- Inhibitory Effect of Chlorophyllin on the Propionibacterium acnes-Induced Chemokine Expression
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Mi-Sun Kang , Jin-Hee Kim , Boo-Ahn Shin , Hyun-Chul Lee , Youn-Shin Kim , Hae-Soon Lim , Jong-Suk Oh
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J. Microbiol. 2014;52(2):184-184.
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DOI: https://doi.org/10.1007/s12275-014-0698-7
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Abstract
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In the article by Kang et al. published in Journal of Microbiology 2013; 51, 844-849. Figure 4 on page 847 should be changed as below.
- Inhibitory Effect of Chlorophyllin on the Propionibacterium acnes-Induced Chemokine Expression
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Mi-Sun Kang , Jin-Hee Kim , Boo-Ahn Shin , Hyun-Chul Lee , Youn-Shin Kim , Hae-Soon Lim , Jong-Suk Oh
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J. Microbiol. 2013;51(6):844-849. Published online December 19, 2013
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DOI: https://doi.org/10.1007/s12275-013-3015-y
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906
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Abstract
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Chlorophyllin (CHL), a chlorophyll-derivative, exhibits several
beneficial properties, including antibacterial, antioxidant,
and anticancer activities. However, its antibacterial and
anti-inflammatory activities against Propionibacterium acnes
have not been described. The antibacterial activity of this compound
was evaluated in vitro using the broth microdilution
method . CHL had an inhibitory effect on the growth of P.
acnes (MIC = 100 μM). In a real-time reverse transcriptionpolymerase
chain reaction and an enzyme-linked immunosorbent
assay, CHL significantly decreased interleukin-8
(IL-8) and monocyte chemoattractant protein-1 (MCP-1)
production in a dose-dependent manner, decreasing both
mRNA and protein levels for these chemokines in THP-1
cells indicating the anti-inflammatory effects of it. To investigate
the molecular mechanisms underlying the anti-inflammatory
properties of CHL in THP-1 cells stimulated
by P. acnes, we used western blotting to analyze the effect of
CHL on activation of the nuclear factor (NF)-κB. CHL inhibited
P. acnes-induced IL-8 and MCP-1 production via
blockade of NF-κB activation in THP-1 cells. Therefore,
based on these results, we suggest that CHL is a useful agent
to control the growth of P. acnes involved in acne inflammation
and prevent acne.
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Citations
Citations to this article as recorded by 
- Copper Chlorophyllin as an Antioxidant and Photosensitizer: Mitigating Ifosfamide Toxicity and Enhancing Photodynamic Therapy
Lamia M. Elashry, Nashwah I. Zaki, Einas Yousef, Omar A. Ahmed‐Farid, Tarek A. El‐Tayeb Journal of Biochemical and Molecular Toxicology.2025;[Epub] CrossRef - A chlorin e6 derivative-mediated photodynamic therapy for mild to moderate acne: A prospective, single-blind, randomized, split-face controlled study
Haiyan Zhang, Yan Zhao, Hui Tao, Chunmei Feng, Peiru Wang, Linglin Zhang, Xiaojing Liu, Yamei Chen, Xiuli Wang Photodiagnosis and Photodynamic Therapy.2024; 49: 104304. CrossRef - Antibacterial and Antibiofilm Potential of Chlorophyllin Against Streptococcus mutans In Vitro and In Silico
Seemrose Khan, Ihtisham Ul Haq, Imran Ali, Abdul Rehman, Mazen Almehmadi, Meshari A. Alsuwat, Tariq Zaman, Muhammad Qasim Antibiotics.2024; 13(9): 899. CrossRef - Anti-Cancer Effect of Chlorophyllin-Assisted Photodynamic Therapy to Induce Apoptosis through Oxidative Stress on Human Cervical Cancer
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Shima Afrasiabi, Maryam Pourhajibagher, Nasim Chiniforush, Mahdi Aminian, Samaneh Sadat Rasi Varaei, Abbas Bahador Photodiagnosis and Photodynamic Therapy.2020; 32: 102044. CrossRef - Chlorophyll degradation by tetracycline and cadmium in spinach (Spinacia oleracea L.) leaves
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- Inhibitory Effect of Lactobacillus reuteri on Periodontopathic and Cariogenic Bacteria
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Mi-Sun Kang , Jong-Suk Oh , Hyun-Chul Lee , Hoi-Soon Lim , Seok-Woo Lee , Kyu-Ho Yang , Nam-Ki Choi , Seon-Mi Kim
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J. Microbiol. 2011;49(2):193-199. Published online May 3, 2011
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DOI: https://doi.org/10.1007/s12275-011-0252-9
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768
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The interaction between Lactobacillus reuteri, a probiotic bacterium, and oral pathogenic bacteria have not been studied adequately. This study examined the effects of L. reuteri on the proliferation of periodontopathic bacteria including Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, and Tannerella forsythia, and on the formation of Streptococcus mutans biofilms. Human-derived L. reuteri strains (KCTC 3594 and KCTC 3678) and rat-derived L. reuteri KCTC 3679 were used. All strains exhibited significant inhibitory effects on the growth of periodontopathic bacteria and the formation of S. mutans
biofilms. These antibacterial activities of L. reuteri were attributed to the production of organic acids, hydrogen peroxide, and a bacteriocin-like compound. Reuterin, an antimicrobial factor, was produced only by L. reuteri KCTC 3594. In addition, L. reuteri inhibited the production of methyl mercaptan by F. nucleatum and P. gingivalis. Overall, these results suggest that L. reuteri may be useful as a probiotic agent for improving oral health.
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- Effect of Leuconostoc spp. on the Formation of Streptococcus mutans Biofilm
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Mi-Sun Kang , In-Chol Kang , Seon-Mi Kim , Hyun-Chul Lee , Jong-Suk Oh
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J. Microbiol. 2007;45(4):291-296.
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DOI: https://doi.org/2570 [pii]
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Abstract
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Insoluble glucans synthesized by Streptococcus mutans enhance the pathogenicity of oral biofilm by promoting the adherence and accumulation of cariogenic bacteria on the surface of the tooth. The objective of this study was to investigate the effect of Leuconostoc spp. on the in vitro formation of S. mutans biofilm. Three strains, Leuconostoc gelidum ATCC 49366, Leuconostoc mesenteroides ssp. cremoris ATCC 19254 and Leuconostoc mesenteroides ssp. mesenteroides ATCC 8293, were used in this study. They exhibited profound inhibitory effects on the formation of S. mutans biofilm and on the proliferation of S. mutans. The water-soluble polymers produced from sucrose were most strongly produced by L. gelidum, followed by L. mesenteroides ssp. cremoris and L. mesenteroides ssp. mesenteroides. The mean wet weights of the artificial biofilm of S. mutans were also significantly reduced as a result of the addition of the water-soluble polymers obtained from Leuconostoc cultures. According to the results of thin-layer chromatographic analysis, the hydrolysates of the water-soluble polymers produced by Leuconostoc were identical to those of dextran T-2000, forming predominately α-(1-6) glucose linkages. These results indicate that dextran-producing Leuconostoc strains are able to inhibit the formation of S. mutans biofilm in vitro.
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