Journal of Microbiology

Review

Adenoviral Vector System: A Comprehensive Overview of Constructions, Therapeutic Applications and Host Responses: Anyeseu Park, Jeong Yoon Lee; J. Microbiol. 2024;62(7):491-509. Published online July 22, 2024; DOI: https://doi.org/10.1007/s12275-024-00159-4

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Adenoviral vectors are crucial for gene therapy and vaccine development, offering a platform for gene delivery into host cells. Since the discovery of adenoviruses, first-generation vectors with limited capacity have evolved to third-generation vectors flacking viral coding sequences, balancing safety and gene-carrying capacity. The applications of adenoviral vectors for gene therapy and anti-viral treatments have expanded through the use of in vitro ligation and homologous recombination, along with gene editing advancements such as CRISPR-Cas9. Current research aims to maintain the efficacy and safety of adenoviral vectors by addressing challenges such as pre-existing immunity against adenoviral vectors and developing new adenoviral vectors from rare adenovirus types and non-human species. In summary, adenoviral vectors have great potential in gene therapy and vaccine development. Through continuous research and technological advancements, these vectors are expected to lead to the development of safer and more effective treatments.

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Engineering an oncolytic adenoviral platform for precise delivery of antisense peptide nucleic acid to modulate PD-L1 overexpression in cancer cells
Andrea Patrizia Falanga, Francesca Greco, Monica Terracciano, Stefano D’Errico, Maria Marzano, Sara Feola, Valentina Sepe, Flavia Fontana, Ilaria Piccialli, Vincenzo Cerullo, Hélder A. Santos, Nicola Borbone
International Journal of Pharmaceutics.2025; 668: 124941. CrossRef
Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology
Emile Youssef, Brandon Fletcher, Dannelle Palmer
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Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics
Lisha Ou, Mekedlawit T. Setegne, Jeandele Elliot, Fangfang Shen, Laura M. K. Dassama
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Waqar Saleem, Ateeqa Aslam, Mehlayl Tariq, Hans Nauwynck
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Chromatin structure and gene transcription of recombinant p53 adenovirus vector within host
Duo Ning, Yuqing Deng, Simon Zhongyuan Tian
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Molecular Engineering of Virus Tropism
Bo He, Belinda Wilson, Shih-Heng Chen, Kedar Sharma, Erica Scappini, Molly Cook, Robert Petrovich, Negin P. Martin
International Journal of Molecular Sciences.2024; 25(20): 11094. CrossRef
Antisolvent 3D Printing of Gene-Activated Scaffolds for Bone Regeneration
Andrey Vyacheslavovich Vasilyev, Irina Alekseevna Nedorubova, Viktoria Olegovna Chernomyrdina, Anastasiia Yurevna Meglei, Viktoriia Pavlovna Basina, Anton Vladimirovich Mironov, Valeriya Sergeevna Kuznetsova, Victoria Alexandrovna Sinelnikova, Olga Anatol
International Journal of Molecular Sciences.2024; 25(24): 13300. CrossRef

Journal Article

Lactobacillus rhamnosus KBL2290 Ameliorates Gut Inflammation in a Mouse Model of Dextran Sulfate Sodium‑Induced Colitis: Woon-ki Kim , Sung-gyu Min , Heeun Kwon , SungJun Park , Min Jung Jo , GwangPyo Ko; J. Microbiol. 2023;61(7):673-682. Published online June 14, 2023; DOI: https://doi.org/10.1007/s12275-023-00061-5

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Abstract

Ulcerative colitis, a major form of inflammatory bowel disease (IBD) associated with chronic colonic inflammation, may be induced via overreactive innate and adaptive immune responses. Restoration of gut microbiota abundance and diversity is important to control the pathogenesis. Lactobacillus spp., well-known probiotics, ameliorate IBD symptoms via various mechanisms, including modulation of cytokine production, restoration of gut tight junction activity and normal mucosal thickness, and alterations in the gut microbiota. Here, we studied the effects of oral administration of Lactobacillus rhamnosus (L. rhamnosus) KBL2290 from the feces of a healthy Korean individual to mice with DSS-induced colitis. Compared to the dextran sulfate sodium (DSS) + phosphate-buffered saline control group, the DSS + L. rhamnosus KBL2290 group evidenced significant improvements in colitis symptoms, including restoration of body weight and colon length, and decreases in the disease activity and histological scores, particularly reduced levels of pro-inflammatory cytokines and an elevated level of anti-inflammatory interleukin-10. Lactobacillus rhamnosus KBL2290 modulated the levels of mRNAs encoding chemokines and markers of inflammation; increased regulatory T cell numbers; and restored tight junction activity in the mouse colon. The relative abundances of genera Akkermansia, Lactococcus, Bilophila, and Prevotella increased significantly, as did the levels of butyrate and propionate (the major short-chain fatty acids). Therefore, oral L. rhamnosus KBL2290 may be a useful novel probiotic.

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Dietary supplementation with proanthocyanidins and rutin alleviates the symptoms of type 2 diabetes mice and regulates gut microbiota
Yue Gao, Binbin Huang, Yunyi Qin, Bing Qiao, Mengfei Ren, Liqing Cao, Yan Zhang, Maozhen Han
Frontiers in Microbiology.2025;[Epub] CrossRef
Probiotics: Shaping the gut immunological responses
Eirini Filidou, Leonidas Kandilogiannakis, Anne Shrewsbury, George Kolios, Katerina Kotzampassi
World Journal of Gastroenterology.2024; 30(15): 2096. CrossRef
Synergistic effects of probiotics with soy protein alleviate ulcerative colitis by repairing the intestinal barrier and regulating intestinal flora
Rentang Zhao, Bingqing Shang, Luyan Sun, Suyuan Lv, Guolong Liu, Qiu Wu, Yue Geng
Journal of Functional Foods.2024; 122: 106514. CrossRef
Lactobacillus gasseri BNR17 and Limosilactobacillus fermentum ABF21069 Ameliorate High Sucrose-Induced Obesity and Fatty Liver via Exopolysaccharide Production and β-oxidation
Yu Mi Jo, Yoon Ji Son, Seul-Ah Kim, Gyu Min Lee, Chang Won Ahn, Han-Oh Park, Ji-Hyun Yun
Journal of Microbiology.2024; 62(10): 907. CrossRef
Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide
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Research Support, Non-U.S. Gov't

Pregnancy - associated human listeriosis: Virulence and genotypic analysis of Listeria monocytogenes from clinical samples: Dharmendra Kumar Soni , Durg Vijai Singh , Suresh Kumar Dubey; J. Microbiol. 2015;53(9):653-660. Published online August 1, 2015; DOI: https://doi.org/10.1007/s12275-015-5243-9

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Abstract

Listeria monocytogenes, a life-threatening pathogen, poses severe risk during pregnancy, may cause abortion, fetal death or neonatal morbidity in terms of septicemia and meningitis. The present study aimed at characterizing L. monocytogenes isolated from pregnant women based on serotyping, antibiotic susceptibility, virulence genes, in vivo pathogenicity test and ERIC- and REP-PCR fingerprint analyses. The results revealed that out of 3700 human clinical samples, a total of 30 (0.81%) isolates [12 (0.80%) from placental bit (1500), 18 (0.81%) from vaginal swab (2200)] were positive for L. monocytogenes. All the isolates belonged to serogroup 4b, and were + ve for virulence genes tested i.e. inlA, inlC, inlJ, plcA, prfA, actA, hlyA, and iap. Based on the mice inoculation tests, 20 isolates showed 100% and 4 isolates 60% relative virulence while 6 isolates were non-pathogenic. Moreover, 2 and 10 isolates were resistant to ciprofloxacin and cefoxitin, respectively, while the rest susceptible to other antibiotics used in this study. ERIC- and REP-PCR collectively depicted that the isolates from placental bit and vaginal swab had distinct PCR fingerprints except a few isolates with identical patterns. This study demonstrates prevalence of pathogenic strains mostly resistant to cefoxitin and/or ciprofloxacin. The results indicate the importance of isolating and characterizing the pathogen from human clinical samples as the pre-requisite for accurate epidemiological investigations.

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A comparative study on the occurrence, genetic characteristics, and factors associated with the distribution of Listeria species on cattle farms and beef abattoirs in Gauteng Province, South Africa
J. Gana, N. Gcebe, R. Moerane, Y. B. Ngoshe, T. Tshuma, K. Moabelo, A. A. Adesiyun
Tropical Animal Health and Production.2024;[Epub] CrossRef
Clinical and Genomic Characteristics of a Clinical Listeria Monocytogenes ST120 Isolate Recovered from a Pregnant Woman
Jingrui Zhang, Zengbin Liu, Zhirong Li, Caihong Xu, Hongbin Wang, Rugang Yang, Li Liu
Infection and Drug Resistance.2024; Volume 17: 229. CrossRef
Systematic review ofListeria monocytogenesfrom food and clinical samples in Chinese mainland from 2010 to 2019
Ying Cheng, Qingli Dong, Yangtai Liu, Hong Liu, Hongzhi Zhang, Xiang Wang
Food Quality and Safety.2022;[Epub] CrossRef
Ecology of Listeria monocytogenes and Listeria species in India: the occurrence, resistance to biocides, genomic landscape and biocontrol
Sukhadeo Baliram Barbuddhe, Deepak Bhiwa Rawool, Swapnil Prakash Doijad, Jess Vergis, Satyaveer Singh Malik, Trinad Chakraborty
Environmental Microbiology.2022; 24(6): 2759. CrossRef
Isolation and characterization of Listeria monocytogenes among women attending Jimma University medical center, Southwest Ethiopia
Lencho Girma, Alene Geteneh, Demisew Amenu, Tesfaye Kassa
BMC Infectious Diseases.2021;[Epub] CrossRef
An Update Review on Listeria Infection in Pregnancy
Zhaoyun Wang, Xiaojing Tao, Shan Liu, Yutong Zhao, Xiuhua Yang
Infection and Drug Resistance.2021; Volume 14: 1967. CrossRef
Evaluation of MALDI–TOF MS as a tool for detection of Listeria spp. directly from selective enrichment broth from food and stool samples
Thais Martins Campos Araújo, Rodrigo de Castro Lisbôa Pereira, Isabelle Geoffroy Ribeiro Freitag, Leonardo Alves Rusak, Larissa Alvarenga Batista Botelho, Ernesto Hofer, Cristina Barroso Hofer, Deyse Christina Vallim
Journal of Microbiological Methods.2020; 173: 105936. CrossRef
Listeria monocytogenes detected in vaginal self-samples of 2 women after spontaneous miscarriage, Senegal, West Africa
Ndeye Safietou Fall, Mariema Sarr, Nafissatou Diagne, Hubert Bassène, Cheikh Sokhna, Jean-Christophe Lagier, Didier Raoult
European Journal of Clinical Microbiology & Infectious Diseases.2020; 39(2): 393. CrossRef
Characterisation of Listeria monocytogenes from Food and Human Clinical Samples at Duhok, Kurdistan Region of Iraq
Azad Mohammed Taher Al-Brefkani, Ismaeil Mohammed Abdulkahar Mammani
Journal of Pure and Applied Microbiology.2019; 13(4): 2215. CrossRef
Pregnancy-related listeriosis: frequency and genotypic characteristics of L. monocytogenes from human specimens in Kerman, Iran
Zahra Zahirnia, Shahla Mansouri, Fereshteh Saffari
Wiener Medizinische Wochenschrift.2019; 169(9-10): 226. CrossRef
Effect of free and nano-encapsulated curcumin on treatment and energetic metabolism of gerbils infected by Listeria monocytogenes
Antonise M. Jaguezeski, Carine F. Souza, Gessica Perin, João H. Reis, Teane M.A. Gomes, Matheus D. Baldissera, Rodrigo A. Vaucher, Cinthia M. de Andrade, Lenita M. Stefani, Samanta S. Gundel, Aline F. Ourique, Aleksandro S. Da Silva
Microbial Pathogenesis.2019; 134: 103564. CrossRef
Retrospective Study of Listeria monocytogenes Isolated in the Territory of Inner Eurasia from 1947 to 1999
Ekaterina K. Psareva, Irina Yu. Egorova, Elena A. Liskova, Irina V. Razheva, Nadezda A. Gladkova, Elena V. Sokolova, Eugene A. Potemkin, Pavel A. Zhurilov, Tatyana V. Mikhaleva, Andrei A. Blokhin, Yaroslava M. Chalenko, Denis V. Kolbasov, Svetlana A. Ermo
Pathogens.2019; 8(4): 184. CrossRef
Listeriolysin S may inhibit the anti-listerial properties of Lactobacillus plantarum
Rokhsareh Mohammadzadeh, Azadeh Azadegan, Behrooz Sadeghi Kalani
Microbial Pathogenesis.2019; 137: 103744. CrossRef
Determination of Dominant Serovars and Molecular Analysis of hly and iap Genes Related to Listeria monocytogenes Strains Isolated from Spontaneous Human Abortions in Tehran
Maryam Rezaei, Nadia Kazemipour, Jalil Vandyousefi, Farokh Rokhbakhshzamin, Gholamreza Irajian
Iranian Journal of Medical Microbiology.2019; 13(2): 102. CrossRef
Clinical management of women with listeriosis risk during pregnancy: a review of national guidelines
Lisa Pucci, Mario Massacesi, Giuseppina Liuzzi
Expert Review of Anti-infective Therapy.2018; 16(1): 13. CrossRef
Listeriosis in pregnancy: under-diagnosis despite over-treatment
Y Fouks, S Amit, A Many, A Haham, D Mandel, S Shinar
Journal of Perinatology.2018; 38(1): 26. CrossRef
Biosensor for the detection of Listeria monocytogenes: emerging trends
Dharmendra Kumar Soni, Rafiq Ahmad, Suresh Kumar Dubey
Critical Reviews in Microbiology.2018; 44(5): 590. CrossRef
Comparative whole genome analysis of Listeria monocytogenes 4b strains reveals least genome diversification irrespective of their niche specificity
Dharmendra K. Soni, Arpita Ghosh, Surendra K. Chikara, Krishna M. Singh, Chaitanya G. Joshi, Suresh K. Dubey
Gene Reports.2017; 8: 61. CrossRef
Progesterone impairs antigen-non-specific immune protection by CD8 T memory cells via interferon-γ gene hypermethylation
Yushi Yao, Hui Li, Jie Ding, Yixin Xia, Lei Wang, Gongyi Zhang
PLOS Pathogens.2017; 13(11): e1006736. CrossRef
Prevalence and molecular characterization of Listeria spp. and Listeria monocytogenes isolated from fish, shrimp, and cooked ready-to-eat (RTE) aquatic products in Iran
Esmail Abdollahzadeh, Seyed Mahdi Ojagh, Hedayat Hosseini, Gholamreza Irajian, Ezzat Allah Ghaemi
LWT.2016; 73: 205. CrossRef
Antimicrobial Hyaluronic Acid–Cefoxitin Sodium Thin Films Produced by Electrospraying
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Journal Articles

The Molecular Characterization of Serogroup C Neisseria meningitidis Strains Circulating in Beijing: Tie-gang Zhang , Jing-guo He , Xiong He , Li-Juan Chen , Zhu-jun Shao , Mei-ping Sun; J. Microbiol. 2006;44(6):685-688.; DOI: https://doi.org/2455 [pii]

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Abstract: The aim of this study was to characterize the molecular features of serogroup C Neisseria meningitidis strains circulating in Beijing, China. Twenty out of 23 strains belonged to ST 4821. The causative serosubtype for meningococcal meningitis was P1.12-1,16-8. All of the strains expressed class 3 PorB protein. Among the five pulsed-field gel electrophoresis patterns observed, pattern III predominated.

Isolation of Cryptococcus neoformans var. grubii (serotype A) from Pigeon Droppings in Seoul, Korea: Hee Youn Chee , Kyung Bok Lee; J. Microbiol. 2005;43(5):469-472.; DOI: https://doi.org/2273 [pii]

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Abstract: Seventy-two pigeon dropping samples were collected from 26 different localities in Seoul and investigated for the occurrence of Cryptococcus neoformans. Seventeen samples from 8 different localities were found to be positive for C. neoformans. All isolates were obtained from withered pigeon droppings. Identification and serotyping of the isolates were determined by means of serological testing and DNA fingerprinting. All isolates belonged to C. neoformans var. grubbi (serotype A).

Review

Shigellosis: Swapan Kumar Niyogi; J. Microbiol. 2005;43(2):133-143.; DOI: https://doi.org/2172 [pii]

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Abstract: Shigellosis is a global human health problem. Four species of Shigella i.e. S. dysenteriae, S. flexneri, S. boydii and S. sonnei are able to cause the disease. These species are subdivided into serotypes on the basis of O-specific polysaccharide of the LPS. Shigella dysenteriae type 1 produces severe disease and may be associated with life-threatening complications. The symptoms of shigellosis include diarrhoea and/or dysentery with frequent mucoid bloody stools, abdominal cramps and tenesmus. Shigella spp. cause dysentery by invading the colonic mucosa. Shigella bacteria multiply within colonic epithelial cells, cause cell death and spread laterally to infect and kill adjacent epithelial cells, causing mucosal ulceration, inflammation and bleeding. Transmission usually occurs via contaminated food and water or through person-to-person contact. Laboratory diagnosis is made by culturing the stool samples using selective/differential agar media. Shigella spp. are highly fragile organism and considerable care must be exercised in collecting faecal specimens, transporting them to the laboratories and in using appropriate media for isolation. Antimicrobial agents are the mainstay of therapy of all cases of shigellosis. Due to the global emergence of drug resistance, the choice of antimicrobial agents for treating shigellosis is limited. Although single dose of norfloxacin and ciprofloxacin has been shown to be effective, they are currently less effective against S. dysenteriae type 1 infection. Newer quinolones, cephalosporin derivatives, and azithromycin are the drug of choice. However, fluoroquinolone-resistant S. dysenteriae type 1 infection have been reported. Currently, no vaccines against Shigella infection exist. Both live and subunit parenteral vaccine candidates are under development. Because immunity to Shigella is serotype-specific, the priority is to develop vaccine against S. dysenteriae type 1 and S. flexneri type 2a. Shigella species are important pathogens responsible for diarrhoeal diseases and dysentery occurring all over the world. The morbidity and mortality due to shigellosis are especially high among children in developing countries. A recent review of literature (Kotloff et al.,1999) concluded that, of the estimated 165 million cases of Shigella diarrhoea that occur annually, 99% occur in developing countries, and in developing countries 69% of episodes occur in children under five years of age. Moreover, of the ca.1.1 million deaths attributed to Shigella infections in developing countries, 60% of deaths occur in the under-five age group. Travellers from developed to developing regions and soldiers serving under field conditions are also at an increased risk to develop shigellosis.

Serotyping of Cryptococcus neoformans Strains Isolated in Korea: Soo-Myung Hwang; J. Microbiol. 2002;40(2):166-169.

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Abstract: Twenty strains of Cryptococcus neoformans isolated from environmental and clinical sources in Korea were examined for their serotypes. Two environmental isolates from pigeon excreta belonged to C. neoformans var. neoformans serotype A. Of the 18 isolates from clinical specimens, 17 belonged to C. neoformans var. neoformans (serotype A : 16, serotype D : 1) and one belonged to C. neoformans var. gattii serotype B, which was culturally unusual, producing mucous colonies. This is the first report of the identification of C. neoformans var. gattii serotype B from a patient in Korea.

Genetic Relatedness within Streptococcus pneumoniae Serotype 19F and 23F Isolates in Korea by Pulsed-Field Gel Electrophoresis: Kwang Jun Lee , Song Mee Bae , Kyu Jam Hwang , Young Hee Lee , Ki Sang Kim; J. Microbiol. 2003;41(1):1-6.

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Abstract: The genetic relatedness of multidrug-resistant pneumococcal isolates of serotypes 19F and 23F was investigated. The DNA fragments digested with Sma I were resolved by pulsed-field gel electrophoresis (PFGE). PFGE analysis of 36 S. pneumoniae isolates showed 13 different patterns. Among 22 isolates of serotype 19F, 9 different PFGE patterns were present and 14 isolates of serotype 23F isolates represented 5 distinct PFGE patterns. Two isolates of serotype 19F and six isolates of serotype 23F shared the same PFGE pattern (Pattern I). Based on the genetic relatedness within the strains (one genetic cluster was defined as having more than 85% homology), we divided the pneumococcal strains into 6 genetic clusters (I, II, III, IV, V, and VI). The 22 strains of serotype 19F belonged to five distinct genetic clusters (I, II, III, IV, V and VI) and 14 strains of serotype 23F represented two genetic clusters (I and II ). These results showed that strains of serotype 19F are genetically more diverse than those of serotype 23F. Serotype 19F isolates with PFGE patterns H and I appeared to be less related to those of the remaining PFGE patterns (A to G) (less than 60% genetic relatedness), but those strains were genetically closely related with serotype 23F. These results suggest that the latter isolates originated from horizontal transfer of the capsular type 19F gene locus to 23F pneumococcal genotypes. In conclusion, the multidrug-resistant pneumococcal isolates of serotype 19F and 23F isolated in Korea are the result of the spread of a limited number of resistant clones.

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