- Antiviral activity of Poncirus trifoliata seed extract against oseltamivirresistant influenza virus
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Yoonki Heo , Yeondong Cho , Kwon sung Ju , Hansam Cho , Ki Hoon Park , Hanul Choi , Jong Kwang Yoon , Chiung Moon , Young Bong Kim
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J. Microbiol. 2018;56(8):586-592. Published online July 25, 2018
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DOI: https://doi.org/10.1007/s12275-018-8222-0
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The emergence of oseltamivir-resistant variants of influenza
virus has highlighted the necessity for the development of
more effective novel antiviral drugs. To date, numerous researchers
have focused on developing antiviral drugs using
natural resources, such as traditional herbal medicines. Poncirus
trifoliata is widely used in oriental medicine as a remedy
for gastritis, dysentery, inflammation and digestive ulcers. In
this study, we investigated the potential antiviral effect of the
Poncirus trifoliata orange seed extract against influenza virus.
An ethanol extract of Poncirus trifoliata seeds (PTex) inhibited
the activity of influenza viruses, in particular, oseltamivir-
resistant strains, in Madin-Darby canine kidney cells. In
contrast to oseltamivir, PTex exerted a significant inhibitory
effect on the cellular penetration pathway of the virus rather
than HA receptor binding. The potent antiviral effect and novel
working mechanism of PTex support its further development
as an effective natural antiviral drug with a wide spectrum
of activity against influenza and oseltamivir-resistant
viruses.
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Citations
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to Cure Respiratory Diseases
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The Natural Products Journal.2024;[Epub] CrossRef - Seed extracts as an effective strategy in the control of plant pathogens: Scalable industry bioactive compounds for sustainable agriculture
Tamara Sánchez-Gómez, Óscar Santamaría, Jorge Martín-García, Jorge Poveda
Biocatalysis and Agricultural Biotechnology.2024; 60: 103332. CrossRef - Insights into identifying resistance genes for cold and disease stresses through chromosome-level reference genome analyses of Poncirus polyandra
Shanshan Zhang, Jian Chen, Chuanguang Zhang, Siqi Zhang, Xiaolei Zhang, Lanjing Gao, Wenzhong Yang
Genomics.2023; 115(3): 110617. CrossRef - Poncirus trifoliata (L.) Raf. Seed Extract Induces Cell Cycle Arrest and Apoptosis in the Androgen Receptor Positive LNCaP Prostate Cancer Cells
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Avram Speranta, Laura Manoliu, Catalina Sogor, Maria Mernea, Corina Duda Seiman, Daniel Duda Seiman, Carmen Chifiriuc
Medicinal Chemistry.2022; 18(3): 382. CrossRef - Bioactive Chemical Constituents and Pharmacological Activities of Ponciri Fructus
Gopal Lamichhane, Jitendra Pandey, Hari Prasad Devkota
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- Therapeutic potential of an AcHERV-HPV L1 DNA vaccine
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Hee-Jung Lee , Jong Kwang Yoon , Yoonki Heo , Hansam Cho , Yeondong Cho , Yongdae Gwon , Kang Chang Kim , Jiwon Choi , Jae Sung Lee , Yu-Kyoung Oh , Young Bong Kim
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J. Microbiol. 2015;53(6):415-420. Published online May 30, 2015
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DOI: https://doi.org/10.1007/s12275-015-5150-0
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956
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6
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Abstract
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Cervical cancer is strongly associated with chronic human
papillomavirus infections, among which HPV16 is the most
common. Two commercial HPV vaccines, Gardasil and
Cervarix are effective for preventing HPV infection, but cannot
be used to treat existing HPV infections. Previously, we
developed a human endogenous retrovirus (HERV)-enveloped
recombinant baculovirus capable of delivering the L1
genes of HPV types 16, 18, and 58 (AcHERV-HP16/18/58L1,
AcHERV-HPV). Intramuscular administration of AcHERVHPV
vaccines induced a strong cellular immune response
as well as a humoral immune response. In this study, to examine
the therapeutic effect of AcHERV-HPV in a mouse
model, we established an HPV16 L1 expressing tumor cell
line. Compared to Cervarix, immunization with AcHERVHPV
greatly enhanced HPV16 L1-specific cytotoxic T lymphocytes
(CTL) in C57BL/6 mice. Although vaccination
could not remove preexisting tumors, strong CTL activity
retarded the growth of inoculated tumor cells. These results
indicate that AcHERV-HPV could serve as a potential therapeutic
DNA vaccine against concurrent infection with HPV
16, 18, and 58.
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Citations
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Cancers.2021; 13(11): 2691. CrossRef - In Silico Design and Immunological Studies of Two Novel Multiepitope DNA-Based Vaccine Candidates Against High-Risk Human Papillomaviruses
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Molecular Biotechnology.2021; 63(12): 1192. CrossRef - Unraveling the Genome-Wide Impact of Recombinant Baculovirus Infection in Mammalian Cells for Gene Delivery
Ha Youn Shin, Hanul Choi, Nahyun Kim, Nayoung Park, Heesun Kim, Jaebum Kim, Young Bong Kim
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Xiang He, Xufeng He, Ping Xu, Lili Yang, Xin Ma, Wen Li, Huimin Zhang
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Swati Gupta, K. P. Mishra, Lilly Ganju
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