- Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies
-
Brian B. Gowen , Brady T. Hickerson
-
J. Microbiol. 2017;55(3):183-195. Published online February 28, 2017
-
DOI: https://doi.org/10.1007/s12275-017-7029-8
-
-
1,046
View
-
0
Download
-
18
Crossref
-
 Abstract
 PDF
-
A growing number of bunyaviruses are known to cause viral
hemorrhagic fever (VHF), a severe febrile illness which can
progress to hypovolemic shock and multi-organ failure and
is characterized by hematologic abnormalities and vascular
leak. At present, there are no approved vaccines or antiviral
therapies to effectively prevent or treat VHF caused by pathogenic
bunyaviruses. Advances in the modeling of bunyaviral
infections have facilitated efforts towards the development
of novel post-exposure prophylactic and therapeutic
countermeasures, several of which may some day be approved
for human use. Here, we review recent progress in animal
models of severe bunyaviral infections essential to this mission,
as well as promising antivirals and biologicals that are
at various stages of the development process.
-
Citations
Citations to this article as recorded by  - La Crosse virus, but not Jamestown Canyon virus, is dependent on the host translation termination factor eRF1 due to changes in the nonstructural protein NSm
Kaeri M. Medina, Sarah Dysinger, Rachel M. Braun, Swechha M. Pokharel, Trevor Griesman, David C. Schultz, Paul Bates, Sara Cherry, Carolyn B. Coyne
mBio.2026;[Epub] CrossRef - Oropouche virus infection: clinical spectrum, geographic expansion, and emerging maternal–fetal implications
Peterson Cruz, Lilith Schuler Faccini, Maikel Rosa Oliveira, Luiza Pretto, Ana Cláudia Franco, Juarez Antônio Simões Quaresma, Fernanda Sales Luiz Vianna, Lavinia Schuler-Faccini, Pedro Fernando da Costa Vasconcelos, Lucas Rosa Fraga
Infection.2026;[Epub] CrossRef -
Establishment of an
ex vivo
vascular tissue model to investigate bunyavirus-triggered vascular endothelial injury
Zihan Guan, Xi Chen, Yujie Fang, Xiangtao Zhu, Shufen Li, Ke Peng, Ling Zhao
mBio.2026;[Epub] CrossRef - Epidemiology, transmission dynamics, treatment strategies, and future perspectives on Oropouche virus
Beema T Yoosuf, Abhay M Gaidhane, Nasir Vadia, Soumya V Menon, Kattela Chennakesavulu, Rajashree Panigrahi, Ganesh Bushi, Anju Rani, Sanjit Sah, Muhammed Shabil, Khang Wen Goh, Diptismita Jena
Diagnostic Microbiology and Infectious Disease.2025; 113(1): 116882. CrossRef - Mysterious Oropouche virus: Transmission, symptoms, and control
Sejal Porwal, Rishabha Malviya, Sathvik Belagodu Sridhar, Javedh Shareef, Tarun Wadhwa
Infectious Medicine.2025; 4(2): 100177. CrossRef - Oropouche Virus: An Emerging Arboviral Threat and Its Implications for Europe
Gaetano Scotto, Vincenzina Fazio, Salvatore Massa
Life.2025; 15(11): 1674. CrossRef - Current insights into human pathogenic phenuiviruses and the host immune system
Chuan-Min Zhou, Ze-Zheng Jiang, Ning Liu, Xue-Jie Yu
Virulence.2024;[Epub] CrossRef - Digoxin is a potent inhibitor of Bunyamwera virus infection in cell culture
Beatriz Pacheco, Alberto Fernández-Oliva, Moisés García-Serradilla, Cristina Risco
Journal of General Virology
.2023;[Epub] CrossRef - Design and evaluation of neutralizing and fusion inhibitory peptides to Crimean-Congo hemorrhagic fever virus
Megan C. Mears, Sergio E. Rodriguez, Katharina S. Schmitz, Angel Padilla, Sudipta Biswas, Maria N.B. Cajimat, Chad E. Mire, Stephen R. Welch, Éric Bergeron, Christopher A. Alabi, Matteo Porotto, Dennis A. Bente
Antiviral Research.2022; 207: 105401. CrossRef - Baseline mapping of Oropouche virology, epidemiology, therapeutics, and vaccine research and development
Megan A. Files, Clairissa A. Hansen, Vanessa C. Herrera, Craig Schindewolf, Alan D. T. Barrett, David W. C. Beasley, Nigel Bourne, Gregg N. Milligan
npj Vaccines.2022;[Epub] CrossRef - Chloroquine, an Anti-Malaria Drug as Effective Prevention for Hantavirus Infections
Valentijn Vergote, Lies Laenen, Raf Mols, Patrick Augustijns, Marc Van Ranst, Piet Maes
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef - Light and electron microscopy imaging unveils new aspects of the antiviral capacity of silver nanoparticles in bunyavirus-infected cells
Moisés García-Serradilla, Cristina Risco
Virus Research.2021; 302: 198444. CrossRef - Antiviral Drugs Against Severe Fever With Thrombocytopenia Syndrome Virus Infection
Mutsuyo Takayama-Ito, Masayuki Saijo
Frontiers in Microbiology.2020;[Epub] CrossRef - Multimeric single-domain antibody complexes protect against bunyavirus infections
Paul J Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, Sara Rodriguez Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard
eLife.2020;[Epub] CrossRef - Crimean-Congo hemorrhagic fever virus strains Hoti and Afghanistan cause viremia and mild clinical disease in cynomolgus monkeys
Robert W. Cross, Abhishek N. Prasad, Viktoriya Borisevich, Joan B. Geisbert, Krystle N. Agans, Daniel J. Deer, Karla A. Fenton, Thomas W. Geisbert, Waleed Saleh Al-Salem
PLOS Neglected Tropical Diseases.2020; 14(8): e0008637. CrossRef - High Prevalence of a Newly Discovered Wutai Mosquito Phasivirus in Mosquitoes from Rio de Janeiro, Brazil
Mário Sérgio Ribeiro, Tania Ayllón, Viviana Malirat, Daniel Cardoso Portela Câmara, Cristina Maria Giordano Dias, Guilherme Louzada, Davis Fernandes-Ferreira, Roberto de Andrade Medronho, Renata Campos Acevedo
Insects.2019; 10(5): 135. CrossRef - Parallel Survey of Two Widespread Renal Syndrome-Causing Zoonoses:Leptospiraspp. andHantavirusin Urban Environment, Hungary
Kornélia Kurucz, Mónika Madai, Dominika Bali, Dávid Hederics, Győző Horváth, Gábor Kemenesi, Ferenc Jakab
Vector-Borne and Zoonotic Diseases.2018; 18(4): 200. CrossRef - A lethal disease model for New World hantaviruses using immunosuppressed Syrian hamsters
Valentijn Vergote, Lies Laenen, Bert Vanmechelen, Marc Van Ranst, Erik Verbeken, Jay W. Hooper, Piet Maes, Michael R. Holbrook
PLOS Neglected Tropical Diseases.2017; 11(10): e0006042. CrossRef
|
MSK
