-Hyuk Yu, Hee-Soo Park
Cells.2023; 12(11): 1544. CrossRef - Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review
Kunlong Yang, Jun Tian, Nancy P. Keller
Environmental Microbiology.2022; 24(7): 2857. CrossRef - The Putative C2H2 Transcription Factor VadH Governs Development, Osmotic Stress Response, and Sterigmatocystin Production in Aspergillus nidulans
Xiaoyu Li, Yanxia Zhao, Heungyun Moon, Jieyin Lim, Hee-Soo Park, Zhiqiang Liu, Jae-Hyuk Yu
Cells.2022; 11(24): 3998. CrossRef
- The velvet repressed vidA gene plays a key role in governing development in Aspergillus nidulans
-
Min-Ju Kim , Won-Hee Jung , Ye-Eun Son , Jae-Hyuk Yu , Mi-Kyung Lee , Hee-Soo Park
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J. Microbiol. 2019;57(10):893-899. Published online August 28, 2019
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DOI: https://doi.org/10.1007/s12275-019-9214-4
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15
Web of Science
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12
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Abstract
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Fungal development is regulated by a variety of transcription
factors in Aspergillus nidulans. Previous studies demonstrated
that the NF-κB type velvet transcription factors regulate certain
target genes that govern fungal differentiation and cellular
metabolism. In this study, we characterize one of the
VosA/VelB-inhibited developmental genes called vidA, which
is predicted to encode a 581-amino acid protein with a C2H2
zinc finger domain at the C-terminus. Levels of vidA mRNA
are high during the early and middle phases of asexual development
and decrease during the late phase of asexual development
and asexual spore (conidium) formation. Deletion
of either vosA or velB results in increased vidA mRNA accumulation
in conidia, suggesting that vidA transcript accumulation
in conidia is repressed by VosA and VelB. Phenotypic
analysis demonstrated that deletion of vidA causes decreased
colony growth, reduced production of asexual spores,
and abnormal formation of sexual fruiting bodies. In addition,
the vidA deletion mutant conidia contain more trehalose
and β-glucan than wild type. Overall, these results suggest
that VidA is a putative transcription factor that plays a
key role in governing proper fungal growth, asexual and sexual
development, and conidia formation in A. nidulans.
-
Citations
Citations to this article as recorded by - Regulators of the Asexual Life Cycle of Aspergillus nidulans
Ye-Eun Son, Jae-Hyuk Yu, Hee-Soo Park
Cells.2023; 12(11): 1544. CrossRef - The Forkhead Gene fkhB is Necessary for Proper Development in Aspergillus nidulans
Seo-Yeong Jang, Ye-Eun Son, Dong-Soon Oh, Kap-Hoon Han, Jae-Hyuk Yu, Hee-Soo Park
Journal of Microbiology and Biotechnology.2023; 33(11): 1420. CrossRef - The function of a conidia specific transcription factor CsgA in Aspergillus nidulans
He-Jin Cho, Hee-Soo Park
Scientific Reports.2022;[Epub] CrossRef - The Putative C2H2 Transcription Factor VadH Governs Development, Osmotic Stress Response, and Sterigmatocystin Production in Aspergillus nidulans
Xiaoyu Li, Yanxia Zhao, Heungyun Moon, Jieyin Lim, Hee-Soo Park, Zhiqiang Liu, Jae-Hyuk Yu
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Minou Nowrousian
Microbiology and Molecular Biology Reviews.2022;[Epub] CrossRef - Functions of PUF Family RNA-Binding Proteins in Aspergillus nidulans
Sung-Hun Son, Seo-Yeong Jang, Hee-Soo Park
Journal of Microbiology and Biotechnology.2021; 31(5): 676. CrossRef - The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
Yanxia Zhao, Mi-Kyung Lee, Jieyin Lim, Heungyun Moon, Hee-Soo Park, Weifa Zheng, Jae-Hyuk Yu
Journal of Microbiology.2021; 59(8): 746. CrossRef - Unveiling the Functions of the VosA-VelB Target GenevidDinAspergillus nidulans
Ye-Eun Son, Hee-Soo Park
Mycobiology.2021; 49(3): 258. CrossRef - Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans
Mi-Kyung Lee, Ye-Eun Son, Hee-Soo Park, Ahmad Alshannaq, Kap-Hoon Han, Jae-Hyuk Yu
Scientific Reports.2020;[Epub] CrossRef - The role of the VosA-repressed dnjA gene in development and metabolism in Aspergillus species
Ye-Eun Son, He-Jin Cho, Wanping Chen, Sung-Hun Son, Mi-Kyung Lee, Jae-Hyuk Yu, Hee-Soo Park
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- Characterization of the velvet regulators in Aspergillus flavus
-
Tae-Jin Eom , Heungyun Moon , Jae-Hyuk Yu , Hee-Soo Park
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J. Microbiol. 2018;56(12):893-901. Published online October 25, 2018
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DOI: https://doi.org/10.1007/s12275-018-8417-4
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73
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32
Crossref
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Abstract
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Fungal development and secondary metabolism are closely
associated via the activities of the fungal NK-kB-type velvet
regulators that are highly conserved in filamentous fungi.
Here, we investigated the roles of the velvet genes in the aflatoxigenic
fungus Aspergillus flavus. Distinct from other Aspergillus
species, the A. flavus genome contains five velvet genes,
veA, velB, velC, velD, and vosA. The deletion of velD blocks
the production of aflatoxin B1, but does not affect the formation
of sclerotia. Expression analyses revealed that vosA and
velB mRNAs accumulated at high levels during the late phase
of asexual development and in conidia. The absence of vosA
or velB decreased the content of conidial trehalose and the
tolerance of conidia to the thermal and UV stresses. In addition,
double mutant analyses demonstrated that VosA and
VelB play an inter-dependent role in trehalose biosynthesis
and conidial stress tolerance. Together with the findings of
previous studies, the results of the present study suggest that
the velvet regulators play the conserved and vital role in sporogenesis,
conidial trehalose biogenesis, stress tolerance, and
aflatoxin biosynthesis in A. flavus.
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- REVIEW] Developmental regulators in Aspergillus fumigatus
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Hee-Soo Park , Jae-Hyuk Yu
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J. Microbiol. 2016;54(3):223-231. Published online February 27, 2016
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DOI: https://doi.org/10.1007/s12275-016-5619-5
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74
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51
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Abstract
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The filamentous fungus Aspergillus fumigatus is the most prevalent
airborne fungal pathogen causing severe and usually
fatal invasive aspergillosis in immunocompromised patients.
This fungus produces a large number of small hydrophobic
asexual spores called conidia as the primary means of reproduction,
cell survival, propagation, and infectivity. The initiation,
progression, and completion of asexual development
(conidiation) is controlled by various regulators that govern
expression of thousands of genes associated with formation
of the asexual developmental structure conidiophore, and
biogenesis of conidia. In this review, we summarize key regulators
that directly or indirectly govern conidiation in this
important pathogenic fungus. Better understanding these
developmental regulators may provide insights into the improvement
in controlling both beneficial and detrimental
aspects of various Aspergillus species.
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- NOTE] Antifungal Activity of Extracellular Hydrolases Produced by Autolysing Aspergillus nidulans Cultures
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Melinda Szilágyi , Fruzsina Anton , Katalin Forgács , Jae-Hyuk Yu , István Pócsi , Tamás Emri
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J. Microbiol. 2012;50(5):849-854. Published online November 4, 2012
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DOI: https://doi.org/10.1007/s12275-012-2001-0
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Abstract
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Carbon-starving Aspergillus nidulans cultures produce high activities of versatile hydrolytic enzymes and, among these, ChiB endochitinase and EngA β-1,3-endoglucanase showed significant antifungal activity against various fungal species. Double deletion of engA and chiB diminished the antifungal activity of the fermentation broths and increased conidiogenesis and long-term viability of A. nidulans, but decreased the growth rate on culture media containing weak carbon sources. Production of ChiB and EngA can influence fungal communities either directly due to their antifungal properties or indirectly through their effects on vegetative growth. Our data suggest saprophytic fungi as promising future candidates to develop novel biocontrol technologies.
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Citations
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- Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans
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Jae-Hyuk Yu
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J. Microbiol. 2006;44(2):145-154.
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DOI: https://doi.org/2371 [pii]
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Abstract
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Heterotrimeric G proteins (G proteins) are conserved in all eukaryotes and are crucial
components sensing and relaying external cues into the cells to elicit appropriate physiological and biochemical responses. Basic units of the heterotrimeric G protein
signaling system include a G protein-coupled receptor (GPCR), a G protein composed of α, β, and γ subunits, and variety of effectors. Sequential sensitization and activation of these G protein elements translates external signals into gene expression changes, resulting in appropriate cellular behaviors. Regulators of G protein signaling (RGSs) constitute a crucial element of appropriate control of the intensity and duration of G protein signaling. For the past decade, G protein signaling and its regulation have been intensively studied in a number of model and/or pathogenic fungi and outcomes of the studies provided better understanding on the upstream regulation of vegetative growth, mating, development, virulence/pathogenicity establishment, and biosynthesis of secondary metabolites in fungi. This review focuses on the characteristics of the basic upstream G protein components and RGS proteins, and their roles controlling various aspects of biological processes in the model filamentous ascomycete fungus Aspergillus nidulans. In particular, their functions in controlling hyphal proliferation, asexual spore formation, sexual fruiting, and the mycotoxin sterigmatocystin production are discussed.
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