- CXCL12/CXCR4 Axis is Involved in the Recruitment of NK Cells by HMGB1 Contributing to Persistent Airway Inflammation and AHR During the Late Stage of RSV Infection
-
Sisi Chen , Wei Tang , Guangyuan Yu , Zhengzhen Tang , Enmei Liu
-
J. Microbiol. 2023;61(4):461-469. Published online February 13, 2023
-
DOI: https://doi.org/10.1007/s12275-023-00018-8
-
-
1,078
View
-
4
Download
-
13
Web of Science
-
12
Crossref
-
 Abstract
 PDF
-
We previously showed that both high-mobility group box-1 (HMGB1) and natural killer (NK) cells contribute to respiratory
syncytial virus (RSV)-induced persistent airway inflammation and airway hyperresponsiveness (AHR). Meanwhile,
Chemokine (C-X-C motif) ligand 12 (CXCL12) and its specific receptor (chemokine receptor 4, CXCR4) play important
roles in recruitment of immune cells. CXCL12 has been reported to form a complex with HMGB1 that binds to CXCR4 and
increases inflammatory cell migration. The relationship between HMGB1, NK cells and chemokines in RSV-infected model
remains unclear. An anti-HMGB1 neutralizing antibody and inhibitor of CXCR4 (AMD3100) was administered to observe
changes of NK cells and airway disorders in nude mice and BALB/c mice. Results showed that the mRNA expression and
protein levels of HMGB1 were elevated in late stage of RSV infection and persistent airway inflammation and AHR were
diminished after administration of anti-HMGB1 antibodies, with an associated significant decrease in CXCR4+
NK cells. In
addition, CXCL12 and CXCR4 were reduced after HMGB1 blockade. Treatment with AMD3100 significantly suppressed
the recruitment of NK cells and alleviated the airway disorders. Thus, CXCL12/CXCR4 axis is involved in the recruitment
of NK cells by HMGB1, contributing to persistent airway inflammation and AHR during the late stage of RSV infection.
-
Citations
Citations to this article as recorded by  - Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei
Medicinal Research Reviews.2026; 46(3): 672. CrossRef - The role of HMGB1 in central nervous system (CNS) diseases: mechanisms and therapeutic perspectives
Ou Du, Yi-Jin Wu, Meng-Yang Li, Jun-Rong Du
Cytokine.2026; 198: 157099. CrossRef - Viral modulation of the CXCL12/CXCR4/CXCR7 axis: mechanisms, impacts on immunity and oncogenesis, and therapeutic opportunities
Usamah Sayed, Aya Mohammed Dhiaa, Djaloliddin Mansurov, Norbek Kholboyev, Rasim M. Salih, Mohaned Adil, Safa alkayyat
Cancer Treatment and Research Communications.2026; 48: 101247. CrossRef - Exploring Ribosomal Genes as Potential Biomarkers of the Immune Microenvironment in Respiratory Syncytial Virus Infection
Lu Lin, Zenghua Liao, Chaoqian Li
Biochemical Genetics.2025; 63(2): 1839. CrossRef - Damage-associated molecular patterns in viral infection: potential therapeutic targets
Huizhen Tian, Qiong Liu, Xiaomin Yu, Yanli Cao, Xiaotian Huang
Critical Reviews in Microbiology.2025; 51(3): 514. CrossRef - Peptides targeting RAB11A–FIP2 complex inhibit HPIV3, RSV, and IAV replication as broad-spectrum antivirals
Yanliang Jiang, Yongliang Zhao, Jie Deng, Xiaoyan Wu, Jian Li, Dong Guo, Ke Xu, Yali Qin, Mingzhou Chen
Cell & Bioscience.2025;[Epub] CrossRef - Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands
Takashi I, Riho Kanai, Makoto Seki, Hideki Agata, Hideaki Kagami, Hiroshi Murata, Izumi Asahina, Simon D. Tran, Yoshinori Sumita
Regenerative Therapy.2025; 30: 476. CrossRef - CXCL12 and CXCL13 as potential biomarkers for disease severity and recurrence in respiratory syncytial virus bronchiolitis
Lin Zhang, Yuanyu Lv, Zhiao Du, Jiawei Chen, Peng Mo, Xuena Xu, Huiming Sun, Yongdong Yan, Canhong Zhu, Li Huang, Chuangli Hao, Xiuxia Zhou, Heting Dong, Zhengrong Chen
Scientific Reports.2025;[Epub] CrossRef - DAMPs in immunosenescence and cancer
Fangquan Chen, Hu Tang, Xiutao Cai, Junhao Lin, Rui Kang, Daolin Tang, Jiao Liu
Seminars in Cancer Biology.2024; 106-107: 123. CrossRef - Advancements in Stimulus-Responsive Co-Delivery Nanocarriers for Enhanced Cancer Immunotherapy
Meng-Ru Zhang, Lin-Lin Fang, Yang Guo, Qin Wang, You-Jie Li, Hong-Fang Sun, Shu-Yang Xie, Yan Liang
International Journal of Nanomedicine.2024; Volume 19: 3387. CrossRef - Immunomodulatory markers and therapies for the management of infant respiratory syncytial virus infection
Ricardo A. Loaiza, Mónica A. Farías, Catalina A. Andrade, Mario A. Ramírez, Linmar Rodriguez-Guilarte, José T. Muñóz, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis
Expert Review of Anti-infective Therapy.2024; 22(8): 631. CrossRef - Activin A, a Novel Chemokine, Induces Mouse NK Cell Migration via AKT and Calcium Signaling
Yunfeng Wang, Zhonghui Liu, Yan Qi, Jiandong Wu, Boyang Liu, Xueling Cui
Cells.2024; 13(9): 728. CrossRef
|
MSK
