- Mycobacterial Regulatory Systems Involved in the Regulation of Gene Expression Under Respiration‑Inhibitory Conditions
-
Yuna Oh , Ha-Na Lee , Eon-Min Ko , Ji-A Jeong , Sae Woong Park , Jeong-Il Oh
-
J. Microbiol. 2023;61(3):297-315. Published online February 27, 2023
-
DOI: https://doi.org/10.1007/s12275-023-00026-8
-
-
1,212
View
-
7
Download
-
4
Web of Science
-
4
Crossref
-
 Abstract
 PDF
-
Mycobacterium tuberculosis is the causative agent of tuberculosis. M. tuberculosis can survive in a dormant state within
the granuloma, avoiding the host-mounting immune attack. M. tuberculosis bacilli in this state show increased tolerance
to antibiotics and stress conditions, and thus the transition of M. tuberculosis to the nonreplicating dormant state acts as
an obstacle to tuberculosis treatment. M. tuberculosis in the granuloma encounters hostile environments such as hypoxia,
nitric oxide, reactive oxygen species, low pH, and nutrient deprivation, etc., which are expected to inhibit respiration of M.
tuberculosis. To adapt to and survive in respiration-inhibitory conditions, it is required for M. tuberculosis to reprogram its
metabolism and physiology. In order to get clues to the mechanism underlying the entry of M. tuberculosis to the dormant
state, it is important to understand the mycobacterial regulatory systems that are involved in the regulation of gene expression
in response to respiration inhibition. In this review, we briefly summarize the information regarding the regulatory
systems implicated in upregulation of gene expression in mycobacteria exposed to respiration-inhibitory conditions. The
regulatory systems covered in this review encompass the DosSR (DevSR) two-component system, SigF partner switching
system, MprBA-SigE-SigB signaling pathway, cAMP receptor protein, and stringent response.
-
Citations
Citations to this article as recorded by  - Genetic and immunologic determinants of BCG disease: from mechanism to prevention
Feng Chen, Yifan Shen, Qianhui Yan, Daishan Zheng, Xiaoli Chen, Longyu Fang, Mengchen Sun, Yuansi Zhang, Maoping Chu, Enhui Yang, Xiu-Feng Huang
Annals of Medicine.2026;[Epub] CrossRef - Recent advances in research on Mycobacterium tuberculosis virulence factors and their role in pathogenesis
Ming-Rui Sun, Jia-Yin Xing, Xiao-Tian Li, Ren Fang, Yang Zhang, Zhao-Li Li, Ning-Ning Song
Journal of Microbiology, Immunology and Infection.2025; 58(5): 497. CrossRef - Host Immune Pathways to Mycobacterium tuberculosis Infection
Eun-Jin Park, Insoo Kim, Eun-Kyeong Jo
Journal of Bacteriology and Virology.2024; 54(3): 167. CrossRef - Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation
Jin-Won Lee
Journal of Microbiology.2023; 61(3): 273. CrossRef
- Protein-Protein Interactions between Histidine Kinases and Response Regulators of Mycobacterium tuberculosis H37Rv
-
Ha-Na Lee , Kwang-Eun Jung , In-Jeong Ko , Hyung Suk Baik , Jeong-Il Oh
-
J. Microbiol. 2012;50(2):270-277. Published online April 27, 2012
-
DOI: https://doi.org/10.1007/s12275-012-2050-4
-
-
794
View
-
0
Download
-
25
Crossref
-
Abstract
PDF
-
Using yeast two-hybrid assay, we investigated protein-protein
interactions between all orthologous histidine kinase
(HK)/response regulator (RR) pairs of M. tuberculosis H37Rv
and identified potential protein-protein interactions between
a noncognate HK/RR pair, DosT/NarL. The protein
interaction between DosT and NarL was verified by phosphotransfer
reaction from DosT to NarL. Furthermore, we
found that the DosT and DosS HKs, which share considerable
sequence similarities to each other and form a twocomponent
system with the DosR RR, have different crossinteraction
capabilities with NarL: DosT interacted with
NarL, while DosS did not. The dimerization domains of
DosT and DosS were shown to be sufficient to confer specificity
for DosR, and the different cross-interaction abilities
of DosS and DosT with NarL were demonstrated to be attributable
to variations in the amino acid sequences of the
α2-helices of their dimerization domains.
-
Citations
Citations to this article as recorded by - Multiple input–multiple output (MIMO) designs in two-component signalling systems of Mycobacterium tuberculosis
Devendra Pratap Singh, Gayathri A S, Ramandeep Singh, Narendra M Dixit, Deepak Kumar Saini, Michael Bott
FEMS Microbiology Reviews.2026;[Epub] CrossRef -
Activation of the MprBA two-component system in
Mycobacterium smegmatis
under acidic and respiration-inhibitory conditions and crosstalk between MprA and KdpD
Yun-Kyung Kim, Ye-Jin Lee, Jeong-Il Oh, Patricia A. Champion
Journal of Bacteriology.2026;[Epub] CrossRef - Harnessing hypoxia: bacterial adaptation and chronic infection in cystic fibrosis
Ciarán J Carey, Niamh Duggan, Joanna Drabinska, Siobhán McClean
FEMS Microbiology Reviews.2025;[Epub] CrossRef - Modulators targeting protein-protein interactions in Mycobacterium tuberculosis
Guofeng Luo, Tianqi Ming, Luchuan Yang, Lei He, Tao Tao, Yanmei Wang
Microbiological Research.2024; 284: 127675. CrossRef - Dual functioning by the PhoR sensor is a key determinant to Mycobacterium tuberculosis virulence
Prabhat Ranjan Singh, Harsh Goar, Partha Paul, Khushboo Mehta, Bhanwar Bamniya, Anil Kumar Vijjamarri, Roohi Bansal, Hina Khan, Subramanian Karthikeyan, Dibyendu Sarkar, Danielle A. Garsin
PLOS Genetics.2023; 19(12): e1011070. CrossRef - Phosphoproteomics of Mycobacterium-host interaction and inspirations for novel measures against tuberculosis
Zilu Wang, Jianping Xie
Cellular Signalling.2022; 91: 110238. CrossRef - PrrA modulates Mycobacterium tuberculosis response to multiple environmental cues and is critically regulated by serine/threonine protein kinases
David Giacalone, Rochelle E. Yap, Alwyn M. V. Ecker, Shumin Tan, Danielle A. Garsin
PLOS Genetics.2022; 18(8): e1010331. CrossRef - Sensing of O2 and nitrate by bacteria: alternative strategies for transcriptional regulation of nitrate respiration by O2 and nitrate
Gottfried Unden, Robin Klein
Environmental Microbiology.2021; 23(1): 5. CrossRef - Nitrate-nitrite fate and oxygen sensing in dormant Mycobacterium tuberculosis: A bioinorganic approach highlighting the importance of transition metals
Eduardo H.S. Sousa, Marta S.P. Carepo, José J.G. Moura
Coordination Chemistry Reviews.2020; 423: 213476. CrossRef - Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and
Sensor Kinase Heme
Huiqing Zheng, John T. Williams, Bilal Aleiwi, Edmund Ellsworth, Robert B. Abramovitch
ACS Chemical Biology.2020; 15(1): 52. CrossRef - Acetylation of Response Regulator Proteins, TcrX and MtrA in M. tuberculosis Tunes their Phosphotransfer Ability and Modulates Two-Component Signaling Crosstalk
Krishna Kumar Singh, Neerupma Bhardwaj, Gaurav D. Sankhe, Niveda Udaykumar, Rambir Singh, Vandana Malhotra, Deepak Kumar Saini
Journal of Molecular Biology.2019; 431(4): 777. CrossRef - In Vivo Methods to Study Protein–Protein Interactions as Key Players in Mycobacterium Tuberculosis Virulence
Romain Veyron-Churlet, Camille Locht
Pathogens.2019; 8(4): 173. CrossRef - Dual control of RegX3 transcriptional activity by SenX3 and PknB
Eun-Jin Park, Yu-Mi Kwon, Jin-Won Lee, Ho-Young Kang, Jeong-Il Oh
Journal of Biological Chemistry.2019; 294(28): 11023. CrossRef - Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure
Josiane Bezerra da Silva Lobão, Ana C. S. Gondim, Wellinson G. Guimarães, Marie‐Alda Gilles‐Gonzalez, Luiz Gonzaga de França Lopes, Eduardo H. S. Sousa
The FEBS Journal.2019; 286(3): 479. CrossRef - Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story
Niels Zondervan, Jesse Van Dam, Peter Schaap, Vitor Martins dos Santos, Maria Suarez-Diez
International Journal of Molecular Sciences.2018; 19(2): 347. CrossRef - Inhibition of the DevSR Two-Component System by Overexpression of Mycobacterium tuberculosis PknB in Mycobacterium smegmatis
Hyun-Jung Bae, Ha-Na Lee, Mi-Na Baek, Eun-Jin Park, Chi-Yong Eom, In-Jeong Ko, Ho-Young Kang, Jeong-Il Oh
Molecules and Cells.2017; 40(9): 632. CrossRef - The two-component signalling networks of Mycobacterium tuberculosis display extensive cross-talk in vitro
Ruchi Agrawal, Akancha Pandey, Mayooreshwar P. Rajankar, Narendra M. Dixit, Deepak K. Saini
Biochemical Journal.2015; 469(1): 121. CrossRef - Phylogenomics of Mycobacterium Nitrate Reductase Operon
Qinqin Huang, Abualgasim Elgaili Abdalla, Jianping Xie
Current Microbiology.2015; 71(1): 121. CrossRef - Genome-wide prediction of prokaryotic two-component system networks using a sequence-based meta-predictor
Altan Kara, Martin Vickers, Martin Swain, David E. Whitworth, Narcis Fernandez-Fuentes
BMC Bioinformatics.2015;[Epub] CrossRef - Two-Component Regulatory Systems of Mycobacteria
Tanya Parish, Graham F. Hatfull, William R. Jacobs Jr.
Microbiology Spectrum.2014;[Epub] CrossRef - Rv1027c–Rv1028c encode functional KdpDE two – Component system in Mycobacterium tuberculosis
Ruchi Agrawal, Deepak Kumar Saini
Biochemical and Biophysical Research Communications.2014; 446(4): 1172. CrossRef - Serine 83 in DosR, a response regulator from Mycobacterium tuberculosis, promotes its transition from an activated, phosphorylated state to an inactive, unphosphorylated state
Ha Yeon Cho, Beom Sik Kang
Biochemical and Biophysical Research Communications.2014; 444(4): 651. CrossRef - Proteome and phosphoproteome analysis of the serine/threonine protein kinase E mutant of Mycobacterium tuberculosis
Dinesh Kumar Parandhaman, Prashant Sharma, Deepa Bisht, Sujatha Narayanan
Life Sciences.2014; 109(2): 116. CrossRef - Improved understanding of pathogenesis from protein interactions inMycobacteriumtuberculosis
Tao Cui, Zheng-Guo He
Expert Review of Proteomics.2014; 11(6): 745. CrossRef - Involvement of the catalytically important Asp54 residue ofMycobacterium smegmatisDevR in protein-protein interactions between DevR and DevS
Ha-Na Lee, Na-On Lee, In-Jeong Ko, Si Wouk Kim, Beom Sik Kang, Jeong-Il Oh
FEMS Microbiology Letters.2013; 343(1): 26. CrossRef
|
MSK
