Host–microbial interactions in metabolic diseases: from diet to immunity

Ju-Hyung Lee; Joo-Hong Park

doi:10.1007/s12275-022-2087-y

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Host–microbial interactions in metabolic diseases: from diet to immunity: Ju-Hyung Lee , Joo-Hong Park; Journal of Microbiology 2022;60(6):561-575.
DOI: https://doi.org/10.1007/s12275-022-2087-y
Published online: May 5, 2022

School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 08826, Republic of KoreaSchool of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 08826, Republic of Korea

Corresponding author: Joo-Hong Park , Tel: +82-2-880-2138,

Received: 24 February 2022 • Revised: 23 March 2022 • Accepted: 1 April 2022

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Abstract

Growing evidence suggests that the gut microbiome is an important contributor to metabolic diseases. Alterations in microbial communities are associated with changes in lipid metabolism, glucose homeostasis, intestinal barrier functions, and chronic inflammation, all of which can lead to metabolic disorders. Therefore, the gut microbiome may represent a novel therapeutic target for obesity, type 2 diabetes, and nonalcoholic fatty liver disease. This review discusses how gut microbes and their products affect metabolic diseases and outlines potential treatment approaches via manipulation of the gut microbiome. Increasing our understanding of the interactions between the gut microbiome and host metabolism may help restore the healthy symbiotic relationship between them.

Keywords: VosA-VelB-activated developmental gene;development;sensor histidine kinase;sterigmatocystin;velvet regulators

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Host–microbial interactions in metabolic diseases: from diet to immunity

J. Microbiol. 2022;60(6):561-575. Published online May 5, 2022

DOI: https://doi.org/10.1007/s12275-022-2087-y

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