- Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice
-
Sehee Park , Jin Il Kim , Joon-Yong Bae , Kirim Yoo , Hyunung Kim , In-Ho Kim , Man-Seong Park , Ilseob Lee
-
J. Microbiol. 2018;56(2):145-149. Published online February 2, 2018
-
DOI: https://doi.org/10.1007/s12275-018-7411-1
-
-
1,070
View
-
1
Download
-
35
Crossref
-
Abstract
PDF
-
The potential use of dietary measures to treat influenza can
be an important alternative for those who lack access to influenza
vaccines or antiviral drugs. Lactobacillus plantarum
(Lp) is one of many lactic acid bacteria that grow in ‘kimchi’,
an essential part of Korean meal, and several strains of Lp
reportedly show protective effects against influenza. Using
heat-killed Lp (nF1) isolated from kimchi, which is known
for its immunomodulatory effects, we investigated whether
regular oral intake of nF1 could influence the outcome of influenza
virus infection in a mouse model. In a lethal challenge
with influenza A (H1N1 and H3N2 subtypes) and influenza
B (Yamagata lineage) viruses, daily oral administration
of nF1 delayed the mean number of days to death of the
infected mice and resulted in increased survival rates compared
with those of the non-treated mice. Consistent with
these observations, nF1 treatment also significantly reduced
viral replication in the lungs of the infected mice. Taken together,
our results might suggest the remedial potential of heatkilled
Lactobacillus probiotics against influenza.
-
Citations
Citations to this article as recorded by 
- Gut Microbiota and Probiotics in Influenza: A Narrative Review of Mechanisms and Emerging Evidence
Feihu Guan, Jie Zhang, Ye Tian, Bofan Fu, Ji Liu, Yafen Song, Aoyang Yan, Bing Zhang, Ling Chen, Min Zhang, Pengfei Du, Lei Wang, Xiaoyue Yang, Sifan Guo, Chenghuai Yang, Hui Zhang, Qianyi Zhang Viruses.2026; 18(5): 553. CrossRef - Silent allies: non-living microbes shaping the future of cardiometabolic health
Sahar Saraf-Bank, Sanaz Mehrabani, Mahdieh Khodarahmi Journal of Functional Foods.2026; 144: 107452. CrossRef - Rising Threats of Viral Infections: Exploring Probiotics as Antiviral Agents
Haneef Mohammad Bhat, Ruqeya Nazir, Zahid Amin Kashoo Indian Journal of Microbiology.2025; 65(4): 1781. CrossRef - Oral Administration of Limosilactobacillus reuteri KBL346 Ameliorates Influenza Virus A/PR8 Infection in Mouse
Doseon Choi, Sung Jae Jang, Sueun Choi, SungJun Park, Woon-Ki Kim, Giljae Lee, Cheonghoon Lee, GwangPyo Ko Probiotics and Antimicrobial Proteins.2025; 17(5): 3546. CrossRef - Postbiotics in Respiratory Health: Functional Components, Innovative Application, and Emerging Challenges
Jianqiang Lan, Shimin Wu, Hong Li, Junfang Wang, Min Li The Journal of Nutrition.2025; 155(11): 3676. CrossRef - Crosstalk between gut microbiota and viral pathogens: oxidative stress and metabolic dysregulation
Jiayu Ma, Yan Yan, Chenhe Lu, Haimin Li, Jie Cai, Jiyong Zhou One Health Advances.2025;[Epub] CrossRef - Effect of Heat-Treated Lactiplantibacillus plantarum nF1 on the Immune System Including Natural Killer Cell Activity: A Randomized, Placebo-Controlled, Double-Blind Study
Geun-Hye Hong, So-Young Lee, In Ah Kim, Jangmi Suk, Chaemin Baeg, Ji Yeon Kim, Sehee Lee, Kyeong Jin Kim, Ki Tae Kim, Min Gee Kim, Kun-Young Park Nutrients.2024; 16(9): 1339. CrossRef - Orange Peel Lactiplantibacillus plantarum: Development of A Mucoadhesive Nasal Spray with Antimicrobial and Anti-inflammatory Activity
Elisa Corazza, Asia Pizzi, Carola Parolin, Barbara Giordani, Angela Abruzzo, Federica Bigucci, Teresa Cerchiara, Barbara Luppi, Beatrice Vitali Pharmaceutics.2024; 16(11): 1470. CrossRef - Beyond probiotics, uses of their next‐generation for poultry and humans: A review
Ahmad Salahi, Wafaa A. Abd El‐Ghany Journal of Animal Physiology and Animal Nutrition.2024; 108(5): 1336. CrossRef - Does kimchi deserve the status of a probiotic food?
Jeongmin Cha, Yeon Bee Kim, Seong-Eun Park, Se Hee Lee, Seong Woon Roh, Hong-Seok Son, Tae Woong Whon Critical Reviews in Food Science and Nutrition.2024; 64(19): 6512. CrossRef -
Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway
Xiaomin Yu, Yejia Zhang, Ke Pei, Junjun Tan, Huizhen Tian, Tian Xu, Fadi Liu, Nanqin Peng, Yilin Huang, Xinying Huang, Xinlei Huang, Jianfeng Wu, Qiong Liu, Lingbing Zeng, Wei Hua, Xiaotian Huang Food & Function.2023; 14(9): 4129. CrossRef - Postbiotics: An overview of concepts, inactivation technologies, health effects, and driver trends
Tatiana Colombo Pimentel, Adriano Gomes Cruz, Eliene Pereira, Whyara Karoline Almeida da Costa, Ramon da Silva Rocha, Geany Targino de Souza Pedrosa, Caíque dos Santos Rocha, Jade Morais Alves, Verônica Ortiz Alvarenga, Anderson S. Sant’Ana, Marciane Magn Trends in Food Science & Technology.2023; 138: 199. CrossRef - Elucidation of the Tissue Distribution and Host Immunostimulatory Activity of Exogenously Administered Probiotic-Derived Extracellular Vesicles for Immunoadjuvant
Masaki Morishita, Masakatsu Kida, Tomomi Motomura, Rihito Tsukamoto, Mizuho Atari, Kazuya Higashiwaki, Kisa Masuda, Hidemasa Katsumi, Akira Yamamoto Molecular Pharmaceutics.2023; 20(12): 6104. CrossRef - A Review of the Health Benefits of Kimchi Functional Compounds and Metabolites
Hyun Ju Kim, Min Sung Kwon, Hyelyeon Hwang, Ha-Sun Choi, WooJe Lee, Sang-Pil Choi, Haeun Jo, Sung Wook Hong Microbiology and Biotechnology Letters.2023; 51(4): 353. CrossRef - Effect of Probiotics on Host-Microbial Crosstalk: A Review on Strategies to Combat Diversified Strain of Coronavirus
Susrita Sahoo, Swati Mohapatra, Swayam prava Dalai, Namrata Misra, Mrutyunjay Suar Encyclopedia.2022; 2(2): 1138. CrossRef - The Beneficial Role of Probiotic Lactobacillus in Respiratory Diseases
Tingfeng Du, Aihua Lei, Naiyu Zhang, Cuiming Zhu Frontiers in Immunology.2022;[Epub] CrossRef - Antiobesity Effect of Dead Lactobacillus plantarum nF1 on High-Fat Diet-Induced C57BL/6 Mice
Xuemei Lee, Geun-Hye Hong, So-Young Lee, Hyun Chul Noh, Kun-Young Park Journal of the Korean Society of Food Science and Nutrition.2022; 51(11): 1119. CrossRef - Prophylactic effects of probiotics on respiratory viruses including COVID-19: a review
Na-Kyoung Lee, Hyun-Dong Paik Food Science and Biotechnology.2021; 30(6): 773. CrossRef - Health benefits and technological effects of Lacticaseibacillus casei-01: An overview of the scientific literature
Tatiana Colombo Pimentel, Larissa Ramalho Brandão, Matthaws Pereira de Oliveira, Whyara Karoline Almeida da Costa, Marciane Magnani Trends in Food Science & Technology.2021; 114: 722. CrossRef - Modulation of gut microbiota protects against viral respiratory tract infections: a systematic review of animal and clinical studies
Hai Yun Shi, Xi Zhu, Wei Lin Li, Joyce W. Y. Mak, Sunny H. Wong, Sheng Tao Zhu, Shui Long Guo, Francis K. L. Chan, Shu Tian Zhang, Siew C. Ng European Journal of Nutrition.2021; 60(8): 4151. CrossRef - Obtaining paraprobiotics from Lactobacilus acidophilus, Lacticaseibacillus casei and Bifidobacterium animalis using six inactivation methods: Impacts on the cultivability, integrity, physiology, and morphology
Caroline N. Almada, Carine N. Almada-Érix, Mariane S. Bonatto, Fernando Pradella, Philipe dos Santos, Yuri K.D. Abud, Alessandro S. Farias, Julian Martínez, Celso B. Sant'Anna Filho, Pablo C. Lollo, Whyara K.A. Costa, Marciane Magnani, Anderson S. Sant'An Journal of Functional Foods.2021; 87: 104826. CrossRef - The Antiviral Potential of Probiotics—A Review on Scientific Outcomes
Periyanaina Kesika, Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Chaiyavat Chaiyasut Applied Sciences.2021; 11(18): 8687. CrossRef - Lactiplantibacillus plantarum as a Potential Adjuvant and Delivery System for the Development of SARS-CoV-2 Oral Vaccines
Julio Villena, Chang Li, Maria Guadalupe Vizoso-Pinto, Jacinto Sacur, Linzhu Ren, Haruki Kitazawa Microorganisms.2021; 9(4): 683. CrossRef - Probiotics: A potential immunomodulator in COVID-19 infection management
Kuljit Singh, Alka Rao Nutrition Research.2021; 87: 1. CrossRef - Lactobacillus plantarum induces innate cytokine responses that potentially provide a protective benefit against COVID‑19: A single‑arm, double‑blind, prospective trial combined with an in vitro cytokine response assay
Yasunari Kageyama, Yasuhiro Nishizaki, Koichi Aida, Katsuyuki Yayama, Tomoka Ebisui, Tetsu Akiyama, Tsutomu Nakamura Experimental and Therapeutic Medicine.2021;[Epub] CrossRef - Korean traditional foods as antiviral and respiratory disease prevention and treatments: A detailed review
Gitishree Das, J. Basilio Heredia, Maria de Lourdes Pereira, Ericsson Coy-Barrera, Sonia Marlene Rodrigues Oliveira, Erick Paul Gutiérrez-Grijalva, Luis Angel Cabanillas-Bojórquez, Han-Seung Shin, Jayanta Kumar Patra Trends in Food Science & Technology.2021; 116: 415. CrossRef - Swine Influenza Virus Infection Decreases the Protective Immune Responses of Subunit Vaccine Against Porcine Circovirus Type 2
Yuhang Sun, Jinlong Zhang, Zixuan Liu, Ying Zhang, Kehe Huang Frontiers in Microbiology.2021;[Epub] CrossRef - Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines
Klaudia Chrzastek, Joy Leng, Mohammad Khalid Zakaria, Dagmara Bialy, Roberto La Ragione, Holly Shelton Animal Microbiome.2021;[Epub] CrossRef - Paraprobiotics obtained by six different inactivation processes: impacts on the biochemical parameters and intestinal microbiota of Wistar male rats
Caroline N. Almada, Carine N. Almada-Érix, Aline R. Roquetto, Valfredo A. Santos-Junior, Lucélia Cabral, Melline F. Noronha, Any Elisa S. S. Gonçalves, Philipe dos Santos, Andrey dos Santos, Julian Martinez, Pablo C. Lollo, Whyara K. A. Costa, Marciane Ma International Journal of Food Sciences and Nutrition.2021; 72(8): 1057. CrossRef - Effect of inactivated Bifidobacterium longum intake on obese diabetes model mice (TSOD)
Mahmoud Ben Othman, Kazuichi Sakamoto Food Research International.2020; 129: 108792. CrossRef - The immunomodulatory effects of probiotics on respiratory viral infections: A hint for COVID-19 treatment?
Mehran Mahooti, Seyed Mohammad Miri, Elahe Abdolalipour, Amir Ghaemi Microbial Pathogenesis.2020; 148: 104452. CrossRef - Short Communication: Oral Administration of Heat-killed Lactobacillus brevis KB290 in Combination with Retinoic Acid Provides Protection against Influenza Virus Infection in Mice
Shohei Satomi, Sofia Khanum, Poppy Miller, Shigenori Suzuki, Hiroyuki Suganuma, Axel Heiser, Sandeep K Gupta Nutrients.2020; 12(10): 2925. CrossRef - The effects of heat-killed Lactobacillus plantarum L-137 supplementation on growth performance, intestinal morphology, and immune-related gene expression in broiler chickens
T. Incharoen, R. Charoensook, S. Onoda, W. Tatrakoon, S. Numthuam, T. Pechkong Animal Feed Science and Technology.2019; 257: 114272. CrossRef - Heat-killed probiotic regulates the body’s regulatory immunity to attenuate subsequent experimental autoimmune arthritis
Hai Jia, Shipu Ren, Xia Wang Immunology Letters.2019; 216: 89. CrossRef - Isolation of immune-regulatory Tetragenococcus halophilus from miso
Toshihiko Kumazawa, Atsuhisa Nishimura, Noriyuki Asai, Takahiro Adachi, Keiko Abe PLOS ONE.2018; 13(12): e0208821. CrossRef
- Anti-influenza Effect of Cordyceps militaris through Immunomodulation in a DBA/2 Mouse Model
-
Hwan Hee Lee , Heejin Park , Gi-Ho Sung , Kanghyo Lee , Taeho Lee , Ilseob Lee , Man-seong Park , Yong Woo Jung , Yu Su Shin , Hyojeung Kang , Hyosun Cho
-
J. Microbiol. 2014;52(8):696-701. Published online July 18, 2014
-
DOI: https://doi.org/10.1007/s12275-014-4300-0
-
-
1,106
View
-
1
Download
-
27
Crossref
-
Abstract
PDF
-
The immune-modulatory as well as anti-influenza effects of Cordyceps extract were investigated using a DBA/2 mouse model. Three different concentrations of Cordyceps extract, red ginseng extract, or drinking water were orally administered
to mice for seven days, and then the mice were intranasally infected with 2009 pandemic influenza H1N1 virus. Body weight changes and survival rate were measured daily post-infection. Plasma IL-12, TNF-α, and the frequency of
natural killer (NK) cells were measured on day 4 post-infection. The DBA/2 strain was highly susceptible to H1N1 virus infection. We also found that Cordyceps extract had an antiinfluenza effect that was associated with stable body weight
and reduced mortality. The anti-viral effect of Cordyceps extract on influenza infection was mediated presumably by increased IL-12 expression and greater number of NK cells. However, high TNF-α expression after infection of H1N1
virus in mice not receiving treatment with Cordyceps extract suggested a two-sided effect of the extract on host immune regulation.
-
Citations
Citations to this article as recorded by 
- Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris
Pradeep Gandhale, Rupesh Chikhale, Pukar Khanal, Vashkar Biswa, Raju Ali, Mohd Shahnawaz Khan, Nilambari Gurav, Muniappan Ayyanar, Sandeep Das, Shailendra Gurav Journal of Ayurveda and Integrative Medicine.2024; 15(3): 100979. CrossRef - Chitin Synthases in Cordyceps militaris: Genome-Wide Gene Identification, Evolutionary Insights, and Life Cycle Transcript Profiling
Shoumian Li, Huihui Ren, Jie Zhang, Shangpai Gao, Zixuan Chen, Guojie Li, Jinghua Tian, Junling Wang, Ming Li, Xiao Li, Caihong Dong Horticulturae.2024; 10(5): 494. CrossRef - Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation
Siddharth Dubhashi, Sagar Sinha, Sankalp Dwivedi, Jaishree Ghanekar, Sameer Kadam, Parineeta Samant, Vibha Datta, Sarman Singh, Irshad H Chaudry, Padma Gurmet, Harshawardhan Kelkar, Rakesh Mishra, Sagar Galwankar, Amit Agrawal Cureus.2023;[Epub] CrossRef - Chitinase Is Involved in the Fruiting Body Development of Medicinal Fungus Cordyceps militaris
Zi-Juan Zhang, Yuan-Yuan Yin, Yao Cui, Yue-Xuan Zhang, Bi-Yang Liu, You-Chu Ma, Yong-Nan Liu, Gao-Qiang Liu Life.2023; 13(3): 764. CrossRef - Boosting cordycepin production through plant-based oils for vegetarian consumption
Watcharin Yuttavanichakul, Nipaporn Kanthong, Nuntaporn Pungsungvorn Journal of Applied Research on Science and Technology (JARST).2023;[Epub] CrossRef - A Possible Synergistic Herbal Solution for COVID-19
Ephraim Shmaya Lansky Frontiers in Bioscience-Scholar.2022;[Epub] CrossRef - Un caso di COVID-19 curato con la micoterapia
Michel G. MALLARD Gazzetta Medica Italiana Archivio per le Scienze Mediche.2022;[Epub] CrossRef - Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms
Abdul-Rehman Phull, Madiha Ahmed, Hye-Jin Park Microorganisms.2022; 10(2): 405. CrossRef - Medicinal Fungi with Antiviral Effect
Yu Zhang, Guoying Zhang, Jianya Ling Molecules.2022; 27(14): 4457. CrossRef - Antioxidant Activity of Mushroom Extracts/Polysaccharides—Their Antiviral Properties and Plausible AntiCOVID-19 Properties
Sechul Chun, Judy Gopal, Manikandan Muthu Antioxidants.2021; 10(12): 1899. CrossRef - Novel Fatty Acid in Cordyceps Suppresses
Influenza A (H1N1) Virus-Induced Proinflammatory Response
Through Regulating Innate Signaling Pathways
Run-Feng Li, Xiao-Bo Zhou, Hong-Xia Zhou, Zi-Feng Yang, Hai-Ming Jiang, Xiao Wu, Wen-Jia Li, Jian-Jian Qiu, Jia-Ning Mi, Ming Chen, Nan-Shan Zhong, Guo-Yuan Zhu, Zhi-Hong Jiang ACS Omega.2021; 6(2): 1505. CrossRef - Cysteine-Rich Hydrophobin Gene Family: Genome Wide Analysis, Phylogeny and Transcript Profiling in Cordyceps militaris
Xiao Li, Fen Wang, Yanyan Xu, Guijun Liu, Caihong Dong International Journal of Molecular Sciences.2021; 22(2): 643. CrossRef - Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies
Akalesh Kumar Verma, Vikas Kumar, Sweta Singh, Bhabesh Ch. Goswami, Ihosvany Camps, Aishwarya Sekar, Sanghwa Yoon, Keun Woo Lee Biomedicine & Pharmacotherapy.2021; 137: 111356. CrossRef - A new nucleoside and two new pyrrole alkaloid derivatives from Cordyceps militaris
Yafu Xue, Leilei Wu, Yulian Ding, Xinming Cui, Zhuzhen Han, Hong Xu Natural Product Research.2020; 34(3): 341. CrossRef - CmVVD is involved in fruiting body development and carotenoid production and the transcriptional linkage among three blue‐light receptors in edible fungus Cordyceps militaris
Jiaojiao Zhang, Fen Wang, Ying Yang, Ying Wang, Caihong Dong Environmental Microbiology.2020; 22(1): 466. CrossRef - Effects of nanobubble water supplementation on biomass accumulation during mycelium cultivation of Cordyceps militaris and the antioxidant activities of extracted polysaccharides
Long Xiao, Shuang Sun, Kejuan Li, Zhongfang Lei, Kazuya Shimizu, Zhenya Zhang, Yasuhisa Adachi Bioresource Technology Reports.2020; 12: 100600. CrossRef - Analysis of reference genes stability and histidine kinase expression under cold stress in Cordyceps militaris
Yong-Nan Liu, Bi-Yang Liu, You-Chu Ma, Hai-Long Yang, Gao-Qiang Liu, Shwet Kamal PLOS ONE.2020; 15(8): e0236898. CrossRef - Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin
Chun-Ting Lee, Keng-Shiang Huang, Jei-Fu Shaw, Jung-Ren Chen, Wen-Shuo Kuo, Gangxu Shen, Alexandru Mihai Grumezescu, Alina Maria Holban, Yi-Ting Wang, Jun-Sheng Wang, Yi-Ping Hsiang, Yu-Mei Lin, Hsiao-Han Hsu, Chih-Hui Yang Frontiers in Pharmacology.2020;[Epub] CrossRef - Effects ofCordyceps militarissupplementation on the immune response and upper respiratory infection in healthy adults: a randomized, double-blind, placebo-controlled study
Su Jin Jung, Ji Hyun Hwang, Mi Ra Oh, Soo Wan Chae Journal of Nutrition and Health.2019; 52(3): 258. CrossRef - Advance in Cordyceps militaris (Linn) Link polysaccharides: Isolation, structure, and bioactivities: A review
Jixian Zhang, Chaoting Wen, Yuqing Duan, Haihui Zhang, Haile Ma International Journal of Biological Macromolecules.2019; 132: 906. CrossRef - The blue-light receptor CmWC-1 mediates fruit body development and secondary metabolism in Cordyceps militaris
Tao Yang, Mingmin Guo, Huaijun Yang, Suping Guo, Caihong Dong Applied Microbiology and Biotechnology.2016; 100(2): 743. CrossRef - Cordyceps militaris (L.) Link: Chemical Bioactive Compounds and Pharmacological Activities
Do Hai Lan, Nguyen Thi Kim Thu, Pham Thi Lan, Pham Van Nha , Bui Thanh Tung Journal of Pharmacy and Nutrition Sciences .2016; 6(4): 153. CrossRef - Partial structural characterization, as well as immunomodulatory and anti-aging activities of CP2-c2-s2 polysaccharide from Cordyceps militaris
Xiaojuan Liu, Yicheng Huang, Yunjiao Chen, Yong Cao RSC Adv..2016; 6(106): 104094. CrossRef - Cultured Mycelium Cordyceps sinensis allevi¬ates CCl4-induced liver inflammation and fibrosis in mice by activating hepatic natural killer cells
Yuan Peng, Kai Huang, Li Shen, Yan-yan Tao, Cheng-hai Liu Acta Pharmacologica Sinica.2016; 37(2): 204. CrossRef - Cordyceps industry in China
Caihong Dong, Suping Guo, Wenfeng Wang, Xingzhong Liu Mycology.2015; 6(2): 121. CrossRef - Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis
Hwan Hee Lee, Seulki Lee, Kanghyo Lee, Yu Su Shin, Hyojeung Kang, Hyosun Cho DARU Journal of Pharmaceutical Sciences.2015;[Epub] CrossRef - Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells
Seulki Lee, Hwan Hee Lee, Jisung Kim, Joohee Jung, Aree Moon, Choon-Sik Jeong, Hyojeung Kang, Hyosun Cho Journal of Microbiology.2015; 53(7): 468. CrossRef
- DBA/2 Mouse as an Animal Model for Anti-influenza Drug Efficacy Evaluation
-
Jin Il Kim , Sehee Park , Sangmoo Lee , Ilseob Lee , Jun Heo , Min-Woong Hwang , Joon-Yong Bae , Donghwan Kim , Seok-Il Jang , Mee Sook Park , Man-Seong Park
-
J. Microbiol. 2013;51(6):866-871. Published online December 19, 2013
-
DOI: https://doi.org/10.1007/s12275-013-3428-7
-
-
1,007
View
-
0
Download
-
16
Crossref
-
Abstract
PDF
-
Influenza viruses are seasonally recurring human pathogens.
Vaccines and antiviral drugs are available for influenza.
However, the viruses, which often change themselves via
antigenic drift and shift, demand constant efforts to update
vaccine antigens every year and develop new agents with
broad-spectrum antiviral efficacy. An animal model is critical
for such efforts. While most human influenza viruses are
unable to kill BALB/c mice, some strains have been shown
to kill DBA/2 mice without prior adaptation. Therefore, in
this study, we explored the feasibility of employing DBA/2
mice as a model in the development of anti-influenza drugs.
Unlike the BALB/c strain, DBA/2 mice were highly susceptible
and could be killed with a relatively low titer (50%
DBA/2 lethal dose = 102.83 plaque-forming units) of the A/
Korea/01/2009 virus (2009 pandemic H1N1 virus). When
treated with a neuraminidase inhibitor, oseltamivir phosphate,
infected DBA/2 mice survived until 14 days postinfection.
The reduced morbidity of the infected DBA/2
mice was also consistent with the oseltamivir treatment.
Taking these data into consideration, we propose that the
DBA/2 mouse is an excellent animal model to evaluate antiviral
efficacy against influenza infection and can be further
utilized for combination therapies or bioactivity models of
existing and newly developed anti-influenza drugs.
-
Citations
Citations to this article as recorded by 
- Nonclinical investigation of the potential of MHAA4549A, an anti-influenza A therapeutic antibody, to mediate antibody-dependent enhancement
Gautham K Rao, Min Xu, Rodney A Prell, Man-Wah Tan, Lee R Swem, Jenny Jiang, Olga Li, Summer Park, Donghong Yan, Daniel Sheinson, Lynn Kamen, Wendy G Halpern, Jacqueline M McBride Toxicological Sciences.2026;[Epub] CrossRef - DNA co-delivery of seasonal H1 influenza hemagglutinin nanoparticle vaccines with chemokine adjuvant CTACK induces potent immunogenicity for heterologous protection in vivo
Kevin Liaw, Kylie M. Konrath, Abigail R. Trachtman, Nicholas J. Tursi, Ebony N. Gary, Cory Livingston, Kaitlyn Flowers, Jacqueline D. Chu, Casey E. Hojecki, Niklas Laenger, Madison E. McCanna, Colby J. Agostino, Neethu Chokkalingam, Kelly Bayruns, Sinja K Vaccine.2025; 59: 127231. CrossRef - Swine influenza A virus isolates containing the pandemic H1N1 origin matrix gene elicit greater disease in the murine model
Shelly J. Curran, Emily F. Griffin, Lucas M. Ferreri, Constantinos S. Kyriakis, Elizabeth W. Howerth, Daniel R. Perez, S. Mark Tompkins, Robert Paul de Vries Microbiology Spectrum.2024;[Epub] CrossRef - Kinetic of the Antibody Response Following AddaVax-Adjuvanted Immunization with Recombinant Influenza Antigens
Ted. M. Ross, Naveen Gokanapudi, Pan Ge, Hua Shi, Robert A. Richardson, Spencer R. Pierce, Pedro Sanchez, Subhan Ullah, Eliana De Luca, Giuseppe A. Sautto Vaccines.2022; 10(8): 1315. CrossRef - Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses
Aisha M. Mergaert, Michael F. Denny, Brock Kingstad-Bakke, Mandar Bawadekar, S. Janna Bashar, Thomas F. Warner, Marulasiddappa Suresh, Miriam A. Shelef, Baohui Xu Journal of Immunology Research.2022; 2022: 1. CrossRef - The morphine/heroin vaccine decreased the heroin-induced antinociceptive and reinforcing effects in three inbred strains mouse
Susana Barbosa-Méndez, Maura Matus-Ortega, Ricardo Hernández-Miramontes, Alberto Salazar-Juárez International Immunopharmacology.2021; 98: 107887. CrossRef - Animal models for the risk assessment of viral pandemic potential
Mee Sook Park, Jin Il Kim, Joon-Yong Bae, Man-Seong Park Laboratory Animal Research.2020;[Epub] CrossRef - In Vivo Assessment of Antibody-Dependent Enhancement of Influenza B Infection
Gautham K Rao, Rodney A Prell, Steven T Laing, Stefanie C M Burleson, Allen Nguyen, Jacqueline M McBride, Crystal Zhang, Daniel Sheinson, Wendy G Halpern Toxicological Sciences.2019; 169(2): 409. CrossRef - Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses
Silke Bergmann, Husni Elbahesh Virology.2019; 534: 54. CrossRef - Effects of heat-killed Lactobacillus plantarum against influenza viruses in mice
Sehee Park, Jin Il Kim, Joon-Yong Bae, Kirim Yoo, Hyunung Kim, In-Ho Kim, Man-Seong Park, Ilseob Lee Journal of Microbiology.2018; 56(2): 145. CrossRef - Alternative Strategy for a Quadrivalent Live Attenuated Influenza Virus Vaccine
Zhimin Wan, Stivalis Cardenas Garcia, Jing Liu, Jefferson Santos, Silvia Carnaccini, Ginger Geiger, Lucas Ferreri, Daniela Rajao, Daniel R. Perez, Adolfo García-Sastre Journal of Virology.2018;[Epub] CrossRef - PPARgamma Deficiency Counteracts Thymic Senescence
David Ernszt, Krisztina Banfai, Zoltan Kellermayer, Attila Pap, Janet M. Lord, Judit E. Pongracz, Krisztian Kvell Frontiers in Immunology.2017;[Epub] CrossRef - Repeated Low-Dose Influenza Virus Infection Causes Severe Disease in Mice: a Model for Vaccine Evaluation
Yufeng Song, Xiang Wang, Hongbo Zhang, Xinying Tang, Min Li, Jufang Yao, Xia Jin, Hildegund C. J. Ertl, Dongming Zhou, D. S. Lyles Journal of Virology.2015; 89(15): 7841. CrossRef - A broadly neutralizing human monoclonal antibody is effective against H7N9
Kannan Tharakaraman, Vidya Subramanian, Karthik Viswanathan, Susan Sloan, Hui-Ling Yen, Dale L. Barnard, Y. H. Connie Leung, Kristy J. Szretter, Tyree J. Koch, James C. Delaney, Gregory J. Babcock, Gerald N. Wogan, Ram Sasisekharan, Zachary Shriver Proceedings of the National Academy of Sciences.2015; 112(35): 10890. CrossRef - Anti-influenza effect of Cordyceps militaris through immunomodulation in a DBA/2 mouse model
Hwan Hee Lee, Heejin Park, Gi-Ho Sung, Kanghyo Lee, Taeho Lee, Ilseob Lee, Man-seong Park, Yong Woo Jung, Yu Su Shin, Hyojeung Kang, Hyosun Cho Journal of Microbiology.2014; 52(8): 696. CrossRef - Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Hyejin Kim, Hee Jin Cheong, Jin-Won Song, Ki-Joon Song, Luck Ju Baek, Man-Seong Park, Balaji Manicassamy PLoS ONE.2014; 9(7): e101325. CrossRef
- The Anti-influenza Virus Effect of Phellinus igniarius Extract
-
Sangmoo Lee , Jin Il Kim , Jun Heo , Ilseob Lee , Sehee Park , Min-Woong Hwang , Joon-Yong Bae , Mee Sook Park , Hyoung Jin Park , Man-Seong Park
-
J. Microbiol. 2013;51(5):676-681. Published online October 31, 2013
-
DOI: https://doi.org/10.1007/s12275-013-3384-2
-
-
1,201
View
-
0
Download
-
31
Crossref
-
Abstract
PDF
-
Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multicomponent nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.
-
Citations
Citations to this article as recorded by 
- Drug Repurposing Approaches for Lassa Virus from Secondary Metabolites of Medicinal Fungi: An Insight from Multifaceted Drug Designing Approaches
Surya Samiya, Singamoorthy Amalraj, Srinivasan Prabhu, Muniappan Ayyanar, Shine Kadaikunnan, Stanislaus Antony Ceasar, Naiyf S Alharbi, Muthu Thiruvengadam, Mohan G. Kalaskar, Shailendra Gurav, Rekha Thiruvengadam Journal of Computational Biophysics and Chemistry.2026; 25(03): 347. CrossRef - Phellinus igniarius targets HIF1A to regulate HK2 and inhibit metabolic reprogramming in acute myeloid leukemia
Zhongyu Li, Yuanyuan Tan, Zhibin Xie, Guizhen Su, Wei Yao, Guiling Liu, Jiajia Li Molecular and Cellular Probes.2026; 88: 102072. CrossRef - Research on Sesquiterpenoids from a Marine-Derived Fungus Phellinus sp. HN-22 and Their Anti-inflammatory Activities
Hong Xiao, Yuyue Qin, Shuo Chen, Fuling Cen, Zhuansheng Gao, Wanshan Li, Guangying Chen Chinese Journal of Organic Chemistry.2025; 45(8): 3033. CrossRef - Phellinus linteus Mycelia Extracts Show Potent Antiviral and Immunomodulatory Effects in H1N1 Influenza Virus-Infected Mice
I-Chen Li, Yi-Lin Chan, Wen-Ting Lu, Lynn-Huey Chiang, Tsung-Ju Li, Tsung-Lin Li, Chin-Chu Chen, Chang-Jer Wu Foods.2025; 14(23): 4047. CrossRef -
Antiviral Activity of Some Compounds of Gasteroid Mushrooms from Western Siberia
Elena V. Makarevich, Tamara V. Teplyakova, Oleg Yu. Mazurkov, Ekaterina I. Filippova, Natalia A. Mazurkova International Journal of Medicinal Mushrooms.2024; 26(1): 45. CrossRef - Comparative genomics and stable isotope analysis reveal the saprotrophic-pathogenic lifestyle of a neotropical fungus
Luiz Marcelo Ribeiro Tomé, Gabriel Quintanilha-Peixoto, Diogo Henrique Costa-Rezende, Carlos A. Salvador-Montoya, Domingos Cardoso, Daniel S. Araújo, Jorge Marcelo Freitas, Gabriela Bielefeld Nardoto, Genivaldo Alves-Silva, Elisandro Ricardo Drechsler-San mBio.2024;[Epub] CrossRef - Antiviral properties of lignicolous fungi of Serbia
Zlatan Radulović, Dragan Karadžić, Ivan Milenković, Katarina Mladenović, Jelena Božović Sustainable Forestry: Collection.2023; (87-88): 197. CrossRef - Medicinal mushrooms: a comprehensive study on their antiviral potential
Mustafa Sevindik, Celal Bal, Emre Cem Eraslan, İmran Uysal, Falah Saleh Mohammed Prospects in Pharmaceutical Sciences.2023; 21(2): 42. CrossRef - Identification of potential edible mushroom as SARS-CoV-2 main protease inhibitor using rational drug designing approach
Debanjan Sen, Bimal Debnath, Pradip Debnath, Sudhan Debnath, Magdi E. A. Zaki, Vijay H. Masand Scientific Reports.2022;[Epub] CrossRef - Anti-Gout Effects of the Medicinal Fungus Phellinus igniarius in Hyperuricaemia and Acute Gouty Arthritis Rat Models
Hongxing Li, Xinyue Zhang, Lili Gu, Qín Li, Yue Ju, Xuebin Zhou, Min Hu, Qīn Li Frontiers in Pharmacology.2022;[Epub] CrossRef - Phenolic compounds of Phellinus spp. with antibacterial and antiviral activities
Francisco Javier Vazquez-Armenta, Juan Manuel Leyva, Veronica Mata-Haro, Gustavo A. Gonzalez-Aguilar, Manuel R. Cruz-Valenzuela, Martin Esqueda, Aldo Gutierrez, Filomena Nazzaro, Florinda Fratianni, Rigoberto Gaitán-Hernández, J. Fernando Ayala-Zavala Brazilian Journal of Microbiology.2022; 53(3): 1187. CrossRef - Medicinal Fungi with Antiviral Effect
Yu Zhang, Guoying Zhang, Jianya Ling Molecules.2022; 27(14): 4457. CrossRef - Selected Species of the Genus Phellinus – Chemical Composition, Biological Activity, and Medicinal Applications
Katarzyna Sułkowska‐Ziaja, Monika Balik, Bożena Muszyńska Chemistry & Biodiversity.2021;[Epub] CrossRef - Preparation and characterization of selenium-rich polysaccharide from Phellinus igniarius and its effects on wound healing
Lujun Luo, Yuxia Wang, Sai Zhang, Li Guo, Guangtao Jia, Weiping Lin, Zhiqin Gao, Yuanyuan Gao, Tongyi Sun Carbohydrate Polymers.2021; 264: 117982. CrossRef - Prospects for the Development of Anti-Influenza Drugs Based on Medicinal Mushrooms (Review)
T. V. Teplyakova, T. N. Ilyicheva, N. A. Markovich Applied Biochemistry and Microbiology.2020; 56(5): 489. CrossRef - Laser Mutagenesis of Phellinus igniarius Protoplasts for the Selective Breeding of Strains with High Laccase Activity
Ziping Zhu, Na Li, Wen Li, Junmin Li, Zhengpeng Li, Jinbin Wang, Xueming Tang Applied Biochemistry and Biotechnology.2020; 190(2): 584. CrossRef - Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms
Supaphorn Seetaha, Siriluk Ratanabunyong, Lueacha Tabtimmai, Kiattawee Choowongkomon, Jatuporn Rattanasrisomporn, Khuanjarat Choengpanya Veterinary World.2020; 13(9): 1798. CrossRef - Polysaccharide from Phellinus Igniarius activates TLR4-mediated signaling pathways in macrophages and shows immune adjuvant activity in mice
Yi-qi Wang, Jin-bo Mao, Ming-qian Zhou, Ya-wei Jin, Cheng-hua Lou, Yu Dong, Dan Shou, Ying Hu, Bo Yang, Chao-ying Jin, Han-cheng Shi, Hua-jun Zhao, Cheng-ping Wen International Journal of Biological Macromolecules.2019; 123: 157. CrossRef - Nitrous Acid and Diethyl Sulfate, as Chemical Mutagenic Agents, to Improve the Biomass, Metabolites, Enzyme Activity, and Antioxidant Activity of Wild Phellinus igniarius
Jinjing Guo, Cheng Liu, Caifang Zhang, Jing Wang, Sa Wang, Xiaoxi Liu, Xiaojuan Gao, Xiuli Wu Food Science and Technology Research.2019; 25(3): 459. CrossRef - Isoquercetin enzymatic production: A true story
Vladimír Křen, Kateřina Valentová Molecular Catalysis.2018; 458: 112. CrossRef - Medicinal mushroom Phellinus igniarius induced cell apoptosis in gastric cancer SGC-7901 through a mitochondria-dependent pathway
Fei-Fei Wang, Chao Shi, Yue Yang, Yong Fang, Li Sheng, Ning Li Biomedicine & Pharmacotherapy.2018; 102: 18. CrossRef - Herbal Medicines with Antiviral Activity Against the Influenza Virus, a Systematic Review
Ju-Young Lee, Michael Edward C. Abundo, Chang-Won Lee The American Journal of Chinese Medicine.2018; 46(08): 1663. CrossRef - Simultaneous Quantification of Antioxidant Compounds in Phellinus igniarius Using Ultra Performance Liquid Chromatography-Photodiode Array Detection-Electrospray Ionization Tandem Mass Spectrometry
Dan Shou, Yu Dong, Nani Wang, Hongyu Li, Yang Zhang, Yan Zhu, Andrew C. Gill PLOS ONE.2016; 11(9): e0163797. CrossRef - Enhanced biocatalysis mechanism under microwave irradiation in isoquercitrin production revealed by circular dichroism and surface plasmon resonance spectroscopy
An Gong, Dan Zhu, Yi-Yuan Mei, Xiao-Hui Xu, Fu-An Wu, Jun Wang Bioresource Technology.2016; 205: 48. CrossRef - Isoquercitrin production from rutin catalyzed by naringinase under ultrasound irradiation
Dan Zhu, An Gong, Yan Xu, D’assise Kinfack Tsabing, Fuan Wu, Jun Wang Journal of Molecular Catalysis B: Enzymatic.2016; 134: 186. CrossRef - Phellinus igniarius: A Pharmacologically Active Polypore Mushroom
Ewa Zapora, Marek Wolkowycki, Slawomir Bakier, Jordan K. Zjawiony Natural Product Communications.2016;[Epub] CrossRef - Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius
Ji-Yul Kim, Dae-Won Kim, Byung Soon Hwang, E-Eum Woo, Yoon-Ju Lee, Kyeong-Woon Jeong, In-Kyoung Lee, Bong-Sik Yun Mycobiology.2016; 44(2): 117. CrossRef - Purification, characterization and antitumor activity of polysaccharides extracted from Phellinus igniarius mycelia
Shi-Chao Li, Xiao-Ming Yang, Hai-Le Ma, Jing-Kun Yan, Dan-Zhao Guo Carbohydrate Polymers.2015; 133: 24. CrossRef - Evaluation of the Antioxidant Activities and Tyrosinase Inhibitory Property from Mycelium Culture Extracts
Ki Moon Park, Kyung Min Kwon, Seung Ho Lee Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1. CrossRef - Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus
Song-Yi Ha, Hana Youn, Chang-Seon Song, Se Chan Kang, Jong Jin Bae, Hee Tae Kim, Kwang Min Lee, Tae Hoon Eom, In Su Kim, Jong Hwan Kwak Journal of Microbiology.2014; 52(4): 340. CrossRef - Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Hyejin Kim, Hee Jin Cheong, Jin-Won Song, Ki-Joon Song, Luck Ju Baek, Man-Seong Park, Balaji Manicassamy PLoS ONE.2014; 9(7): e101325. CrossRef
- Susceptibility of Human H3N2 Influenza Virus to Oseltamivir in South Korea, 2009–2011
-
Sehee Park , Jin Il Kim , Ilseob Lee , Sangmoo Lee , Min-Woong Hwang , Joon-Yong Bae , Jun Heo , Eun-Joo Lim , Won-Seok Seok , Hee Jin Cheong , Joon Young Song , Woo Joo Kim , Man-Seong Park
-
J. Microbiol. 2012;50(6):1067-1070. Published online December 30, 2012
-
DOI: https://doi.org/10.1007/s12275-012-2541-3
-
-
783
View
-
1
Download
-
4
Crossref
-
Abstract
PDF
-
During the 2009–2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.
-
Citations
Citations to this article as recorded by 
- Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Hyejin Kim, Hee Jin Cheong, Jin-Won Song, Ki-Joon Song, Luck Ju Baek, Man-Seong Park, Balaji Manicassamy PLoS ONE.2014; 9(7): e101325. CrossRef - Effects of a hemagglutinin D222G substitution on the pathogenicity of 2009 influenza A (H1N1) virus in mice
Jin Il Kim, Ilseob Lee, Sehee Park, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Seok-Il Jang, Jin-Won Song, Man-Seong Park Archives of Virology.2014; 159(10): 2559. CrossRef - The anti-influenza virus effect of Phellinus igniarius extract
Sangmoo Lee, Jin Il Kim, Jun Heo, Ilseob Lee, Sehee Park, Min-Woong Hwang, Joon-Yong Bae, Mee Sook Park, Hyoung Jin Park, Man-Seong Park Journal of Microbiology.2013; 51(5): 676. CrossRef - Strategy for Developing Medical Arsenals by Modulation of Membrane Fusion Activity of Influenza Virus Hemagglutinin
Sangmoo Lee, Jin Il Kim, Ilseob Lee, Man-Seong Park Journal of Bacteriology and Virology.2013; 43(4): 337. CrossRef
- GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents
-
Jin Il Kim , Sehee Park , Ilseob Lee , Sangmoo Lee , Saem Shin , Yongkwan Won , Min-Woong Hwang , Joon-Yong Bae , Jun Heo , Hye-Eun Hyun , Hyejin Jun , Soon Sung Lim , Man-Seong Park
-
J. Microbiol. 2012;50(2):359-362. Published online April 27, 2012
-
DOI: https://doi.org/10.1007/s12275-012-2163-9
-
-
750
View
-
2
Download
-
14
Crossref
-
Abstract
PDF
-
To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.
-
Citations
Citations to this article as recorded by 
- Segmented, Negative-Sense RNA Viruses of Humans: Genetic Systems and Experimental Uses of Reporter Strains
Cait E. Hamele, M. Ariel Spurrier, Rebecca A. Leonard, Nicholas S. Heaton
Annual Review of Virology
.2023; 10(1): 261. CrossRef - Development of a recombinant reporter Getah virus for antiviral drug screening assays
Tongwei Ren, Lingshan Zhou, Xiangling Min, Mengqi Sui, Xuechun Zhi, Yongfang Mo, Jing Huang, Kang Zhang, Wenbo Liu, Hao Wang, Xindong Wang, Kang Ouyang, Ying Chen, Weijian Huang, Zuzhang Wei Veterinary Microbiology.2023; 281: 109742. CrossRef - Developing therapeutic approaches for twenty-first-century emerging infectious viral diseases
Rita M. Meganck, Ralph S. Baric Nature Medicine.2021; 27(3): 401. CrossRef - Construction of eGFP-Tagged Senecavirus A for Facilitating Virus Neutralization Test and Antiviral Assay
Fuxiao Liu, Yilan Huang, Qianqian Wang, Hu Shan Viruses.2020; 12(3): 283. CrossRef - Novel Small Molecule Targeting the Hemagglutinin Stalk of Influenza Viruses
Jin Il Kim, Sangmoo Lee, Gong Yeal Lee, Sehee Park, Joon-Yong Bae, Jun Heo, Hong-Youb Kim, Seok-Hun Woo, Hae Un Lee, Chung Am Ahn, Hye Jin Bang, Hyun Soo Ju, Kiwon Ok, Youngjoo Byun, Dae-Jin Cho, Jae Soo Shin, Dong-Yeon Kim, Mee Sook Park, Man-Seong Park, Journal of Virology.2019;[Epub] CrossRef - Illumina MiSeq sequencing disfavours a sequence motif in the GFP reporter gene
Silvie Van den Hoecke, Judith Verhelst, Xavier Saelens Scientific Reports.2016;[Epub] CrossRef - MDA7/IL-24 is an anti-viral factor that inhibits influenza virus replication
Rak-Kyun Seong, Young-Ki Choi, Ok Sarah Shin Journal of Microbiology.2016; 54(10): 695. CrossRef - Replication-Competent Influenza A Viruses Expressing Reporter Genes
Michael Breen, Aitor Nogales, Steven Baker, Luis Martínez-Sobrido Viruses.2016; 8(7): 179. CrossRef - Oligonol promotes anti-aging pathwaysviamodulation of SIRT1-AMPK-Autophagy Pathway
Seul-Ki Park, Rak-Kyun Seong, Ji-Ae Kim, Seok-Jun Son, Younghoon Kim, Takako Yokozawa, Ok Sarah Shin Nutrition Research and Practice.2016; 10(1): 3. CrossRef - Development of a Reverse Genetic System for Infectious Salmon Anemia Virus: Rescue of Recombinant Fluorescent Virus by Using Salmon Internal Transcribed Spacer Region 1 as a Novel Promoter
Daniela Toro-Ascuy, Carolina Tambley, Carolina Beltran, Carolina Mascayano, Nicolas Sandoval, Eduardo Olivares, Rafael A. Medina, Eugenio Spencer, Marcelo Cortez-San Martín, M. W. Griffiths Applied and Environmental Microbiology.2015; 81(4): 1210. CrossRef - Strategy for Developing Medical Arsenals by Modulation of Membrane Fusion Activity of Influenza Virus Hemagglutinin
Sangmoo Lee, Jin Il Kim, Ilseob Lee, Man-Seong Park Journal of Bacteriology and Virology.2013; 43(4): 337. CrossRef - The anti-influenza virus effect of Phellinus igniarius extract
Sangmoo Lee, Jin Il Kim, Jun Heo, Ilseob Lee, Sehee Park, Min-Woong Hwang, Joon-Yong Bae, Mee Sook Park, Hyoung Jin Park, Man-Seong Park Journal of Microbiology.2013; 51(5): 676. CrossRef - Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses
Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Donghwan Kim, Sang-Zin Han, Man-Seong Park Biochemical and Biophysical Research Communications.2013; 440(1): 14. CrossRef - Susceptibility of human H3N2 influenza virus to oseltamivir in South Korea, 2009–2011
Sehee Park, Jin Il Kim, Ilseob Lee, Sangmoo Lee, Min-Woong Hwang, Joon-Yong Bae, Jun Heo, Eun-Joo Lim, Won-Seok Seok, Hee Jin Cheong, Joon Young Song, Woo Joo Kim, Man-Seong Park Journal of Microbiology.2012; 50(6): 1067. CrossRef
|