- Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells
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Seulki Lee , Hwan Hee Lee , Jisung Kim , Joohee Jung , Aree Moon , Choon-Sik Jeong , Hyojeung Kang , Hyosun Cho
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J. Microbiol. 2015;53(7):468-474. Published online June 27, 2015
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DOI: https://doi.org/10.1007/s12275-015-5198-x
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Cordyceps extract has been reported to have various pharmacological
activities including an anti-cancer effect. We
investigated the inhibitory effect of Cordyceps militaris on
hepatitis C virus-infected human hepatocarcinoma 7.5 cells
(J6/JFH1-huh 7.5 cells). The huh7.5 cells with or without
HCV infection were treated with various concentrations of
ethanol extract of Cordyceps militaris (CME) for 48 h and the
cytotoxicity was measured by CCK-8 assay. Both J6/JFH1-
huh7.5 cells and huh7.5 cells were highly susceptible to CME.
To examine the molecular mechanisms of the inhibitory effect
on huh7.5 cells, the effect of CME on cell apoptosis was
measured using flow cytometry and the expressions of p53,
Bim, Bax, PARP, (cleaved) caspase-9, and (cleaved) caspase-
3 in huh 7.5 cells were detected by western blot assays. CME
significantly increased early apoptosis and up-regulated the
expression of Bim, Bax, cleaved PARP, cleaved caspase 9
and cleaved caspase-3. We also found the decrease of HCV
Core or NS3 protein by CME in HCV-infected huh 7.5 cells.
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Citations
Citations to this article as recorded by  - Visualized Nucleic Acid Hybridization Lateral Flow Strip Integrating with Microneedle for the Point-of-Care Authentication of Ophiocordyceps sinensis
Haibin Liu, Xinyue Wang, Hang Tian, Yi Yuan, Jing Wang, Yani Cheng, Linyao Sun, Hongshuo Chen, Xiaoming Song
International Journal of Molecular Sciences.2024; 25(24): 13599. CrossRef - Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies
Rakhee, Jigni Mishra, Renu Bala Yadav, D. K. Meena, Rajesh Arora, R. K. Sharma, Kshipra Misra
3 Biotech.2021;[Epub] CrossRef - A new nucleoside and two new pyrrole alkaloid derivatives from Cordyceps militaris
Yafu Xue, Leilei Wu, Yulian Ding, Xinming Cui, Zhuzhen Han, Hong Xu
Natural Product Research.2020; 34(3): 341. CrossRef - Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression
Hwan Hee Lee, Joohee Jung, Aree Moon, Hyojeung Kang, Hyosun Cho
International Journal of Molecular Sciences.2019; 20(13): 3143. CrossRef - Cytokine-Modulated Natural Killer Cells Differentially Regulate the Activity of the Hepatitis C Virus
Yoo Cho, Hwan Lee, Hyojeung Kang, Hyosun Cho
International Journal of Molecular Sciences.2018; 19(9): 2771. CrossRef - The genus Cordyceps : An extensive review of its traditional uses, phytochemistry and pharmacology
Opeyemi Joshua Olatunji, Jian Tang, Adesola Tola, Florence Auberon, Omolara Oluwaniyi, Zhen Ouyang
Fitoterapia.2018; 129: 293. CrossRef - Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis
Jingbo Wang, Rui Liu, Baoxiu Liu, Yan Yang, Jun Xie, Naishuo Zhu
Scientific Reports.2017;[Epub] CrossRef - Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma
Hwan Lee, Seulki Lee, Yu Shin, Miyeon Cho, Hyojeung Kang, Hyosun Cho
Molecules.2016; 21(10): 1286. CrossRef - Anti-tumor effect of Inonotus obliquus in xenograft animals with EBV+human gastric carcinoma
Seulki Lee, Hyosun Cho
The Korean Journal of Microbiology.2016; 52(4): 482. CrossRef
- Anti-influenza Effect of Cordyceps militaris through Immunomodulation in a DBA/2 Mouse Model
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Hwan Hee Lee , Heejin Park , Gi-Ho Sung , Kanghyo Lee , Taeho Lee , Ilseob Lee , Man-seong Park , Yong Woo Jung , Yu Su Shin , Hyojeung Kang , Hyosun Cho
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J. Microbiol. 2014;52(8):696-701. Published online July 18, 2014
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DOI: https://doi.org/10.1007/s12275-014-4300-0
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1,106
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The immune-modulatory as well as anti-influenza effects of Cordyceps extract were investigated using a DBA/2 mouse model. Three different concentrations of Cordyceps extract, red ginseng extract, or drinking water were orally administered
to mice for seven days, and then the mice were intranasally infected with 2009 pandemic influenza H1N1 virus. Body weight changes and survival rate were measured daily post-infection. Plasma IL-12, TNF-α, and the frequency of
natural killer (NK) cells were measured on day 4 post-infection. The DBA/2 strain was highly susceptible to H1N1 virus infection. We also found that Cordyceps extract had an antiinfluenza effect that was associated with stable body weight
and reduced mortality. The anti-viral effect of Cordyceps extract on influenza infection was mediated presumably by increased IL-12 expression and greater number of NK cells. However, high TNF-α expression after infection of H1N1
virus in mice not receiving treatment with Cordyceps extract suggested a two-sided effect of the extract on host immune regulation.
-
Citations
Citations to this article as recorded by - Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris
Pradeep Gandhale, Rupesh Chikhale, Pukar Khanal, Vashkar Biswa, Raju Ali, Mohd Shahnawaz Khan, Nilambari Gurav, Muniappan Ayyanar, Sandeep Das, Shailendra Gurav
Journal of Ayurveda and Integrative Medicine.2024; 15(3): 100979. CrossRef - Chitin Synthases in Cordyceps militaris: Genome-Wide Gene Identification, Evolutionary Insights, and Life Cycle Transcript Profiling
Shoumian Li, Huihui Ren, Jie Zhang, Shangpai Gao, Zixuan Chen, Guojie Li, Jinghua Tian, Junling Wang, Ming Li, Xiao Li, Caihong Dong
Horticulturae.2024; 10(5): 494. CrossRef - Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation
Siddharth Dubhashi, Sagar Sinha, Sankalp Dwivedi, Jaishree Ghanekar, Sameer Kadam, Parineeta Samant, Vibha Datta, Sarman Singh, Irshad H Chaudry, Padma Gurmet, Harshawardhan Kelkar, Rakesh Mishra, Sagar Galwankar, Amit Agrawal
Cureus.2023;[Epub] CrossRef - Chitinase Is Involved in the Fruiting Body Development of Medicinal Fungus Cordyceps militaris
Zi-Juan Zhang, Yuan-Yuan Yin, Yao Cui, Yue-Xuan Zhang, Bi-Yang Liu, You-Chu Ma, Yong-Nan Liu, Gao-Qiang Liu
Life.2023; 13(3): 764. CrossRef - Boosting cordycepin production through plant-based oils for vegetarian consumption
Watcharin Yuttavanichakul, Nipaporn Kanthong, Nuntaporn Pungsungvorn
Journal of Applied Research on Science and Technology (JARST).2023;[Epub] CrossRef - A Possible Synergistic Herbal Solution for COVID-19
Ephraim Shmaya Lansky
Frontiers in Bioscience-Scholar.2022;[Epub] CrossRef - Un caso di COVID-19 curato con la micoterapia
Michel G. MALLARD
Gazzetta Medica Italiana Archivio per le Scienze Mediche.2022;[Epub] CrossRef - Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms
Abdul-Rehman Phull, Madiha Ahmed, Hye-Jin Park
Microorganisms.2022; 10(2): 405. CrossRef - Medicinal Fungi with Antiviral Effect
Yu Zhang, Guoying Zhang, Jianya Ling
Molecules.2022; 27(14): 4457. CrossRef - Antioxidant Activity of Mushroom Extracts/Polysaccharides—Their Antiviral Properties and Plausible AntiCOVID-19 Properties
Sechul Chun, Judy Gopal, Manikandan Muthu
Antioxidants.2021; 10(12): 1899. CrossRef - Novel Fatty Acid in Cordyceps Suppresses
Influenza A (H1N1) Virus-Induced Proinflammatory Response
Through Regulating Innate Signaling Pathways
Run-Feng Li, Xiao-Bo Zhou, Hong-Xia Zhou, Zi-Feng Yang, Hai-Ming Jiang, Xiao Wu, Wen-Jia Li, Jian-Jian Qiu, Jia-Ning Mi, Ming Chen, Nan-Shan Zhong, Guo-Yuan Zhu, Zhi-Hong Jiang
ACS Omega.2021; 6(2): 1505. CrossRef - Cysteine-Rich Hydrophobin Gene Family: Genome Wide Analysis, Phylogeny and Transcript Profiling in Cordyceps militaris
Xiao Li, Fen Wang, Yanyan Xu, Guijun Liu, Caihong Dong
International Journal of Molecular Sciences.2021; 22(2): 643. CrossRef - Repurposing potential of Ayurvedic medicinal plants derived active principles against SARS-CoV-2 associated target proteins revealed by molecular docking, molecular dynamics and MM-PBSA studies
Akalesh Kumar Verma, Vikas Kumar, Sweta Singh, Bhabesh Ch. Goswami, Ihosvany Camps, Aishwarya Sekar, Sanghwa Yoon, Keun Woo Lee
Biomedicine & Pharmacotherapy.2021; 137: 111356. CrossRef - A new nucleoside and two new pyrrole alkaloid derivatives from Cordyceps militaris
Yafu Xue, Leilei Wu, Yulian Ding, Xinming Cui, Zhuzhen Han, Hong Xu
Natural Product Research.2020; 34(3): 341. CrossRef - CmVVD is involved in fruiting body development and carotenoid production and the transcriptional linkage among three blue‐light receptors in edible fungus Cordyceps militaris
Jiaojiao Zhang, Fen Wang, Ying Yang, Ying Wang, Caihong Dong
Environmental Microbiology.2020; 22(1): 466. CrossRef - Effects of nanobubble water supplementation on biomass accumulation during mycelium cultivation of Cordyceps militaris and the antioxidant activities of extracted polysaccharides
Long Xiao, Shuang Sun, Kejuan Li, Zhongfang Lei, Kazuya Shimizu, Zhenya Zhang, Yasuhisa Adachi
Bioresource Technology Reports.2020; 12: 100600. CrossRef - Analysis of reference genes stability and histidine kinase expression under cold stress in Cordyceps militaris
Yong-Nan Liu, Bi-Yang Liu, You-Chu Ma, Hai-Long Yang, Gao-Qiang Liu, Shwet Kamal
PLOS ONE.2020; 15(8): e0236898. CrossRef - Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin
Chun-Ting Lee, Keng-Shiang Huang, Jei-Fu Shaw, Jung-Ren Chen, Wen-Shuo Kuo, Gangxu Shen, Alexandru Mihai Grumezescu, Alina Maria Holban, Yi-Ting Wang, Jun-Sheng Wang, Yi-Ping Hsiang, Yu-Mei Lin, Hsiao-Han Hsu, Chih-Hui Yang
Frontiers in Pharmacology.2020;[Epub] CrossRef - Effects ofCordyceps militarissupplementation on the immune response and upper respiratory infection in healthy adults: a randomized, double-blind, placebo-controlled study
Su Jin Jung, Ji Hyun Hwang, Mi Ra Oh, Soo Wan Chae
Journal of Nutrition and Health.2019; 52(3): 258. CrossRef - Advance in Cordyceps militaris (Linn) Link polysaccharides: Isolation, structure, and bioactivities: A review
Jixian Zhang, Chaoting Wen, Yuqing Duan, Haihui Zhang, Haile Ma
International Journal of Biological Macromolecules.2019; 132: 906. CrossRef - The blue-light receptor CmWC-1 mediates fruit body development and secondary metabolism in Cordyceps militaris
Tao Yang, Mingmin Guo, Huaijun Yang, Suping Guo, Caihong Dong
Applied Microbiology and Biotechnology.2016; 100(2): 743. CrossRef - Cordyceps militaris (L.) Link: Chemical Bioactive Compounds and Pharmacological Activities
Do Hai Lan, Nguyen Thi Kim Thu, Pham Thi Lan, Pham Van Nha , Bui Thanh Tung
Journal of Pharmacy and Nutrition Sciences .2016; 6(4): 153. CrossRef - Partial structural characterization, as well as immunomodulatory and anti-aging activities of CP2-c2-s2 polysaccharide from Cordyceps militaris
Xiaojuan Liu, Yicheng Huang, Yunjiao Chen, Yong Cao
RSC Adv..2016; 6(106): 104094. CrossRef - Cultured Mycelium Cordyceps sinensis allevi¬ates CCl4-induced liver inflammation and fibrosis in mice by activating hepatic natural killer cells
Yuan Peng, Kai Huang, Li Shen, Yan-yan Tao, Cheng-hai Liu
Acta Pharmacologica Sinica.2016; 37(2): 204. CrossRef - Cordyceps industry in China
Caihong Dong, Suping Guo, Wenfeng Wang, Xingzhong Liu
Mycology.2015; 6(2): 121. CrossRef - Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis
Hwan Hee Lee, Seulki Lee, Kanghyo Lee, Yu Su Shin, Hyojeung Kang, Hyosun Cho
DARU Journal of Pharmaceutical Sciences.2015;[Epub] CrossRef - Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells
Seulki Lee, Hwan Hee Lee, Jisung Kim, Joohee Jung, Aree Moon, Choon-Sik Jeong, Hyojeung Kang, Hyosun Cho
Journal of Microbiology.2015; 53(7): 468. CrossRef
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