- Next-Generation Sequencing-Based Transcriptome Analysis of L-Lysine-Producing Corynebacterium glutamicum ATCC 21300 Strain
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Hong-Il Kim , Jae-Young Nam , Jae-Yong Cho , Chang-Soo Lee , Young-Jin Park
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J. Microbiol. 2013;51(6):877-880. Published online December 19, 2013
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DOI: https://doi.org/10.1007/s12275-013-3236-0
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In the present study, 151 genes showed a significant change
in their expression levels in Corynebacterium glutamicum
ATCC 21300 compared with those of C. glutamicum ATCC
13032. Of these 151 genes, 56 genes (2%) were up-regulated
and 95 genes (3%) were down-regulated. RNA sequencing
analysis also revealed that 11 genes, involved in the L-lysine
biosynthetic pathway of C. glutamicum, were up- or downregulated
compared with those of C. glutamicum ATCC
13032. Of the 151 genes, 10 genes were identified to have
mutations including SNP (9 genes) and InDel (1 gene). This
information will be useful for genome breeding of C. glutamicum
to develop an industrial amino acid-producing strain
with minimal mutation.
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Citations
Citations to this article as recorded by  - Review of the Proteomics and Metabolic Properties of Corynebacterium glutamicum
Juhwan Park, Sooa Lim
Microorganisms.2024; 12(8): 1681. CrossRef - Transcriptome analysis of l-leucine-producing Corynebacterium glutamicum under the addition of trimethylglycine
Jian Wang, Xuesong Wang, Qing Liang, Deheng Li, Dawei Li, Qunqun Guo
Amino Acids.2022; 54(2): 229. CrossRef - RETRACTED ARTICLE: Comparative analysis of the Corynebacterium glutamicum transcriptome in response to changes in dissolved oxygen levels
Xiuxia Liu, Sun Yang, Fen Wang, Xiaofeng Dai, Yankun Yang, Zhonghu Bai
Journal of Industrial Microbiology and Biotechnology.2017; 44(2): 181. CrossRef - Transcriptome and Gene Ontology (GO) Enrichment Analysis Reveals Genes Involved in Biotin Metabolism That Affect l-Lysine Production in Corynebacterium glutamicum
Hong-Il Kim, Jong-Hyeon Kim, Young-Jin Park
International Journal of Molecular Sciences.2016; 17(3): 353. CrossRef
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