Journal of Microbiology

Hyoung Jin Kim

4 Articles

IgG and IgM responses to human papillomavirus L1 virus-like particle as a function of dosing schedule and vaccine formulation: Min-Hye Park , Ji Won You , Hyoung Jin Kim , Hong-Jin Kim; J. Microbiol. 2019;57(9):821-827. Published online August 27, 2019; DOI: https://doi.org/10.1007/s12275-019-9308-z

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Most commercialized virus-like particle (VLP) vaccines use aluminum salt as adjuvant, even though VLPs provoke adequate antibody responses without adjuvant. We do not have detailed knowledge of how adjuvant affects the profile of anti- VLP antibodies. Meanwhile, there is evidence that differences between vaccination protocols influence the glycosylation of antibodies, which may alter their effector functions. In the present study a murine model was used to investigate the effects of dosing schedule and adjuvant on the antibody profiles and glycosylation levels of antigen-specific antibody responses to human papillomavirus type 16 L1 (HPV16 L1) VLPs. Mice received subcutaneously 2,000 ng of antigen divided into 4 or 7 doses. The HPV16 L1 VLPs elicited > 4 log10 anti-HPV16 L1 IgG titers without adjuvant, and aluminum hydroxide as adjuvant increased IgG titers 1.3- to 4-fold and reduced the anti-HPV16 L1 IgG2a / anti-HPV16 L1 IgG1 ratio value (use of aluminum hydroxide reduced the ratio of the IgG2a). Immunization with HPV16 L1 VLPs in combination with Freund’s adjuvant enhanced IgG titers 5- to 12- fold. Seven-dose immunization markedly increased anti- HPV16 L1 IgM titers compared to four-dose immunization, as well as increasing the proportion of glycosylated antibodies. Our results suggest that antibody glycosylation can be controlled immunologically, and IgG and IgM profiles and glycosylation profiles of the vaccine-induced antibodies can be used as indicators reflecting the vaccine characteristics. These
results
indicate that the HPV16 L1 VLP dosing schedule can affect the quality of antigen-specific antibody responses. We suggest that dosing schedules should be noted in vaccination protocols for VLP-based vaccines.

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Human papillomavirus vaccines: organisation and experience of preclinical studies
A. S. Korovkin, T. N. Nikitina, T. Yu. Kozlova, D. V. Gorenkov, A. R. Volgin
Biological Products. Prevention, Diagnosis, Treatment.2024; 24(3): 243. CrossRef
Chimeric Hepatitis B core virus-like particles harboring SARS-CoV2 epitope elicit a humoral immune response in mice
Sima Sazegari, Malihe Akbarzadeh Niaki, Alireza Afsharifar, Ali Niazi, Abdollah Derakhshandeh, Maryam Moradi Vahdat, Farshad Hemmati, Mohammad Hadi Eskandari
Microbial Cell Factories.2023;[Epub] CrossRef
Anti-JMH alloantibody in inherited JMH-negative patients leads to immunogenic destruction of JMH-positive RBCs
Zhaohu Yuan, Yaming Wei, Xiaojie Chen, Shufei He, Kui Cai, Minglu Zhong, Huiying Huang, Xinxin Tong, Zhen Liu, Xuexin Yang
Clinical and Experimental Immunology.2021; 205(2): 182. CrossRef
Prevalence of antibodies against a cyclic peptide mimicking the FG loop of the human papillomavirus type 16 capsid among Tunisian women
Elham Hassen, Devendra Bansal, Randa Ghdira, Anouar Chaieb, Hedi Khairi, Abdelfattah Zakhama, Sami Remadi, Johan Hoebeke, Ali A. Sultan, Lotfi Chouchane
Journal of Translational Medicine.2020;[Epub] CrossRef

The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse: Mei Ling Xu , Hyoung Jin Kim , Ga Ram Wi , Hong-Jin Kim; J. Microbiol. 2015;53(9):661-666. Published online August 27, 2015; DOI: https://doi.org/10.1007/s12275-015-5353-4

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Human respiratory syncytial virus (hRSV) is the most common cause of respiratory tract infection among young children because of immature T cell immunity of them against hRSV. CD8 T cells play a pivotal role in clearing hRSV and preventing subsequent infection. We examined the effects of dietary bovine colostrum on virus infection and CD8 T cell responses following hRSV infection in the mouse model. Mice received bovine colostrum for 14 days prior to hRSV challenge, and lung indexes (severity of symptom) and lung virus titers were analyzed. In addition, the activation of CD8 T cells in the bronchoalveolar lavage fluids (BALFs) of mice receiving bovine colostrum were compared with those in the BALFs of mice receiving phosphate-buffered saline (PBS) or ribavirin, post virus challenge. The severity of infection and lung virus titers were reduced in the mice receiving bovine colostrum, compared to those receiving PBS. Moreover CD8 T cell responses were selectively enhanced in the former. Our results suggest that dietary bovine colostrum exerts the effects to inhibit hRSV and ameliorate the symptom by hRSV infection, and enhances the CD8 T cell response during the hRSV infection.

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Bovine Colostrum: Unveiling its Potent Health Benefits and Emerging Trends in Optimizing Well-being
Archna Singh, Avijit Mazumder, Saumya Das, Anmol Kanda, Vishnu Prabhakar, Rashmi Mishra, MVNL Chaitanya
The Natural Products Journal.2025;[Epub] CrossRef
Improved physical disability and nutritional status by bovine colostrum supplementation in adults with traumatic peri-trochanteric femoral fracture: A randomized, controlled, clinical trial
Faezeh Gouhari, Reza Zandi, Amir Mehrvar, Shahin Talebi, Zahra Vahdat Shariatpanahi
Injury.2024; 55(3): 111253. CrossRef
Systemic immune markers and infection risk in preterm infants fed human milk fortified with bovine colostrum or conventional fortifier, a secondary analysis of the FortiColos trial
Ole Bæk, Tik Muk, Lise Aunsholt, Gitte Zachariasen, Per Torp Sangild, Duc Ninh Nguyen
Infection.2024; 52(6): 2315. CrossRef
Role of bovine colostrum against various diseases
Yalçın Mert Yalçıntaş, Hatice Duman, João Miguel Rocha, Elena Bartkiene, Sercan Karav, Fatih Ozogul
Food Bioscience.2024; 61: 104818. CrossRef
Colostrum supplement, immune variables and hospital-acquired infection in acute respiratory failure: A double-blind, randomized, placebo-controlled study
Elham Roohelhami, Seyed Hossein Ardehali, Elham Makiabadi, Zahra Vahdat Shariatpanahi
Journal of Functional Foods.2023; 111: 105909. CrossRef
Review: Colostrum as an Emerging food: Nutraceutical Properties and Food Supplement
Carlotta Ceniti, Nicola Costanzo, Valeria Maria Morittu, Bruno Tilocca, Paola Roncada, Domenico Britti
Food Reviews International.2023; 39(7): 4636. CrossRef
Bovine colostrum and its potential contributions for treatment and prevention of COVID-19
Hatice Duman, Sercan Karav
Frontiers in Immunology.2023;[Epub] CrossRef
Hyper-Immune Bovine Milk as an Immunological and Nutritional Supplement for COVID-19
Hassan Nili, Majid Bouzari, Hamid Reza Attaran, Nader Ghalegolab, Mohammad Rabani, Ahmad Mahmoudian
Frontiers in Nutrition.2022;[Epub] CrossRef
A REVIEW ON LACTOFERRIN PRINCIPLE CONSTITUENT OF BOVINE COLOSTRUM: IN COVID19
AISHWARYA S. PATIL, RANI PURI, B. S. WAKURE
International Journal of Current Pharmaceutical Research.2022; : 1. CrossRef
Direct Binding of Bovine IgG-Containing Immune Complexes to Human Monocytes and Their Putative Role in Innate Immune Training
Mojtaba Porbahaie, Huub F. J. Savelkoul, Cornelis A. M. de Haan, Malgorzata Teodorowicz, R. J. Joost van Neerven
Nutrients.2022; 14(21): 4452. CrossRef
Promising traditional Indian medicinal plants for the management of novel Coronavirus disease: A systematic review
Rahul Soloman Singh, Ashutosh Singh, Harpinder Kaur, Gitika Batra, Phulen Sarma, Hardeep Kaur, Anusuya Bhattacharyya, Amit Raj Sharma, Subodh Kumar, Sujata Upadhyay, Vinod Tiwari, Pramod Avti, Ajay Prakash, Bikash Medhi
Phytotherapy Research.2021; 35(8): 4456. CrossRef
Bovine colostrum: benefits for the human respiratory system and potential contributions for clinical management of COVID-19
Alyne Batista da Silva Galdino, Adriano Henrique do Nascimento Rangel, Harpal Singh Buttar, Manuela Sales Lima Nascimento, Elaine Cristina Gavioli, Riva de Paula Oliveira, Danielle Cavalcanti Sales, Stela Antas Urbano, Katya Anaya
Food and Agricultural Immunology.2021; 32(1): 143. CrossRef
The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma
Betty C. A. M. van Esch, Mojtaba Porbahaie, Suzanne Abbring, Johan Garssen, Daniel P. Potaczek, Huub F. J. Savelkoul, R. J. Joost van Neerven
Frontiers in Immunology.2020;[Epub] CrossRef
Can Drinking Microfiltered Raw Immune Milk From Cows Immunized Against SARS-CoV-2 Provide Short-Term Protection Against COVID-19?
Samir Jawhara
Frontiers in Immunology.2020;[Epub] CrossRef
Bovine IgG Prevents Experimental Infection With RSV and Facilitates Human T Cell Responses to RSV
Maaike Nederend, Arthur H. van Stigt, J. H. Marco Jansen, Shamir R. Jacobino, Sylvia Brugman, Cornelis A. M. de Haan, Louis J. Bont, R. J. Joost van Neerven, Jeanette H. W. Leusen
Frontiers in Immunology.2020;[Epub] CrossRef
Therapeutic Applications of Human and Bovine Colostrum in the Treatment of Gastrointestinal Diseases and Distinctive Cancer Types: The Current Evidence
Siddhi Bagwe-Parab, Pratik Yadav, Ginpreet Kaur, Hardeep Singh Tuli, Harpal Singh Buttar
Frontiers in Pharmacology.2020;[Epub] CrossRef
Enriched bovine IgG fraction prevents infections with Enterohaemorrhagic Escherichia coli O157:H7, Salmonella enterica serovar Enteritidis, and Mycobacterium avium
Keiji Funatogawa, Tatsuya Tada, Kyoko Kuwahara‐Arai, Teruo Kirikae, Masao Takahashi
Food Science & Nutrition.2019; 7(8): 2726. CrossRef
Melatonin, a toll‐like receptor inhibitor: Current status and future perspectives
Omid Reza Tamtaji, Moein Mobini, Russel J. Reiter, Abolfazl Azami, Mohammad Saeed Gholami, Zatollah Asemi
Journal of Cellular Physiology.2019; 234(6): 7788. CrossRef
Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection
Laurien H. Ulfman, Jeanette H. W. Leusen, Huub F. J. Savelkoul, John O. Warner, R. J. Joost van Neerven
Frontiers in Nutrition.2018;[Epub] CrossRef
Ameliorating Effect of Dietary Xylitol on Human Respiratory Syncytial Virus (hRSV) Infection
Mei Ling Xu, Ga Ram Wi, Hyoung Jin Kim, Hong-Jin Kim
Biological & Pharmaceutical Bulletin.2016; 39(4): 540. CrossRef

The Effect of Dietary Intake of the Acidic Protein Fraction of Bovine Colostrum on Influenza A (H1N1) Virus Infection: Mei Ling Xu , Hyoung Jin Kim , Don Yong Chang , Hong-Jin Kim; J. Microbiol. 2013;51(3):389-393. Published online April 26, 2013; DOI: https://doi.org/10.1007/s12275-013-2683-y

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Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.

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The Toxic Effects of Low Molecular Weight Components of Cow Colostrums: The Short-Term and Long-Term Effects
A.I. Bozhkov, E.G. Ivanov, N.I. Kurguzova, Muhammad M.A. Alsardia, R.A. Akzhigitov, S.Ya. Baranikova, V.I. Potapova, A.S. Chuprikova
Journal of Nutritional Therapeutics.2021; 6(4): 84. CrossRef
Bovine colostrum: benefits for the human respiratory system and potential contributions for clinical management of COVID-19
Alyne Batista da Silva Galdino, Adriano Henrique do Nascimento Rangel, Harpal Singh Buttar, Manuela Sales Lima Nascimento, Elaine Cristina Gavioli, Riva de Paula Oliveira, Danielle Cavalcanti Sales, Stela Antas Urbano, Katya Anaya
Food and Agricultural Immunology.2021; 32(1): 143. CrossRef
Influenza A in Bovine Species: A Narrative Literature Review
Chithra C. Sreenivasan, Milton Thomas, Radhey S. Kaushik, Dan Wang, Feng Li
Viruses.2019; 11(6): 561. CrossRef
Effective Components of Bovine Colostrum and Its Applications
Sang-Ah Seo, Hye-Ryoung Seo, Young-Tae Heo
Journal of Animal Reproduction and Biotechnology.2018; 33(3): 159. CrossRef
The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse
Mei Ling Xu, Hyoung Jin Kim, Ga Ram Wi, Hong-Jin Kim
Journal of Microbiology.2015; 53(9): 661. CrossRef
Effect of dietary bovine colostrum on the responses of immune cells to stimulation with bacterial lipopolysaccharide
Mei Ling Xu, Hyoung Jin Kim, Hong-Jin Kim
Archives of Pharmacal Research.2014; 37(4): 494. CrossRef

The Production and Immunogenicity of Human Papillomavirus Type 58 Virus-like Particles Produced in Saccharomyces cerevisiae: Hye-Lim Kwag , Hyoung Jin Kim , Don Yong Chang , Hong-Jin Kim; J. Microbiol. 2012;50(5):813-820. Published online November 4, 2012; DOI: https://doi.org/10.1007/s12275-012-2292-1

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Human papillomavirus (HPV) is the cause of most cases of cervical cancer. HPV type 58 (HPV58) is the second most frequent cause of cervical cancer and high-grade squamous intraepithelial lesions (HSIL) in Asia and South / Central America, respectively. However, there is no vaccine against HPV58, although there are commercially available vaccines against HPV16 and 18. In this study, we produced HPV58 L1 protein from Saccharomyces cerevisiae, and investigated its immunogenicity. We first determined the optimum period of culture for obtaining HPV58 L1. We found that a considerable portion of the HPV58 L1 resulting from 48 h culture cannot be recovered by purification, while the HPV58 L1 resulting from 144 h culture is recovered efficiently: the yield of HPV58 L1 finally recovered from 144 h culture was 2.3 times higher than that from 48 h culture, although the production level of L1 protein from 144 h culture was lower than that from 48 h culture. These results indicate that the proportion of functional L1 protein from 144 h-cultured cells is significantly higher than that of 48 h-cultured cells. The HPV58 L1 purified from the 144 h culture was correctly assembled into structures similar to naturally occurring HPV virions. Immunization with the HPV58 L1 efficiently elicited anti-HPV58 neutralizing antibodies and antigen-specific CD4+ and CD8+ T cell proliferations, without the need for adjuvant. Our findings provide a convenient method for obtaining substantial amounts of highly immunogenic HPV58 L1 from S. cerevisiae.

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