- Mutational inactivation of OprD in carbapenem-resistant Pseudomonas aeruginosa isolates from Korean hospitals
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Chi Hyun Kim , Hee Young Kang , Bo Ra Kim , Hyejin Jeon , Yoo Chul Lee , Sang Hwa Lee , Je Chul Lee
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J. Microbiol. 2016;54(1):44-49. Published online January 5, 2016
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DOI: https://doi.org/10.1007/s12275-016-5562-5
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1,464
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2
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26
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This study investigated the mechanisms underlying the carbapenem
resistance of bloodstream isolates of Pseudomonas
aeruginosa obtained from two Korean hospitals. Of the 79
P. aeruginosa isolates, 22 and 21 were resistant to imipenem
and meropenem, respectively. The 22 imipenem-resistant
P. aeruginosa isolates were classified into 7 sequence types
(STs) and 13 pulsotypes. Twelve imipenem-resistant isolates
from one hospital were found to belong to the international
clone ST111. Two imipenem-resistant P. aeruginosa ST235
isolates carried the blaIMP-6 gene, but the remaining 20 isolates
did not produce carbapenemases. Mutations in the oprD
gene and a related decrease in gene expression were found
in 21 and 5 isolates, respectively. However, all imipenemresistant
P. aeruginosa isolates showed no significant expression
of OprD in the outer membrane as compared with that
of carbapenem-susceptible PAO1 strain. Overexpression of
genes associated with efflux pumps, including mexB, mexD,
mexF, and mexY, was not found in any imipenem-resistant
isolate. One imipenem-resistant P. aeruginosa isolate overexpressed
the ampC gene. Our results show that the low permeability
of drugs due to the mutational inactivation of OprD
is primarily responsible for carbapenem resistance in bloodstream
isolates of P. aeruginosa from Korean hospitals.
-
Citations
Citations to this article as recorded by 
- A Simple Colorimetric Method for Testing Antimicrobial Susceptibility of Biofilmed Bacteria
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Shukho Kim , Mi Jin Kim , Hee Young Kang , Sung Yong Seol , Dong Taek Cho , Jungmin Kim
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J. Microbiol. 2010;48(5):709-711. Published online November 3, 2010
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DOI: https://doi.org/10.1007/s12275-010-0299-z
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831
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1
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21
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Abstract
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This study introduces a simple colorimetric method which can measure the antimicrobial susceptibility of bacteria in biofilms using trimethyl tetrazolium chloride (TTC) as an indicator of viable bacteria. The new method was utilized for the evaluation of antibiotic susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus biofilms.
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Anna Duda-Madej, Szymon Viscardi, Katarzyna Pacyga, Robert Kupczyński, Wanda Mączka, Małgorzata Grabarczyk, Paweł Pacyga, Ewa Topola, Michał Ostrówka, Jacek Bania, Antoni Szumny, Katarzyna Wińska
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Mustafa Nakipoglu, Ayşen Tezcaner, Christopher H. Contag, Nasim Annabi, Nureddin Ashammakhi
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Hafez Al-Momani, Dua’a Al Balawi, Saja Hamed, Borhan Aldeen Albiss, Muna Almasri, Hadeel AlGhawrie, Lujain Ibrahim, Hadeel Al Balawi, Sameer Al Haj Mahmoud, Jeffrey Pearson, Christopher Ward
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Zuzanna Sycz, Dorota Wojnicz, Dorota Tichaczek-Goska
Pharmaceutics.2022; 14(8): 1691. CrossRef - Are Uropathogenic Bacteria Living in Multispecies Biofilm Susceptible to Active Plant Ingredient—Asiatic Acid?
Zuzanna Sycz, Dorota Tichaczek-Goska, Anna Jezierska-Domaradzka, Dorota Wojnicz
Biomolecules.2021; 11(12): 1754. CrossRef - Antibacterial activities of and biofilm removal by Ablysin, an endogenous lysozyme-like protein originated from Acinetobacter baumannii 1656-2
Shukho Kim, Jong-Sook Jin, Da-Won Lee, Jungmin Kim
Journal of Global Antimicrobial Resistance.2020; 23: 297. CrossRef - Antibacterial action of nitric oxide-releasing hyperbranched polymers against ex vivo dental biofilms
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Lukasz Palka, Justyna Mazurek-Popczyk, Katarzyna Arkusz, Katarzyna Baldy-Chudzik
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Hee-Young Kang, Shukho Kim, Jungmin Kim
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Parastoo Sabaeifard, Ahya Abdi-Ali, Mohammad Reza Soudi, Rasoul Dinarvand
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Jung Wook Kang, Jun Tae Bae, Jae Young Yeon, Young Ho Kim, Jin Hwa Kim, Geun Soo Lee, Hyeong Bae Pyo
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Shukho Kim, Marzia Rahman, Sung Yong Seol, Sang Sun Yoon, Jungmin Kim
Applied and Environmental Microbiology.2012; 78(17): 6380. CrossRef - The inhibitory effect of phloretin on the formation of Escherichia coli O157:H7 biofilm in a microfluidic system
Aeri Park, Heon-Ho Jeong, Jintae Lee, Chang-Soo Lee
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The Journal of Microbiology.2011; 49(3): 512. CrossRef
- Characterization of Conjugative Plasmids Carrying Antibiotic Resistance Genes Encoding 16S rRNA Methylase, Extended-Spectrum Beta-Lactamase, and/or Plasmid-Mediated AmpC Beta-Lactamase
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Hee Young Kang , Jungmin Kim , Sung Yong Seol , Yoo Chul Lee , Je Chul Lee , Dong Taek Cho
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J. Microbiol. 2009;47(1):68-75. Published online February 20, 2009
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DOI: https://doi.org/10.1007/s12275-008-0158-3
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709
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0
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18
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Abstract
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In this study, we identified extended-spectrum ß-lactamase (ESBL) and plasmid-mediated AmpC ß-lactamase which were associated with 16S rRNA methylase gene on the conjugative plasmid. Among 82 clinical isolates of Enterobacteriaceae that carry 16S rRNA methylase gene (64 strains, armA, and 18 strains, rmtB), blaSHV-12 was detected either alone or combined with blaDHA-1, blaCTX-M-3, and blaCTX-M-14 in 30 strains carrying armA and 6 strains carrying rmtB. The blaCTX-M-3 was detected in 13 of 64 strains carrying armA but no strains carrying rmtB. Whereas blaCTX-M-14 was detected in 15 of 18 strains carrying rmtB but only 2 of 64 strains carrying armA. Overall, blaSHV-12 and blaCTX-M-14 was the most common ESBL gene which was associated with armA and rmtB, respectively. In addition, we found that blaCTX-M-3 localized with armA on the same IncL/M plasmid and blaCTX-M-14 localized with rmtB on the same IncA/C plasmid. Restriction fragment length polymorphism of conjugative plasmids and pulsed-field gel electrophoresis of genomic DNAs revealed that intercellular horizontal transfer of conjugative plasmid and clonal transmission have been occurred at the same time.
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Citations
Citations to this article as recorded by - Antibiotic-resistant characteristics and horizontal gene transfer ability analysis of extended-spectrum β-lactamase-producing Escherichia coli isolated from giant pandas
Haifeng Liu, Siping Fan, Xiaoli Zhang, Yu Yuan, Wenhao Zhong, Liqin Wang, Chengdong Wang, Ziyao Zhou, Shaqiu Zhang, Yi Geng, Guangneng Peng, Ya Wang, Kun Zhang, Qigui Yan, Yan Luo, Keyun Shi, Zhijun Zhong
Frontiers in Veterinary Science.2024;[Epub] CrossRef - ArmAandRmtBWere the Predominant 16S RMTase Genes Responsible for Aminoglycoside-resistant Isolates in Korea
Tae Hee Lee, Joo-Hee Hwang, Woo Kon Lee, Min-Kyoung Shin, Hye Ryun Woo, Kyung Min Chung, Chang-Seop Lee
Journal of Korean Medical Science.2018;[Epub] CrossRef - Prevalence of extended-spectrum cephalosporin-resistant Escherichia coli in a farrowing farm: ST1121 clone harboring IncHI2 plasmid contributes to the dissemination of blaCMY-2
Hui Deng, Hong-Bin Si, Shu-Yi Zeng, Jian Sun, Liang-Xing Fang, Run-Shi Yang, Ya-Hong Liu, Xiao-Ping Liao
Frontiers in Microbiology.2015;[Epub] CrossRef - Prevalence of 16S rRNA methylase, modifying enzyme, and extended-spectrum beta-lactamase genes amongAcinetobacter baumanniiisolates
Zhenru Liu, Baodong Ling, Liming Zhou
Journal of Chemotherapy.2015; 27(4): 207. CrossRef - Selection of a Multidrug Resistance Plasmid by Sublethal Levels of Antibiotics and Heavy Metals
Erik Gullberg, Lisa M. Albrecht, Christoffer Karlsson, Linus Sandegren, Dan I. Andersson, Fernando Baquero
mBio.2014;[Epub] CrossRef -
Prevalence and Characterization of Cefotaxime and Ciprofloxacin Co-Resistant
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Xiao Xu, Shenghui Cui, Fenglan Zhang, Yanping Luo, Yihai Gu, Baowei Yang, Fengqin Li, Qian Chen, Gang Zhou, Yeru Wang, Lu Pang, Lan Lin
Microbial Drug Resistance.2014; 20(1): 73. CrossRef - Novel arrangement of theblaCTX-M-55gene in anEscherichia coliisolate coproducing 16S rRNA methylase
Yu-Shan Pan, Jian-Hua Liu, Han Hu, Jin-Feng Zhao, Li Yuan, Hua Wu, Ling-Fei Wang, Gong-Zheng Hu
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David M. Livermore
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Qiongfen Yao, Zhenling Zeng, Jianxia Hou, Yuting Deng, Liangying He, Wei Tian, Hongqing Zheng, Zhangliu Chen, Jian-Hua Liu
Journal of Antimicrobial Chemotherapy.2011; 66(11): 2475. CrossRef - A Survey of β-Lactamase and 16S rRNA Methylase Genes Among Fluoroquinolone-Resistant Escherichia coli Isolates and Their Horizontal Transmission in Shandong, China
Li-Ning Xia, Xiao-Qi Tao, Jian-Zhong Shen, Lei Dai, Yang Wang, Xia Chen, Cong-Ming Wu
Foodborne Pathogens and Disease.2011; 8(12): 1241. CrossRef -
F33:A−:B− and F2:A−:B− Plasmids Mediate Dissemination of
rmtB-bla
CTX-M-9
Group Genes and
rmtB-qepA
in Enterobacteriaceae Isolates from Pets in China
Yuting Deng, Liangying He, Sheng Chen, Hongqing Zheng, Zhenling Zeng, Yahong Liu, Yan Sun, Junying Ma, Zhangliu Chen, Jian-Hua Liu
Antimicrobial Agents and Chemotherapy.2011; 55(10): 4926. CrossRef - Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides
Y. Zhou, H. Yu, Q. Guo, X. Xu, X. Ye, S. Wu, Y. Guo, M. Wang
European Journal of Clinical Microbiology & Infectious Diseases.2010; 29(11): 1349. CrossRef - Dissemination of Cefotaxime-M-Producing Escherichia coli Isolates in Poultry Farms, But Not Swine Farms, in China
Jingyun Li, Yue Ma, Changqin Hu, Shaohong Jin, Qingsheng Zhang, Hong Ding, Lu Ran, Shenghui Cui
Foodborne Pathogens and Disease.2010; 7(11): 1387. CrossRef - High prevalence of blaCTX-M extended-spectrum β-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China
Y. Sun, Z. Zeng, S. Chen, J. Ma, L. He, Y. Liu, Y. Deng, T. Lei, J. Zhao, J.-H. Liu
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Alma Brolund, Karin Tegmark Wisell, Petra J. Edquist, Lisbeth Elfström, Mats Walder, Christian G. Giske
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Fang-you Yu, Dan Yao, Jing-ye Pan, Chong Chen, Zhi-qiang Qin, Chris Parsons, Le-he Yang, Qiao-qiao Li, Xue-qing Zhang, Di Qu, Liang-xing Wang
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Resistance Plasmid Families in
Enterobacteriaceae
Alessandra Carattoli
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- The Identification of CTX-M-14, TEM-52, and CMY-1 Enzymes in Escherichia coli Isolated from the Han River in Korea
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Jungmin Kim , Hee Young Kang , Yeonhee Lee
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J. Microbiol. 2008;46(5):478-481. Published online October 31, 2008
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DOI: https://doi.org/10.1007/s12275-008-0150-y
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912
View
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0
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-
24
Crossref
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Abstract
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From water samples collected monthly between 2000 and 2001 from the Han River in Seoul, sixteen strains of Escherichia coli which confer resistance to at least 10 kinds of antimicrobial agents were isolated. From these isolates, 2 kinds of extended-spectrum β-lactamases (ESBLs) and one plasmid-mediated AmpC β-lactamase were detected; CTX-M-14 from 10 isolates, TEM-52 from 5 isolates, and CMY-1 from one isolate. Class 1 integron gene cassettes, such as aadA1, dfr12-orfF-aadA2, and dfr17-aadA5, were also detected and the integrons are the same as those found in E. coli isolated from swine, poultry, and humans in Korea. The result of this study indicated the importance of river water as a reservoir for antimicrobial resistance genes and resistant bacteria.
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Citations
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Hetty Blaak, Angela H.A.M. van Hoek, Christiaan Veenman, Arieke E. Docters van Leeuwen, Gretta Lynch, Wendy M. van Overbeek, Ana Maria de Roda Husman
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Jin Yeol Park , Jong Sook Jin , Hee Young Kang , Eun Hee Jeong , Je Chul Lee , Yoo Chul Lee , Sung Yong Seol , Dong Taek Cho , Jungmin Kim
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J. Microbiol. 2007;45(5):447-452.
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DOI: https://doi.org/2591 [pii]
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Abstract
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In this study, we compared the phenotypic and genotypic characteristics of 138 MRSA isolates obtained from adult and pediatric patients (adult, 50; children, 88). The resistance rates against gentamicin, clindamycin, and ciprofloxacin were much higher in the adult MRSA isolates than in the pediatric MRSA isolates. The ermC gene, which is responsible for inducible clindamycin resistance, was detected in 52(59.1%) of the 88 pediatric MRSA isolates but in only 5(10.0%) of the 50 adult MRSA isolates. MRSA isolates of clonal type ST5 with an integration of SCCmec type II/II variants was the most predominant clone among the adult isolates, while clonal type ST72 with an integration of SCCmec IV/IVA was the most predominant clone among the pediatric MRSA isolates. Staphylococcal enterotoxin A and toxic shock syndrome toxin-1 were prevalent among the adult MRSA isolates but not among the pediatric MRSA isolates. The results of this study demonstrated remarkable differences between adult and pediatric MRSA isolates in terms of their antimicrobial susceptibility profiles, SCCmec type, multilocus sequence type, staphylococcal toxin genes, and erythromycin resistance genes.
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