Journal of Microbiology

Gi-Ho Sung

10 Articles

Metabolomic profiling reveals enrichment of cordycepin in senescence process of Cordyceps militaris fruit bodies: Junsang Oh , Deok-Hyo Yoon , Bhushan Shrestha , Hyung-Kyoon Choi , Gi-Ho Sung; J. Microbiol. 2019;57(1):54-63. Published online December 29, 2018; DOI: https://doi.org/10.1007/s12275-019-8486-z

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Cordyceps militaris is a species of Cordyceps that is classified in the Cordycipitaceae family and is well known in East Asia as a traditional medicinal mushroom. Its artificial fruit body has been widely cultivated for commercial use in cosmetics, functional food, and medicine. To explore the metabolites associated with fruit body development, we conducted gas chromatography mass spectrometry (GC-MS) analyses based on developmental stage, which was divided into the growth period (stage 1, stage 2, and stage 3) and aging period (stage 4). We detected 39 biochemical metabolites associated with nucleotide, carbohydrate, and amino acid metabolism. Cordycepin, one of the representative bioactive compounds in C. militaris, was significantly enriched in stage 4 of aging period and is associated with glucose accumulation. The accumulation of cordycepin in stage 4 of aging period also seems to be related to the glutamine and glutamic acid pathway. Our
results
also showed enrichment of other bioactive compounds such as mannitol and xylitol in stage 4 of aging period. Our metabolomic profiling based on the developmental stages of C. militaris is useful for exploring bioactive compounds (e.g., cordycepin, mannitol, GABA, and xylitol) that are enriched in stage 4 of aging period and understanding the biosynthetic mechanisms associated with cordycepin production. Through optimization of fruit body cultivation by selecting stage 4 of aging period as a harvesting time, our findings can be utilized in food and medical applications of C. militaris in future.

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Analysis of the Functional Components of Four “Sanghuang”‐Like Species Using UPLC‐ESI‐MS/MS‐Based Widely Targeted Metabolomics and TCMSP Database
Xiao-Ying Guo, Yue Qi, Xiao-Dan Yu, Ai-Guo Xu, Chun-Yang Zhi, Hong-Bo Guo, Charalampos Proestos
Journal of Food Biochemistry.2026;[Epub] CrossRef
Integrative Network Pharmacology Study of Cordyceps militaris Compounds for Prostate Cancer Treatment
Sarah Cecilia Astrid Laihad, Trina Ekawati Tallei , Lydia Estelina Naomi Tendean , Grace Lendawati Amelia Turalaki, Sylvia Ritta Marunduh, Diana Shintawati Purwanto , Billy Johnson Kepel, Abdul Hawil Abas
Heca Journal of Applied Sciences.2026; 4(1): 70. CrossRef
Application of Metabolomics in the Exploration of Bioactive Compounds and Drug Development from Medicinal Fungi
Yan Tong, Chuyu Tang, Bing Jia, Haoxu Tang, Jinxuan Yan, Yuling Li, Xiuzhang Li
Metabolites.2026; 16(8): 576. CrossRef
Influence of Culture Conditions on Bioactive Compounds in Cordyceps militaris: A Comprehensive Review
Hye-Jin Park
Foods.2025; 14(19): 3408. CrossRef
Light-Exposed Metabolic Responses of Cordyceps militaris through Transcriptome-Integrated Genome-Scale Modeling
Panyawarin Soommat, Nachon Raethong, Ratchaprapa Ruengsang, Roypim Thananusak, Teeraphan Laomettachit, Kobkul Laoteng, Treenut Saithong, Wanwipa Vongsangnak
Biology.2024; 13(3): 139. CrossRef
Core microbes in Cordyceps militaris sclerotia and their nitrogen metabolism-related ecological functions
Li Luo, Fei Dai, Zhongshun Xu, Jingqiang Guan, Gangxiang Fei, Jiaojiao Qu, Min Yao, Yuan Xue, Yeming Zhou, Xiao Zou, Christina A. Cuomo
Microbiology Spectrum.2024;[Epub] CrossRef
Widely targeted metabolomics analysis of Sanghuangporus vaninii mycelia and fruiting bodies at different harvest stages
Yue Qi, Xiao-Ying Guo, Xin-Yue Xu, Jian-Xuan Hou, Shi-Lai Liu, Hong-Bo Guo, Ai-Guo Xu, Rui-Heng Yang, Xiao-Dan Yu
Frontiers in Microbiology.2024;[Epub] CrossRef
Current Progress Regarding Cordyceps militaris, Its Metabolite Function, and Its Production
Yu-Chieh Chou, Ting-Hsuan Sung, Shi-Jing Hou, Darin Khumsupan, Shella Permatasari Santoso, Kuan-Chen Cheng, Shin-Ping Lin
Applied Sciences.2024; 14(11): 4610. CrossRef
Enhancement of Cordycepin Production through Liquid Static Fermentation of Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes)
Mahesh Borde, Shweta Kumawat, Sanjay K. Singh
International Journal of Medicinal Mushrooms.2024; 26(11): 65. CrossRef
Genomic and Transcriptome Analysis Reveals the Biosynthesis Network of Cordycepin in Cordyceps militaris
Linshan Chai, Jianmei Li, Lingling Guo, Shuyu Zhang, Fei Chen, Wanqin Zhu, Yu Li
Genes.2024; 15(5): 626. CrossRef
Future of Scarlet Caterpillar Club Fungus: A Review on Molecular Strategies for Cordycepin Enhancement
Rubi Kumari, Nayna Mukherjee, Aryan Sharma, Amitesh Chaman, Shankar Narayana Reddy, Shivika Sharma
Biosciences Biotechnology Research Asia.2024; 21(3): 839. CrossRef
Transcriptome and metabolome profiling unveils the mechanisms of naphthalene acetic acid in promoting cordycepin synthesis in Cordyceps militaris
Xin Wang, Yin Li, Xiue Li, Lei Sun, Yetong Feng, Fangping Sa, Yupeng Ge, Shude Yang, Yu Liu, Weihuan Li, Xianhao Cheng
Frontiers in Nutrition.2023;[Epub] CrossRef
Enhanced production of cordycepin under solid-state fermentation of Cordyceps militaris by using combinations of grains/substrates
Mahesh Borde, Sanjay K. Singh
Brazilian Journal of Microbiology.2023; 54(4): 2765. CrossRef
Microbial synthesis of cordycepin, current systems and future perspectives
Xiyu Duan, Hui Yang, Chong Wang, Huhu Liu, Xiangyang Lu, Yun Tian
Trends in Food Science & Technology.2023; 132: 162. CrossRef
Air Atmospheric Pressure Plasma Jet to Improve Fruiting Body Production and Enhance Bioactive Phytochemicals from Mutant Cordyceps militaris (White Cordyceps militaris)
Sujarinee Sangwanna, Weerasak Seelarat, Teerapap Panklai, Natthaphon Chaosuan, Ahkasit Subcharoen, Nuttapon Subcharoen, Nattapong Chanchula, Tanapak Inyod, Thanaphat Toemarrom, Atipong Bootchanont, Chakkaphan Wattanawikkam, Sorapong Pavasupree, Dheerawan
Food and Bioprocess Technology.2023; 16(9): 1976. CrossRef
Dissecting Metabolic Regulation in Mycelial Growth and Fruiting Body Developmental Stages of Cordyceps militaris through Integrative Transcriptome Analysis
Roypim Thananusak, Kobkul Laoteng, Nachon Raethong, Mattheos Koffas, Wanwipa Vongsangnak
Biotechnology and Bioprocess Engineering.2023; 28(3): 406. CrossRef
Functional genomics and systems biology of Cordyceps species for biotechnological applications
Nachon Raethong, Roypim Thananusak, Pattsarun Cheawchanlertfa, Pranesha Prabhakaran, Kittipong Rattanaporn, Kobkul Laoteng, Mattheos Koffas, Wanwipa Vongsangnak
Current Opinion in Biotechnology.2023; 81: 102939. CrossRef
Effect of Cultivation Stages of Hericium erinaceus on the Contents of Major Components and α-Glucosidase Inhibitory Activity
Se Hwan Ryu, Beom Seok Kim, Ayman Turk, Sang Won Yeon, Solip Lee, Hak Hyun Lee, Sung Min Ko, Bang Yeon Hwang, Kyeong Lee
Natural Product Sciences.2023; 29(3): 132. CrossRef
Enhanced Fruiting Body Production and Bioactive Phytochemicals from White Cordyceps militaris by Blending Cordyceps militaris and Using Cold Plasma Jet
Weerasak Seelarat, Sujarinee Sangwanna, Teerapap Panklai, Natthaphon Chaosuan, Atipong Bootchanont, Chakkaphan Wattanawikkam, Ahkasit Subcharoen, Nuttapon Subcharoen, Nattapong Chanchula, Dheerawan Boonyawan, Porramain Porjai
Plasma Chemistry and Plasma Processing.2023; 43(1): 139. CrossRef
Cordycepin production by the potential fungal strains Cordyceps militaris BCC 2819 and Cordyceps cicadae BCC 19788 in submerged culture during batch and Fed-batch fermentation
Werapan Borworn, Nutaratat Pumin, Ariyaphuttarat Siriporn, Prathumpai Wai
African Journal of Biotechnology.2022; 21(10): 483. CrossRef
Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris
Li Wang, Huanhuan Yan, Bin Zeng, Zhihong Hu
Bioengineering.2022; 9(2): 69. CrossRef
Application of Metabolomics in Fungal Research
Guangyao Li, Tongtong Jian, Xiaojin Liu, Qingtao Lv, Guoying Zhang, Jianya Ling
Molecules.2022; 27(21): 7365. CrossRef
Cordycepin production by a novel endophytic fungus Irpex lacteus CHG05 isolated from Cordyceps hawkesii Gray
Ziying Liu, Guihua Leng, Jingbai Wen, Ganqi Deng, Jiayao Jiang
Folia Microbiologica.2022; 67(6): 851. CrossRef
Heavy Metals, Halogenated Hydrocarbons, Phthalates, Glyphosate, Cordycepin, Alcohol, Drugs, and Herbs, Assessed for Liver Injury and Mechanistic Steps
Rolf Teschke, Tran Dang Xuan
Frontiers in Bioscience-Landmark.2022;[Epub] CrossRef
Effects on total phenolic and flavonoid content, antioxidant properties, and angiotensin I-converting enzyme inhibitory activity of beans by solid-state fermentation with Cordyceps militaris
Weiwei Liu, Mengqian Dun, Xinyuan Liu, Guoying Zhang, Jianya Ling
International Journal of Food Properties.2022; 25(1): 477. CrossRef
Effect of Spirulina biomass residue on yield and cordycepin and adenosine production of Cordyceps militaris culture
Siriluck Iamtham, Adisak Kaewkam, Sermsiri Chanprame, Wanida Pan-utai
Bioresource Technology Reports.2022; 17: 100893. CrossRef
Enhancement of cordycepin production from Cordyceps militaris culture by epigenetic modification
Phongsakorn Kunhorm, Phongsakorn Chueaphromsri, Nipha Chaicharoenaudomrung, Parinya Noisa
Biotechnology Letters.2022; 44(4): 581. CrossRef
Improved Cordycepin Production by Cordyceps militaris KYL05 Using Casein Hydrolysate in Submerged Conditions
Soo Kweon Lee, Ju Hun Lee, Hyeong Ryeol Kim, Youngsang Chun, Ja Hyun Lee, Hah Young Yoo, Chulhwan Park, Seung Wook Kim
Biomolecules.2019; 9(9): 461. CrossRef
Cordyceps militaris polysaccharides exerted protective effects on diabetic nephropathy in mice via regulation of autophagy
Dan-Dan Chen, Rui Xu, Jiu-Yao Zhou, Jun-Qi Chen, Lin Wang, Xu-Sheng Liu, Chun-ling Liang, Bi-Hao Liu, Rui-Rui Lu, Jun-Biao Wu, Hua Lin
Food & Function.2019; 10(8): 5102. CrossRef

Species identity of Phellinus linteus (sanghuang) extensively used as a medicinal mushroom in Korea: Jae-Gu Han , Min-Woo Hyun , Chang Sun Kim , Jong Won Jo , Jae-Han Cho , Kang-Hyo Lee , Won-Sik Kong , Sang-Kuk Han , Junsang Oh , Gi-Ho Sung; J. Microbiol. 2016;54(4):290-295. Published online April 1, 2016; DOI: https://doi.org/10.1007/s12275-016-5520-2

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Abstract PDF

Sanghuang is a medicinal mushroom that has gained particular attention in Korea. It has been extensively studied for the past few decades as a natural immune booster and cancer suppressor. Although the scientific name, Phellinus linteus, has been commonly used to refer to the sanghuang mushroom, the species identity of sanghuang has been called into question due to the ambiguity of its circumscription and the inadequacy of morphological distinctions within allied species. Because the species concept of sanghuang has been elucidated by recent molecular phylogenetic studies, it has become necessary to clarify the taxonomic positions of sanghuang strains extensively utilized in Korea. We conducted a phylogenetic analysis of 74 strains belonging to the P. linteus-baumii complex based on ITS nrDNA sequences. Parental stains of sanghuang varieties formally registered in the Korea Seed & Variety Service, including ASI 26046 (Corea sanghuang), 26114 (Boolro), and 26115 (HK 1-ho) were grouped with Sanghuangporus sanghuang instead of P. linteus in the inferred phylogeny.

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Studies on seasonal dynamics of soil-higher fungal communities in Mongolian oak-dominant Gwangneung forest in Korea: Chang Sun Kim , Jong Woo Nam , Jong Won Jo , Sang-Yong Kim , Jae-Gu Han , Min Woo Hyun , Gi-Ho Sung , Sang-Kuk Han; J. Microbiol. 2016;54(1):14-22. Published online January 5, 2016; DOI: https://doi.org/10.1007/s12275-016-5521-1

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Abstract PDF

We surveyed macrofungi biweekly at defined plots from April to December in 2014, in the Mongolian oak-dominant forest, Gwangneung Forest, Pochen-si, Korea, and analyzed a soilhigher fungal diversity during four seasons (represented by April, August, October, and December). Based on morphological observation of collected specimens, the collected macrofungi were classified into 2 phyla 3 classes 7 orders, 14 families, 21 genera, and 33 species (36 specimens). DNA-based community analyses indicated that soil-higher fungi were classified into 2 phyla, 18 classes, 49 orders, 101 families, and 155 genera (83,360 sequence reads), defined herein as 155 genus-level operational taxonomic units (GOTUs). In the present study, we evaluated and discussed the fungal diversity in seasonal dynamics and soil layers based on collected macrofungi and pyrosequencing data while considering environmental parameters (pH, exchangeable K, T-P, NH4+, NO3-, OM, WR, TOC, and T-N). Moreover, principal components analysis (PCA) showed distinct clusters of the GOTU assemblage associated with the seasons.

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Genipin as a novel chemical activator of EBV lytic cycle: Myoungki Son , Minjung Lee , Eunhyun Ryu , Aree Moon , Choon-Sik Jeong , Yong Woo Jung , Gyu Hwan Park , Gi-Ho Sung , Hyosun Cho , Hyojeung Kang; J. Microbiol. 2015;53(2):155-165. Published online January 28, 2015; DOI: https://doi.org/10.1007/s12275-015-4672-9

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Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that causes acute infection and establishes life-long latency. EBV causes several human cancers, including Burkitt's lymphoma, nasopharyngeal and gastric carcinoma. Antiviral agents can be categorized as virucides, antiviral chemotherapeutic agents, and immunomodulators. Most antiviral agents affect actively replicating viruses, but not their latent forms. Novel antiviral agents must be active on both the replicating and the latent forms of the virus. Gardenia jasminoides is an evergreen flowering plant belonging to the Rubiaceae family and is most commonly found growing wild in Vietnam, Southern China, Taiwan, Japan, Myanmar, and India. Genipin is an aglycone derived from an iridoid glycoside called geniposide, which is present in large quantities in the fruit of G. jasminoides. In this study, genipin was evaluated for its role as an antitumor and antiviral agent that produces inhibitory effects against EBV and EBV associated gastric carcinoma (EBVaGC). In SNU719 cells, one of EBVaGCs, genipin caused significant cytotoxicity (70 μM), induced methylation on EBV C promoter and tumor suppressor gene BCL7A, arrested cell-cycle progress (S phases), upregulated EBV latent/lytic genes in a dose-dependent manner, stimulated EBV progeny production, activated EBV F promoter for EBV lytic activation, and suppressed EBV infection. These
results
indicated that genipin could be a promising candidate for antiviral and antitumor agents against EBV and EBVaGC.

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Anti-influenza Effect of Cordyceps militaris through Immunomodulation in a DBA/2 Mouse Model: Hwan Hee Lee , Heejin Park , Gi-Ho Sung , Kanghyo Lee , Taeho Lee , Ilseob Lee , Man-seong Park , Yong Woo Jung , Yu Su Shin , Hyojeung Kang , Hyosun Cho; J. Microbiol. 2014;52(8):696-701. Published online July 18, 2014; DOI: https://doi.org/10.1007/s12275-014-4300-0

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Abstract PDF

The immune-modulatory as well as anti-influenza effects of Cordyceps extract were investigated using a DBA/2 mouse model. Three different concentrations of Cordyceps extract, red ginseng extract, or drinking water were orally administered to mice for seven days, and then the mice were intranasally infected with 2009 pandemic influenza H1N1 virus. Body weight changes and survival rate were measured daily post-infection. Plasma IL-12, TNF-α, and the frequency of natural killer (NK) cells were measured on day 4 post-infection. The DBA/2 strain was highly susceptible to H1N1 virus infection. We also found that Cordyceps extract had an antiinfluenza effect that was associated with stable body weight and reduced mortality. The anti-viral effect of Cordyceps extract on influenza infection was mediated presumably by increased IL-12 expression and greater number of NK cells. However, high TNF-α expression after infection of H1N1 virus in mice not receiving treatment with Cordyceps extract suggested a two-sided effect of the extract on host immune regulation.

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Bioactive Activities of Natural Products against Herpesvirus Infection: Myoungki Son , Minjung Lee , Gi-Ho Sung , Taeho Lee , Yu Su Shin , Hyosun Cho , Paul M. Lieberman , Hyojeung Kang; J. Microbiol. 2013;51(6):888-888.; DOI: https://doi.org/10.1007/s12275-013-0726-z

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Abstract PDF: In the article by Son et al. published in the Journal of Microbiology 2013; 51, 545-551. - Acknowledgement should appear as shown below. We gratefully acknowledge financial supports of Next Generation BioGreen 21 Program (Project No. PJ009508) and Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ009241) from Rural Development Administration, Republic of Korea. - Co-corresponding author’s (Dr. Paul M. Lieberman) affiliation should appear as shown below. 6The Wistar Institute, Philadelphia, PA 19104, USA

Two Novel Talaromyces Species Isolated from Medicinal Crops in Korea: Hyunkyu Sang , Tae-Jin An , Chang Sun Kim , Gyu-Sub Shin , Gi-Ho Sung , Seung Hun Yu; J. Microbiol. 2013;51(5):704-708. Published online October 31, 2013; DOI: https://doi.org/10.1007/s12275-013-3361-9

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Abstract PDF

Two novel biverticillate Talaromyces species, T. angelicus and T. cnidii, were collected from the medicinal crops Angelica gigas and Cnidium officinale, respectively, in Korea. Phylogenetic analyses with the nuclear ribosomal internal transcribed spacer (ITS) region and the β-tubulin gene as well as morphological analyses revealed that the two species differ from any known Talaromyces species. Talaromyces angelicus is related to T. flavovirens in the phylogeny of the ITS region, but the new species is grouped together with Penicillium liani and T. pinophilus in terms of its β-tubulin phylogeny, and its growth rate on Czapek yeast autolysate differs from that of T. flavovirens. Talaromyces cnidii is phylogenetically similar to T. siamensis, but exhibits differences in the morphologies of the colony margin, metulae, and conidia.

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Bioactive Activities of Natural Products against Herpesvirus Infection: Myoungki Son , Minjung Lee , Gi-Ho Sung , Taeho Lee , Yu Su Shin , Hyosun Cho , Paul M. Lieberman , Hyojeung Kang; J. Microbiol. 2013;51(5):545-551. Published online October 31, 2013; DOI: https://doi.org/10.1007/s12275-013-3450-9

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Abstract PDF

More than 90% of adults have been infected with at least one human herpesvirus, which establish long-term latent infection for the life of the host. While anti-viral drugs exist that limit herpesvirus replication, many of these are ineffective against latent infection. Moreover, drug-resistant strains of herpesvirus emerge following chemotherapeutic treatment. For example, resistance to acyclovir and related nucleoside analogues can occur when mutations arise in either HSV thymidine kinase or DNA polymerases. Thus, there exists an unmet medical need to develop new anti-herpesvirus agents with different mechanisms of action. In this Review, we discuss the promise of anti-herpetic substances derived from natural products including extracts and pure compounds from potential herbal medicines. One example is Glycyrrhizic acid isolated from licorice that shows promising antiviral activity towards human gammaherpesviruses. Secondly, we discuss anti-herpetic mechanisms utilized by several natural products in molecular level. While nucleoside analogues inhibit replicating herpesviruses in lytic replication, some natural products can disrupt the herpesvirus latent infection in the host cell. In addition, natural products can stimulate immune responses against herpesviral infection. These findings suggest that natural products could be one of the best choices for development of new treatments for latent herpesvirus infection, and may provide synergistic anti-viral activity when supplemented with nucleoside analogues. Therefore, it is important to identify which natural products are more efficacious anti-herpetic agents, and to understand the molecular mechanism in detail for further advance in the anti-viral therapies.

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Penicillium daejeonium sp. nov., a New Species Isolated from a Grape and Schisandra Fruit in Korea: Hyunkyu Sang , Tae-Jin An , Chang Sun Kim , Young Phil Choi , Jian-Xin Deng , Narayan Chandra Paul , Gi-Ho Sung , Seung Hun Yu; J. Microbiol. 2013;51(4):536-539. Published online August 30, 2013; DOI: https://doi.org/10.1007/s12275-013-3291-6

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Two isolates of monoverticillate Penicillium species were collected from a grape and schisandra fruit in Korea. Multigene phylogenetic analyses with the nuclear ribosomal internal transcribed spacer (ITS) region and genes encoding β-tubulin (benA) and calmodulin (cmd), as well as morphological analyses revealed that the two isolates are members of the P. sclerotiorum complex in Penicillium subgenus Aspergilloides, but different from species of the P. sclerotiorum complex. The isolates are closely related to P. cainii, P. jacksonii, and P. viticola in terms of their multigene phylogeny, but their colony and conidiophore morphologies differ from those of closely related species. The name P. daejeonium is proposed for this unclassified new species belonging to the P. sclerotiorum complex in subgenus Aspergilloides.

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Dysregulation of KSHV Replication by Extracts from Carthamus tinctorius L.: Han Lee , Hyosun Cho , Myoungki Son , Gi-Ho Sung , Taeho Lee , Sang-Won Lee , Yong Woo Jung , Yu Su Shin , Hyojeung Kang; J. Microbiol. 2013;51(4):490-498. Published online August 30, 2013; DOI: https://doi.org/10.1007/s12275-013-3282-7

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Abstract PDF

Carthamus tinctorius L. (CT) is traditionally used to reduce ailments from diseases of the musculoskeletal system and connective tissue and diseases of blood circulation and the cardiovascular system. Flower extracts from CT are known to have antibacterial activity, anti-inflammatory activity, and to inhibit tumor promotion in mouse skin carcinogenesis. In order to discover new antiviral agents from CT extracts, we tested whether CT extracts contain antiviral activity against gammaherpesvirus infection. This study demonstrated that treatment with CT extracts disrupted KSHV latency in the viral-infected host cells, iSLK-BAC16. n-Hexane and EtOH fractions of CT extracts critically affected at least two stages of the KHSV life-cycle by abnormally inducing KSHV lytic reactivation and by severely preventing KSHV virion release from the viral host cells. In addition to the effects on KSHV itself, CT extract treatments induced cellular modifications by dysregulating cell-cycle and producing strong cytotoxicity. This study demonstrated for the first time that CT extracts have antiviral activities that could be applied to development of new anti-gammaherpesviral agents.

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