- Bacterial Crosstalk via Antimicrobial Peptides on the Human Skin: Therapeutics from a Sustainable Perspective
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Seon Mi Lee , Hye Lim Keum , Woo Jun Sul
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J. Microbiol. 2023;61(1):1-11. Published online January 31, 2023
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DOI: https://doi.org/10.1007/s12275-022-00002-8
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 Abstract
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The skin’s epidermis is an essential barrier as the first guard against invading pathogens, and physical protector from external
injury. The skin microbiome, which consists of numerous bacteria, fungi, viruses, and archaea on the epidermis, play a key
role in skin homeostasis. Antibiotics are a fast-acting and effective treatment method, however, antibiotic use is a nuisance
that can disrupt skin homeostasis by eradicating beneficial bacteria along with the intended pathogens and cause antibioticresistant
bacteria spread. Increased numbers of antimicrobial peptides (AMPs) derived from humans and bacteria have been
reported, and their roles have been well defined. Recently, modulation of the skin microbiome with AMPs rather than artificially
synthesized antibiotics has attracted the attention of researchers as many antibiotic-resistant strains make treatment
mediation difficult in the context of ecological problems. Herein, we discuss the overall insights into the skin microbiome,
including its regulation by different AMPs, as well as their composition and role in health and disease.
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Citations
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