- Weigela florida inhibits the expression of inflammatory mediators induced by Pseudomonas aeruginosa and Staphylococcus aureus infection
-
Hyo Bin Kim , Soomin Cho , Yeji Lee , Weihui Wu , Un-Hwan Ha
-
J. Microbiol. 2022;60(6):649-656. Published online April 30, 2022
-
DOI: https://doi.org/10.1007/s12275-022-1638-6
-
-
968
View
-
5
Download
-
3
Web of Science
-
4
Crossref
-
 Abstract
 PDF
-
Inflammatory responses involve the action of inflammatory
mediators that are necessary for the clearance of invading bacterial
pathogens. However, excessive production of inflammatory
mediators can damage tissues, thereby impairing bacterial
clearance. Here, we examined the effects of Weigela florida
on the expression of inflammatory cytokines induced by
Pseudomonas aeruginosa or Staphylococcus aureus infection
in macrophages. The results showed that pre-treatment with
W. florida markedly downregulated the bacterial infectionmediated
expression of cytokines. Additionally, post-treatment
also triggered anti-inflammatory effects in cells infected
with S. aureus to a greater extent than in those infected with
P. aeruginosa. Bacterial infection activated inflammation-associated
AKT (Thr308 and Ser473)/NF-κB and MAPK (p38,
JNK, and ERK) signaling pathways, whereas W. florida treatment
typically inhibited the phosphorylation of AKT/NF‐κB
and p38/JNK, supporting the anti‐inflammatory effects of
W. florida. The present results suggest that W. florida decreases
the infection-mediated expression of inflammatory
mediators by inhibiting the AKT/NF-κB and MAPK signaling
pathways, implying that it may have potential use as an
inhibitory agent of excessive inflammatory responses.
-
Citations
Citations to this article as recorded by  - Multifunctional fluorescence probe for simultaneous detection of viscosity, polarity, and ONOO− and its bioimaging in vitro and vivo
Yuan-Yuan Li, Jia-Ling Hu, Ji-Rou Wu, Yi-Ru Wang, Ai-Hong Zhang, Yu-Wei Tan, Ya-Jing Shang, Ting Liang, Min Li, Ya-Li Meng, Yan-Fei Kang
Biosensors and Bioelectronics.2024; 254: 116233. CrossRef - Polymicrobial interactions influence Mycobacterium abscessus co-existence and biofilm forming capabilities
Nishant Nandanwar, Geoffery Gu, Joy E. Gibson, Michael N. Neely
Frontiers in Microbiology.2024;[Epub] CrossRef - Tissue damage alleviation and mucin inhibition by P5 in a respiratory infection mouse model with multidrug-resistant Acinetobacter baumannii
Jun Hee Oh, Jonggwan Park, Hee Kyoung Kang, Hee Joo Park, Yoonkyung Park
Biomedicine & Pharmacotherapy.2024; 181: 117724. CrossRef - Spatiotemporal Deep-Learning-Based Algal Bloom Prediction for Lake Okeechobee Using Multisource Data Fusion
Yufei Tang, Yingqi Feng, Sasha Fung, Veronica Ruiz Xomchuk, Mingshun Jiang, Tim Moore, Jordon Beckler
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing.2022; 15: 8318. CrossRef
|
MSK
