Journal of Microbiology

Don Yong Chang

2 Articles

The Effect of Dietary Intake of the Acidic Protein Fraction of Bovine Colostrum on Influenza A (H1N1) Virus Infection: Mei Ling Xu , Hyoung Jin Kim , Don Yong Chang , Hong-Jin Kim; J. Microbiol. 2013;51(3):389-393. Published online April 26, 2013; DOI: https://doi.org/10.1007/s12275-013-2683-y

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Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.

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The Toxic Effects of Low Molecular Weight Components of Cow Colostrums: The Short-Term and Long-Term Effects
A.I. Bozhkov, E.G. Ivanov, N.I. Kurguzova, Muhammad M.A. Alsardia, R.A. Akzhigitov, S.Ya. Baranikova, V.I. Potapova, A.S. Chuprikova
Journal of Nutritional Therapeutics.2021; 6(4): 84. CrossRef
Bovine colostrum: benefits for the human respiratory system and potential contributions for clinical management of COVID-19
Alyne Batista da Silva Galdino, Adriano Henrique do Nascimento Rangel, Harpal Singh Buttar, Manuela Sales Lima Nascimento, Elaine Cristina Gavioli, Riva de Paula Oliveira, Danielle Cavalcanti Sales, Stela Antas Urbano, Katya Anaya
Food and Agricultural Immunology.2021; 32(1): 143. CrossRef
Influenza A in Bovine Species: A Narrative Literature Review
Chithra C. Sreenivasan, Milton Thomas, Radhey S. Kaushik, Dan Wang, Feng Li
Viruses.2019; 11(6): 561. CrossRef
Effective Components of Bovine Colostrum and Its Applications
Sang-Ah Seo, Hye-Ryoung Seo, Young-Tae Heo
Journal of Animal Reproduction and Biotechnology.2018; 33(3): 159. CrossRef
The effect of dietary bovine colostrum on respiratory syncytial virus infection and immune responses following the infection in the mouse
Mei Ling Xu, Hyoung Jin Kim, Ga Ram Wi, Hong-Jin Kim
Journal of Microbiology.2015; 53(9): 661. CrossRef
Effect of dietary bovine colostrum on the responses of immune cells to stimulation with bacterial lipopolysaccharide
Mei Ling Xu, Hyoung Jin Kim, Hong-Jin Kim
Archives of Pharmacal Research.2014; 37(4): 494. CrossRef

The Production and Immunogenicity of Human Papillomavirus Type 58 Virus-like Particles Produced in Saccharomyces cerevisiae: Hye-Lim Kwag , Hyoung Jin Kim , Don Yong Chang , Hong-Jin Kim; J. Microbiol. 2012;50(5):813-820. Published online November 4, 2012; DOI: https://doi.org/10.1007/s12275-012-2292-1

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Abstract PDF

Human papillomavirus (HPV) is the cause of most cases of cervical cancer. HPV type 58 (HPV58) is the second most frequent cause of cervical cancer and high-grade squamous intraepithelial lesions (HSIL) in Asia and South / Central America, respectively. However, there is no vaccine against HPV58, although there are commercially available vaccines against HPV16 and 18. In this study, we produced HPV58 L1 protein from Saccharomyces cerevisiae, and investigated its immunogenicity. We first determined the optimum period of culture for obtaining HPV58 L1. We found that a considerable portion of the HPV58 L1 resulting from 48 h culture cannot be recovered by purification, while the HPV58 L1 resulting from 144 h culture is recovered efficiently: the yield of HPV58 L1 finally recovered from 144 h culture was 2.3 times higher than that from 48 h culture, although the production level of L1 protein from 144 h culture was lower than that from 48 h culture. These results indicate that the proportion of functional L1 protein from 144 h-cultured cells is significantly higher than that of 48 h-cultured cells. The HPV58 L1 purified from the 144 h culture was correctly assembled into structures similar to naturally occurring HPV virions. Immunization with the HPV58 L1 efficiently elicited anti-HPV58 neutralizing antibodies and antigen-specific CD4+ and CD8+ T cell proliferations, without the need for adjuvant. Our findings provide a convenient method for obtaining substantial amounts of highly immunogenic HPV58 L1 from S. cerevisiae.

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