- Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells
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Seulki Lee , Hwan Hee Lee , Jisung Kim , Joohee Jung , Aree Moon , Choon-Sik Jeong , Hyojeung Kang , Hyosun Cho
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J. Microbiol. 2015;53(7):468-474. Published online June 27, 2015
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DOI: https://doi.org/10.1007/s12275-015-5198-x
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Cordyceps extract has been reported to have various pharmacological
activities including an anti-cancer effect. We
investigated the inhibitory effect of Cordyceps militaris on
hepatitis C virus-infected human hepatocarcinoma 7.5 cells
(J6/JFH1-huh 7.5 cells). The huh7.5 cells with or without
HCV infection were treated with various concentrations of
ethanol extract of Cordyceps militaris (CME) for 48 h and the
cytotoxicity was measured by CCK-8 assay. Both J6/JFH1-
huh7.5 cells and huh7.5 cells were highly susceptible to CME.
To examine the molecular mechanisms of the inhibitory effect
on huh7.5 cells, the effect of CME on cell apoptosis was
measured using flow cytometry and the expressions of p53,
Bim, Bax, PARP, (cleaved) caspase-9, and (cleaved) caspase-
3 in huh 7.5 cells were detected by western blot assays. CME
significantly increased early apoptosis and up-regulated the
expression of Bim, Bax, cleaved PARP, cleaved caspase 9
and cleaved caspase-3. We also found the decrease of HCV
Core or NS3 protein by CME in HCV-infected huh 7.5 cells.
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Citations
Citations to this article as recorded by  - Visualized Nucleic Acid Hybridization Lateral Flow Strip Integrating with Microneedle for the Point-of-Care Authentication of Ophiocordyceps sinensis
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International Journal of Molecular Sciences.2024; 25(24): 13599. CrossRef - Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies
Rakhee, Jigni Mishra, Renu Bala Yadav, D. K. Meena, Rajesh Arora, R. K. Sharma, Kshipra Misra
3 Biotech.2021;[Epub] CrossRef - A new nucleoside and two new pyrrole alkaloid derivatives from Cordyceps militaris
Yafu Xue, Leilei Wu, Yulian Ding, Xinming Cui, Zhuzhen Han, Hong Xu
Natural Product Research.2020; 34(3): 341. CrossRef - Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression
Hwan Hee Lee, Joohee Jung, Aree Moon, Hyojeung Kang, Hyosun Cho
International Journal of Molecular Sciences.2019; 20(13): 3143. CrossRef - Cytokine-Modulated Natural Killer Cells Differentially Regulate the Activity of the Hepatitis C Virus
Yoo Cho, Hwan Lee, Hyojeung Kang, Hyosun Cho
International Journal of Molecular Sciences.2018; 19(9): 2771. CrossRef - The genus Cordyceps : An extensive review of its traditional uses, phytochemistry and pharmacology
Opeyemi Joshua Olatunji, Jian Tang, Adesola Tola, Florence Auberon, Omolara Oluwaniyi, Zhen Ouyang
Fitoterapia.2018; 129: 293. CrossRef - Systems Pharmacology-based strategy to screen new adjuvant for hepatitis B vaccine from Traditional Chinese Medicine Ophiocordyceps sinensis
Jingbo Wang, Rui Liu, Baoxiu Liu, Yan Yang, Jun Xie, Naishuo Zhu
Scientific Reports.2017;[Epub] CrossRef - Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma
Hwan Lee, Seulki Lee, Yu Shin, Miyeon Cho, Hyojeung Kang, Hyosun Cho
Molecules.2016; 21(10): 1286. CrossRef - Anti-tumor effect of Inonotus obliquus in xenograft animals with EBV+human gastric carcinoma
Seulki Lee, Hyosun Cho
The Korean Journal of Microbiology.2016; 52(4): 482. CrossRef
- Genipin as a novel chemical activator of EBV lytic cycle
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Myoungki Son , Minjung Lee , Eunhyun Ryu , Aree Moon , Choon-Sik Jeong , Yong Woo Jung , Gyu Hwan Park , Gi-Ho Sung , Hyosun Cho , Hyojeung Kang
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J. Microbiol. 2015;53(2):155-165. Published online January 28, 2015
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DOI: https://doi.org/10.1007/s12275-015-4672-9
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Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus
that causes acute infection and establishes life-long latency.
EBV causes several human cancers, including Burkitt's lymphoma,
nasopharyngeal and gastric carcinoma. Antiviral
agents can be categorized as virucides, antiviral chemotherapeutic
agents, and immunomodulators. Most antiviral agents
affect actively replicating viruses, but not their latent forms.
Novel antiviral agents must be active on both the replicating
and the latent forms of the virus. Gardenia jasminoides is an
evergreen flowering plant belonging to the Rubiaceae family
and is most commonly found growing wild in Vietnam,
Southern China, Taiwan, Japan, Myanmar, and India. Genipin
is an aglycone derived from an iridoid glycoside called geniposide,
which is present in large quantities in the fruit of
G. jasminoides. In this study, genipin was evaluated for its
role as an antitumor and antiviral agent that produces inhibitory
effects against EBV and EBV associated gastric carcinoma
(EBVaGC). In SNU719 cells, one of EBVaGCs, genipin
caused significant cytotoxicity (70 μM), induced methylation
on EBV C promoter and tumor suppressor gene
BCL7A, arrested cell-cycle progress (S phases), upregulated
EBV latent/lytic genes in a dose-dependent manner, stimulated
EBV progeny production, activated EBV F promoter
for EBV lytic activation, and suppressed EBV infection. These
results
indicated that genipin could be a promising candidate
for antiviral and antitumor agents against EBV and
EBVaGC.
-
Citations
Citations to this article as recorded by - Research Progress of EB Virus-Associated Gastric Cancer
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Advances in Clinical Medicine.2024; 14(08): 862. CrossRef - Genipin’s potential as an anti-cancer agent: from phytochemical origins to clinical prospects
Lapava Natallia, Aida Dama, Era Gorica, Karaliova Darya, Sheila I. Peña-Corona, Hernán Cortés, Antonello Santini, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad
Medical Oncology.2024;[Epub] CrossRef - Update of Natural Products and Their Derivatives Targeting Epstein–Barr Infection
Rosamaria Pennisi, Paola Trischitta, Marianna Costa, Assunta Venuti, Maria Pia Tamburello, Maria Teresa Sciortino
Viruses.2024; 16(1): 124. CrossRef - Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review
Dewi Utami Nike, Nur Izzah Md Fadilah, Nusaibah Sallehuddin, Ahmad Yasser Hamdi Nor Azlan, Farrah Hani Imran, Manira Maarof, Mh Busra Fauzi
Frontiers in Bioengineering and Biotechnology.2022;[Epub] CrossRef - Genipin, an Inhibitor of UCP2 as a Promising New Anticancer Agent: A Review of the Literature
Young Seok Cho
International Journal of Molecular Sciences.2022; 23(10): 5637. CrossRef - Preparation, characterization, and in vitro release kinetics of doxorubicin-loaded magnetosomes
Shuang Zhang, Xinxin Fan, Guojing Zhang, Weidong Wang, Lei Yan
Journal of Biomaterials Applications.2022; 36(8): 1469. CrossRef - An Integrated Analysis Reveals Geniposide Extracted From Gardenia jasminoides J.Ellis Regulates Calcium Signaling Pathway Essential for Influenza A Virus Replication
Lirun Zhou, Lei Bao, Yaxin Wang, Mengping Chen, Yingying Zhang, Zihan Geng, Ronghua Zhao, Jing Sun, Yanyan Bao, Yujing Shi, Rongmei Yao, Shanshan Guo, Xiaolan Cui
Frontiers in Pharmacology.2021;[Epub] CrossRef - Synthesis of [3H] and [14C]genipin
Adele.E. Queen, David Hesk, David.M. Lindsay, William.J. Kerr, Kenneth Rehder, Tim Fennell, Wayne Mascarella, Desong Zhong, Scott Runyon
Journal of Labelled Compounds and Radiopharmaceuticals.2020; 63(4): 196. CrossRef - Genipin inhibits rotavirus-induced diarrhea by suppressing viral replication and regulating inflammatory responses
Jong-Hwa Kim, Kiyoung Kim, Wonyong Kim
Scientific Reports.2020;[Epub] CrossRef - Genipap (Genipa americana L.) juice intake biomarkers after medium-term consumption
Livia Dickson, Mathieu Tenon, Ljubica Svilar, Pascale Fança-Berthon, Jean-Charles Martin, Hervé Rogez, Fabrice Vaillant
Food Research International.2020; 137: 109375. CrossRef - Evaluation on the antiviral activity of genipin against white spot syndrome virus in crayfish
Ai-Guo Huang, Xiao-Ping Tan, Shen-Ye Qu, Gao-Xue Wang, Bin Zhu
Fish & Shellfish Immunology.2019; 93: 380. CrossRef - Comparative investigation on metabolite changes in ‘wu mi’ production by Vaccinium bracteatum Thunb. leaves based on multivariate data analysis using UPLC–QToF–MS
Mingcong Fan, Yihui Fan, Zhiming Rao, Yan Li, Haifeng Qian, Hui Zhang, Gangcheng Wu, Xiguang Qi, Li Wang
Food Chemistry.2019; 286: 146. CrossRef - Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by Euphorbia extracts
Dong-eun Kim, Sunhee Jung, Hyung Won Ryu, Miri Choi, Mingu Kang, Hyunju Kang, Heung Joo Yuk, Hyejeong Jeong, Jiyeon Baek, Jae-Hyoung Song, Janghwan Kim, Hyojeung Kang, Sang-Bae Han, Sei-Ryang Oh, Sungchan Cho
Journal of Functional Foods.2018; 42: 146. CrossRef - Curcuminoids as EBV Lytic Activators for Adjuvant Treatment in EBV-Positive Carcinomas
Octavia Ramayanti, Mitch Brinkkemper, Sandra Verkuijlen, Leni Ritmaleni, Mei Go, Jaap Middeldorp
Cancers.2018; 10(4): 89. CrossRef - EBV transformation induces overexpression of hMSH2/3/6 on B lymphocytes and enhances γδT‐cell‐mediated cytotoxicity via TCR and NKG2D
Yu‐mei Dai, Hai‐ying Liu, Yun‐feng Liu, Yuan Zhang, Wei He
Immunology.2018; 154(4): 673. CrossRef - Infection‐associated epigenetic alterations in gastric cancer: New insight in cancer therapy
Sadegh Fattahi, Mohadeseh Kosari‐Monfared, Elham Ghadami, Monireh Golpour, Parastoo Khodadadi, Mohammad Ghasemiyan, Haleh Akhavan‐Niaki
Journal of Cellular Physiology.2018; 233(12): 9261. CrossRef - Plant-Derived Anticancer Agents: Lessons from the Pharmacology of Geniposide and Its Aglycone, Genipin
Solomon Habtemariam, Giovanni Lentini
Biomedicines.2018; 6(2): 39. CrossRef - Main Human Urinary Metabolites after Genipap (Genipa americana L.) Juice Intake
Livia Dickson, Mathieu Tenon, Ljubica Svilar, Pascale Fança-Berthon, Raphael Lugan, Jean-Charles Martin, Fabrice Vaillant, Hervé Rogez
Nutrients.2018; 10(9): 1155. CrossRef - Genipin: A natural blue pigment for food and health purposes
Iramaia Angélica Neri-Numa, Marina Gabriel Pessoa, Bruno Nicolau Paulino, Glaucia Maria Pastore
Trends in Food Science & Technology.2017; 67: 271. CrossRef - Geniposide and geniposidic acid, modified forms of genipin, attenuate genipin-induced mitochondrial apoptosis without altering the anti-inflammatory ability in KGN cell line
Tao Zuo, Wenming Xu, Henli Li, Hang Song, Minghui Zhu
Medicinal Chemistry Research.2017; 26(2): 499. CrossRef - Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
Sangmin Kang, Jinjong Myoung
Journal of Microbiology.2017; 55(5): 319. CrossRef - Expression of toll‐like receptors in T lymphocytes stimulated with N‐(3‐oxododecanoyl)‐L‐homoserine lactone from Pseudomonas aeruginosa
Lei Bao, Jialin Yu, Haiying Zhong, Daochao Huang, Qi Lu
APMIS.2017; 125(6): 553. CrossRef - Chemical Constituents from the Flowers of Wild Gardenia jasminoides J.Ellis
Hu Zhang, Ning Feng, Yan‐Tong Xu, Tian‐Xiang Li, Xiu‐Mei Gao, Yan Zhu, Yun Seon Song, Ya‐Nan Wang, Hong‐Hua Wu
Chemistry & Biodiversity.2017;[Epub] CrossRef - The Suppressive Effects of Geniposide and Genipin on Helicobacter pylori Infections In Vitro and In Vivo
Chiung‐Hung Chang, Jin‐Bin Wu, Jai‐Sing Yang, Yen‐Ju Lai, Chiu‐Hsian Su, Chi‐Cheng Lu, Yuan‐Man Hsu
Journal of Food Science.2017; 82(12): 3021. CrossRef - Antitumor Effects of Genipin: New and Emerging Insights from Recent Studies
Yu Su Shin, Miyeon Cho, Gyu Hwan Park, Hyosun Cho, Hyojeung Kang
Journal of Bacteriology and Virology.2016; 46(2): 108. CrossRef - Iridoids are natural glycation inhibitors
Brett J. West, Shixin Deng, Akemi Uwaya, Fumiyuki Isami, Yumi Abe, Sho-ichi Yamagishi, C. Jarakae Jensen
Glycoconjugate Journal.2016; 33(4): 671. CrossRef - Genipin Enhances Kaposi’s Sarcoma-Associated Herpesvirus Genome Maintenance
Miyeon Cho, Seok Won Jung, Soomin Lee, Kuwon Son, Gyu Hwan Park, Jong-Wha Jung, Yu Su Shin, Taegun Seo, Hyosun Cho, Hyojeung Kang, Shou-Jiang Gao
PLOS ONE.2016; 11(10): e0163693. CrossRef - Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis
Hwan Hee Lee, Seulki Lee, Kanghyo Lee, Yu Su Shin, Hyojeung Kang, Hyosun Cho
DARU Journal of Pharmaceutical Sciences.2015;[Epub] CrossRef - Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells
Seulki Lee, Hwan Hee Lee, Jisung Kim, Joohee Jung, Aree Moon, Choon-Sik Jeong, Hyojeung Kang, Hyosun Cho
Journal of Microbiology.2015; 53(7): 468. CrossRef
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