- Fresh Washed Microbiota Transplantation Alters Gut Microbiota Metabolites to Ameliorate Sleeping Disorder Symptom of Autistic Children
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Nai-Hua Liu , Hong-Qian Liu , Jia-Yi Zheng , Meng-Lu Zhu , Li-Hao Wu , Hua-Feng Pan , Xing-Xiang He
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J. Microbiol. 2023;61(8):741-753. Published online September 4, 2023
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DOI: https://doi.org/10.1007/s12275-023-00069-x
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Accumulating studies have raised concerns about gut dysbiosis associating autism spectrum disorder (ASD) and its related
symptoms. However, the effect of gut microbiota modification on the Chinese ASD population and its underlying mechanism
were still elusive. Herein, we enrolled 24 ASD children to perform the first course of fresh washed microbiota transplantation
(WMT), 18 patients decided to participate the second course, 13 of which stayed to participate the third course, and there were
8 patients at the fourth course. Then we evaluated the effects of fresh WMT on these patients and their related symptoms.
Our results found that the sleeping disorder symptom was positively interrelated to ASD, fresh WMT significantly alleviated
ASD and its sleeping disorder and constipation symptoms. In addition, WMT stably and continuously downregulated Bacteroides/
Flavonifractor/Parasutterella while upregulated Prevotella_9 to decrease toxic metabolic production and improve
detoxification by regulating glycolysis/myo-inositol/D-glucuronide/D-glucarate degradation, L-1,2-propanediol degradation,
fatty acid β-oxidation. Thus, our results suggested that fresh WMT moderated gut microbiome to improve the behavioral
and sleeping disorder symptoms of ASD via decrease toxic metabolic production and improve detoxification. Which thus
provides a promising gut ecological strategy for ASD children and its related symptoms treatments.
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Citations
Citations to this article as recorded by  - Gut microbiota on sleep disorders throughout the lifespan
Zulun Zhang, Qianqian Li, Xianglu Wang, Wenjing Wang, Faming Zhang
Microbiological Research.2027; 314: 128724. CrossRef - Clinical response and risk factors of fecal microbiota transplantation in children: a systematic review and meta-analysis
Jiashun Liu, Xiao Sun, Ping Yuan, Yaya Qin, Wenhui Wu, Yuqing Fan, Yue Zhang, Lu Zou, Changjun Ren, Shangbin Li
European Journal of Pediatrics.2026;[Epub] CrossRef - Sleep in Autism Spectrum Disorder: A Systematic Update
Marco Veneruso, Antonella Barbieri, Giulia Silvestrini, Elisa De Grandis, Ramona Cordani, Lino Nobili
Current Sleep Medicine Reports.2026;[Epub] CrossRef - Washed microbiota transplantation improves clinical symptoms, gut microbiota, and metabolic profiles in autism spectrum disorder in a twin cohort
Shuo Feng, Xinyu Si, Caimei Lu, Zheng Gao, Jiangyan Wang, Qingqing Yang, Shenghua Lu, Ting Su, Juan Yang, Xingxiang He, Lei Wu
Frontiers in Microbiology.2026;[Epub] CrossRef - Gut microbiota dysbiosis in autism spectrum disorder: 10 years of progress on compositional alterations, metabolic/immune mechanisms, and therapeutic strategies
Yan Zeng, Fengyang Wang, Silu Li, Qianfang Liu, Lin Liu, Bin Song
Frontiers in Neuroscience.2026;[Epub] CrossRef - Psychobiotics in pediatric autism spectrum disorder: A systematic review of efficacy, mechanisms, and clinical translation
Mohammed Al-Beltagi, Nermin Kamal Saeed, Yousif M Elbeltagi
World Journal of Clinical Pediatrics.2026;[Epub] CrossRef - Effects of gastrointestinal symptoms on the efficacy of washed microbiota transplantation in patients with autism
Dong-Xia Hu, Cai-Mei Lu, Xin-Yu Si, Qing-Ting Wu, Li-Hao Wu, Hao-Jie Zhong, Xing-Xiang He
Frontiers in Pediatrics.2025;[Epub] CrossRef - The Impact of Fecal Microbiota Transplantation on Gastrointestinal and Behavioral Symptoms in Children and Adolescents with Autism Spectrum Disorder: A Systematic Review
Anna Liber, Małgorzata Więch
Nutrients.2025; 17(13): 2250. CrossRef - Pathogenic bacteria enriched in the oral microbiota might be associated with recurrent pulmonary infections in elderly individuals
Jingyi Xu, Ruyi Qu, Keke Yang, Yuezhu Wang, Meiyun Nie, Xiaodong Qi, Huajun Zheng, Ling Yang
Aging Clinical and Experimental Research.2025;[Epub] CrossRef - Does constipation affect the effectiveness of washed microbiota transplantation in treating autism spectrum disorders?
Zihao Pan, Zheng Gao, Junyi Chen, Yongxi Quan, Jiating Xu, Xiaofeng Liang, Wenrui Xie, Xingxiang He, Lihao Wu
Frontiers in Neuroscience.2025;[Epub] CrossRef - Brain-gut-microbiota interactions in sleep disorders
Zhe Wang, Tingting Wu, Juan Li, Tangsheng Lu, Yifan Yu, Zichun Guan, Guohao Yuan, Zhaoyan Lv, Yiming Shan, Wei Yan, Xiaoxing Liu, Michael V. Vitiello, Qingqing Yin, Jie Sun, Lin Lu
Brain Medicine.2025; : 1. CrossRef - Washed microbiota transplantation: candidates for a novel strategy for ameliorating autism spectrum disorder
Shuo Feng, Jiangyan Wang, Xinyu Si, Shenghua Lu, Caimei Lu, Zheng Gao, Juan Yang, Jiali Wu, Xingxiang He, Lei Wu
Frontiers in Microbiology.2025;[Epub] CrossRef - Microbiota-based interventions for autism spectrum disorder: a systematic review of efficacy and clinical potential
Hana Taha, Ahmad Issa, Zaid Muhanna, Majdi Al-Shehab, Tuleen Wadi, Suhib Awamleh, Yousef A. Ateiwi, Mohammad Abusido, Vanja Berggren
Frontiers in Microbiology.2025;[Epub] CrossRef - Fecal Microbiota Transplantation for Autism Spectrum Disorder in Children: Results from a Prospective Open-Label Controlled Observational Study
Dominykas Varnas, Arnas Kunevičius, Aurelijus Burokas, Vaidotas Urbonas
Medicina.2025; 62(1): 65. CrossRef - Untargeted urine metabolomics and machine learning provide potential metabolic signatures in children with autism spectrum disorder
Xian Liu, Xin Sun, Cheng Guo, Zhi-Fang Huang, Yi-Ru Chen, Fang-Mei Feng, Li-Jie Wu, Wen-Xiong Chen
Frontiers in Psychiatry.2024;[Epub] CrossRef - Washed Microbiota Transplantation Improves the Sleep Quality in Patients with Inflammatory Bowel Disease
Qianqian Li, Yujie Liu, Zulun Zhang, Sheng Zhang, Xiao Ding, Faming Zhang
Nature and Science of Sleep.2024; Volume 16: 1141. CrossRef
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