Journal of Microbiology

Dong Wook Kim

2 Articles

Sublingual Administration of Bacteria-Expressed Influenza Virus Hemagglutinin 1 (HA1) Induces Protection against Infection with 2009 Pandemic H1N1 Influenza Virus: Byoung-Shik Shim , Jung-ah Choi , Ho-Hyun Song , Sung-Moo Park , In Su Cheon , Ji-Eun Jang , Sun Je Woo , Chung Hwan Cho , Min-Suk Song , Hyemi Kim , Kyung Joo Song , Jae Myun Lee , Suhng Wook Kim , Dae Sub Song , Young Ki Choi , Jae-Ouk Kim , Huan Huu Nguyen , Dong Wook Kim , Young Yil Bahk , Cheol-Heui Yun , Man Ki Song; J. Microbiol. 2013;51(1):130-135. Published online March 2, 2013; DOI: https://doi.org/10.1007/s12275-013-2399-z

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Influenza viruses are respiratory pathogens that continue to pose a significantly high risk of morbidity and mortality of humans worldwide. Vaccination is one of the most effective strategies for minimizing damages by influenza outbreaks. In addition, rapid development and production of efficient vaccine with convenient administration is required in case of influenza pandemic. In this study, we generated recombinant influenza virus hemagglutinin protein 1 (sHA1) of 2009 pandemic influenza virus as a vaccine candidate using a wellestablished bacterial expression system and administered it into mice via sublingual (s.l.) route. We found that s.l. immunization with the recombinant sHA1 plus cholera toxin (CT) induced mucosal antibodies as well as systemic antibodies including neutralizing Abs and provided complete protection against infection with pandemic influenza virus A/CA/04/09 (H1N1) in mice. Indeed, the protection efficacy was comparable with that induced by intramuscular (i.m.) immunization route utilized as general administration route of influenza vaccine. These results suggest that s.l. vaccination with the recombinant non-glycosylated HA1 protein offers an alternative strategy to control influenza outbreaks including pandemics.

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Classification of Hybrid and Altered Vibrio cholerae Strains by CTX Prophage and RS1 Element Structure: Je Hee Lee , Seon Young Choi , Yoon-Seong Jeon , Hye Ri Lee , Eun Jin Kim , Binh Minh Nguyen , Nguyen Tran Hien , M. Ansaruzzaman , M. Sirajul Islam , Nurul A. Bhuiyan , S.K. Niyogi , B.L. Sarkar , G. Balakrish Nair , Dae Shick Kim , Anna Lena Lopez , Cecil Czerkinsky , John D. Clemens , Jongsik Chun , Dong Wook Kim; J. Microbiol. 2009;47(6):783-788. Published online February 4, 2010; DOI: https://doi.org/10.1007/s12275-009-0292-6

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Abstract PDF

Analysis of the CTX prophage and RS1 element in hybrid and altered Vibrio cholera O1 strains showed two classifiable groups. Group I strains contain a tandem repeat of classical CTX prophage on the small chromosome. Strains in this group either contain no element(s) or an additional CTX prophage or RS1 element(s) on the large chromosome. Group II strains harbor RS1 and CTX prophage, which has an El Tor type rstR and classical ctxB on the large chromosome.

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