- Helicobacter pylori-mediated gastric pathogenesis is attenuated by treatment of 2-deoxyglucose and metformin
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Hanfu Su , Eun-Jung Bak , Aeryun Kim , Kavinda Tissera , Jeong-Heon Cha , Sungil Jang
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J. Microbiol. 2022;60(8):849-858. Published online June 22, 2022
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DOI: https://doi.org/10.1007/s12275-022-2130-z
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Helicobacter pylori infection causes chronic inflammation
in the stomach, which is linked to the development of gastric
cancer. The anti-inflammatory and anticancer effects of a
glycolysis inhibitor 2-deoxyglucose (2DG) and an antidiabetic
medication metformin (Met) have gotten attention. Using a
Mongolian gerbil animal model, we investigated H. pylorimediated
gastric pathogenesis and how this pathogenesis is
influenced by 2DG and Met. Five-week-old male gerbils were
infected with H. pylori strain 7.13. After 2 weeks of infection,
gerbils were fed 2DG-containing food (0.03% w/w), Met-containing
water (0.5% w/v), or both (Combi) for 2 (short-term)
or 10 weeks (long-term). Gastric pathogenesis and host response
to H. pylori infection were examined by macroscopic
and histopathologic analysis of gerbils’ stomach. As a result,
indicators of gastric pathogenesis by H. pylori infection including
infiltration of polymorphonuclear neutrophils and
lymphocytes, intestinal metaplasia, atrophy, and proliferation
of gastric epithelial cells were attenuated by short-term administration
of 2DG, Met, or Combi. When the infection was
sustained for long-term, gastric pathogenesis in drug-treated
gerbils was equivalent to that in untreated gerbils, with the
exception that the infiltration of neutrophil was reduced by
2DG. Colonization of H. pylori in stomach was unaffected
by both short- and long-term treatments. Our findings demonstrate
that the progression of gastric pathogenesis induced
by H. pylori infection can be attenuated by the shortterm
individual or combinational treatment of 2DG and
Met, implying that 2DG or Met could be considered as a
treatment option for gastric diseases in the early stages of
infection.
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Citations
Citations to this article as recorded by  - Metabolic reprogramming as a key regulator in Helicobacter pylori-infected gastric cancer
Ruofan Cao, Feifei Zhou, Cuiyu Zhu, Hongwei Xu
Gastric Cancer.2026; 29(1): 1. CrossRef - Chemoprevention strategies for precancerous gastric lesions beyond Helicobacter pylori eradication
Tai Zhang, Xudong Tang
QJM: An International Journal of Medicine.2025; 118(6): 385. CrossRef - Antibacterial and Immunoregulatory Effects of Metformin against Helicobacter pylori Infection in Rat Model
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BioMed Research International.2023;[Epub] CrossRef - Effect of Metformin on the Prognosis of Gastric Cancer Patients with Type 2 Diabetes Mellitus: A Meta-Analysis Based on Retrospective Cohort Studies
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International Journal of Endocrinology.2023; 2023: 1. CrossRef
- N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection
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Sungil Jang , Eun-Jung Bak , Jeong-Heon Cha
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J. Microbiol. 2017;55(5):396-402. Published online April 29, 2017
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DOI: https://doi.org/10.1007/s12275-017-7089-9
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3,896
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Abstract
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Helicobacter pylori (H. pylori) is a human gastric pathogen, causing various gastric diseases ranging from gastritis to gas-tric adenocarcinoma. It has been reported that combining N-acetylcysteine (NAC) with conventional antibiotic therapy increases the success rate of H. pylori eradication. We evalu-ated the effect of NAC itself on the growth and coloniza-tion of H. pylori, and development of gastritis, using in vitro liquid culture system and in vivo animal models. H. pylori growth was evaluated in broth culture containing NAC. The H. pylori load and histopathological scores of stomachs were measured in Mongolian gerbils infected with H. pylori strain 7.13, and fed with NAC-containing diet. In liquid culture, NAC inhibited H. pylori growth in a concentration-depen-dent manner. In the animal model, 3-day administration of NAC after 1 week from infection reduced the H. pylori load; 6-week administration of NAC after 1 week from infection prevented the development of gastritis and reduced H. pylori colonization. However, no reduction in the bacterial load or degree of gastritis was observed with a 6-week administ-ration of NAC following 6-week infection period. Our results indicate that NAC may exert a beneficial effect on reduction of bacterial colonization, and prevents the development of severe inflammation, in people with initial asymptomatic or mild H. pylori infection.
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Citations
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Hanfu Su, Eun-Jung Bak, Aeryun Kim, Kavinda Tissera, Jeong-Heon Cha, Sungil Jang
Journal of Microbiology.2022; 60(8): 849. CrossRef - Population Pharmacokinetics of Doxycycline, Administered Alone or with N-Acetylcysteine, in Chickens with Experimental Mycoplasma gallisepticum Infection
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