- Exploring the Therapeutic Potential of Scorpion-Derived Css54 Peptide against Candida albicans
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Jonggwan Park , Hyeongsun Kim , Da Dam Kang , Yoonkyung Park
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J. Microbiol. 2024;62(2):101-112. Published online April 8, 2024
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DOI: https://doi.org/10.1007/s12275-024-00113-4
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Candida albicans (C. albicans) is one of the most common opportunistic fungi worldwide, which is associated with a high
mortality rate. Despite treatment, C. albicans remains the leading cause of life-threatening invasive infections. Consequently,
antimicrobial peptides (AMPs) are potential alternatives as antifungal agents with excellent antifungal activity. We previously
reported that Css54, found in the venom of Centrurodies suffusus suffusus (C. s. suffusus) showed antibacterial activity
against zoonotic bacteria. However, the antifungal activity of Css54 has not yet been elucidated. The obj!ective of this study
was to identify the antifungal activity of Css54 against C. albicans and analyze its mechanism. Css54 showed high antifungal
activity against C. albicans. Css54 also inhibited biofilm formation in fluconazole-resistant fungi. The antifungal mechanism
of action of Css54 was investigated using membrane-related assays, including the membrane depolarization assay and
analysis of the membrane integrity of C. albicans after treatment with Css54. Css54 induced reactive oxygen species (ROS)
production in C. albicans, which affected its antifungal activity. Our results indicate that Css54 causes membrane damage
in C. albicans, highlighting its value as a potential therapeutic agent against C. albicans infection.
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Citations
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