- A murine colitis model developed using a combination of dextran sulfate sodium and Citrobacter rodentium
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Jin-Il Park , Sun-Min Seo , Jong-Hyung Park , Hee-Yeon Jeon , Jun-Young Kim , Seung-Hyun Ryu , Yang-Kyu Choi
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J. Microbiol. 2018;56(5):372-372.
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DOI: https://doi.org/10.1007/s12275-018-0578-7
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In the article by Park et al. published in Journal of Microbiology 2018; 56, 272–279, the supplementary data Figs S1 and S2
should be corrected as below. The original article can be found online at https://doi.org/10.1007/s12275-018-7504-x.
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Citations
Citations to this article as recorded by  - A novel multifunctional Lactiplantibacillus plantarum HMPM2111 strain: antibacterial and anti-inflammatory effects against stresses caused by pathogenic bacteria
Yaqi Liu, Junhui Wang, Leyi Wang, Jialing Cao, Shiqi Lu, Pengfei Li, Yujie Wang, Jingmin Wang, Kangliang Sheng, Yongzhong Wang
Food & Function.2025; 16(24): 9504. CrossRef
- A murine colitis model developed using a combination of dextran sulfate sodium and Citrobacter rodentium
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Jin-Il Park , Sun-Min Seo , Jong-Hyung Park , Hee-Yeon Jeon , Jun-Young Kim , Seung-Hyun Ryu , Yang-Kyu Choi
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J. Microbiol. 2018;56(4):272-279. Published online April 2, 2018
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DOI: https://doi.org/10.1007/s12275-018-7504-x
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1,019
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Abstract
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Adult mice were treated with dextran sulfate sodium (DSS)
and infected with Citrobacter rodentium for developing a
novel murine colitis model. C57BL/6N mice (7-week-old)
were divided into four groups. Each group composed of control,
dextran sodium sulfate-treated (DSS), C. rodentiuminfected
(CT), and DSS-treated and C. rodentium-infected
(DSS-CT) mice. The DSS group was administered 1% DSS
in drinking water for 7 days. The CT group was supplied
with normal drinking water for 7 days and subsequently infected
with C. rodentium via oral gavage. The DSS-CT group
was supplied with 1% DSS in drinking water for 7 days and
subsequently infected with C. rodentium via oral gavage. The
mice were sacrificed 10 days after the induction of C. rodentium
infection. The DSS-CT group displayed significantly
shorter colon length, higher spleen to body weight ratio, and
higher histopathological score compared to the other three
groups. The mRNA expression levels of tumor necrosis factor
(TNF)-α and interferon (INF)-γ were significantly upregulated;
however, those of interleukin (IL)-6 and IL-10 were
significantly downregulated in the DSS-CT group than in
the control group. These results demonstrated that a combination
of low DSS concentration (1%) and C. rodentium
infection could effectively induce inflammatory bowel disease
(IBD) in mice. This may potentially be used as a novel
IBD model, in which colitis is induced in mice by the combination
of a chemical and a pathogen.
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PLOS ONE.2024; 19(11): e0311310. CrossRef - Protective Role of the Toll-Like Receptor 5 Agonist KMRC011 against Murine Colitis Induced by Citrobacter rodentium and Dextran Sulfate Sodium
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Journal of Functional Foods.2021; 86: 104652. CrossRef - Probiotic Bacillus cereus Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice through Improvement of the Intestinal Barrier Function, Anti-Inflammation, and Gut Microbiota Modulation
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