- Probiotic supplements alleviate gestational diabetes mellitus by restoring the diversity of gut microbiota: a study based on 16S rRNA sequencing
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Qing-Xiang Zheng , Xiu-Min Jiang , Hai-Wei Wang , Li Ge , Yu-Ting Lai , Xin-Yong Jiang , Fan Chen , Ping-Ping Huang
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J. Microbiol. 2021;59(9):827-839. Published online August 12, 2021
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DOI: https://doi.org/10.1007/s12275-021-1094-8
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 Abstract
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Probiotics effectively prevent and improve metabolic diseases
such as diabetes by regulating the intestinal microenvironment
and gut microbiota. However, the effects of probiotics
in gestational diabetes mellitus are not clear. Here, we
showed that probiotic supplements significantly improved
fasting blood glucose in a gestational diabetes mellitus rat
model. To further understand the mechanisms of probiotics
in gestational diabetes mellitus, the gut microbiota were analyzed
via 16S rRNA sequencing. We found that compared
with the normal pregnant group, the gestational diabetes mellitus
rats had decreased diversity of gut microbiota. Moreover,
probiotic supplementation restored the diversity of the
gut microbiota in gestational diabetes mellitus rats, and the
gut microbiota structure tended to be similar to that of normal
pregnant rats. In particular, compared with gestational
diabetes mellitus rats, the abundance of Firmicutes and Actinobacteria
was higher after probiotic supplementation. Furthermore,
activating carbohydrate metabolism and membrane
transport pathways may be involved in the potential mechanisms
by which probiotic supplements alleviate gestational
diabetes mellitus. Overall, our results suggested that probiotic
supplementation might be a novel approach to restore the gut
microbiota of gestational diabetes mellitus rats and provided
an experimental evidence for the use of probiotic supplements
to treat gestational diabetes melitus.
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Citations
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