- Inhibitory Effect of Chlorophyllin on the Propionibacterium acnes-Induced Chemokine Expression
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Mi-Sun Kang , Jin-Hee Kim , Boo-Ahn Shin , Hyun-Chul Lee , Youn-Shin Kim , Hae-Soon Lim , Jong-Suk Oh
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J. Microbiol. 2014;52(2):184-184.
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DOI: https://doi.org/10.1007/s12275-014-0698-7
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 Abstract
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In the article by Kang et al. published in Journal of Microbiology 2013; 51, 844-849. Figure 4 on page 847 should be changed as below.
- Inhibitory Effect of Chlorophyllin on the Propionibacterium acnes-Induced Chemokine Expression
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Mi-Sun Kang , Jin-Hee Kim , Boo-Ahn Shin , Hyun-Chul Lee , Youn-Shin Kim , Hae-Soon Lim , Jong-Suk Oh
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J. Microbiol. 2013;51(6):844-849. Published online December 19, 2013
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DOI: https://doi.org/10.1007/s12275-013-3015-y
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Abstract
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Chlorophyllin (CHL), a chlorophyll-derivative, exhibits several
beneficial properties, including antibacterial, antioxidant,
and anticancer activities. However, its antibacterial and
anti-inflammatory activities against Propionibacterium acnes
have not been described. The antibacterial activity of this compound
was evaluated in vitro using the broth microdilution
method
. CHL had an inhibitory effect on the growth of P.
acnes (MIC = 100 μM). In a real-time reverse transcriptionpolymerase
chain reaction and an enzyme-linked immunosorbent
assay, CHL significantly decreased interleukin-8
(IL-8) and monocyte chemoattractant protein-1 (MCP-1)
production in a dose-dependent manner, decreasing both
mRNA and protein levels for these chemokines in THP-1
cells indicating the anti-inflammatory effects of it. To investigate
the molecular mechanisms underlying the anti-inflammatory
properties of CHL in THP-1 cells stimulated
by P. acnes, we used western blotting to analyze the effect of
CHL on activation of the nuclear factor (NF)-κB. CHL inhibited
P. acnes-induced IL-8 and MCP-1 production via
blockade of NF-κB activation in THP-1 cells. Therefore,
based on these results, we suggest that CHL is a useful agent
to control the growth of P. acnes involved in acne inflammation
and prevent acne.
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Citations
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