Exploring the Therapeutic Potential of Scorpion‑Derived Css54 Peptide Against Candida albicans

Jonggwan Park; Hyeongsun Kim; Da Dam Kang; Yoonkyung Park

doi:10.1007/s12275-024-00113-4

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Exploring the Therapeutic Potential of Scorpion‑Derived Css54 Peptide Against Candida albicans: Jonggwan Park ¹, Hyeongsun Kim ², Da Dam Kang ², Yoonkyung Park ²; Journal of Microbiology 2024;62(2):101-112.
DOI: https://doi.org/10.1007/s12275-024-00113-4
Published online: April 8, 2024

¹Department of Bioinformatics, Kongju National University, Kongju 32588, Republic of Korea, ²Department of Biomedical Science, Chosun University, Gwangju 61452, Republic of Korea

Corresponding author: Yoonkyung Park ,

Received: 19 December 2023 • Revised: 23 January 2024 • Accepted: 23 January 2024

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Abstract

Candida albicans (C. albicans) is one of the most common opportunistic fungi worldwide, which is associated with a high mortality rate. Despite treatment, C. albicans remains the leading cause of life-threatening invasive infections. Consequently, antimicrobial peptides (AMPs) are potential alternatives as antifungal agents with excellent antifungal activity. We previously reported that Css54, found in the venom of Centrurodies suffusus suffusus (C. s. suffusus) showed antibacterial activity against zoonotic bacteria. However, the antifungal activity of Css54 has not yet been elucidated. The obj!ective of this study was to identify the antifungal activity of Css54 against C. albicans and analyze its mechanism. Css54 showed high antifungal activity against C. albicans. Css54 also inhibited biofilm formation in fluconazole-resistant fungi. The antifungal mechanism of action of Css54 was investigated using membrane-related assays, including the membrane depolarization assay and analysis of the membrane integrity of C. albicans after treatment with Css54. Css54 induced reactive oxygen species (ROS) production in C. albicans, which affected its antifungal activity. Our results indicate that Css54 causes membrane damage in C. albicans, highlighting its value as a potential therapeutic agent against C. albicans infection.

Keywords: Antimicrobial peptide · Candida albicans · Antifungal activity · Antifungal mechanism

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Exploring the Therapeutic Potential of Scorpion‑Derived Css54 Peptide Against Candida albicans

J. Microbiol. 2024;62(2):101-112. Published online April 8, 2024

DOI: https://doi.org/10.1007/s12275-024-00113-4

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