- Trichoderma reesei Sch9 and Yak1 regulate vegetative growth, conidiation, and stress response and induced cellulase production
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Xinxing Lv† , Weixin Zhang† , Guanjun Chen , Weifeng Liu
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J. Microbiol. 2015;53(4):236-242. Published online January 31, 2015
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DOI: https://doi.org/10.1007/s12275-015-4639-x
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Protein kinases are key players in controlling many basic
cellular processes in almost all the organisms via mediating
signal transduction processes. In the present study, we characterized
the cellulolytic Trichoderma reesei orthologs of
Saccharomyces cerevisiae Sch9 and Yak1 by sequence alignment
and functional analysis. The T. reesei Trsch9Δ and
Tryak1Δ mutant strains displayed a decreased growth rate
on different carbon sources and produced less conidia. The
absence of these two kinases also resulted in different but
abnormal polarized apical growth as well as sensitivity to
various stresses. In addition, disruption of the genes Trsch9 or
Tryak1 resulted in perturbation of cell wall integrity. Interestingly,
while the induced production of cellulases was slightly
compromised in the Trsch9Δ strain, the extracellular production
of cellulases was significantly improved in the absence
of Yak1. The results indicate that TrSch9 and TrYak1
play an important role in filamentous growth, stress response
and induced production of cellulases in T. reesei.
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