- Transcriptome analysis of differential gene expression in Dichomitus squalens during interspecific mycelial interactions and the potential link with laccase induction
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Zixuan Zhong , Nannan Li , Binghui He , Yasuo Igarashi , Feng Luo
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J. Microbiol. 2019;57(2):127-137. Published online September 13, 2018
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DOI: https://doi.org/10.1007/s12275-019-8398-y
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Interspecific mycelial interactions between white rot fungi
are always accompanied by an increased production of laccase.
In this study, the potential of the white rot fungus Dichomitus
squalens to enhance laccase production during interactions
with two other white rot fungi, Trametes versicolor or Pleurotus
ostreatus, was assessed. To probe the mechanism of laccase
induction and the role that laccase plays during combative
interaction, we analyzed the differential gene expression profile
of the laccase induction response to stressful conditions
during fungal interaction. We further confirmed the expression
patterns of 16 selected genes by qRT-PCR analysis. We
noted that many differentially expressed genes (DEGs) encoded
proteins that were involved in xenobiotic detoxification
and reactive oxygen species (ROS) generation or reduction,
including aldo/keto reductase, glutathione S-transferases,
cytochrome P450 enzymes, alcohol oxidases and dehydrogenase,
manganese peroxidase and laccase. Furthermore, many
DEG-encoded proteins were involved in antagonistic mechanisms
of nutrient acquisition and antifungal properties, including
glycoside hydrolase, glucanase, chitinase and terpenoid
synthases. DEG analyses effectively revealed that laccase
induction was likely caused by protective responses to
oxidative stress and nutrient competition during interspecific
fungal interactions.
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