Journal of Microbiology

Review

Targeting innate immune sensors for therapeutic strategies in infectious diseases: Seyun Shin, Young Ki Choi, SangJoon Lee; J. Microbiol. 2025;63(6):e2503009. Published online June 30, 2025; DOI: https://doi.org/10.71150/jm.2503009

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Abstract PDF: The innate immune system relies on innate immune sensors, such as pattern recognition receptors (PRRs), to detect pathogens and initiate immune responses, crucial for controlling infections but also implicated in inflammatory diseases. These innate immune sensors, including Toll-like receptors (TLRs), nod-like receptors (NLRs), RIG-I-like receptors (RLRs), absent in melanoma 2 (AIM2), and Z-DNA binding protein 1 (ZBP1) trigger signaling pathways that produce cytokines, modulating inflammation and cell death. Traditional therapies focus on directly targeting pathogens; however, host-targeting therapeutic strategies have emerged as innovative approaches to modulate innate immune sensor activity. These strategies aim to fine-tune the immune response, either enhancing antiviral defenses or mitigating hyperinflammation to prevent tissue damage. This review explores innate immune sensor-based therapeutic approaches, including inhibitors, agonists, and antagonists, that enhance antiviral defense or suppress harmful inflammation, highlighting innate immune sensors as promising targets in infectious and inflammatory disease treatment.

Full article

Role of the LAMMER kinase LkhA in fungal development and aflatoxin production in Aspergillus flavus: Seong-Hwan Jeong, He-Jin Cho, Jae-Hyuk Yu, Hee-Moon Park, Hee-Soo Park; J. Microbiol. 2025;63(5):e2503007. Published online May 27, 2025; DOI: https://doi.org/10.71150/jm.2503007

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Abstract PDF: A well-conserved LAMMER kinase in yeast and filamentous fungi, is a dual-specificity kinase with multiple roles in fungal biology. In this study, we assessed the roles of LkhA in Aspergillus flavus, a toxigenic fungus that produces aflatoxin B1. lkhA deletion mutants exhibited defects in fungal growth, conidiophore development, and sclerotia formation. These mutants exhibited impaired tolerance to oxidative and cell wall stresses. Moreover, the absence of lkhA resulted in a decrease in aflatoxin B1 production. The kernel assay revealed that the lkhA deletion mutants exhibited reduced production of conidia and aflatoxin B1, implying that LkhA can affect fungal toxigenesis and pathogenicity. Taken together, these results demonstrate that LkhA is important for differentiation, mycotoxin production, and pathogenicity in A. flavus.

Review

Small regulatory RNAs as key modulators of antibiotic resistance in pathogenic bacteria: Yubin Yang, Hana Hyeon, Minju Joo, Kangseok Lee, Eunkyoung Shin; J. Microbiol. 2025;63(4):e2501027. Published online April 2, 2025; DOI: https://doi.org/10.71150/jm.2501027

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Abstract PDF

The escalating antibiotic resistance crisis poses a significant challenge to global public health, threatening the efficacy of current treatments and driving the emergence of multidrug-resistant pathogens. Among the various factors associated with bacterial antibiotic resistance, small regulatory RNAs (sRNAs) have emerged as pivotal post-transcriptional regulators which orchestrate bacterial adaptation to antibiotic pressure via diverse mechanisms. This review consolidates the current knowledge on sRNA-mediated mechanisms, focusing on drug uptake, drug efflux systems, lipopolysaccharides, cell wall modification, biofilm formation, and mutagenesis. Recent advances in transcriptomics and functional analyses have revealed novel sRNAs and their regulatory networks, expanding our understanding of resistance mechanisms. These findings highlight the potential of targeting sRNA-mediated pathways as an innovative therapeutic strategy to combat antibiotic resistance, and offer promising avenues for managing challenging bacterial infections.

Citations

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Biofilm, resistance, and quorum sensing: The triple threat in bacterial pathogenesis
Mohammad Nazrul Islam Bhuiyan
The Microbe.2025; 9: 100578. CrossRef
Biofilm maturation in carbapenem-resistant Pseudomonas aeruginosa is regulated by the sRNA PA213 and its corresponding encoded small protein
Yongli Song, Jie Li, Yating Zhang, Lingge Su, Shuang Qin, Chunyan Wu, Guibo Song
International Journal of Antimicrobial Agents.2025; 66(6): 107625. CrossRef

Journal Articles

Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection: Xiaomin Lin, Chun Lin, Xin Li, Fen Yao, Xiaoling Guo, Meimei Wang, Mi Zeng, Yumeng Yuan, Qingdong Xie, Xudong Huang, Xiaoyang Jiao; J. Microbiol. 2024;62(12):1113-1124. Published online December 2, 2024; DOI: https://doi.org/10.1007/s12275-024-00190-5

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Abstract PDF

To study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing. The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.001), and beta diversity was significantly differentiated between the two groups (PERMANOVA, P = 0.001). The four keystone species [Roseburia, Faecalibacterium, Prevotella, and Enterococcus (LDA > 4)] differed significantly between the two groups. Dysbiosis of fecal microbial ecology is a common condition present in patients with BSI. The proliferation of certain pathogens or reduction of SCFA-producing bacteria would cause susceptibility to BSI.

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Targeting gut microbiotasu-derived butyrate for Ferroptosis inhibition in Sepsis-induced myocardial dysfunction
Jianfei Xiong, Guoxiang Liu, Tianyuan Jia, Qian Yang, Changqing Zhu, Shiwei Wang
Journal of Molecular and Cellular Cardiology.2025;[Epub] CrossRef

Flavobacterium psychrotrophum sp. nov. and Flavobacterium panacagri sp. nov., Isolated from Freshwater and Soil: Yong-Seok Kim , Eun-Mi Hwang , Chang-Myeong Jeong , Chang-Jun Cha; J. Microbiol. 2023;61(10):891-901. Published online October 18, 2023; DOI: https://doi.org/10.1007/s12275-023-00081-1

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Abstract PDF

Two novel bacterial strains CJ74T and CJ75T belonging to the genus Flavobacterium were isolated from freshwater of Han River and ginseng soil, South Korea, respectively. Strain CJ74T was Gram-stain-negative, aerobic, rod-shaped, non-motile, and non-flagellated, and did not produce flexirubin-type pigments. Strain CJ75T was Gram-stain-negative, aerobic, rodshaped, motile by gliding, and non-flagellated, and produced flexirubin-type pigments. Both strains were shown to grow optimally at 30 °C in the absence of NaCl on R2A medium. Phylogenetic analysis based on 16S rRNA gene sequences showed that strains CJ74T and CJ75T belonged to the genus Flavobacterium and were most closely related to Flavobacterium niveum TAPW14T and Flavobacterium foetidum CJ42T with 96.17% and 97.29% 16S rRNA sequence similarities, respectively. Genomic analyses including the reconstruction of phylogenomic tree, average nucleotide identity, and digital DNA-DNA hybridization suggested that they were novel species of the genus Flavobacterium. Both strains contained menaquinone 6 (MK-6) as the primary respiratory quinone and phosphatidylethanolamine as a major polar lipid. The predominant fatty acids of both strains were iso-C15:0 and summed feature 3 ( C16:1 ω7c and/or C16: 1 ω6c). Based on the polyphasic taxonomic study, strains CJ74T and CJ75T represent novel species of the genus Flavobacterium, for which names Flavobacterium psychrotrophum sp. nov. and Flavobacterium panacagri sp. nov. are proposed, respectively. The type strains are CJ74T (=KACC 19819T =JCM 32889T) and CJ75T (=KACC 23149T =JCM 36132T).

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Discovery of two novel Flavobacterium species with potential for complex polysaccharide degradation
Xu-Dong Lian, Yong Guan, Yue Jiang, Dong-Heui Kwak, Mi-Kyung Lee, Zhun Li
Scientific Reports.2025;[Epub] CrossRef
Ammonia-oxidizing activity and microbial structure of ammonia-oxidizing bacteria, ammonia-oxidizing archaea and complete ammonia oxidizers in biofilm systems with different salinities
Haojie Qiu, Weihua Zhao, Yingying Qin, Yanyan Wang, Meng Bai, Shaoqing Su, Chao Wang, Zhisheng Zhao
Bioresource Technology.2025; 423: 132248. CrossRef
mKmer: an unbiased K-mer embedding of microbiomic single-microbe RNA sequencing data
Fangyu Mo, Qinghong Qian, Xiaolin Lu, Dihuai Zheng, Wenjie Cai, Jie Yao, Hongyu Chen, Yujie Huang, Xiang Zhang, Sanling Wu, Yifei Shen, Yinqi Bai, Yongcheng Wang, Weiqin Jiang, Longjiang Fan
Briefings in Bioinformatics.2025;[Epub] CrossRef
Congregibacter variabilis sp. nov. and Congregibacter brevis sp. nov. Within the OM60/NOR5 Clade, Isolated from Seawater, and Emended Description of the Genus Congregibacter
Hyeonsu Tak, Miri S. Park, Hyerim Cho, Yeonjung Lim, Jang-Cheon Cho
Journal of Microbiology.2024; 62(9): 739. CrossRef
Flavobacterium rivulicola sp. nov., Isolated from a Freshwater Stream
Sumin Kim, Miri S. Park, Ilnam Kang, Jang-Cheon Cho
Current Microbiology.2024;[Epub] CrossRef
Validation List no. 218. Valid publication of new names and new combinations effectively published outside the IJSEM
Aharon Oren, Markus Göker
International Journal of Systematic and Evolutionary Microbiology .2024;[Epub] CrossRef

Editorial

Editorial] Bacterial Regulatory Mechanisms for the Control of Cellular Processes: Simple Organisms’ Complex Regulation: Jin-Won Lee; J. Microbiol. 2023;61(3):273-276. Published online April 3, 2023; DOI: https://doi.org/10.1007/s12275-023-00036-6

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Abstract PDF

Bacteria employ a diverse array of cellular regulatory mechanisms to successfully adapt and thrive in ever-changing environments, including but not limited to temperature changes, fluctuations in nutrient availability, the presence or absence of electron acceptors such as oxygen, the availability of metal ions crucial for enzyme activity, and the existence of antibiotics. Bacteria can virtually modulate any step of gene expression from transcr!ptional initiation to posttranslational modification of a protein for the control of cellular processes. Furthermore, one gene regulator often controls another in a complex gene regulatory network. Thus, it is not easy to fully understand the intricacies of bacterial regulatory mechanisms in various environments. In this special issue, while acknowledging the challenge of covering all aspects of bacterial regulatory mechanisms across diverse environments, seven review articles are included to provide insight into the recent progress in understanding such mechanisms from different perspectives: positive regulatory mechanisms by secondary messenger (cAMP receptor protein), two-component signal transduction mechanisms (Rcs and Cpx), diverse regulatory mechanisms by a specific environmental factor in specific bacteria (oxygen availability in Mycobacterium and manganese ion availability in Salmonella), diverse regulatory mechanisms by a specific environmental factor (temperature and antibiotics), and regulatory mechanisms by antibiotics in cell wall synthesis. Bacteria, as ubiquitous organisms that can be found in almost every environment, carry out complex cellular processes that allow them to survive and thrive in a variety of different conditions despite their small size and relative simplicity. One of the key factors that allows bacteria to carry out these complex processes is their ability to regulate gene expression through various mechanisms. Gene expression is a fundamental biological process by which the genetic information encoded in a gene is transcribed into an RNA molecule and subsequently translated into a functional gene product, often a protein. Furthermore, the activity levels of proteins may further be altered by posttranslational modification. Regulation of gene expression refers to the control of the amount and timing of gene expression, and thus it can be divided into transcr!ptional, translational, and posttranslational levels.

Citations

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The PhoBR two-component system upregulates virulence in Aeromonas dhakensis C4–1
Wei Feng, Xuesong Li, Nuo Yang, Lixia Fan, Guiying Guo, Jun Xie, Xiuqing Cai, Yuqi Meng, Jifeng Zeng, Yu Han, Jiping Zheng
Aquaculture.2025; 595: 741665. CrossRef
Molecular mechanisms of cold stress response in cotton: Transcriptional reprogramming and genetic strategies for tolerance
Washu Dev, Fahmida Sultana, Hongge Li, Daowu Hu, Zhen Peng, Shoupu He, Haobo Zhang, Muhammad Waqas, Xiaoli Geng, Xiongming Du
Plant Science.2025; 352: 112390. CrossRef
Identificación de Proteínas Clave en la Captación de Hemo por Pseudomonas aeruginosa mediante Análisis In Silico: Nuevos Blancos Terapéuticos
Elena Marcia Gutiérrez Cárdenas, José de Jesús Olivares Trejo , Marco Antonio González López
Revista Bio Ciencias.2025;[Epub] CrossRef
A Methanolic Urea-Enhanced Protein Extraction Enabling the Largest Bacterial Phosphorylation Resource
Pei-Shan Wu, Ting-An Chen, Bo-Yu Chen, Yasushi Ishihama, Miao-Hsia Lin
Molecular & Cellular Proteomics.2025; 24(8): 101019. CrossRef
PhoPQ-mediated lipopolysaccharide modification governs intrinsic resistance to tetracycline and glycylcycline antibiotics in Escherichia coli
Byoung Jun Choi, Umji Choi, Dae-Beom Ryu, Chang-Ro Lee, Mehrad Hamidian, You-Hee Cho
mSystems.2024;[Epub] CrossRef
Navigating the signaling landscape of Ralstonia solanacearum: a study of bacterial two-component systems
Mohit Yadav, Janhavi Sathe, Valentina Teronpi, Aditya Kumar
World Journal of Microbiology and Biotechnology.2024;[Epub] CrossRef

Review

The “Cins” of Our Fathers: Rejuvenated Interest in Colicins to Combat Drug Resistance: Sumudu Upatissa , Robert J. Mitchell; J. Microbiol. 2023;61(2):145-158. Published online February 8, 2023; DOI: https://doi.org/10.1007/s12275-023-00023-x

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Abstract PDF

With the growing threat of antibiotic resistance, researchers around the globe are seeking alternatives to stem bacterial pathogenesis. One such alternative is bacteriocins, proteins produced by bacterial species to inhibit the growth and viability of related bacterial species. With their diverse mechanisms, which include pore formation and nuclease activities, and narrow spectrum of activities, which limit their impact to only certain bacterial species, unlike many chemical antibiotics, bacteriocins offer intriguing possibilities to selectively control individual bacterial populations. Within this review, therefore, we highlight current research exploring the application of colicins and microcins, a subset of bacteriocins, with an emphasis on their activities against drug-resistant pathogens, both in in vitro and in vivo settings.

Citations

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Isolation, Genomics-Based and Biochemical Characterization of Bacteriocinogenic Bacteria and Their Bacteriocins, Sourced from the Gastrointestinal Tract of Meat-Producing Pigs
Ester Sevillano, Irene Lafuente, Nuria Peña, Luis M. Cintas, Estefanía Muñoz-Atienza, Pablo E. Hernández, Juan Borrero
International Journal of Molecular Sciences.2024; 25(22): 12210. CrossRef
Intelligent Biological Networks: Improving Anti-Microbial Resistance Resilience through Nutritional Interventions to Understand Protozoal Gut Infections
Avinash V. Karpe, David J. Beale, Cuong D. Tran
Microorganisms.2023; 11(7): 1800. CrossRef
Pairing Colicins B and E5 with Bdellovibrio bacteriovorus To Eradicate Carbapenem- and Colistin-Resistant Strains of Escherichia coli
Sumudu Upatissa, Wonsik Mun, Robert J. Mitchell, Minsu Kim
Microbiology Spectrum.2023;[Epub] CrossRef
Bacteriocin-Producing Escherichia coli Q5 and C41 with Potential Probiotic Properties: In Silico, In Vitro, and In Vivo Studies
Veronika S. Mihailovskaya, Dmitry A. Sutormin, Marina O. Karipova, Anna B. Trofimova, Victor A. Mamontov, Konstantin Severinov, Marina V. Kuznetsova
International Journal of Molecular Sciences.2023; 24(16): 12636. CrossRef

Journal Articles

Construction of high-density transposon mutant library of Staphylococcus aureus using bacteriophage ϕ11: Wonsik Lee; J. Microbiol. 2022;60(12):1123-1129. Published online November 24, 2022; DOI: https://doi.org/10.1007/s12275-022-2476-2

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Transposon mutant libraries are an important resource to study bacterial metabolism and pathogenesis. The fitness analysis of mutants in the libraries under various growth conditions provides important clues to study the physiology and biogenesis of structural components of a bacterial cell. A transposon library in conjunction with next-generation sequencing techniques, collectively named transposon sequencing (Tnseq), enables high-throughput genome profiling and synthetic lethality analysis. Tn-seq has also been used to identify essential genes and to study the mode of action of antibacterials. To construct a high-density transposon mutant library, an efficient delivery system for transposition in a model bacterium is essential. Here, I describe a detailed protocol for generating a high-density phage-based transposon mutant library in a Staphylococcus aureus strain, and this protocol is readily applicable to other S. aureus strains including USA300 and MW2.

Citations

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Optimizing phage-based mutant recovery and minimizing heat effect in the construction of transposon libraries in Staphylococcus aureus
Sally W. Yousief, Nader Abdelmalek, Bianca Paglietti
Scientific Reports.2024;[Epub] CrossRef

Microbial metabolic responses and CO2 emissions differentiated by soil water content variation in subarctic tundra soils: Dockyu Kim , Namyi Chae , Mincheol Kim , Sungjin Nam , Tai Kyoung Kim , Ki-Tea Park , Bang Yong Lee , Eungbin Kim , Hyoungseok Lee; J. Microbiol. 2022;60(12):1130-1138. Published online November 24, 2022; DOI: https://doi.org/10.1007/s12275-022-2378-3

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Recent rapid air temperature increases across the northernlatitude tundra have prolonged permafrost thawing and snow melting periods, resulting in increased soil temperature (Ts) and volumetric soil water content (SWC). Under prolonged soil warming at 8°C, Alaskan tundra soils were incubated in a microcosm system and examined for the SWC differential influence on the microbial decomposition activity of large molecular weight (MW) humic substances (HS). When one microcosm soil (AKC1-1) was incubated at a constant SWC of 41% for 90 days (T = 90) and then SWC was gradually decreased from 41% to 29% for another T = 90, the initial HS was partly depolymerized. In contrast, in AKC1-2 incubated at a gradually decreasing SWC from the initial 32% to 10% for T = 90 and then increasing to 27% for another T = 90, HS depolymerization was undetected. Overall, the microbial communities in AKC1-1 could maintain metabolic activity at sufficient and constant SWC during the initial T = 90 incubation. In contrast, AKC1-2 microbes may have been damaged by drought stress during the drying SWC regimen, possibly resulting in the loss of HS decomposition activity, which did not recover even after re-wetting to an optimal SWC range (20–40%). After T = 90, the CO2 production in both treatments was attributed to the increased decomposition of small-MW organic compounds (including aerobic HS-degradative products) within an optimal SWC range. We expect this study to provide new insights into the early effects of warming- and topography-induced SWC variations on the microbial contribution to CO2 emissions via HS decomposition in northern-latitude tundra soil.

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Unidirectional freeze–thaw redistributes water and amplifies soil microbial heterogeneity in a mecrocosm experiment
Huimin Liu, Yaxian Hu, Yuan Song, Xianwen Li, Xiaorong Wei
Geoderma.2025; 453: 117126. CrossRef
Analysis of CO2 Emission from Urban Soils of the Kola Peninsula (European Arctic)
M. V. Korneykova, V. I. Vasenev, N. V. Saltan, M. V. Slukovskaya, A. S. Soshina, M. S. Zavodskikh, Yu. L. Sotnikova, A. V. Dolgikh
Eurasian Soil Science.2023; 56(11): 1653. CrossRef
Analysis of CO₂ Emission by Urban Soils under the Conditions of the Kola North
M. V. Korneykova, V. I. Vasenev, N. V. Saltan, M. V. Slukovskaya, A. S. Soshina, M. S. Zavodskikh, Y. L. Sotnikova, A. V. Dolgikh
Почвоведение.2023; (11): 1385. CrossRef

Correlation between fat accumulation and fecal microbiota in crossbred pigs: Xin Li , Mengyu Li , Jinyi Han , Chuang Liu , Xuelei Han , Kejun Wang , Ruimin Qiao , Xiu-Ling Li , Xin-Jian Li; J. Microbiol. 2022;60(11):1077-1085. Published online September 9, 2022; DOI: https://doi.org/10.1007/s12275-022-2218-5

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Backfat thickness (BF) is an important indicator of fat deposition capacity and lean meat rate in pigs and is very important in porcine genetics and breeding. Intestinal microbiota plays a key role in nutrient digestion and utilization with a profound impact on fat deposition of livestock animals. To investigate the relationship between the pig gut microbiome and BF, 20 low-BF (L-BF) and 20 high-BF (H-BF) pigs were selected as two groups from Yunong Black pigs in the present study. Fecal samples from pigs were analyzed for microbial diversity, composition, and predicted functionality using 16S rRNA gene sequencing. The results showed that there were significant differences in microbial β diversity between the two groups. LEfSe analysis revealed a number of bacterial features being differentially enriched in either L-BF or H-BF pigs. Spearman correlation analysis identified the abundance of Oscillospira, Peptococcus, and Bulleidia were significantly positive correlations with BF (P < 0.05), while Sutterella and Bifidobacterium were significantly negatively correlated with BF (P < 0.05). Importantly, the bacteria significantly positively correlated with BF mainly belong to Clostridium, which can ferment host-indigestible plant polysaccharides into shortchain fatty acid (SCFA) and promote fat synthesis and deposition. Predictive functional analysis indicated that the pathway abundance of cell motility and glycan biosynthesis were significantly widespread in the microbiota of the H-BF group. The results of this study will be useful for the development of microbial biomarkers for predicting and improving porcine BF, as well as for the investigation of targets for dietary strategies.

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Molecular Mechanisms and Regulatory Factors Governing Feed Utilization Efficiency in Laying Hens: Insights for Sustainable Poultry Production and Breeding Optimization
Zhouyang Gao, Jiangxia Zheng, Guiyun Xu
International Journal of Molecular Sciences.2025; 26(13): 6389. CrossRef
Carboxymethyl chitosan-dialdehyde glucan/polydopamine carrier targeted delivery Bacillus subtilis on enhancing oral utilization and intestinal colonization in mice
Lulu Chu, Luyu Xie, Bingzhi Chen, Yuji Jiang, Wenjie Wang
International Journal of Biological Macromolecules.2024; 280: 135574. CrossRef
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The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis: Kyung-Tae Lee , Dong-Gi Lee , Ji Won Choi , Jong-Hyun Park , Ki Duk Park , Jong-Seung Lee , Yong-Sun Bahn; J. Microbiol. 2022;60(4):438-443. Published online March 14, 2022; DOI: https://doi.org/10.1007/s12275-022-2016-0

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Systemic candidiasis, which is mainly caused by Candida albicans, is a serious acute fungal infection in the clinical setting. In a previous study, we reported that compound 22h (designated as AB-22 in this study), a vinyl sulfate compound, is a fast-acting fungicidal agent against a broad spectrum of fungal pathogens. In this study, we aimed to further analyze the in vitro and in vivo efficacy of AB-22 against filamentation, biofilm formation, and virulence of C. albicans. Under in vitro hyphal growth-inducing condition, AB-22 effectively inhibited germ tube formation and hyphal growth, which are required for the initiation of biofilm formation. Indeed, AB-22 significantly suppressed C. albicans biofilm formation in a dose-dependent manner. Moreover, AB-22 treatment inhibited the normal induction of ALS3, HWP1, and ECE1, which are all required for hyphal transition in C. albicans. Furthermore, AB-22 treatment increased the survival of mice systemically infected with C. albicans. In conclusion, in addition to its fungicidal activity, AB-22 inhibits filamentation and biofilm formation in C. albicans, which could collectively contribute to its potent in vivo efficacy against systemic candidiasis.

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Preparation and analysis of quinoa active protein (QAP) and its mechanism of inhibiting Candida albicans from a transcriptome perspective
Xufei Zhang, Chunmei Zheng, Wenxuan Ge, Xueying Li, Xiuzhang Wang, Yanxia Sun, Xiaoyong Wu
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Journal of Microbiology.2025; 63(6): e2504019. CrossRef

Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice: Jaeyeong Park , Eunkyoung Shin , Ji-Hyun Yeom , Younkyung Choi , Minju Joo , Minho Lee , Je Hyeong Kim , Jeehyeon Bae , Kangseok Lee; J. Microbiol. 2022;60(1):128-136. Published online December 29, 2021; DOI: https://doi.org/10.1007/s12275-022-1620-3

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Acinetobacter baumannii causes multidrug resistance, leading to fatal infections in humans. In this study, we showed that Lys AB2 P3-His–a hexahistidine-tagged form of an antimicrobial peptide (AMP) loaded onto DNA aptamer-functionalized gold nanoparticles (AuNP-Apt)–can effectively inhibit A. baumannii infection in mice. When A. baumannii-infected mice were intraperitoneally injected with AuNP-Apt loaded with Lys AB2 P3-His, a marked reduction in A. baumannii colonization was observed in the mouse organs, leading to prominently increased survival time and rate of the mice compared to those of the control mice treated with AuNP-Apt or Lys AB2 P3-His only. This study shows that AMPs loaded onto AuNP-Apt could be an effective therapeutic tool against infections caused by multidrug-resistant pathogenic bacteria in humans.

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Sara M. Robledo, Silvia Pérez-Silanes, Celia Fernández-Rubio, Ana Poveda, Lianet Monzote, Víctor M. González, Paloma Alonso-Collado, Javier Carrión
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Diandian Li, Yuan Su, Jie Li, Rong Liu, Bing Fang, Jingjing He, Wentao Xu, Longjiao Zhu
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Genetic diversity and population structure of the amylolytic yeast Saccharomycopsis fibuligera associated with Baijiu fermentation in China: Ju-Wei Wang , Pei-Jie Han , Da-Yong Han , Sen Zhou , Kuan Li , Peng-Yu He , Pan Zhen , Hui-Xin Yu , Zhen-Rong Liang , Xue-Wei Wang , Feng-Yan Bai; J. Microbiol. 2021;59(8):753-762. Published online July 5, 2021; DOI: https://doi.org/10.1007/s12275-021-1115-7

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The amylolytic yeast Saccharomycopsis fibuligera is a predominant species in starters and the early fermentation stage of Chinese liquor (Baijiu). However, the genetic diversity of the species remains largely unknown. Here we sequenced the genomes of 97 S. fibuligera strains from different Chinese Baijiu companies. The genetic diversity and population structure of the strains were analyzed based on 1,133 orthologous genes and the whole genome single nucleotide polymorphisms (SNPs). Four main lineages were recognized. One lineage contains 60 Chinese strains which are exclusively homozygous with relatively small genome sizes (18.55–18.72 Mb) and low sequence diversity. The strains clustered in the other three lineages are heterozygous with larger genomes (21.85–23.72 Mb) and higher sequence diversity. The genomes of the homozygous strains showed nearly 100% coverage with the genome of the reference strain KPH12 and the sub-genome A of the hybrid strain KJJ81 at the above 98% sequence identity level. The genomes of the heterozygous strains showed nearly 80% coverage with both the sub-genome A and the whole genome of KJJ81, suggesting that the Chinese heterozygous strains are also hybrids with nearly 20% genomes from an unidentified source. Eighty-three genes were found to show significant copy number variation between different lineages. However, remarkable lineage specific variations in glucoamylase and α-amylase activities and growth profiles in different carbon sources and under different environmental conditions were not observed, though strains exhibiting relatively high glucoamylase activity were mainly found from the homozygous lineage.

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Qi Yu, Feiyan Mou, Junwen Xiao, Cheng Zhan, Liang Li, Xu Chang, Xiaoyuan Dong, Maobin Chen, Xinrui Wang, Mei Chen, Shangling Fang
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Isolation of a novel strain, Sphingorhabdus sp. YGSMI21 and characterization of its enantioselective epoxide hydrolase activity: Jung-Hee Woo , Hae-Seon Kim , Nyun-Ho Park , Ho Young Suk; J. Microbiol. 2021;59(7):675-680. Published online June 1, 2021; DOI: https://doi.org/10.1007/s12275-021-1023-x

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Sphingorhabdus sp. YGSMI21, a novel microbial strain with an enantioselective epoxide hydrolase activity, was isolated from tidal samples contaminated by accidental oil spills subjected to enriched culture with polycyclic aromatic hydrocarbon. This strain was able to optically decompose (R)-styrene oxide (SO) and showed 100% optical purity. In addition, it showed a good enantioselectivity for the derivatives of (S)- SO, (S)-2-chlorostyrene oxide (CSO), (S)-3-CSO and (S)-4- CSO. For (S)-2-CSO, (S)-3-CSO and (S)-4-CSO, 99.9%ee was obtained with the yield of 26.2%, 24.8%, and 11.0%, respectively, when using 10 mg cells of Sphingorhabdus sp. YGSMI21 at pH 8.0 with 4 mM racemic substrates at pH 8.0 and 25°C. The values obtained in this study for (S)-2-CSO, particularly the yield of 26.2%, is noteworthy, considering that obtaining an enantiomerically pure form is difficult. Taken together, Sphingorhabdus sp. YGSMI21 can be regarded as a wholecell biocatalyst in the production of various (S)-CSO with the chlorine group at a different position.

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Epoxide Hydrolases: Multipotential Biocatalysts
Marek Bučko, Katarína Kaniaková, Helena Hronská, Peter Gemeiner, Michal Rosenberg
International Journal of Molecular Sciences.2023; 24(8): 7334. CrossRef
Effects of submerged macrophytes (Elodea nuttallii) on water quality and microbial communities of largemouth bass (Micropterus salmoides) ponds
Zhijuan Nie, Zhaowei Zheng, Haojun Zhu, Yi Sun, Jun Gao, Jiancao Gao, Pao Xu, Gangchuan Xu
Frontiers in Microbiology.2023;[Epub] CrossRef
Description of Polaribacter batillariae sp. nov., Polaribacter cellanae sp. nov., and Polaribacter pectinis sp. nov., novel bacteria isolated from the gut of three types of South Korean shellfish
Su-Won Jeong, Jeong Eun Han, June-Young Lee, Ji-Ho Yoo, Do-Yeon Kim, In Chul Jeong, Jee-Won Choi, Yun-Seok Jeong, Jae-Yun Lee, So-Yeon Lee, Euon Jung Tak, Hojun Sung, Hyun Sik Kim, Pil Soo Kim, Dong-Wook Hyun, Jin-Woo Bae
Journal of Microbiology.2022; 60(6): 576. CrossRef

Effect of biostimulation and bioaugmentation on hydrocarbon degradation and detoxification of diesel-contaminated soil: a microcosm study: Patricia Giovanella , Lídia de Azevedo Duarte , Daniela Mayumi Kita , Valéria Maia de Oliveira , Lara Durães Sette; J. Microbiol. 2021;59(7):634-643. Published online May 15, 2021; DOI: https://doi.org/10.1007/s12275-021-0395-2

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Soil contamination with diesel oil is quite common during processes of transport and storage. Bioremediation is considered a safe, economical, and environmentally friendly approach for contaminated soil treatment. In this context, studies using hydrocarbon bioremediation have focused on total petroleum hydrocarbon (TPH) analysis to assess process effectiveness, while ecotoxicity has been neglected. Thus, this study aimed to select a microbial consortium capable of detoxifying diesel oil and apply this consortium to the bioremediation of soil contaminated with this environmental pollutant through different bioremediation approaches. Gas chromatography (GC-FID) was used to analyze diesel oil degradation, while ecotoxicological bioassays with the bioindicators Artemia sp., Aliivibrio fischeri (Microtox), and Cucumis sativus were used to assess detoxification. After 90 days of bioremediation, we found that the biostimulation and biostimulation/ bioaugmentation approaches showed higher rates of diesel oil degradation in relation to natural attenuation (41.9 and 26.7%, respectively). Phytotoxicity increased in the biostimulation and biostimulation/bioaugmentation treatments during the degradation process, whereas in the Microtox test, the toxicity was the same in these treatments as that in the natural attenuation treatment. In both the phytotoxicity and Microtox tests, bioaugmentation treatment showed lower toxicity. However, compared with natural attenuation, this approach did not show satisfactory hydrocarbon degradation. Based on the microcosm experiments results, we conclude that a broader analysis of the success of bioremediation requires the performance of toxicity bioassays.

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Heavy fuel oil-contaminated soil remediation by individual and bioaugmentation-assisted phytoremediation with Medicago sativa and with cold plasma-treated M. sativa
Jūratė Žaltauskaitė, Rimas Meištininkas, Austra Dikšaitytė, Laima Degutytė-Fomins, Vida Mildažienė, Zita Naučienė, Rasa Žūkienė, Kazunori Koga
Environmental Science and Pollution Research.2024; 31(20): 30026. CrossRef
Soil Corrosivity Under Natural Attenuation
Larissa O. da Silva, Sara H. de Oliveira, Rafael G. C. da Silva, Magda R. S. Vieira, Ivanilda R. de Melo, Severino L. Urtiga Filho
Materials Research.2024;[Epub] CrossRef
Updating risk remediation-endpoints for petroleum-contaminated soils? A case study in the Ecuadorian Amazon region
Daniel Hidalgo-Lasso, Karina García-Villacís, Jeaneth Urvina Ulloa, Darwin Marín Tapia, Patricio Gómez Ortega, Frederic Coulon
Heliyon.2024; 10(9): e30395. CrossRef
Recent advances in the development and applications of luminescent bacteria–based biosensors
Yingying Li, Yuankun Zhao, Yiyang Du, Xuechun Ren, He Ding, Zhimin Wang
Luminescence.2024;[Epub] CrossRef
Oil biodegradation studies with an immobilized bacterial consortium in plant biomass for the construction of bench-scale bioreactor
Rachel M. Ferreira, Bernardo D. Ribeiro, Danielle.M.A. Stapelfeldt, Rodrigo P. do Nascimento, Maria de.F.R. Moreira
Cleaner Chemical Engineering.2023; 6: 100107. CrossRef
Application of Luminescent Bacteria Bioassay in the Detection of Pollutants in Soil
Kai Zhang, Meng Liu, Xinlong Song, Dongyu Wang
Sustainability.2023; 15(9): 7351. CrossRef
Salicylate or Phthalate: The Main Intermediates in the Bacterial Degradation of Naphthalene
Vasili M. Travkin, Inna P. Solyanikova
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Rab27b regulates extracellular vesicle production in cells infected with Kaposi’s sarcoma–associated herpesvirus to promote cell survival and persistent infection: Hyungtaek Jeon , Su-Kyung Kang , Myung-Ju Lee , Changhoon Park , Seung-Min Yoo , Yun Hee Kang , Myung-Shin Lee; J. Microbiol. 2021;59(5):522-529. Published online April 20, 2021; DOI: https://doi.org/10.1007/s12275-021-1108-6

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Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication. EVs and viruses share several properties related to their structure and the biogenesis machinery in cells. EVs from virus-infected cells play a key role in virus spread and suppression using various loading molecules, such as viral proteins, host proteins, and microRNAs. However, it remains unclear how and why viruses regulate EV production inside host cells. The purpose of this study is to investigate the molecular mechanisms underlying EV production and their roles in Kaposi’s sarcoma-associated herpesvirus (KSHV)-infected cells. Here, we found that KSHV induced EV production in human endothelial cells via Rab- 27b upregulation. The suppression of Rab27b expression in KSHV-infected cells enhanced cell death by increasing autophagic flux and autolysosome formation. Our results indicate that Rab27b regulates EV biogenesis to promote cell survival and persistent viral infection during KSHV infection, thereby providing novel insights into the crucial role of Rab- 27b in the KSHV life cycle.

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Engineered small extracellular vesicles as a novel platform to suppress human oncovirus-associated cancers
Iman Owliaee, Mehran khaledian, Armin Khaghani Boroujeni, Ali Shojaeian
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HMGB1, a potential regulator of tumor microenvironment in KSHV-infected endothelial cells
Myung-Ju Lee, Joohee Park, Seokjoo Choi, Seung-Min Yoo, Changhoon Park, Hong Seok Kim, Myung-Shin Lee
Frontiers in Microbiology.2023;[Epub] CrossRef
Alpha-2-macroglobulin as a novel diagnostic biomarker for human bladder cancer in urinary extracellular vesicles
Jisu Lee, Hyun Sik Park, Seung Ro Han, Yun Hee Kang, Ji Young Mun, Dong Wook Shin, Hyun-Woo Oh, Yoon-Kyoung Cho, Myung-Shin Lee, Jinsung Park
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Long non-coding RNAs in Sus scrofa ileum under starvation stress
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Animal Bioscience.2022; 35(7): 975. CrossRef

Review

Minor and major circRNAs in virus and host genomes: Zhihao Lou , Rui Zhou , Yinghua Su , Chun Liu , Wenting Ruan , Che Ok Jeon , Xiao Han , Chun Lin , Baolei Jia; J. Microbiol. 2021;59(3):324-331. Published online February 23, 2021; DOI: https://doi.org/10.1007/s12275-021-1021-z

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As a special type of noncoding RNA, circular RNAs (circRNAs) are prevalent in many organisms. They can serve as sponges for microRNAs and protein scaffolds, or templates for protein translation, making them linked to cellular homeostasis and disease progression. In recent years, circRNAs have been found to be abnormally expressed during the processes of viral infection and pathogenesis, and can help a virus escape the immune response of a host. Thus, they are now considered to play important functions in the invasion and development of viruses. Moreover, the potential application of circRNAs as biomarkers of viral infection or candidates for therapeutic targeting deserves consideration. This review summarizes circRNAs in the transcriptome, including their classification, production, functions, and value as biomarkers. This review paper also describes research progress on circRNAs in viral infection (mainly hepatitis B virus, HIV, and some human herpes viruses) and aims to provide new ideas for antiviral therapies targeting circRNAs.

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Combining circ_0054633 and clinical features to predict refractory Mycoplasma pneumoniae pneumonia in children
Shiyin Mu, Jia Zhai, Yongsheng Guo, Bing Huang, Yingxue Zou
Scientific Reports.2025;[Epub] CrossRef
Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of cardiovascular diseases (Review)
Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Molecular Medicine Reports.2025; 33(1): 1. CrossRef
Host combats porcine reproductive and respiratory syndrome virus infection at non-coding RNAs level
Zhi Qin, Weiye Liu, Zhihua Qin, Hongliang Zhang, Xuewei Huang
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miRNA, lncRNA and circRNA: targeted molecules with therapeutic promises in Mycoplasma pneumoniae infection
Tian Gan, Jianwei Yu, Jun He
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Circ_0138959/miR-495-3p/TRAF6 axis regulates proliferation, wound healing and osteoblastic differentiation of periodontal ligament cells in periodontitis
Wenjuan Deng, Xiaoliang Wang, Jin Zhang, Sainan Zhao
Journal of Dental Sciences.2022; 17(3): 1125. CrossRef
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
Yuncong Shi, Huanji Zhang, Suli Huang, Li Yin, Feng Wang, Pei Luo, Hui Huang
Signal Transduction and Targeted Therapy.2022;[Epub] CrossRef
Omics-based microbiome analysis in microbial ecology: from sequences to information
Jang-Cheon Cho
Journal of Microbiology.2021; 59(3): 229. CrossRef

Journal Articles

[PROTOCOL]A Signature-Tagged Mutagenesis (STM)-based murine-infectivity assay for Cryptococcus neoformans: Kwang-Woo Jung , Kyung-Tae Lee , Yong-Sun Bahn; J. Microbiol. 2020;58(10):823-831. Published online September 29, 2020; DOI: https://doi.org/10.1007/s12275-020-0341-8

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Signature-tagged mutagenesis (STM) is a high-throughput genetic technique that can be used to investigate the function of genes by constructing a large number of mutant strains with unique DNA identification tags, pooling them, and screening them for a particular phenotypic trait. STM was first designed for the identification of genes that contribute to the virulence or infectivity of a pathogen in its host. Recently, this
method
has also been applied for the identification of mutants with specific phenotypes, such as antifungal drug resistance and proliferation. In the present study, we describe an STM
method
for the identification of genes contributing to the infectivity of Cryptococcus neoformans using a mutant library, in which each strain was tagged with a unique DNA sequence.

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Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of Vibrio vulnificus
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Jae-Hyung Jin, Myung Kyung Choi, Hyun-Soo Cho, Yong-Sun Bahn
Journal of Microbiology.2021; 59(7): 658. CrossRef

Paenibacillus lycopersici sp. nov. and Paenibacillus rhizovicinus sp. nov., isolated from the rhizosphere of tomato (Solanum lycopersicum): Shin Ae Lee , Tae-Wan Kim , Mee-Kyung Sang , Jaekyeong Song , Soon-Wo Kwon , Hang-Yeon Weon; J. Microbiol. 2020;58(10):832-840. Published online September 29, 2020; DOI: https://doi.org/10.1007/s12275-020-0258-2

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Two Gram-stain-positive, rod-shaped, endospore-forming bacteria, designated 12200R-189T and 14171R-81T were isolated from the rhizosphere of tomato plants. The 16S rRNA gene sequence similarity between strains 12200R-189T and 14171R-81T were 97.2%. Both strains showed the highest 16S rRNA gene sequence similarities to Paenibacillus sacheonensis SY01T (96.3% and 98.0%, respectively). The genome of strain 12200R-189T was approximately 6.7 Mb in size with 5,750 protein-coding genes (CDSs) and the G + C content was 58.1 mol%, whereas that of strain 14171R-81T comprised one chromosome of 7.0 Mb and two plasmids (0.2 Mb each) with 6,595 CDSs and the G + C content was 54.5 mol%. Comparative genome analysis revealed that average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values among 12200R-189T, 14171R-81T, and other closely related species were below the cut-off levels 95% and 70%, respectively. Strain 12200R-189T grew at a temperature range of 15–40°C, pH 6.0–9.0, and 0–3% NaCl (w/v), whereas strain 14171R-81T grew at a temperature range of 10–37°C, pH 6.0– 8.0, and 0–1% NaCl (w/v). Menaquinone-7 (MK-7) was the only isoprenoid quinone detected in both strains. The predominant cellular fatty acids (> 10%) were iso-C15:0, anteiso- C15:0, and iso-C16:0. The polar lipids of strain 12200R- 189T were diphosphatidylglycerol (DPG), phosphatidylglycerol (PG), phosphatidylethanolamine (PE), aminophospholipid (APL), phospholipid (PL), phosphatidylglycolipid (PGL), and four aminophosphoglycolipids (APGLs) and those of strain 14171R-81T were DPG, PG, PE, APL, three PLs, two PGLs, and three APGLs. Based on phylogenetic, genomic, phenotypic, and chemotaxonomic analyses, strains 12200R- 189T and 14171R-81T represent two novel species of the genus Paenibacillus, for which the names Paenibacillus lycopersici sp. nov. and Paenibacillus rhizovicinus sp. nov. are proposed. The type strains are 12200R-189T (= KACC 19916T = CCTCC AB 2020027T) and 14171R-81T (= KACC 19915T = CCTCC AB 2020026T).

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Description and genomic characterization of Jiella flava sp. nov., isolated from Acrostichum aureum
Ming-Sheng Chen, Xiu-Long Pu, Ming-Dan Weng, Li Chen, Lan-Ying Zhu, Li Tuo
International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
Jiella sonneratiae sp. nov., a novel endophytic bacterium isolated from bark of Sonneratia apetala
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International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
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International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
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Fungal diversity in deep-sea sediments from Magellan seamounts environment of the western Pacific revealed by high-throughput Illumina sequencing: Shuai Yang , Wei Xu , Yuanhao Gao , Xiaoyao Chen , Zhu-Hua Luo; J. Microbiol. 2020;58(10):841-852. Published online September 2, 2020; DOI: https://doi.org/10.1007/s12275-020-0198-x

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There are lots of seamounts globally whose primary production is disproportionally greater than the surrounding areas. Compared to other deep-sea environments, however, the seamounts environment is relatively less explored for fungal diversity. In the present study, we explored the fungal community structure in deep-sea sediments from four different stations of the Magellan seamounts environment by using high-throughput sequencing of the ITS1 region. A total of 1,897,618 ITS1 sequences were obtained. Among these sequences, fungal ITS1 sequences could be clustered into 1,662 OTUs. The majority of these sequences belonged to Ascomycota. In the genera level, the most abundant genus was Mortierella (4.79%), which was reported as a common fungal genus in soil and marine sediments, followed by Umbelopsis (3.80%), Cladosporium (2.98%), Saccharomycopsis (2.53%), Aspergillus (2.42%), Hortaea (2.36%), Saitozyma (2.20%), Trichoderma (2.12%), Penicillium (2.11%), Russula (1.86%), and Verticillium (1.40%). Most of these recovered genera belong to Ascomycota. The Bray-Curtis analysis showed that there was 37 to 85% dissimilarity of fungal communities between each two sediment samples. The Principal coordinates analysis clearly showed variations in the fungal community among different sediment samples. These results suggested that there was a difference in fungal community structures not only among four different sampling stations but also for different layers at the same station. The depth and geographical distance significantly affect the fungal community, and the effect of depth and geographical distance on the structure of the fungal community in the Magellan seamounts is basically same. Most of the fungi were more or less related to plants, these plant parasitic/symbiotic/endophytic fungi constitute a unique type of seamounts environmental fungal ecology, different from other marine ecosystems.

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In vitro disinfection efficacy and clinical protective effects of common disinfectants against acute hepatopancreatic necrosis disease (AHPND)-causing Vibrio isolates in Pacific white shrimp Penaeus vannamei: Peizhuo Zou , Qian Yang , Hailiang Wang , Guosi Xie , Zhi Cao , Xing Chen , Wen Gao , Jie Huang; J. Microbiol. 2020;58(8):675-686. Published online July 27, 2020; DOI: https://doi.org/10.1007/s12275-020-9537-1

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Acute hepatopancreatic necrosis disease (AHPND) is one of the most significant bacterial diseases in global shrimp culture, causing severe economic losses. In the present study, we carried out in vitro antimicrobial tests to investigate the disinfection efficacy of 14 common disinfectants toward different AHPND-causing Vibrio spp., including eight isolates of V. parahaemolyticus, four isolates of V. campbellii, and one isolate of V. owensii. Polyhexamethylene biguanidine hydrochloride (PHMB) was revealed to possess the strongest inhibitory activity. Through analyzing and evaluating the results of antimicrobial tests and acute toxicity test, we selected PHMB and hydrogen peroxide (H2O2) for further clinical protection test. Clinical manifestations indicated that both PHMB (2 mg/L and 4 mg/L) and H2O2 (12 mg/L) could effectively protect juvenile Penaeus vannamei from the infection of V. parahaemolyticus isolate Vp362 at 106 CFU/ml, and the survival rate was over 80%. When the bacterial concentration was reduced to 105 CFU/ml, 104 CFU/ml, and 103 CFU/ml, the survival rate after treated by 1 mg/L PHMB was 64.44%, 93.33%, and 100%, respectively. According to the results, PHMB and H2O2 showed a lower toxicity while a better protection activity, particularly against a lower concentration of the pathogens. Therefore, these two disinfectants are proved to be promising disinfectants that can be applied to prevent and control AHPND in shrimp culture. Moreover, the methods of this study also provided valuable information for the prevention of other important bacterial diseases and suggested a reliable means for screening potential drugs in aquaculture.

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Lanting Wu, Chunyuan Wang, Yingeng Wang, Yongxiang Yu, Zheng Zhang, Cuiping Ma, Xiaojun Rong, Ling Chen, Meijie Liao, Yapeng Yang
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The relationship between bacterial diversity and organic carbon mineralization in soft rock and sand compound soil: Zhen Guo , Juan Li , Lei Ge , Chenxi Yang , Jichang Han; J. Microbiol. 2020;58(9):750-760. Published online July 24, 2020; DOI: https://doi.org/10.1007/s12275-020-0130-4

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The soil organic carbon (SOC) mineralization rate in sandy soil plays an important role in improving soil quality, and a research is needed to determine management practices that optimize the mineralization rate. When sandy soil is improved by adding soft rock, the specific promotion process of bacterium to SOC mineralization remain unclear. To investigate these mechanisms, we selected four treatments with soft rock to sand volume ratios of 0:1 (CK), 1:5 (C1), 1:2 (C2) and 1:1 (C3) to study. The mineralization rate of organic carbon was measured using the lye absorption method. Highthroughput sequencing and scanning electron microscopy were used to determine the bacterial community structure and soil microstructure, respectively. The results showed that the organic carbon content of the sandy soil increased significantly (182.22–276.43%) after using the soft rock treatments. The SOC mineralization rate could be divided into two stages: a rapid decline during days 1–8 and a slow decline during days 8–60. With increased incubation time, the intensity of the cumulative release of organic carbon gradually weakened. Compared with the CK treatment, the SOC mineralization accumulation (Ct) and the potential mineralizable organic carbon content (C0) in the C1, C2, and C3 treatments increased significantly, by 106.98–225.94% and 112.22– 254.08%, respectively. The cumulative mineralization rate (Cr) was 18.11% and 21.38% smaller with treatments C2 and C3, respectively. The SOC mineralization rate constant (k) decreased significantly after the addition of soft rock, while the half-turnover period (Th) changed inversely with k. Compared with the CK treatment, the number of gene copies of the soil bacteria increased by 15.38–272.53% after adding soft rock, with the most significant increase in treatment C3. The bacterial diversity index also increased significantly under treatment C3. The three dominant bacteria were Proteobacteria, Actinobacteria, and Chloroflexi. The correlation between Cr and one of the non-dominant bacteria, Firmicutes, was large, and the bacteria had a significant positive correlation with k. At the same time, the abundance of Firmicutes under treatments C2 and C3 was small. As the proportion of soft rock increased, the soil particles changed from point contact to surface contact, and the adhesion on the surface of the particles gradually increased. Results from this study show that the retention time of SOC can be increased and the carbon sequestration effect is better when the ratio of soft rock to sand is set to 1:2.

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Azohydromonas aeria sp. nov., isolated from air: Han Xue , Chun-gen Piao , Dan-ran Bian , Min-wei Guo , Yong Li; J. Microbiol. 2020;58(7):543-549. Published online June 27, 2020; DOI: https://doi.org/10.1007/s12275-020-9423-x

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A grey pink colored bacterium, strain t3-1-3T, was isolated from the air at the foot of the Xiangshan Mountain in Beijing, China. The cells are aerobic, Gram-stain-negative, non-sporeforming, motile and coccoid-rod shaped (0.9–1.2 × 1.9–2.1 μm). Strain t3-1-3T was catalase-positive and oxidase-negative and this strain grew at 4–42°C (optimum 28°C), a pH of 4.0–9.0 (optimum pH 7.0) and under 0–2% (w/v) NaCl (optimum 0–1% NaCl). A phylogenetic analysis based on 16S rRNA gene sequences revealed that strain t3-1-3T was closely related to Azohydromonas riparia UCM-11T (97.4% similarity), followed by Azohydromonas australica G1-2T (96.8%) and Azohydromonas ureilytica UCM-80T (96.7%). The genome of strain t3-1-3T contains 6,895 predicted protein-encoding genes, 8 rRNA genes, 62 tRNA genes and one sRNA gene, as well as five potential biosynthetic gene clusters, including clusters of genes coding for non-ribosomal peptide synthetase (NRPS), bacteriocin and arylpolyene and two clusters of genes for terpene. The predominant cellular fatty acids (> 10.0% of the total) in strain t3-1-3T were summed feature 3 (C16:1ω7c and/or C16:1ω6c, 37.8%), summed feature 8 (C18:1ω7c and/or C18:1ω6c, 29.7%) and C16:0 (17.3%). Strain t3-1-3T contained ubiquinone-8 (Q-8) as the predominant respiratory quinone. The polar lipids of strain t3-1-3T comprised phosphatidyl ethanolamine (PE), phosphatidyl glycerol (PG), diphosphatidyl glycerol (DPG), an unidentified glycolipid (GL), an unidentified aminophospholipid (APL), two unidentified phospholipid (PL1-2) and five unidentified lipid (L1-5). The DNA G + C content of the type strain is 70.3%. The broader range of growth temperature, assimilation of malic acid and trisodium citrate, presence of C18:3ω6c and an unidentified glycolipid and absence of C12:0 2-OH and C16:0iso differentiate strain t3-1-3T from related species. Based on the taxonomic data presented in this study, we suggest that strain t3-1-3T represents a novel species within the genus Azohydromonas, for which the name Azohydromonas aeria sp. nov. is proposed. The type strain of Azohydromonas aeria is t3-1-3T (= CFCC 13393T = LMG 30135T).

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Short-term effects of returning granulated straw on soil microbial community and organic carbon fractions in dryland farming: Wei Fan , Jinggui Wu; J. Microbiol. 2020;58(8):657-667. Published online June 25, 2020; DOI: https://doi.org/10.1007/s12275-020-9266-5

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We conducted a 2-year field experiment which was comprised of five treatments, namely no straw returning (CK), straw mulching (SM), straw plowed into the soil (SP), and straw returned in granulated form (SG). The aim of this study was to investigate the effects of different straw returning modes on soil bacterial and fungal community structure and their relationships to soil organic carbon (SOC) fractions at three different soil depths (0–20, 20–40, and 40–60 cm) in a dryland under maize cultivation in Northeast (NE) China. SM, SP, and SG treatments significantly increased SOC content. Compared with SM and SP treatments, SG treatment significantly increased the content of SOC and easily oxidizable carbon (EOC) in the topsoil (0–20 cm depth), and increased dissolved organic carbon (DOC) and SOC content of the light fraction (LFOC) in the 20–40 cm layer. Meanwhile, SG treatment exhibited the highest microbial biomass C (MBC) content in all of the three soil depths. SG treatment also enhanced bacterial richness as well as fungal richness and diversity in the upper 40 cm of soil. In addition, SG treatment increased the relative abundance of Proteobacteria in all depths, and had the highest relative abundance of Basidiomycota in the first 20 cm of soil. SP treatment showed the lowest soil organic carbon content in all fractions and soil microbial community composition. SM treatment exhibited similar results to SG treatment in SOC, DOC, and LFOC contents, and bacterial diversity in the topsoil and subsoil. As a whole, treatment SG improved soil quality and maize yield, hence we recommend returning granulated straw as the most effective practice for enhancing labile SOC fractions as well as maintaining soil diversity and microbial richness of arid farmlands in NE China.

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Rapid determination of carbapenem resistance by low-cost colorimetric methods: Propidium Iodide and alamar blue staining: Jiyoon Choi , Jiwon Baek , Daehyuk Kweon , Kwan Soo Ko , Hyunjin Yoon; J. Microbiol. 2020;58(5):415-421. Published online March 28, 2020; DOI: https://doi.org/10.1007/s12275-020-9549-x

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Carbapenems are a class of β-lactam antibiotics with a broad antimicrobial activity spectrum. Owing to their sturdy structures resistant to most β-lactamases, they have been regarded as one of the last-resort antibiotics for combating multidrugresistant bacterial infections. However, the emergence of carbapenem resistance increases predominantly in nosocomial pathogens. To prevent spread of carbapenem resistance in early stages, it is imperative to develop rapid diagnostic tests that will substantially reduce the time and cost in determining carbapenem resistance. Thus, we devised a staining-based diagnostic method applicable to three different Gram-negative pathogens of Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae, all with the high potential to develop carbapenem resistance. Regardless of the resistance mechanisms presented by bacterial species and strains, double staining with propidium iodide (PI) and alamar blue (AB) identified resistant bacteria with an average sensitivity of 95.35%, 7 h after imipenem treatments in 343 clinical isolates. Among the three species tested, A. baumannii showed the highest diagnostic sensitivity of 98.46%. The PI and ABmediated staining method could be a promising diagnostic
method
with high-throughput efficacy and low cost.

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A histone deacetylase, MoHOS2 regulates asexual development and virulence in the rice blast fungus: Jongjune Lee , Jae-Joon Lee , Junhyun Jeon; J. Microbiol. 2019;57(12):1115-1125. Published online November 22, 2019; DOI: https://doi.org/10.1007/s12275-019-9363-5

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Histone acetylation/deacetylation represent a general and efficient epigenetic mechanism through which fungal cells control gene expression. Here we report developmental requirement of MoHOS2-mediated histone deacetylation (HDAC) for the rice blast fungus, Magnaporthe oryzae. Structural similarity and nuclear localization indicated that MoHOS2 is an ortholog of Saccharomyces cerevisiae Hos2, which is a member of class I histone deacetylases and subunit of Set3 complex. Deletion of MoHOS2 led to 25% reduction in HDAC activity, compared to the wild-type, confirming that it is a bona-fide HDAC. Lack of MoHOS2 caused decrease in radial growth and impinged dramatically on asexual sporulation. Such reduction in HDAC activity and phenotypic defects of ΔMohos2 were recapitulated by a single amino acid change in conserved motif that is known to be important for HDAC activity. Expression analysis revealed up-regulation of MoHOS2 and concomitant down-regulation of some of the key genes involved in asexual reproduction under sporulation-promoting condition. In addition, the deletion mutant exhibited defect in appressorium formation from both germ tube tip and hyphae. As a result, ΔMohos2 was not able to cause disease symptoms. Wound-inoculation showed that the mutant is compromised in its ability to grow inside host plants as well. We found that some of ROS detoxifying genes and known effector genes are de-regulated in the mutant. Taken together, our data suggest that MoHOS2-dependent histone deacetylation is pivotal for proper timing and induction of transcription of the genes that coordinate developmental changes and host infection in M. oryzae.

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Transcriptome analysis to understand the effects of the toxoflavin and tropolone produced by phytopathogenic Burkholderia on Escherichia coli: Jungwook Park , Hyun-Hee Lee , Hyejung Jung , Young-Su Seo; J. Microbiol. 2019;57(9):781-794. Published online August 27, 2019; DOI: https://doi.org/10.1007/s12275-019-9330-1

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The phytopathogenic Burkholderia species B. glumae and B. plantarii are the causal agents of bacterial wilt, grain rot, and seedling blight, which threaten the rice industry globally. Toxoflavin and tropolone are produced by these phytopathogens and are considered the most hostile biohazards with a broad spectrum of target organisms. However, despite their nonspecific toxicity, the effects of toxoflavin and tropolone on bacteria remain unknown. RNA-seq based transcriptome analysis was employed to determine the genome-wide expression patterns under phytotoxin treatment. Expression of 2327 and 830 genes was differentially changed by toxoflavin and tropolone, respectively. Enriched biological pathways reflected the down-regulation of oxidative phosphorylation and ribosome function, beginning with the inhibition of membrane biosynthesis and nitrogen metabolism under oxidative stress or iron starvation. Conversely, several systems such as bacterial chemotaxis, flagellar assembly, biofilm formation, and sulfur/taurine transporters were highly expressed as countermeasures against the phytotoxins. In addition, our findings revealed that three hub genes commonly induced by both phytotoxins function as the siderophore enterobactin, an ironchelator. Our study provides new insights into the effects of phytotoxins on bacteria for better understanding of the interactions between phytopathogens and other microorganisms. These data will also be applied as a valuable source in subsequent applications against phytotoxins, the major virulence factor.

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A membrane protein of the rice pathogen Burkholderia glumae required for oxalic acid secretion and quorum sensing
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Toxoflavin secreted by Pseudomonas alcaliphila inhibits the growth of Legionella pneumophila and Vermamoeba vermiformis
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Characterization of a Salmonella Enteritidis bacteriophage showing broad lytic activity against Gram-negative enteric bacteria: Shukho Kim , Sung-Hun Kim , Marzia Rahman , Jungmin Kim; J. Microbiol. 2018;56(12):917-925. Published online October 25, 2018; DOI: https://doi.org/10.1007/s12275-018-8310-1

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In this study, we sought to isolate Salmonella Enteritidis-specific lytic bacteriophages (phages), and we found a lytic phage that could lyse not only S. Enteritidis but also other Gramnegative foodborne pathogens. This lytic phage, SS3e, could lyse almost all tested Salmonella enterica serovars as well as other enteric pathogenic bacteria including Escherichia coli, Shigella sonnei, Enterobacter cloacae, and Serratia marcescens. This SS3e phage has an icosahedral head and a long tail, indicating belong to the Siphoviridae. The genome was 40,793 base pairs, containing 58 theoretically determined open reading frames (ORFs). Among the 58 ORFs, ORF49, and ORF25 showed high sequence similarity with tail spike protein and lysozyme-like protein of Salmonella phage SE2, respectively, which are critical proteins recognizing and lysing host bacteria. Unlike SE2 phage whose host restricted to Salmonella enterica serovars Enteritidis and Gallinarum, SS3e showed broader host specificity against Gram-negative enteric bacteria; thus, it could be a promising candidate for the phage utilization against various Gram-negative bacterial infection including foodborne pathogens.

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Wild birds and urban pigeons as reservoirs for diarrheagenic Escherichia coli with zoonotic potential: Clarissa A. Borges , Marita V. Cardozo , Livia G. Beraldo , Elisabete S. Oliveira , Renato P. Maluta , Kaline B. Barboza , Karin Werther , Fernando A. Ávila; J. Microbiol. 2017;55(5):344-348. Published online March 9, 2017; DOI: https://doi.org/10.1007/s12275-017-6523-3

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In order to describe the role of wild birds and pigeons in the transmission of shiga toxigenic Escherichia coli (STEC) and enteropathogenic Escherichia coli (EPEC) to humans and other animals, samples were collected from cloacae and oropharynx of free-living wild birds and free-living pigeons. Two STEC (0.8%) and five EPEC strains (2.0%) were isolated from wild birds and four EPEC strains (2.0%) were recovered from pi-geons. Serogroups, sequence types (STs) and virulence genes, such as saa, iha, lpfAO113, ehxA, espA, nleB and nleE, detected in this study had already been implicated in human and ani-mal diseases. Multidrug resistance (MDR) was found in 25.0% of the pigeon strains and in 57.0% of the wild bird strains; the wild birds also yielded one isolate carrying extended-spec-trum β-lactamases (ESBLs) gene blaCTX-M-8. The high varia-bility shown by PFGE demonstrates that there are no preva-lent E. coli clones from these avian hosts. Wild birds and pi-geons could act as carriers of multidrug-resistant STEC and EPEC and therefore may constitute a considerable hazard to human and animal health by transmission of these strains to the environment.

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Reviews

REVIEW] Zika virus: An emerging flavivirus: Sang-Im Yun , Young-Min Lee; J. Microbiol. 2017;55(3):204-219. Published online February 28, 2017; DOI: https://doi.org/10.1007/s12275-017-7063-6

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Abstract PDF

Zika virus (ZIKV) is a previously little-known flavivirus closely related to Japanese encephalitis, West Nile, dengue, and yellow fever viruses, all of which are primarily transmitted by blood-sucking mosquitoes. Since its discovery in Uganda in 1947, ZIKV has continued to expand its geographic range, from equatorial Africa and Asia to the Pacific Islands, then further afield to South and Central America and the Caribbean. Currently, ZIKV is actively circulating not only in much of Latin America and its neighbors but also in parts of the Pacific Islands and Southeast Asia. Although ZIKV infection generally causes only mild symptoms in some infected individuals, it is associated with a range of neuroimmunological disorders, including Guillain-Barré syndrome, meningoencephalitis, and myelitis. Recently, maternal ZIKV infection during pregnancy has been linked to neonatal malformations,
result
ing in various degrees of congenital abnormalities, microcephaly, and even abortion. Despite its emergence as an important public health problem, however, little is known about ZIKV biology, and neither vaccine nor drug is available to control ZIKV infection. This article provides a brief introduction to ZIKV with a major emphasis on its molecular virology, in order to help facilitate the development of diagnostics, therapeutics, and vaccines.

Citations

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The first possible case of airport Zika virus infection in the EU/EEA
Jana Kerlik, Ján Hockicko, Mária Avdičová, Monika Musilová, Veronika Tarkovská, Elena Tichá, Hana Zelená
Travel Medicine and Infectious Disease.2025; 66: 102864. CrossRef
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Haolong Cong, Xiaodong Han, Mengyuan Lv, Yutong Chang, Xinyi Wang, Rong Lei
Talanta.2025; 294: 128195. CrossRef
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Senfeng Sun, Tingting Sun, Xinyu Lei, Fangfei Li, Jing Wang, Rui Zhou, Quanjie Li, Dongrong Yi, Jing Wang, Hongwei Jin, Shan Cen, Shizhong Chen
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Sanjit Boora, Sapna Wadhwa, Sulochana Kaushik, Vatsla Vats, Samander Kaushik
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Comparison of Five Serological Methods for the Detection of West Nile Virus Antibodies
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Viruses.2024; 16(5): 788. CrossRef
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Viruses.2024; 16(4): 629. CrossRef
Optimal control problem for mathematical modeling of Zika virus transmission using fractional order derivatives
Abdelfatah Kouidere, Amine El Bhih, Issam Minifi, Omar Balatif, Khalid Adnaoui
Frontiers in Applied Mathematics and Statistics.2024;[Epub] CrossRef
Analysis of RNA virus pathogenicity and development of novel prevention methods.
Ryuta URAKI
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Differences in the Membrane-Binding Properties of Flaviviral Nonstructural 1 (NS1) Protein: Comparative Simulations of Zika and Dengue Virus NS1 Proteins in Explicit Bilayers
Rajagopalan Muthukumaran, Ramasubbu Sankararamakrishnan
ACS Bio & Med Chem Au.2024; 4(3): 137. CrossRef
Bovine serum albumin nanoparticles containing Poly (I:C) can enhance the neutralizing antibody response induced by envelope protein of Orthoflavivirus zikaense
Raíne Piva-Amaral, Gabriel Augusto Pires de Souza, João Carlos Vilela Vieira Júnior, Renato Fróes Goulart de Castro, William Permagnani Gozzi, Sergio Pereira Lima Neto, Ana Luisa Cauvilla dos Santos, Helena Pavani Cassiano, Lorena Christine Ferreira da Si
International Immunopharmacology.2024; 128: 111523. CrossRef
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International Journal of Molecular Sciences.2024; 26(1): 195. CrossRef
Mice as an Animal Model for Japanese Encephalitis Virus Research: Mouse Susceptibility, Infection Route, and Viral Pathogenesis
Jordan C. Frank, Byung-Hak Song, Young-Min Lee
Pathogens.2023; 12(5): 715. CrossRef
Zika Virus: A Comprehensive Review
Snehal Dilip Kothavale, Rinaj Rasul Attar, S. K. Mohite, Sagar B. Patil
Research Journal of Pharmacology and Pharmacodynamics.2023; : 24. CrossRef
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Daed El Safadi, Grégorie Lebeau, Jonathan Turpin, Christian Lefebvre d’Hellencourt, Nicolas Diotel, Wildriss Viranaicken, Pascale Krejbich-Trotot
Viruses.2023; 16(1): 24. CrossRef
Synthesis of copaiba (Copaifera officinalis) oil nanoemulsion and the potential against Zika virus: An in vitro study
Tamara Carvalho, Marcela Guimarães Landim, Maria Letícia Duarte Lima, Cíntia Bittar, Beatriz Carvalho de Araújo Oliveira Faria, Paula Rahal, Milena Campelo Freitas de Lima, Valdir Florêncio da Veiga Junior, Graziella Anselmo Joanitti, Marilia Freitas Calm
PLOS ONE.2023; 18(9): e0283817. CrossRef
Epidemiological evidence of acute transmission of Zika virus infection in dengue suspected patients in Sri-Lanka
Mya Myat Ngwe Tun, Sandra Kendra Raini, Lakkumar Fernando, YINS Gunawardene, Shingo Inoue, Yuki Takamatsu, Takeshi Urano, Rohitha Muthugala, Menaka Hapugoda, Kouichi Morita
Journal of Infection and Public Health.2023; 16(9): 1435. CrossRef
The Drosophila melanogaster prophenoloxidase system participates in immunity against Zika virus infection
Ghada Tafesh‐Edwards, Ioannis Eleftherianos
European Journal of Immunology.2023;[Epub] CrossRef
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Hannah Maus, Andrea Gellert, Olivia R. Englert, Jia-Xuan Chen, Tanja Schirmeister, Fabian Barthels
RSC Medicinal Chemistry.2023; 14(11): 2365. CrossRef
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Md Ashraf-Uz-Zaman, Xin Li, Yuan Yao, Chandra Bhushan Mishra, Bala Krishna Moku, Yongcheng Song
Journal of Medicinal Chemistry.2023; 66(15): 10746. CrossRef
Reprogramming of red blood cell metabolism in Zika virus–infected donors
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Transfusion.2022; 62(5): 1045. CrossRef
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Yanchao Xiong, Fei Cheng, Junyi Zhang, Haixia Su, Hangchen Hu, Yi Zou, Minjun Li, Yechun Xu
Bioorganic Chemistry.2022; 128: 106109. CrossRef
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Shenyou Nie, Yuan Yao, Fangrui Wu, Xiaowei Wu, Jidong Zhao, Yuanda Hua, Jingyu Wu, Tong Huo, Yi-Lun Lin, Alexander R. Kneubehl, Megan B. Vogt, Josephine Ferreon, Rebecca Rico-Hesse, Yongcheng Song
Journal of Medicinal Chemistry.2021; 64(5): 2777. CrossRef
Zika virus lateral flow assays using reverse transcription-loop-mediated isothermal amplification
Gna Ahn, SeonHyung Lee, Se Hee Lee, Yun Hee Baek, Min-Suk Song, Yang-Hoon Kim, Ji-Young Ahn
RSC Advances.2021; 11(29): 17800. CrossRef
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Emily N. Kirby, Byron Shue, Paul Q. Thomas, Michael R. Beard
Viruses.2021; 13(11): 2157. CrossRef
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Eduardo Evangelista, Antônio Ralph Medeiros-Sousa, Walter Ceretti-Junior, Rafael Oliveira-Christe, Ramon Wilk-da-Silva, Ana Maria Ribeiro de Castro Duarte, Daniel Pagotto Vendrami, Gabriela Cristina de Carvalho, Luis Filipe Mucci, Mauro Toledo Marrelli
Acta Tropica.2021; 221: 106009. CrossRef
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Molecules.2020; 25(10): 2316. CrossRef
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Sang-Im Yun, Byung-Hak Song, Michael E. Woolley, Jordan C. Frank, Justin G. Julander, Young-Min Lee
Viruses.2020; 12(5): 572. CrossRef
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Natalie Rutkowski, Yuemei Dong, George Dimopoulos
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Rosa C. Coldbeck-Shackley, Nicholas S. Eyre, Michael R. Beard
Vaccines.2020; 8(3): 530. CrossRef
Detection of Zika and dengue viruses in wild-caught mosquitoes collected during field surveillance in an environmental protection area in São Paulo, Brazil
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PLOS ONE.2020; 15(10): e0227239. CrossRef
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Denise Rampini, Diego Campos Prieto, Ana Luisa Colzi, Renan Vinícius de Araújo, Jeanine Giarolla
Mini-Reviews in Medicinal Chemistry.2020; 20(18): 1917. CrossRef
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Virus Research.2020; 284: 197986. CrossRef
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Frontiers of Medicine.2020; 14(2): 160. CrossRef
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Archives of Virology.2020; 165(8): 1863. CrossRef
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Archives of Virology.2019; 164(12): 3027. CrossRef
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Journal of the American Chemical Society.2019; 141(17): 6832. CrossRef
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Biochemistry.2019; 58(36): 3735. CrossRef
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Wai-Lok Yau, Van Nguyen-Dinh, Elin Larsson, Richard Lindqvist, Anna K. Överby, Richard Lundmark, Julie K. Pfeiffer
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Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?
Marc Desforges, Alain Le Coupanec, Philippe Dubeau, Andréanne Bourgouin, Louise Lajoie, Mathieu Dubé, Pierre J. Talbot
Viruses.2019; 12(1): 14. CrossRef
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Penghui Li, Xianliang Ke, Ting Wang, Zhongyuan Tan, Dan Luo, Yuanjiu Miao, Jianhong Sun, Yuan Zhang, Yan Liu, Qinxue Hu, Fuqiang Xu, Hanzhong Wang, Zhenhua Zheng, Julie K. Pfeiffer
Journal of Virology.2018;[Epub] CrossRef
The Recent Epidemic Spread of Zika Virus Disease
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Uirusu.2018; 68(1): 1. CrossRef
Zika Virus in the Male Reproductive Tract
Liesel Stassen, Charles W. Armitage, David J. Van der Heide, Kenneth W. Beagley, Francesca D. Frentiu
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Maternal immunization with a DNA vaccine candidate elicits specific passive protection against post-natal Zika virus infection in immunocompetent BALB/c mice
Ran Wang, Xianzheng Liao, Dongying Fan, Lei Wang, Ji Song, Kaihao Feng, Mingyuan Li, Peigang Wang, Hui Chen, Jing An
Vaccine.2018; 36(24): 3522. CrossRef
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Ilaria Vicenti, Adele Boccuto, Alessia Giannini, Filippo Dragoni, Francesco Saladini, Maurizio Zazzi
Virus Research.2018; 244: 64. CrossRef
The use of humanized mice for studies of viral pathogenesis and immunity
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Immunization with phage virus-like particles displaying Zika virus potential B-cell epitopes neutralizes Zika virus infection of monkey kidney cells
Rupsa Basu, Lukai Zhai, Alice Contreras, Ebenezer Tumban
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Human Sertoli cells support high levels of Zika virus replication and persistence
Anil Kumar, Juan Jovel, Joaquin Lopez-Orozco, Daniel Limonta, Adriana M. Airo, Shangmei Hou, Iryna Stryapunina, Chad Fibke, Ronald B. Moore, Tom C. Hobman
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Zika virus and autoimmunity. One-step forward
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Autoimmunity Reviews.2017; 16(12): 1237. CrossRef
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Wildriss Viranaicken, Alexia Ndebo, Sandra Bos, Philippe Souque, Gilles Gadea, Chaker El-Kalamouni, Pascale Krejbich-Trotot, Pierre Charneau, Philippe Desprès, Marjolaine Roche
International Journal of Molecular Sciences.2017; 19(1): 38. CrossRef
Differential diagnosis of multiple sclerosis in Latin America
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Brain grants permission of access to Zika virus but denies entry to drugs: a molecular modeling perspective to infiltrate the boundary
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MINIREVIEW] The therapeutic applications of antimicrobial peptides (AMPs): a patent review: Hee-Kyoung Kang , Cheolmin Kim , Chang Ho Seo , Yoonkyung Park; J. Microbiol. 2017;55(1):1-12. Published online December 30, 2016; DOI: https://doi.org/10.1007/s12275-017-6452-1

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Abstract PDF

Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.

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Angela Michela Immacolata Montone, Sara Elsa Aita, Federico Capuano, Angelo Citro, Alessandra Esposito, Alfonso Gallo, Morena Nappa, Enrico Taglioni, Carmela Maria Montone
International Dairy Journal.2025; 160: 106074. CrossRef
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Mahfoozur Rahman, Janhvi Singh, Alhussain Aodah, Majed Alrobaian, Nabil K Alruwaili, Waleed H Almalki, Salem Salman Almujri, Safia Obaidur Rab, Osama A. Madkhali, Ankit Sahoo, Jonathan A Lal
Expert Opinion on Drug Delivery.2025; 22(2): 143. CrossRef
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ACS Infectious Diseases.2025; 11(2): 493. CrossRef
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Current Functional Foods.2025;[Epub] CrossRef
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E3S Web of Conferences.2025; 602: 02004. CrossRef
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International Journal of Molecular Sciences.2025; 26(19): 9701. CrossRef
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Chemical and Pharmaceutical Bulletin.2024; 72(2): 149. CrossRef
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Fish & Shellfish Immunology.2024; 154: 109958. CrossRef
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One Health Outlook.2024;[Epub] CrossRef
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Biomedicines.2024; 12(2): 345. CrossRef
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Aquaculture Reports.2024; 39: 102430. CrossRef
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Antibiotics.2024; 13(9): 794. CrossRef
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Pharmaceutics.2024; 16(7): 860. CrossRef
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Aquaculture.2024; 583: 740592. CrossRef
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Michał Czarnowski, Urszula Wnorowska, Milena Łuckiewicz, Ewelina Dargiewicz, Jakub Spałek, Sławomir Okła, Beata Sawczuk, Paul B. Savage, Robert Bucki, Ewelina Piktel
Pharmaceuticals.2024; 17(12): 1725. CrossRef
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Athira P. P., Anju M. V., Anooja V. V., Archana K., Neelima S., Muhammed Musthafa S., I. S. Bright Singh, Rosamma Philip
Marine Biotechnology.2024; 26(4): 696. CrossRef
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Zijian Hong, Tsz Tin Yu, Muhammad Yasir, Manjulatha Sara, David StC Black, Mark DP Willcox, Rajesh Kuppusamy, Naresh Kumar
ChemistrySelect.2024;[Epub] CrossRef
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Qingping Liang, Zhemin Liu, Ziyu Liang, Changliang Zhu, Dongyu Li, Qing Kong, Haijin Mou
Science of The Total Environment.2024; 927: 172150. CrossRef
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Bioorganic Chemistry.2024; 153: 107939. CrossRef
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Nana Zhou, Tai An, Yuan Zhang, Guomiao Zhao, Chao Wei, Xuemei Shen, Fan Li, Xiaoyan Wang
Protein & Peptide Letters.2024; 31(2): 141. CrossRef
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Francisco ES Lopes, Pedro FN Souza, Daiane MS Brito, Felipe P Mesquita, Raquel C Montenegro, Jackson L Amaral, José HA Filho, Valder N Freire, Rossana A Cordeiro
Future Microbiology.2024; 19(17): 1463. CrossRef
Interaction of designed cationic antimicrobial peptides with the outer membrane of gram-negative bacteria
Shelley He, Charles M. Deber
Scientific Reports.2024;[Epub] CrossRef
Artificial Intelligence-Based Model for Predicting the Minimum Inhibitory Concentration of Antibacterial Peptides Against ESKAPEE Pathogens
Ritesh Sharma, Sameer Shrivastava, Sanjay Kumar Singh, Abhinav Kumar, Amit Kumar Singh, Sonal Saxena
IEEE Journal of Biomedical and Health Informatics.2024; 28(4): 1949. CrossRef
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Tao Han, Linhong Song, Xinxin Niu, Meng Qiu, Yi Wang, Jing Wang, Xiuyan Sun, Jiali Ma, Siqi Hu, Zhichun Feng
Heliyon.2024; 10(9): e30489. CrossRef
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Dilyana Dimitrova, Veronica Nemska, Tsvetelina Foteva, Ivan Iliev, Nelly Georgieva, Dancho Danalev
Pharmaceutics.2024; 16(6): 716. CrossRef
PACAP sequence modifications modulate the peptide antimicrobial activity against bacterial pathogens affecting aquaculture
Laura Rivera Méndez, Tania Rodríguez-Cornejo, Tania Rodríguez-Ramos, Lowia Al-Hussinee, Janet Velázquez, James Hugh Campbell, Yamila Carpio, Mario Pablo Estrada, Brian Dixon
Fish & Shellfish Immunology.2024; 148: 109512. CrossRef
Antimicrobial and immunomodulatory activities of porcine cathelicidin Protegrin-1
Ali Javed, Trishana Oedairadjsingh, Irene S. Ludwig, Thomas M. Wood, Nathaniel I. Martin, Femke Broere, Markus H. Weingarth, Edwin J.A. Veldhuizen
Molecular Immunology.2024; 173: 100. CrossRef
Antimicrobial Peptides: Sources, Expression Systems, and Applications
Mengru Li, Weitao Lu, Yanyan Sun, Chunming Dong
Current Protein & Peptide Science.2023; 24(8): 640. CrossRef
Operative Management of Burns: Traditional Care
David G. Greenhalgh
European Burn Journal.2023; 4(2): 262. CrossRef
Antimicrobial Peptides
Noorul Samsoon Maharifa Haja Mohaideen, S. Vaani, S. Hemalatha
Current Pharmacology Reports.2023; 9(6): 433. CrossRef
Advances in Research on Titanium and Titanium Alloys with Antibacterial Functionality for Medical Use—A Review
Yong Shen, Zhankui Jin, Ming Ling, Zhengming Sun, Min Feng, Cuixiang Xu, Shizhang Liu
Journal of Biomaterials and Tissue Engineering.2023; 13(1): 1. CrossRef
An active domain SA-2 derived from cystatin-SA, and its antifungal activity
Xiaoyun Liu, Xiaowei Huang, Jian Wang, Meina Zhang, Mengyuan Liu, Changlin Zhou, Lingman Ma
Amino Acids.2023; 55(1): 101. CrossRef
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Alexandra Lupu, Luiza Madalina Gradinaru, Vasile Robert Gradinaru, Maria Bercea
Gels.2023; 9(5): 376. CrossRef
Bioactive peptides derived from fermented foods: Preparation and biological activities
Qingyan Guo, Pengfei Chen, Xianggui Chen
Journal of Functional Foods.2023; 101: 105422. CrossRef
Anti-microbial Peptides against Methicillin-resistant Staphylococcus aureus: Promising Therapeutics
Priyanka Sinoliya, Pooran Singh Solanki, Sakshi Piplani, Ravi Ranjan Kumar Niraj, Vinay Sharma
Current Protein & Peptide Science.2023; 24(2): 156. CrossRef
Natural and synthetic peptides in antimicrobial therapy
Karina A. Khlystova, Narine G. Sarkisyan, Natalia N. Kataeva
Russian Journal of Immunology.2023; 26(2): 105. CrossRef
Biomimetic antimicrobial polymers—Design, characterization, antimicrobial, and novel applications
Haruko Takahashi, Iva Sovadinova, Kazuma Yasuhara, Satyavani Vemparala, Gregory A. Caputo, Kenichi Kuroda
WIREs Nanomedicine and Nanobiotechnology.2023;[Epub] CrossRef
Antimicrobial peptides: Structure, mechanism, and modification
Na Chen, Cheng Jiang
European Journal of Medicinal Chemistry.2023; 255: 115377. CrossRef
Repairing the intestinal mucosal barrier of traditional Chinese medicine for ulcerative colitis: a review
Yichen Zong, Jie Meng, Tangyou Mao, Qiang Han, Peng Zhang, Lei Shi
Frontiers in Pharmacology.2023;[Epub] CrossRef
Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides
Xiaofang Luo, Huifang Chen, Yannan Song, Zuodong Qin, Lijian Xu, Nongyue He, Yimin Tan, Wubliker Dessie
European Journal of Pharmaceutical Sciences.2023; 181: 106363. CrossRef
Therapeutic Prospection of Animal Venoms-Derived Antimicrobial Peptides against Infections by Multidrug-Resistant Acinetobacter baumannii: A Systematic Review of Pre-Clinical Studies
William Gustavo Lima, Maria Elena de Lima
Toxins.2023; 15(4): 268. CrossRef
Antimicrobial Efficacy and Prevalence of Microcins: Low Molecular Mass Bacteriocins Produced by Escherichia coli
Farzaneh Mohammadzadeh Rostami, Sharareh Moghim, Saeid Javdan, Bahram Nasr Esfahani
International Journal of Peptide Research and Therapeutics.2023;[Epub] CrossRef
Chiral-engineered supraparticles: Emerging tools for drug delivery
Mahfoozur Rahman, Waleed H. Almalki, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Shehla Nasar Mir Najib Ullah, Md. Abul Barkat, Sarwar Beg
Drug Discovery Today.2023; 28(1): 103420. CrossRef
In Vitro Biological Evaluation and Mechanism of Action of Peptoid Analogue Based on Cationic, Amphipathic Peptide A-12
Lalita Sharma, Gopal Singh Bisht
International Journal of Peptide Research and Therapeutics.2023;[Epub] CrossRef
Recombinant production of human antimicrobial peptide LL- 37 and its secondary structure
Antonín Pavelka, Lukáš Vacek, Adam Norek, Šárka Kobzová, Lubomír Janda
Biologia.2023; 79(1): 263. CrossRef
Synergistic Effect, Improved Cell Selectivity, and Elucidating the Action Mechanism of Antimicrobial Peptide YS12
Suzia Aktar Suchi, Dae Young Lee, Young Kyun Kim, Seong Soo Kang, Tahmina Bilkis, Jin Cheol Yoo
International Journal of Molecular Sciences.2023; 24(17): 13522. CrossRef
Dual-action potential of cationic cryptides against infections and cancers
Amr A.A. Abd El-Aal, Fairen A. Jayakumar, Kavita Reginald
Drug Discovery Today.2023; 28(11): 103764. CrossRef
Natural Amphibian-Derived Host Defense Peptides: Peptide Immunomodulators with Potential Therapeutic Value
Jie Shi, Jing Wu, Guizhu Feng, Hailong Yang, Lixian Mu
Protein & Peptide Letters.2023; 30(7): 562. CrossRef
Self-assembled and Zn(II)-coordinated dipeptide nanoparticles with membrane-rupturing action on bacteria
Shahzad Anwar, Muhammad Babar Khawar, Ali Afzal, Muhammad Ovais, Zhang Xiang
Applied Microbiology and Biotechnology.2023; 107(18): 5775. CrossRef
Therapeutic Peptides for Treatment of Lung Diseases: Infection, Fibrosis, and Cancer
Shujiao Li, Yuying Li, Ying Liu, Yifan Wu, Qiuyu Wang, Lili Jin, Dianbao Zhang
International Journal of Molecular Sciences.2023; 24(10): 8642. CrossRef
The biological role of charge distribution in linear antimicrobial peptides
Harry Morales Duque, Gisele Rodrigues, Lucas Souza Santos, Octávio Luiz Franco
Expert Opinion on Drug Discovery.2023; 18(3): 287. CrossRef
Colitis-Mediated Dysbiosis of the Intestinal Flora and Impaired Vitamin A Absorption Reduce Ovarian Function in Mice
Ze Li, Chengzhen Chen, Wenjie Yu, Lingxia Xu, Haitao Jia, Chen Wang, Na Pei, Zibin Liu, Dan Luo, Jun Wang, Wenfa Lv, Bao Yuan, Jiabao Zhang, Hao Jiang
Nutrients.2023; 15(11): 2425. CrossRef
Insect Meals and Insect Antimicrobial Peptides as an Alternative for Antibiotics and Growth Promoters in Livestock Production
Ewelina Patyra, Krzysztof Kwiatek
Pathogens.2023; 12(6): 854. CrossRef
Simultaneous control of infection and inflammation with keratin-derived antibacterial peptides targeting TLRs and co-receptors
Yan Sun, Jonathan Chan, Karthikeyan Bose, Connie Tam
Science Translational Medicine.2023;[Epub] CrossRef
Structural Characterization, Functional Profiling, and Mechanism Study of Four Antimicrobial Peptides for Antibacterial and Anticancer Applications
Zihuayuan Yang, Jie Zhang, Fu-Gen Wu, Fengming Lin
Langmuir.2023; 39(6): 2161. CrossRef
Enhancement of hypericin nanoparticle-mediated sonoinduced disruption of biofilm and persister cells of Streptococcus mutans by dermcidin-derived peptide DCD-1L
Maryam Pourhajibagher, Steven Parker, Babak Pourakbari, Nasrin Keshavarz Valian, Reza Raoofian, Abbas Bahador
Photodiagnosis and Photodynamic Therapy.2023; 41: 103308. CrossRef
Biomimetic AgNPs@antimicrobial peptide/silk fibroin coating for infection-trigger antibacterial capability and enhanced osseointegration
Wenhao Zhou, Tian Bai, Lan Wang, Yan Cheng, Dandan Xia, Sen Yu, Yufeng Zheng
Bioactive Materials.2023; 20: 64. CrossRef
Preparation, Purification and Characterization of Antibacterial and ACE Inhibitory Peptides from Head Protein Hydrolysate of Kuruma Shrimp, Marsupenaeus japonicus
Jie Zhou, Qiuyu Han, Tomoyuki Koyama, Shoichiro Ishizaki
Molecules.2023; 28(2): 894. CrossRef
Brevicillin, a novel lanthipeptide from the genusBrevibacilluswith antimicrobial, antifungal, and antiviral activity
Shelley Sardul Singh, Deepika Sharma, Charandeep Singh, Sahil Kumar, Prashant Singh, Anshul Sharma, Deepjyoti Kumar Das, Anil Kumar Pinnaka, Krishan Gopal Thakur, Rajesh P Ringe, Suresh Korpole
Journal of Applied Microbiology.2023;[Epub] CrossRef
Fungicidal activity of human antimicrobial peptides and their synergistic interaction with common antifungals against multidrug-resistant Candida auris
Siham Shaban, Mrudula Patel, Aijaz Ahmad
International Microbiology.2022; 26(2): 165. CrossRef
Aptamer Decorated Emodin Nanoparticles-Assisted Delivery of Dermcidin-Derived Peptide DCD-1L: Photoactive Bio-Theragnostic Agent for Enterococcus Faecalis Biofilm Destruction
Maryam Pourhajibagher, Abbas Bahador
SSRN Electronic Journal .2022;[Epub] CrossRef
Aptamer decorated emodin nanoparticles-assisted delivery of dermcidin-derived peptide DCD-1L: Photoactive bio-theragnostic agent for Enterococcus faecalis biofilm destruction
Maryam Pourhajibagher, Abbas Bahador
Photodiagnosis and Photodynamic Therapy.2022; 39: 103020. CrossRef
Production of Antimicrobial Peptides (Cathelicidin Analogues) and Evaluation of Their Biological Properties
V. A. Gasanov, E. A. Vorotelyak, A. V. Vasiliev
Biology Bulletin.2022; 49(S2): S148. CrossRef
Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
Jayaseelan Murugaiyan, P. Anand Kumar, G. Srinivasa Rao, Katia Iskandar, Stephen Hawser, John P. Hays, Yara Mohsen, Saranya Adukkadukkam, Wireko Andrew Awuah, Ruiz Alvarez Maria Jose, Nanono Sylvia, Esther Patience Nansubuga, Bruno Tilocca, Paola Roncada,
Antibiotics.2022; 11(2): 200. CrossRef
Strategies for improving antimicrobial peptide production
Soumya Deo, Kristi L. Turton, Tajinder Kainth, Ayush Kumar, Hans-Joachim Wieden
Biotechnology Advances.2022; 59: 107968. CrossRef
Riemerella anatipestifer T9SS Effector SspA Functions in Bacterial Virulence and Defending Natural Host Immunity
Zongchao Chen, Pengfei Niu, Xiaomei Ren, Wenlong Han, Ruyu Shen, Min Zhu, Yang Yu, Chan Ding, Shengqing Yu, Martha Vives
Applied and Environmental Microbiology.2022;[Epub] CrossRef
Antibacterial and Antibiofilm Activities of Novel Cyclic Peptides against Methicillin-Resistant Staphylococcus aureus
Guoxing Wei, Yun He
International Journal of Molecular Sciences.2022; 23(14): 8029. CrossRef
Effect of Flagellin Pre-Exposure on the Inflammatory and Antifungal Response of Bronchial Epithelial Cells to Fungal Pathogens
Jeanne Bigot, Manon Ruffin, Juliette Guitard, Sandra Vellaissamy, Sophie Thorez, Harriet Corvol, Loïc Guillot, Viviane Balloy, Christophe Hennequin
Journal of Fungi.2022; 8(12): 1268. CrossRef
Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice
Jaeyeong Park, Eunkyoung Shin, Ji-Hyun Yeom, Younkyung Choi, Minju Joo, Minho Lee, Je Hyeong Kim, Jeehyeon Bae, Kangseok Lee
Journal of Microbiology.2022; 60(1): 128. CrossRef
Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds
Mine Erdem Büyükkiraz, Zülal Kesmen
Journal of Applied Microbiology.2022; 132(3): 1573. CrossRef
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Gianluca Bossù, Riccardo Di Sario, Edoardo Muratore, Davide Leardini, Andrea Pession, Susanna Esposito, Riccardo Masetti
Antibiotics.2022; 11(10): 1316. CrossRef
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Zihao Song, Yue Yu, Xinpeng Bai, Yiguo Jia, Jiayi Tian, Kui Gu, Mengyu Zhao, Changyu Zhou, Xiangyu Zhang, Hongning Wang, Yizhi Tang, Sandeep Tamber
Microbiology Spectrum.2022;[Epub] CrossRef
Role of lipopolysaccharide in antimicrobial and cell penetrating peptide membrane interactions probed by deuterium NMR of whole cells
Sarika Kumari, Michael R. Morrow, Valerie Booth
BBA Advances.2022; 2: 100057. CrossRef
Multidrug-Resistant Microbial Therapy Using Antimicrobial Peptides and the CRISPR/Cas9 System
Yared Abate Getahun, Destaw Asfaw Ali, Bihonegn Wodajnew Taye, Yismaw Alemie Alemayehu
Veterinary Medicine: Research and Reports.2022; Volume 13: 173. CrossRef
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Cristina García-Mouton, Elisa Parra-Ortiz, Martin Malmsten, Antonio Cruz, Jesús Pérez-Gil
European Journal of Pharmaceutics and Biopharmaceutics.2022; 180: 33. CrossRef
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Xiu Li, Yu Jiang, Ying Lin
Journal of Biotechnology.2022; 347: 49. CrossRef
Review and perspective on bioactive peptides: A roadmap for research, development, and future opportunities
Zhenjiao Du, Yonghui Li
Journal of Agriculture and Food Research.2022; 9: 100353. CrossRef
Human Antimicrobial Peptide Triggered Colloidal Transformations in Bacteria Membrane Lipopolysaccharides
Linda Hong, Mark Gontsarik, Heinz Amenitsch, Stefan Salentinig
Small.2022;[Epub] CrossRef
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Michelle Häring, Valerie Amann, Ann-Kathrin Kissmann, Tilmann Herberger, Christopher Synatschke, Nicole Kirsch-Pietz, Julio A. Perez-Erviti, Anselmo J. Otero-Gonzalez, Fidel Morales-Vicente, Jakob Andersson, Tanja Weil, Steffen Stenger, Armando Rodríguez,
Pharmaceutics.2022; 14(7): 1332. CrossRef
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Carolina Nunes da Silva, Lays Fernanda Nunes Dourado, Luciana Maria Silva, Aline Brito de Lima, Maria Elena de Lima, Armando Silva-Cunha, Silvia Ligório Fialho
International Journal of Peptide Research and Therapeutics.2022;[Epub] CrossRef
Effect of a monovalent salt on the energetics of an antimicrobial-peptide: micelle dissociation
Suvankar Ghosh, Sunanda Chatterjee, Priyadarshi Satpati
Physical Chemistry Chemical Physics.2022; 24(38): 23669. CrossRef
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Rosa Bellavita, Elisabetta Buommino, Bruno Casciaro, Francesco Merlino, Floriana Cappiello, Noemi Marigliano, Anella Saviano, Francesco Maione, Rosaria Santangelo, Maria Luisa Mangoni, Stefania Galdiero, Paolo Grieco, Annarita Falanga
Antibiotics.2022; 11(10): 1285. CrossRef
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Suvankar Ghosh, Sunanda Chatterjee, Priyadarshi Satpati
The Journal of Physical Chemistry B.2022; 126(28): 5262. CrossRef
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Hiba Alaoui Mdarhri, Rachid Benmessaoud, Houda Yacoubi, Lina Seffar, Houda Guennouni Assimi, Mouhsine Hamam, Rihabe Boussettine, Najoie Filali-Ansari, Fatima Azzahra Lahlou, Idrissa Diawara, Moulay Mustapha Ennaji, Mohamed Kettani-Halabi
Antibiotics.2022; 11(12): 1826. CrossRef
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Masoud Keikha, Hossein Kamali, Kiarash Ghazvini, Mohsen Karbalaei
VirusDisease.2022; 33(4): 445. CrossRef
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Lynn M. Pezzanite, Lyndah Chow, Alyssa Strumpf, Valerie Johnson, Steven W. Dow
Veterinary Sciences.2022; 9(11): 610. CrossRef
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Yeojin Hong, Gi Yong Lee, Soo-Jin Yang, Hyun Soon Lillehoj, Yeong Ho Hong
Korean Journal of Poultry Science.2022; 49(2): 69. CrossRef
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Chih-Lung Wu, Ya-Han Chih, Hsin-Ying Hsieh, Kuang-Li Peng, Yi-Zong Lee, Bak-Sau Yip, Shih-Che Sue, Jya-Wei Cheng
Biomedicines.2022; 10(6): 1351. CrossRef
The antimicrobial peptides LL-37, KR-20, FK-13 and KR-12 inhibit the growth of a sensitive and a metronidazole-resistant strain of Trichomonas vaginalis
María G. Ramírez-Ledesma, Mayra C. Rodríguez, Nayeli Alva-Murillo, Eva E. Avila
Parasitology Research.2022; 121(12): 3503. CrossRef
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Milad Chizari, Sadjad Khosravimelal, Hamid Tebyaniyan, Mehrdad Moosazadeh Moghaddam, Mazaher Gholipourmalekabadi
International Journal of Peptide Research and Therapeutics.2022;[Epub] CrossRef
Interaction of a short antimicrobial peptide on charged lipid bilayer: A case study on aurein 1.2 peptide
Shuo Qian, Piotr A. Zolnierczuk
BBA Advances.2022; 2: 100045. CrossRef
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Jia An, Yuqing Liu, Yiqi Wang, Ru Fan, Xiaorong Hu, Fen Zhang, Jinhua Yang, Junwei Chen
Frontiers in Immunology.2022;[Epub] CrossRef
Effect of C‐terminal and N‐terminal dimerization and alanine scanning on antibacterial activity of the analogs of the peptide p‐BthTX‐I
Norival Alves Santos‐Filho, Gabriela Marinho Righetto, Marina Rodrigues Pereira, Julia Pinto Piccoli, Larissa Mathias Teizen Almeida, Thainá Cristina Leal, Ilana Lopes Baratella Cunha Camargo, Eduardo Maffud Cilli
Peptide Science.2022;[Epub] CrossRef
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Laura Medina, Fanny Guzmán, Claudio Álvarez, Jean Paul Delgado, Belfran Carbonell-M
Pharmaceutics.2022; 14(12): 2579. CrossRef
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Luisa Zupin, Carlos André dos Santos-Silva, Aya R. Hamad Al Mughrbi, Livia Maria Batista Vilela, Ana Maria Benko-Iseppon, Sergio Crovella
Microorganisms.2022; 10(8): 1591. CrossRef
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Sarika Kumari, Valerie Booth
International Journal of Molecular Sciences.2022; 23(5): 2740. CrossRef
In silico screening and characterization of novel natural peptides as spike protein inhibitors of novel coronavirus (severe acute respiratory syndrome coronavirus 2)
Raghunath Satpathy, Namrata Dash
Journal of Preventive, Diagnostic and Treatment Strategies in Medicine.2022; 1(1): 54. CrossRef
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Lucia Falcigno, Gabriella D’Auria, Gianna Palmieri, Marta Gogliettino, Bruna Agrillo, Rosarita Tatè, Principia Dardano, Luigi Nicolais, Marco Balestrieri
International Journal of Molecular Sciences.2021; 22(18): 10011. CrossRef
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I.M. Assane, N.A. Santos‐Filho, E.L. Sousa, M.C.O. Arruda Brasil, E.M. Cilli, F. Pilarski
Journal of Applied Microbiology.2021; 131(4): 1762. CrossRef
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Huiru Zhang, Zhihao Xu, Ying Mao, Yingjie Zhang, Yan Li, Jihong Lao, Lu Wang
Polymers.2021; 13(22): 3942. CrossRef
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Rui Li, Tongtong Chen, Xiangliang Pan
ACS Nano.2021; 15(3): 3808. CrossRef
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Tsz Tin Yu, Rajesh Kuppusamy, Muhammad Yasir, Md. Musfizur Hassan, Manjulatha Sara, Junming Ho, Mark D. P. Willcox, David StC. Black, Naresh Kumar
International Journal of Molecular Sciences.2021; 22(14): 7344. CrossRef
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Qi-Wen Cen, Zheng-Yun Wang, Zhen-Xing Tang, Yu Zhang, Tao Chen, Da-Wei Xue, Ming-Feng Xu, Xue-Lian Bai, Ting Zhou, Lu-E Shi
LWT.2021; 148: 111785. CrossRef
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Ritesh Sharma, Sameer Shrivastava, Sanjay Kumar Singh, Abhinav Kumar, Sonal Saxena, Raj Kumar Singh
Briefings in Bioinformatics.2021;[Epub] CrossRef
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Daniel B. Lowy, Preet G. S. Makker, Gila Moalem-Taylor
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Oriana Simonetti, Giulio Rizzetto, Giulia Radi, Elisa Molinelli, Oscar Cirioni, Andrea Giacometti, Annamaria Offidani
Antibiotics.2021; 10(11): 1377. CrossRef
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Qi-Yu Zhang, Zhi-Bin Yan, Yue-Ming Meng, Xiang-Yu Hong, Gang Shao, Jun-Jie Ma, Xu-Rui Cheng, Jun Liu, Jian Kang, Cai-Yun Fu
Military Medical Research.2021;[Epub] CrossRef
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Markus Muttenthaler, Glenn F. King, David J. Adams, Paul F. Alewood
Nature Reviews Drug Discovery.2021; 20(4): 309. CrossRef
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Zi Lin, Yao Luo, Pengfei Liu, Yanjun Li, Jun Yue, Lelun Jiang
Colloids and Surfaces B: Biointerfaces.2021; 204: 111831. CrossRef
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Armando A. Rodríguez, Anselmo Otero-González, Maretchia Ghattas, Ludger Ständker
Biomedicines.2021; 9(10): 1381. CrossRef
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Ruijiao Jiang, Pengfei Zhang, Xulong Wu, Yin Wang, Tayyab Rehman, Xueping Yao, Yan Luo, Zexiao Yang
Electronic Journal of Biotechnology.2021; 50: 16. CrossRef
Structure–activity relationship study of amphipathic antimicrobial peptides using helix‐destabilizing sarcosine
Hidetomo Yokoo, Motoharu Hirano, Nobumichi Ohoka, Takashi Misawa, Yosuke Demizu
Journal of Peptide Science.2021;[Epub] CrossRef
The barrier beyond the skin
Elisa MOLITERNI, Giovanni PAOLINO, Antonio G. RICHETTA, Sara GRASSI, Stefano CALVIERI
Italian Journal of Dermatology and Venereology.2021;[Epub] CrossRef
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Frontiers in Microbiology.2021;[Epub] CrossRef
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V.R. Sperotto, L.B. Denardi, C. Weiblen, F.P.K. de Jesus, M.R. Dorneles, L.B. Ianiski, J.M. Santurio
Journal of Dairy Science.2021; 104(3): 3554. CrossRef
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K. L. Dhanya Lenin, Rajeswary Vasu Iyer, Athira Raveendran, M. V. Anju, Rosamma Philip, Swapna P. Antony
Molecular Biology Reports.2021; 48(5): 4943. CrossRef
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Emilia Galdiero, Maria Michela Salvatore, Angela Maione, Federica Carraturo, Stefania Galdiero, Annarita Falanga, Anna Andolfi, Francesco Salvatore, Marco Guida
Pathogens.2021; 10(2): 214. CrossRef
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Annarita Falanga, Valentina Del Genio, Stefania Galdiero
Pharmaceutics.2021; 13(1): 101. CrossRef
Antimicrobial peptides and their application in food packaging
Yaowen Liu, Dur E. Sameen, Saeed Ahmed, Jianwu Dai, Wen Qin
Trends in Food Science & Technology.2021; 112: 471. CrossRef
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Tomasz Róg, Mykhailo Girych, Alex Bunker
Pharmaceuticals.2021; 14(10): 1062. CrossRef
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Fernando Cuevas, Carlos J. Saavedra, Ivan Romero‐Estudillo, Alicia Boto, Mario Ordóñez, Irene Vergara
European Journal of Organic Chemistry.2021; 2021(6): 933. CrossRef
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Stella Cascioferro, Daniela Carbone, Barbara Parrino, Camilla Pecoraro, Elisa Giovannetti, Girolamo Cirrincione, Patrizia Diana
ChemMedChem.2021; 16(1): 65. CrossRef
Uncoupling Amphipathicity and Hydrophobicity: Role of Charge Clustering in Membrane Interactions of Cationic Antimicrobial Peptides
Shelley He, Tracy A. Stone, Charles M. Deber
Biochemistry.2021; 60(34): 2586. CrossRef
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Omkar Singh, Debashree Chakraborty
Journal of Molecular Liquids.2021; 344: 117789. CrossRef
Synthesis and Antibacterial Activity of Cationic Amino Acid-Conjugated Dendrimers Loaded with a Mixture of Two Triterpenoid Acids
Anna Maria Schito, Gian Carlo Schito, Silvana Alfei
Polymers.2021; 13(4): 521. CrossRef
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Ziyan Tang, Quantao Ma, Xiaoling Chen, Tianbao Chen, Yuan Ying, Xinping Xi, Lei Wang, Chengbang Ma, Chris Shaw, Mei Zhou
Antibiotics.2021; 10(8): 990. CrossRef
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Minkyung Ryu, Jaeyeong Park, Ji-Hyun Yeom, Minju Joo, Kangseok Lee
Journal of Microbiology.2021; 59(2): 113. CrossRef
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Pasquale Marrazzo, Valeria Pizzuti, Silvia Zia, Azzurra Sargenti, Daniele Gazzola, Barbara Roda, Laura Bonsi, Francesco Alviano
Antibiotics.2021; 10(7): 750. CrossRef
Chiral self-assembly of peptides: Toward the design of supramolecular polymers with enhanced chemical and biological functions
Yuhe Shen, Yuefei Wang, Ian W. Hamley, Wei Qi, Rongxin Su, Zhimin He
Progress in Polymer Science.2021; 123: 101469. CrossRef
Amphiphilic polymer therapeutics: an alternative platform in the fight against antibiotic resistant bacteria
Haruko Takahashi, Gregory A. Caputo, Kenichi Kuroda
Biomaterials Science.2021; 9(8): 2758. CrossRef
Self-Assembly Pathways and Antimicrobial Properties of Lysozyme in Different Aggregation States
Nico Kummer, Tingting Wu, Kevin J. De France, Flavia Zuber, Qun Ren, Peter Fischer, Silvia Campioni, Gustav Nyström
Biomacromolecules.2021; 22(10): 4327. CrossRef
Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G
Morgan A. Hitchner, Matthew R. Necelis, Devanie Shirley, Gregory A. Caputo
Probiotics and Antimicrobial Proteins.2021; 13(2): 527. CrossRef
Apoptosis-induction effect of ε-poly-lysine against Staphylococcus aureus and its application on pasteurized milk
Hou-Qi Ning, Ying-Qiu Li, Hong Lin, Jing-Xue Wang
LWT.2021; 137: 110493. CrossRef
Marine Invertebrate Peptides: Antimicrobial Peptides
Ran Wu, Jiri Patocka, Eugenie Nepovimova, Patrik Oleksak, Martin Valis, Wenda Wu, Kamil Kuca
Frontiers in Microbiology.2021;[Epub] CrossRef
Generation of antimicrobial peptides Leg1 and Leg2 from chickpea storage protein, active against food spoilage bacteria and foodborne pathogens
Marie-Louise Heymich, Ulrike Friedlein, Marius Trollmann, Karin Schwaiger, Rainer A. Böckmann, Monika Pischetsrieder
Food Chemistry.2021; 347: 128917. CrossRef
Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis
Praveen Kumar Jadi, Prerana Sharma, Bharathi Bhogapurapu, Sanhita Roy
Frontiers in Chemistry.2021;[Epub] CrossRef
His-Rich Peptides, Gly- and His-Rich Peptides: Functionally Versatile Compounds with Potential Multi-Purpose Applications
Luiz G. P. Nunes, Thais Reichert, M. Teresa Machini
International Journal of Peptide Research and Therapeutics.2021; 27(4): 2945. CrossRef
Effect of monovalent salt concentration and peptide secondary structure in peptide-micelle binding
Suvankar Ghosh, Gopal Pandit, Swapna Debnath, Sunanda Chatterjee, Priyadarshi Satpati
RSC Advances.2021; 11(58): 36836. CrossRef
Polyalanine peptide variations may have different mechanisms of action against multidrug-resistant bacterial pathogens
Mário R Felício, Gislaine G O S Silveira, Karen G N Oshiro, Beatriz T Meneguetti, Octávio L Franco, Nuno C Santos, Sónia Gonçalves
Journal of Antimicrobial Chemotherapy.2021; 76(5): 1174. CrossRef
Challenge in the Discovery of New Drugs: Antimicrobial Peptides against WHO-List of Critical and High-Priority Bacteria
Cesar Augusto Roque-Borda, Patricia Bento da Silva, Mosar Corrêa Rodrigues, Ricardo Bentes Azevedo, Leonardo Di Filippo, Jonatas L. Duarte, Marlus Chorilli, Eduardo Festozo Vicente, Fernando Rogério Pavan
Pharmaceutics.2021; 13(6): 773. CrossRef
Natural and Synthetic Halogenated Amino Acids—Structural and Bioactive Features in Antimicrobial Peptides and Peptidomimetics
Mario Mardirossian, Marina Rubini, Mauro F. A. Adamo, Marco Scocchi, Michele Saviano, Alessandro Tossi, Renato Gennaro, Andrea Caporale
Molecules.2021; 26(23): 7401. CrossRef
Alleviation of DSS-induced colitisvia Lactobacillus acidophilustreatment in mice
Woon-Ki Kim, Dae Hee Han, You Jin Jang, SungJun Park, Sung Jae Jang, Giljae Lee, Hyuk Seung Han, GwangPyo Ko
Food & Function.2021; 12(1): 340. CrossRef
Antibacterial activity of antimicrobial peptide-conjugated nanofibrous membranes
Günnur Onak, Utku Kürşat Ercan, Ozan Karaman
Biomedical Materials.2021; 16(1): 015020. CrossRef
Stability and Activity of the Antimicrobial Peptide Leg1 in Solution and on Meat and Its Optimized Generation from Chickpea Storage Protein
Marie-Louise Heymich, Showmika Srirangan, Monika Pischetsrieder
Foods.2021; 10(6): 1192. CrossRef
Is it time to reconsider prophylactic antimicrobial use for hematopoietic stem cell transplantation? a narrative review of antimicrobials in stem cell transplantation
Dilshad Jahan, Ed Peile, Md Arif Sheikh, Salequl Islam, Sharlene Parasnath, Paras Sharma, Katia Iskandar, Sameer Dhingra, Jaykaran Charan, Timothy Craig Hardcastle, Nandeeta Samad, Tajkera Sultana Chowdhury, Siddhartha Dutta, Mainul Haque
Expert Review of Anti-infective Therapy.2021; 19(10): 1259. CrossRef
Identifying the Potential Therapeutic Targets for Atopic Dermatitis Through the Immune Infiltration Analysis and Construction of a ceRNA Network
Shixiong Peng, Mengjiao Chen, Ming Yin, Hao Feng
Clinical, Cosmetic and Investigational Dermatology.2021; Volume 14: 437. CrossRef
A novel apidaecin Api-PR19 synergizes with the gut microbial community to maintain intestinal health and promote growth performance of broilers
Shengru Wu, Jian Wang, Liqin Zhu, Hao Ren, Xiaojun Yang
Journal of Animal Science and Biotechnology.2020;[Epub] CrossRef
Dietary effects of antimicrobial peptides in therapeutics
Olalekan Olanrewaju Bakare, Adewale Oluwaseun Fadaka, Ashwil Klein, Ashley Pretorius
All Life.2020; 13(1): 78. CrossRef
Characterization, Cytotoxic Analysis and Action Mechanism of Antilisterial Bacteriocin Produced by Lactobacillus plantarum Isolated from Cheddar Cheese
Fariha Ibrahim, Nadir Naveed Siddiqui, Afsheen Aman, Shah Ali Ul Qader, Asma Ansari
International Journal of Peptide Research and Therapeutics.2020; 26(4): 1751. CrossRef
Positively Charged Polymers as Promising Devices against Multidrug Resistant Gram-Negative Bacteria: A Review
Silvana Alfei, Anna Maria Schito
Polymers.2020; 12(5): 1195. CrossRef
Effects of Peptide Thanatin on the Growth and Transcriptome of Penicillium digitatum
Guirong Feng, Xindan Li, Wenjun Wang, Lili Deng, Kaifang Zeng
Frontiers in Microbiology.2020;[Epub] CrossRef
A novel in silico antimicrobial peptide DP7 combats MDR Pseudomonas aeruginosa and related biofilm infections
Qi Yin, Siwen Wu, Lei Wu, Zhenling Wang, Yandong Mu, Rui Zhang, Chunyan Dong, Bailing Zhou, Binyan Zhao, Jiajun Zheng, Ying Sun, Xingjun Cheng, Li Yang
Journal of Antimicrobial Chemotherapy.2020; 75(11): 3248. CrossRef
β-defensins and the inflammatory periodontal diseases: a systematic review
E. A. Tikhomirova, E. S. Slazhneva, V. G. Atrushkevich
Parodontologiya.2020; 25(4): 276. CrossRef
Strategies to Combat Multidrug-Resistant and Persistent Infectious Diseases
Olga Pacios, Lucia Blasco, Inès Bleriot, Laura Fernandez-Garcia, Mónica González Bardanca, Antón Ambroa, María López, German Bou, Maria Tomás
Antibiotics.2020; 9(2): 65. CrossRef
Ultra-Short Antimicrobial Peptoids Show Propensity for Membrane Activity Against Multi-Drug Resistant Mycobacterium tuberculosis
Jasmeet Singh Khara, Biljana Mojsoska, Devika Mukherjee, Paul R. Langford, Brian D. Robertson, Håvard Jenssen, Pui Lai Rachel Ee, Sandra M. Newton
Frontiers in Microbiology.2020;[Epub] CrossRef
Scorpion-Venom-Derived Antimicrobial Peptide Css54 Exerts Potent Antimicrobial Activity by Disrupting Bacterial Membrane of Zoonotic Bacteria
Jonggwan Park, Jun Hee Oh, Hee Kyoung Kang, Moon-Chang Choi, Chang Ho Seo, Yoonkyung Park
Antibiotics.2020; 9(11): 831. CrossRef
Cationic amphipathic peptide analogs of cathelicidin LL‐37 as a probe in the development of antimicrobial/anticancer agents
Athanasios Tzitzilis, Anastasia Boura‐Theodorou, Vassilios Michail, Stylianos Papadopoulos, Dimitrios Krikorian, Marilena E. Lekka, Anna‐Irini Koukkou, Maria Sakarellos‐Daitsiotis, Eugenia Panou‐Pomonis
Journal of Peptide Science.2020;[Epub] CrossRef
Antimicrobial Peptides from Rat-Tailed Maggots of the Drone Fly Eristalis tenax Show Potent Activity against Multidrug-Resistant Gram-Negative Bacteria
Rolf Hirsch, Jochen Wiesner, Armin Bauer, Alexander Marker, Heiko Vogel, Peter Eugen Hammann, Andreas Vilcinskas
Microorganisms.2020; 8(5): 626. CrossRef
The protective and pathogenic roles of CXCL17 in human health and disease: Potential in respiratory medicine
José Alberto Choreño-Parra, Shyamala Thirunavukkarasu, Joaquín Zúñiga, Shabaana A. Khader
Cytokine & Growth Factor Reviews.2020; 53: 53. CrossRef
The global preclinical antibacterial pipeline
Ursula Theuretzbacher, Kevin Outterson, Aleks Engel, Anders Karlén
Nature Reviews Microbiology.2020; 18(5): 275. CrossRef
Combating Implant Infections: Shifting Focus from Bacteria to Host
Saber Amin Yavari, Suzanne M. Castenmiller, Jos A. G. van Strijp, Michiel Croes
Advanced Materials.2020;[Epub] CrossRef
Identification of two carcinin isoforms (MnCarc1 and MnCarc2) and their function in the antimicrobial immunity of Macrobrachium nipponense
Xiaoling Dai, Kaiqiang Wang, Ruidong Zhang, Chao Zhang, Xueying Cao, Xin Huang, Yufei Zhang, Qian Ren
Fish & Shellfish Immunology.2020; 106: 205. CrossRef
Antimicrobial Peptides: a New Frontier in Antifungal Therapy
Giuseppe Buda De Cesare, Shane A. Cristy, Danielle A. Garsin, Michael C. Lorenz, J. Andrew Alspaugh
mBio.2020;[Epub] CrossRef
Lactoferrin Functionalized Biomaterials: Tools for Prevention of Implant-Associated Infections
Emoke Pall, Alexandra Roman
Antibiotics.2020; 9(8): 522. CrossRef
Immunopathogenesis of COVID-19 and early immunomodulators
Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang
Clinical and Experimental Pediatrics.2020; 63(7): 239. CrossRef
Analysis of mutations of defensin protein using accelerated molecular dynamics simulations
Bharati Pandey, Chetna Tyagi, Gopal Kumar Prajapati, Awdhesh Kumar Mishra, Abeer Hashem, Abdulaziz A. Alqarawi, Elsayed Fathi Abd_Allah, Tapan Kumar Mohanta, Ayyalusamy Ramamoorthy
PLOS ONE.2020; 15(11): e0241679. CrossRef
Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus
Jeanne Bigot, Loïc Guillot, Juliette Guitard, Manon Ruffin, Harriet Corvol, Viviane Balloy, Christophe Hennequin
Frontiers in Immunology.2020;[Epub] CrossRef
Neutrophil Extracellular Traps in Periodontitis
Antonio Magán-Fernández, Sarmad Muayad Rasheed Al-Bakri, Francisco O’Valle, Cristina Benavides-Reyes, Francisco Abadía-Molina, Francisco Mesa
Cells.2020; 9(6): 1494. CrossRef
Salmonid Antibacterial Immunity: An Aquaculture Perspective
Shawna L. Semple, Brian Dixon
Biology.2020; 9(10): 331. CrossRef
Polymeric and inorganic nanoscopical antimicrobial fillers in dentistry
Pooyan Makvandi, Jun Ting Gu, Ehsan Nazarzadeh Zare, Behnaz Ashtari, Arash Moeini, Franklin R. Tay, Li-na Niu
Acta Biomaterialia.2020; 101: 69. CrossRef
Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review
András Fodor, Birhan Addisie Abate, Péter Deák, László Fodor, Ervin Gyenge, Michael G. Klein, Zsuzsanna Koncz, Josephat Muvevi, László Ötvös, Gyöngyi Székely, Dávid Vozik, László Makrai
Pathogens.2020; 9(7): 522. CrossRef
Assessing the effectiveness of AS-48 in experimental mice models of Chagas’ disease
Rubén Martín-Escolano, Rubén Cebrián, Mercedes Maqueda, Desirée Romero, Maria José Rosales, Manuel Sánchez-Moreno, Clotilde Marín
Journal of Antimicrobial Chemotherapy.2020; 75(6): 1537. CrossRef
Nanostructured antimicrobial peptides: The last push towards clinics
Jose Vicente Carratalá, Naroa Serna, Antonio Villaverde, Esther Vázquez, Neus Ferrer-Miralles
Biotechnology Advances.2020; 44: 107603. CrossRef
Functional peptide-based drug delivery systems
Zheng Lian, Tianjiao Ji
Journal of Materials Chemistry B.2020; 8(31): 6517. CrossRef
Gel Chromatographic Fractionation of Metabolic Complexes of L. rhamnosus GG and S. boulardii and their Antimicrobial Activity
O. Isaуenko, E. Babych , T. Gorbach, O. Semenchenko, O. Kotsar
Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2020; 5(4): 240. CrossRef
Antibacterial Activity of Non-Cytotoxic, Amino Acid-Modified Polycationic Dendrimers against Pseudomonas aeruginosa and Other Non-Fermenting Gram-Negative Bacteria
Anna Maria Schito, Silvana Alfei
Polymers.2020; 12(8): 1818. CrossRef
Antimicrobial activity of Ib-M peptides against Escherichia coli O157: H7
Sergio Prada-Prada, Johanna Flórez-Castillo, Ana Farfán-García, Fanny Guzmán, Indira Hernández-Peñaranda, Iddya Karunasagar
PLOS ONE.2020; 15(2): e0229019. CrossRef
Antimicrobial Peptides: An Approach to Combat Resilient Infections
Debaprasad Parai, Pia Dey, Samir K. Mukherjee
Current Drug Discovery Technologies.2020; 17(4): 542. CrossRef
Proof of concept: could snake venoms be a potential source of bioactive compounds for control of mould growth and mycotoxin production
C. Verheecke‐Vaessen, J. Monte, E. Garcia‐Cela, N. Magan, A. Medina
Letters in Applied Microbiology.2020; 71(5): 459. CrossRef
Application of Biophysical Techniques to Investigate the Interaction of Antimicrobial Peptides With Bacterial Cells
Maria Luisa Gelmi, Luca Domenico D'Andrea, Alessandra Romanelli
Frontiers in Medical Technology.2020;[Epub] CrossRef
Crotamine and crotalicidin, membrane active peptides from Crotalus durissus terrificus rattlesnake venom, and their structurally-minimized fragments for applications in medicine and biotechnology
Claudio Borges Falcao, Gandhi Radis-Baptista
Peptides.2020; 126: 170234. CrossRef
Protecting the outside: biological tools to manipulate the skin microbiota
Julie N O'Sullivan, Mary C Rea, Colin Hill, R Paul Ross
FEMS Microbiology Ecology.2020;[Epub] CrossRef
Therapeutic potential of a designed CSαβ peptide ID13 in Staphylococcus aureus-induced endometritis of mice
Bing Li, Na Yang, Yuxue Shan, Xiumin Wang, Ya Hao, Ruoyu Mao, Da Teng, Huan Fan, Jianhua Wang
Applied Microbiology and Biotechnology.2020; 104(15): 6693. CrossRef
Ark shell protein‐derived bioactive peptides promote osteoblastic differentiation through upregulation of the canonical Wnt/β‐catenin signaling in human bone marrow‐derived mesenchymal stem cells
Yunok Oh, Chang‐Bum Ahn, Jae‐Young Je
Journal of Food Biochemistry.2020;[Epub] CrossRef
Influence of Different Aromatic Hydrophobic Residues on the Antimicrobial Activity and Membrane Selectivity of BRBR-NH2 Tetrapeptide
Lei Liu, Liling Zhao, Lixia Liu, Shizhong Yue, Jihua Wang, Zanxia Cao
Langmuir.2020; 36(50): 15331. CrossRef
Direct antimicrobial activity of cationic amphipathic peptide WLBU2 against Staphylococcus aureus biofilms is enhanced in physiologic buffered saline
Jonathan B. Mandell, John A. Koch, Berthony Deslouches, Kenneth L. Urish
Journal of Orthopaedic Research.2020; 38(12): 2657. CrossRef
Clinical Applications of Antimicrobial Peptides (AMPs): Where do we Stand Now?
Mithoor Divyashree, Madhu K. Mani, Dhanasekhar Reddy, Ranjith Kumavath, Preetam Ghosh, Vasco Azevedo, Debmalya Barh
Protein & Peptide Letters.2020; 27(2): 120. CrossRef
Microwave‐assisted extraction (MAE) combined with gas chromatography–mass spectrometry (GC–MS) for determination of volatile small molecules to evaluate compatibility of antimicrobial peptide PL‐5 spray with packaging materials
Chu Liu, Xiangyong Yu, Zhaorui Meng, Ning Zhao, Fujuan Bai, Longshan Zhao
Biomedical Chromatography.2020;[Epub] CrossRef
Temporin L-derived peptide as a regulator of the acute inflammatory response in zymosan-induced peritonitis
Rosa Bellavita, Federica Raucci, Francesco Merlino, Marialuisa Piccolo, Maria Grazia Ferraro, Carlo Irace, Rita Santamaria, Asif J. Iqbal, Ettore Novellino, Paolo Grieco, Nicola Mascolo, Francesco Maione
Biomedicine & Pharmacotherapy.2020; 123: 109788. CrossRef
An automatic representation of peptides for effective antimicrobial activity classification
Jesus A. Beltran, Gabriel Del Rio, Carlos A. Brizuela
Computational and Structural Biotechnology Journal.2020; 18: 455. CrossRef
Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials
Izabela Małuch, Oktawian Stachurski, Paulina Kosikowska-Adamus, Marta Makowska, Marta Bauer, Dariusz Wyrzykowski, Aleksandra Hać, Wojciech Kamysz, Milena Deptuła, Michał Pikuła, Emilia Sikorska
International Journal of Molecular Sciences.2020; 21(23): 8944. CrossRef
Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy
Derry K. Mercer, Marcelo D. T. Torres, Searle S. Duay, Emma Lovie, Laura Simpson, Maren von Köckritz-Blickwede, Cesar de la Fuente-Nunez, Deborah A. O'Neil, Alfredo M. Angeles-Boza
Frontiers in Cellular and Infection Microbiology.2020;[Epub] CrossRef
Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential
Nelson G. J. Oliveira, Marlon H. Cardoso, Nadya Velikova, Marcel Giesbers, Jerry M. Wells, Taia M. B. Rezende, Renko de Vries, Octávio L. Franco
Scientific Reports.2020;[Epub] CrossRef
Pseudonajide peptide derived from snake venom alters cell envelope integrity interfering on biofilm formation in Staphylococcus epidermidis
Rafael Schneider, Muriel Primon-Barros, Rafael Gomes Von Borowski, Sophie Chat, Sylvie Nonin-Lecomte, Reynald Gillet, Alexandre José Macedo
BMC Microbiology.2020;[Epub] CrossRef
An Enhanced Variant Designed From DLP4 Cationic Peptide Against Staphylococcus aureus CVCC 546
Bing Li, Na Yang, Xiumin Wang, Ya Hao, Ruoyu Mao, Zhanzhan Li, Zhenlong Wang, Da Teng, Jianhua Wang
Frontiers in Microbiology.2020;[Epub] CrossRef
Strategies for recombinant production of antimicrobial peptides with pharmacological potential
Kamila Botelho Sampaio de Oliveira, Michel Lopes Leite, Gisele Regina Rodrigues, Harry Morales Duque, Rosiane Andrade da Costa, Victor Albuquerque Cunha, Lorena Sousa de Loiola Costa, Nicolau Brito da Cunha, Octavio Luiz Franco, Simoni Campos Dias
Expert Review of Clinical Pharmacology.2020; 13(4): 367. CrossRef
Kinetoplastid Membrane Protein-11 Induces Pores in Anionic Phospholipid Membranes: Effect of Cholesterol
Animesh Halder, Achinta Sannigrahi, Nayan De, Krishnananda Chattopadhyay, Sanat Karmakar
Langmuir.2020; 36(13): 3522. CrossRef
Interactions of “de novo” designed peptides with bacterial membranes: Implications in the antimicrobial activity
Patricia Maturana, Sónia Gonçalves, Melina Martinez, Juan C. Espeche, Nuno C. Santos, Liliana Semorile, Paulo C. Maffia, Axel Hollmann
Biochimica et Biophysica Acta (BBA) - Biomembranes.2020; 1862(11): 183443. CrossRef
Tailoring the Physicochemical Properties of Antimicrobial Peptides onto a Thiazole-Based γ-Peptide Foldamer
Clément Bonnel, Baptiste Legrand, Matthieu Simon, Margaux Clavié, Agnès Masnou, Estelle Jumas-Bilak, Young Kee Kang, Patricia Licznar-Fajardo, Ludovic T. Maillard, Nicolas Masurier
Journal of Medicinal Chemistry.2020; 63(17): 9168. CrossRef
Expression and Roles of Antimicrobial Peptides in Innate Defense of Airway Mucosa: Potential Implication in Cystic Fibrosis
Regina Geitani, Carole Ayoub Moubareck, Zhengzhong Xu, Dolla Karam Sarkis, Lhousseine Touqui
Frontiers in Immunology.2020;[Epub] CrossRef
PACAP Is Lethal to Flavobacterium psychrophilum Through Either Direct Membrane Permeabilization or Indirectly, by Priming the Immune Response in Rainbow Trout Macrophages
Shawna L. Semple, Tania Rodríguez-Ramos, Yamila Carpio, John S. Lumsden, Mario P. Estrada, Brian Dixon
Frontiers in Immunology.2019;[Epub] CrossRef
Self-Association of Antimicrobial Peptides: A Molecular Dynamics Simulation Study on Bombinin
Peicho Petkov, Elena Lilkova, Nevena Ilieva, Leandar Litov
International Journal of Molecular Sciences.2019; 20(21): 5450. CrossRef
A Comparative Study of the Antimicrobial and Structural Properties of Short Peptides and Lipopeptides Containing a Repetitive Motif KLFK
María Verónica Húmpola, María Carolina Rey, Pablo Gabriel Spontón, Arturo Carlos Simonetta, Georgina Guadalupe Tonarelli
Protein & Peptide Letters.2019; 26(3): 192. CrossRef
Perspectives on synthetic pharmacotherapy for the treatment of nosocomial pneumonia
Ana Motos, Hua Yang, Minlan Yang, Antoni Torres
Expert Opinion on Pharmacotherapy.2019; 20(12): 1439. CrossRef
Disulfide engineering on temporin‐SHf: Stabilizing the bioactive conformation of an ultra‐short antimicrobial peptide
Ashwini Dolle, Veera Babu Nagati, Yamanappa Hunashal, Kiran Krishnamurthy, Anil Kumar Pasupulati, Srinivasarao Raghothama, Konkallu Hanumae Gowd
Chemical Biology & Drug Design.2019; 94(3): 1634. CrossRef
Antimicrobial peptides activity in the skin
Anna Herman, Andrzej P. Herman
Skin Research and Technology.2019; 25(2): 111. CrossRef
Structural determinants conferring unusual long life in human serum to rattlesnake‐derived antimicrobial peptide Ctn[15‐34]
Clara Pérez‐Peinado, Susana A. Dias, Diogo A. Mendonça, Miguel A.R.B. Castanho, Ana S. Veiga, David Andreu
Journal of Peptide Science.2019;[Epub] CrossRef
A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications
Sebastián Ayala‐Ruano, Daniela Santander‐Gordón, Eduardo Tejera, Yunierkis Perez‐Castillo, Vinicio Armijos-Jaramillo
Ecology and Evolution.2019; 9(5): 2602. CrossRef
A Novel Dermaseptin Isolated from the Skin Secretion of Phyllomedusa tarsius and Its Cationicity-Enhanced Analogue Exhibiting Effective Antimicrobial and Anti-Proliferative Activities
Miaoran Li, Xinping Xi, Chengbang Ma, Xiaoling Chen, Mei Zhou, James F. Burrows, Tianbao Chen, Lei Wang
Biomolecules.2019; 9(10): 628. CrossRef
Antimicrobial Peptides: Recent Insights on Biotechnological Interventions and Future Perspectives
Rajeshwari Sinha, Pratyoosh Shukla
Protein & Peptide Letters.2019; 26(2): 79. CrossRef
Cationic antimicrobial peptides: alternatives and/or adjuvants to antibiotics active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Pseudomonas aeruginosa
Regina Geitani, Carole Ayoub Moubareck, Lhousseine Touqui, Dolla Karam Sarkis
BMC Microbiology.2019;[Epub] CrossRef
Supramolecular Antibacterial Materials for Combatting Antibiotic Resistance
Xingshu Li, Haotian Bai, Yuchong Yang, Juyoung Yoon, Shu Wang, Xi Zhang
Advanced Materials.2019;[Epub] CrossRef
Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32
Bomai K. Kerenga, James A. McKenna, Peta J. Harvey, Pedro Quimbar, Donovan Garcia-Ceron, Fung T. Lay, Thanh Kha Phan, Prem K. Veneer, Shaily Vasa, Kathy Parisi, Thomas M. A. Shafee, Nicole L. van der Weerden, Mark D. Hulett, David J. Craik, Marilyn A. And
Frontiers in Microbiology.2019;[Epub] CrossRef
Péptidos antimicrobianos, una alternativa prometedora para el tratamiento de enfermedades infecciosas
Kevin Samael Olascoaga-Del Angel, Grecia Sánchez-Evangelista, Israel Carmona-Navarrete, María del Carmen Galicia-Sanchez, Angélica Gómez-Luna, Susan Janneth Islas-Arollo, Jorge Ismael Castañeda-Sánchez
Kompass Neumología.2019; 1(1): 15. CrossRef
Susceptibility of microbial cells to the modified PIP2-binding sequence of gelsolin anchored on the surface of magnetic nanoparticles
Robert Bucki, Katarzyna Niemirowicz-Laskowska, Piotr Deptuła, Agnieszka Z. Wilczewska, Paweł Misiak, Bonita Durnaś, Krzysztof Fiedoruk, Ewelina Piktel, Joanna Mystkowska, Paul A. Janmey
Journal of Nanobiotechnology.2019;[Epub] CrossRef
Positive Charge Patterning and Hydrophobicity of Membrane-Active Antimicrobial Peptides as Determinants of Activity, Toxicity, and Pharmacokinetic Stability
Tracy A. Stone, Gregory B. Cole, Dorna Ravamehr-Lake, Huong Q. Nguyen, Farheen Khan, Simon Sharpe, Charles M. Deber
Journal of Medicinal Chemistry.2019; 62(13): 6276. CrossRef
Designer Peptide and Protein Dendrimers: A Cross-Sectional Analysis
Rachit Sapra, Ram P. Verma, Govind P. Maurya, Sameer Dhawan, Jisha Babu, V. Haridas
Chemical Reviews.2019; 119(21): 11391. CrossRef
A Synthetic Derivative of Antimicrobial Peptide Holothuroidin 2 from Mediterranean Sea Cucumber (Holothuria tubulosa) in the Control of Listeria monocytogenes
Maria Grazia Cusimano, Angelo Spinello, Giampaolo Barone, Domenico Schillaci, Stella Cascioferro, Alessandra Magistrato, Barbara Parrino, Vincenzo Arizza, Maria Vitale
Marine Drugs.2019; 17(3): 159. CrossRef
Systematical Analysis of the Protein Targets of Lactoferricin B and Histatin-5 Using Yeast Proteome Microarrays
Pramod Shah, Wei-Sheng Wu, Chien-Sheng Chen
International Journal of Molecular Sciences.2019; 20(17): 4218. CrossRef
Antiseptic Effect of Ps-K18: Mechanism of Its Antibacterial and Anti-Inflammatory Activities
Mihee Jang, Jieun Kim, Yujin Choi, JeongKyu Bang, Yangmee Kim
International Journal of Molecular Sciences.2019; 20(19): 4895. CrossRef
Pullulan nanofibers containing the antimicrobial palindromic peptide LfcinB (21–25)Palobtainedviaelectrospinning
Julieth Tatiana Román, Carlos Alberto Fuenmayor, Carlos Mario Zuluaga Dominguez, Dianney Clavijo-Grimaldo, Martha Acosta, Javier Eduardo García-Castañeda, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy
RSC Advances.2019; 9(35): 20432. CrossRef
Replacement of l-Amino Acids by d-Amino Acids in the Antimicrobial Peptide Ranalexin and Its Consequences for Antimicrobial Activity and Biodistribution
Cornelius Domhan, Philipp Uhl, Christian Kleist, Stefan Zimmermann, Florian Umstätter, Karin Leotta, Walter Mier, Michael Wink
Molecules.2019; 24(16): 2987. CrossRef
A New Hope: Self-Assembling Peptides with Antimicrobial Activity
Lucia Lombardi, Annarita Falanga, Valentina Del Genio, Stefania Galdiero
Pharmaceutics.2019; 11(4): 166. CrossRef
Effects of the antimicrobial peptide L12 against multidrug‑resistant Staphylococcus aureus
Fu Xiong, Xiaotian Dai, Yu‑Xue Li, Rui Wei, Li An, Yajuan Wang, Zhenhong Chen
Molecular Medicine Reports.2019;[Epub] CrossRef
Utilization of antimicrobial peptides, analogues and mimics in creating antimicrobial surfaces and bio-materials
Ingrid Batista Pinto, Leandro dos Santos Machado, Beatriz Torres Meneguetti, Micaella Lima Nogueira, Cristiano Marcelo Espínola Carvalho, Antonia Railda Roel, Octávio Luiz Franco
Biochemical Engineering Journal.2019; 150: 107237. CrossRef
Drug delivery systems designed to overcome antimicrobial resistance
Thanh‐Nhat Pham, Pauline Loupias, Alexandra Dassonville‐Klimpt, Pascal Sonnet
Medicinal Research Reviews.2019; 39(6): 2343. CrossRef
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Yubo Wu, Libang Zhou, Fengxia Lu, Xiaomei Bie, Haizhen Zhao, Chong Zhang, Zhaoxin Lu, Yingjian Lu
Journal of Agricultural and Food Chemistry.2019; 67(45): 12452. CrossRef
Biotechnological Production of the Cell Penetrating Antifungal PAF102 Peptide in Pichia pastoris
Crina Popa, Xiaoqing Shi, Tarik Ruiz, Pau Ferrer, María Coca
Frontiers in Microbiology.2019;[Epub] CrossRef
Hepcidin gene of Indian major carp, Labeo rohita: Molecular, structural and functional characterization, and antibacterial activity of recombinant hepcidin
Amruta Mohapatra, A. Dixit, L.C. Garg, P.K. Sahoo
Aquaculture.2019; 511: 734218. CrossRef
Profiling antimicrobial peptides from the medical maggotLucilia sericataas potential antibiotics for MDR Gram-negative bacteria
Rolf Hirsch, Jochen Wiesner, Alexander Marker, Yvonne Pfeifer, Armin Bauer, Peter E Hammann, Andreas Vilcinskas
Journal of Antimicrobial Chemotherapy.2019; 74(1): 96. CrossRef
Profiling of Polar Metabolites in Mouse Feces Using Four Analytical Platforms to Study the Effects Of Cathelicidin-Related Antimicrobial Peptide in Alcoholic Liver Disease
Liqing He, Fengyuan Li, Xinmin Yin, Patrick Bohman, Seongho Kim, Craig J. McClain, Wenke Feng, Xiang Zhang
Journal of Proteome Research.2019; 18(7): 2875. CrossRef
Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide
Junya de Lacorte Singulani, Mariana Cristina Galeane, Marina Dorisse Ramos, Paulo César Gomes, Claudia Tavares dos Santos, Bibiana Monson de Souza, Mario Sergio Palma, Ana Marisa Fusco Almeida, Maria José Soares Mendes Giannini
Frontiers in Cellular and Infection Microbiology.2019;[Epub] CrossRef
Tryptophan-Rich and Proline-Rich Antimicrobial Peptides
Awdhesh Mishra, Jaehyuk Choi, Eunpyo Moon, Kwang-Hyun Baek
Molecules.2018; 23(4): 815. CrossRef
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Urszula Piotrowska, Ewa Oledzka, Wojciech Kamysz, Sławomir Białek, Marcin Sobczak
Nanomaterials.2018; 8(7): 482. CrossRef
Über bisherige Denkweisen hinaus – neue Wirkstoffe zur Überwindung der Antibiotika‐Krise
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Angewandte Chemie.2018; 130(44): 14642. CrossRef
Antitumor activity of RT2 peptide derived from crocodile leukocyte peptide on human colon cancer xenografts in nude mice
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Environmental Toxicology.2018; 33(9): 972. CrossRef
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Louise C. Kenny, Douglas B. Kell
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Biomolecules.2018; 8(4): 118. CrossRef
Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics
Michael R. Yeaman, Sabrina Büttner, Karin Thevissen, Alessandra Ricelli
Oxidative Medicine and Cellular Longevity.2018;[Epub] CrossRef
Antimicrobial peptides of buffalo and their role in host defenses
Khangembam Victoria Chanu, Dimpal Thakuria, Satish Kumar
Veterinary World.2018; 11(2): 192. CrossRef
The Evolutionary Conserved γ-Core Motif Influences the Anti-Candida Activity of the Penicillium chrysogenum Antifungal Protein PAF
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Frontiers in Microbiology.2018;[Epub] CrossRef
Antimicrobial activities of a proline-rich proprotein from Spodoptera litura
Li-Ling Yang, Ming-Yue Zhan, Yu-Li Zhuo, Yue-Min Pan, Yang Xu, Xiu-Hong Zhou, Pei-Jin Yang, Hong-Li Liu, Zi-Hao Liang, Xiao-Dan Huang, Xiao-Qiang Yu, Xiang-Jun Rao
Developmental & Comparative Immunology.2018; 87: 137. CrossRef
Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics
Sheetal Sinha, Munesh Kumar Harioudh, Rikeshwer P. Dewangan, Wun Jern Ng, Jimut Kanti Ghosh, Surajit Bhattacharjya
ACS Omega.2018; 3(11): 14650. CrossRef
Thinking Outside the Box—Novel Antibacterials To Tackle the Resistance Crisis
Markus Lakemeyer, Weining Zhao, Franziska A. Mandl, Peter Hammann, Stephan A. Sieber
Angewandte Chemie International Edition.2018; 57(44): 14440. CrossRef
Breaking the frontiers of cosmetology with antimicrobial peptides
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Biotechnology Advances.2018; 36(8): 2019. CrossRef
From Antimicrobial Peptides to Antimicrobial Poly(α‐amino acid)s
Wei Shen, Pan He, Chunsheng Xiao, Xuesi Chen
Advanced Healthcare Materials.2018;[Epub] CrossRef
Designing improved active peptides for therapeutic approaches against infectious diseases
Bárbara Gomes, Marcelo T. Augusto, Mário R. Felício, Axel Hollmann, Octávio L. Franco, Sónia Gonçalves, Nuno C. Santos
Biotechnology Advances.2018; 36(2): 415. CrossRef
Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds
Anja Pfalzgraff, Klaus Brandenburg, Günther Weindl
Frontiers in Pharmacology.2018;[Epub] CrossRef
Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges
Lubhandwa S. Biswaro, Mauricio G. da Costa Sousa, Taia M. B. Rezende, Simoni C. Dias, Octavio L. Franco
Frontiers in Microbiology.2018;[Epub] CrossRef
Bioinspired Designs, Molecular Premise and Tools for Evaluating the Ecological Importance of Antimicrobial Peptides
Elvis Legala Ongey, Stephan Pflugmacher, Peter Neubauer
Pharmaceuticals.2018; 11(3): 68. CrossRef
Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
Ana Gomes, Cátia Teixeira, Ricardo Ferraz, Cristina Prudêncio, Paula Gomes
Molecules.2017; 22(10): 1743. CrossRef
Potential role of an antimicrobial peptide, KLK in inhibiting lipopolysaccharide-induced macrophage inflammation
Pornpimon Jantaruk, Sittiruk Roytrakul, Sutthirat Sitthisak, Duangkamol Kunthalert, Anirban Bhunia
PLOS ONE.2017; 12(8): e0183852. CrossRef
Design, Recombinant Fusion Expression and Biological Evaluation of Vasoactive Intestinal Peptide Analogue as Novel Antimicrobial Agent
Chunlan Xu, Yu Guo, Xiangjin Qiao, Xiaoya Shang, Weining Niu, Mingliang Jin
Molecules.2017; 22(11): 1963. CrossRef
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
Sónia Troeira Henriques, Nicole Lawrence, Stephanie Chaousis, Anjaneya S. Ravipati, Olivier Cheneval, Aurélie H. Benfield, Alysha G. Elliott, Angela Maria Kavanagh, Matthew A. Cooper, Lai Yue Chan, Yen-Hua Huang, David J. Craik
ACS Chemical Biology.2017; 12(9): 2324. CrossRef
Peptides with Dual Antimicrobial and Anticancer Activities
Mário R. Felício, Osmar N. Silva, Sônia Gonçalves, Nuno C. Santos, Octávio L. Franco
Frontiers in Chemistry.2017;[Epub] CrossRef
Novel antimicrobial peptide CPF‐C1 analogs with superior stabilities and activities against multidrug‐resistant bacteria
Junqiu Xie, Qian Zhao, Sisi Li, Zhibin Yan, Jing Li, Yao Li, Lingyun Mou, Bangzhi Zhang, Wenle Yang, Xiaokang Miao, Xianxing Jiang, Rui Wang
Chemical Biology & Drug Design.2017; 90(5): 690. CrossRef
Antimicrobial peptide repertoire of Thitarodes armoricanus, a host species of Ophiocordyceps sinensis, predicted based on de novo transcriptome sequencing and analysis
Min Wang, Xianda Hu
Infection, Genetics and Evolution.2017; 54: 238. CrossRef
Testing cathelicidin susceptibility of bacterial mastitis isolates: Technical challenges and data output for clinical isolates
Melissa N. Langer, Stefanie Blodkamp, Martin Bayerbach, Andrea T. Feßler, Nicole de Buhr, Thomas Gutsmann, Lothar Kreienbrock, Stefan Schwarz, Maren von Köckritz-Blickwede
Veterinary Microbiology.2017; 210: 107. CrossRef
Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity
Naroa Serna, Laura Sánchez-García, Alejandro Sánchez-Chardi, Ugutz Unzueta, Mónica Roldán, Ramón Mangues, Esther Vázquez, Antonio Villaverde
Acta Biomaterialia.2017; 60: 256. CrossRef

Journal Articles

Potential for colonization of O111:H25 atypical enteropathogenic E. coli: Marta O. Domingos , Keyde C.M. Melo , Irys Viana Neves , Cristiane M. Mota , Rita C. Ruiz , Bruna S. Melo , Raphael C. Lima , Denise S.P.Q. Horton , Monamaris M. Borges , Marcia R. Franzolin; J. Microbiol. 2016;54(11):745-752. Published online October 29, 2016; DOI: https://doi.org/10.1007/s12275-016-6015-x

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Abstract PDF

Using clonal phylogenetic methods, it has been demonstrated that O111:H25 atypical enteropathogenic E. coli (aEPEC) strains belong to distinct clones, suggesting the possibility that their ability to interact with different hosts and abiotic surfaces can vary from one clone to another. Accordingly, the ability of O111:H25 aEPEC strains derived from human, cat and dogs to adhere to epithelial cells has been investigated, along with their ability to interact with macrophages and to form biofilms on polystyrene, a polymer used to make biomedical devices. The results demonstrated that all the strains analyzed were able to adhere to, and to form pedestals on, epithelial cells, mechanisms used by E. coli to become strongly attached to the host. The strains also show a Localized-Adherence- Like (LAL) pattern of adhesion on HEp-2 cells, a behavior associated with acute infantile diarrhea. In addition, the O111:H25 aEPEC strains derived either from human or domestic animals were able to form long filaments, a phenomenon used by some bacteria to avoid phagocytosis. O111:H25 aEPEC strains were also encountered inside vacuoles, a characteristic described for several bacterial strains as a way of protecting themselves against the environment. They were also able to induce TNF-α release via two routes, one dependent on TLR-4 and the other dependent on binding of Type I fimbriae. These O111:H25 strains were also able to form biofilms on polystyrene. In summary the results suggest that, regardless of their source (i.e. linked to human origin or otherwise), O111:H25 aEPEC strains carry the potential to cause human disease.

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D-Galactose as an autoinducer 2 inhibitor to control the biofilm formation of periodontopathogens: Eun-Ju Ryu , Jaehyun Sim , Jun Sim , Julian Lee , Bong-Kyu Choi; J. Microbiol. 2016;54(9):632-637. Published online August 31, 2016; DOI: https://doi.org/10.1007/s12275-016-6345-8

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Abstract PDF

Autoinducer 2 (AI-2) is a quorum sensing molecule to which bacteria respond to regulate various phenotypes, including virulence and biofilm formation. AI-2 plays an important role in the formation of a subgingival biofilm composed mostly of Gram-negative anaerobes, by which periodontitis is initiated. The aim of this study was to evaluate D-galactose as an inhibitor of AI-2 activity and thus of the biofilm formation of periodontopathogens. In a search for an AI-2 receptor of Fusobacterium nucleatum, D-galactose binding protein (Gbp, Gene ID FN1165) showed high sequence similarity with the ribose binding protein (RbsB), a known AI-2 receptor of Aggregatibacter actinomycetemcomitans. D-Galactose was evaluated for its inhibitory effect on the AI-2 activity of Vibrio harveyi BB152 and F. nucleatum, the major coaggregation bridge organism, which connects early colonizing commensals and late pathogenic colonizers in dental biofilms. The inhibitory effect of D-galactose on the biofilm formation of periodontopathogens was assessed by crystal violet staining and confocal laser scanning microscopy in the absence or presence of AI-2 and secreted molecules of F. nucleatum. D-Galactose significantly inhibited the AI-2 activity of V. harveyi and F. nucleatum. In addition, D-galactose markedly inhibited the biofilm formation of F. nucleatum, Porphyromonas gingivalis, and Tannerella forsythia induced by the AI-2 of F. nucleatum without affecting bacterial growth. Our
results
demonstrate that the Gbp may function as an AI-2 receptor and that galactose may be used for prevention of the biofilm formation of periodontopathogens by targeting AI-2 activity.

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Peng Zhou, Bibek G C, Bo Hu, Chenggang Wu, Justin R. Kaspar
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Ana C. Afonso, Maria J. Saavedra, Manuel Simões, Lúcia C. Simões
Biotechnology Advances.2025; 79: 108505. CrossRef
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Jiawen Tao, Yirong Sun, Guoliang Wang, Jingru Sun, Shujun Dong, Jianxun Ding
Bioactive Materials.2025; 48: 474. CrossRef
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Ana Duran-Pinedo, Jose O Solbiati, Flavia Teles, Zhang Yanping, Jorge Frias-Lopez
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Yuki Iwawaki, Takaharu Goto, Takahiro Kishimoto, Takashi Matsuda, Keiko Fujimoto, Kan Nagao, Kenji Yoshimura, Teppei Tajikara, Yoshiyuki Eshita, Yoshitaka Yano, Tetsuo Ichikawa
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Aquaculture Journal.2024; 4(2): 76. CrossRef
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Teppei Tajikara, Morihide Itano, Yoshitaka Yano, Natsuko Toshida, Katsuya Ueno, Yoichiro Miyake
Oral Science International.2024; 21(3): 457. CrossRef
Gum Arabic as a potential candidate in quorum quenching and treatment of periodontal diseases
Nada Tawfig Hashim, Rasha Babiker, Mohammed Mustahsen Rahman, Nallan C. S. K. Chaitanya, Riham Mohammed, Shahistha Parveen Dasnadi, Bakri Gobara Gismalla
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International Journal of Molecular Sciences.2024; 25(23): 12808. CrossRef
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Hassan Valadbeigi, Saeed Khoshnood, Babak Negahdari, Abbas Maleki, Medya Mohammadinejat, Mohammad Hossein Haddadi
Oral Diseases.2024; 30(6): 3582. CrossRef
Effects of AI-2 quorum sensing inhibitors on mitigating bacterial contamination in bioethanol production
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Biomass and Bioenergy.2024; 184: 107211. CrossRef
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Molecular Aspects of Medicine.2024; 100: 101304. CrossRef
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Journal of Dental Hygiene Science.2024; 24(2): 84. CrossRef
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Kranti Kiran Reddy Ealla, Neema Kumari, Srikanth Chintalapani, Supriya Uppu, Vikas Sahu, Vishnu Priya Veeraraghavan, Pratibha Ramani, Sharaschandra Reddy Govindool
Archives of Microbiology.2024;[Epub] CrossRef
Multi-omics analysis of the biofilm forming mechanism of Bifidobacterium longum
Ting Zhang, Zongmin Liu, Jianxin Zhao, Hao Zhang, Wei Chen, Haitao Li, Wenwei Lu, Yue Xiao, Xiuwen Zhou
LWT.2023; 188: 115415. CrossRef
Multiomics reveals the mechanism of B. longum in promoting the formation of mixed-species biofilms
Tao Xu, Yue Xiao, Hongchao Wang, Jinlin Zhu, Wenwei Lu, Wei Chen
Food & Function.2023; 14(18): 8276. CrossRef
Light-Based Anti-Biofilm and Antibacterial Strategies
Ambreen Kauser, Emilio Parisini, Giulia Suarato, Rossella Castagna
Pharmaceutics.2023; 15(8): 2106. CrossRef
Use of whole-genome analysis to study the effect of various quorum-sensing inhibitors on the biofilm formation of Lactobacillus fermentum
Yue Zhang, Huachen Zhong, Yanxue Zheng, Yan Wang, Yinfeng He, Yue Gu
LWT.2023; 173: 114378. CrossRef
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Rakesh Mogul, Daniel R. Miller, Brian Ramos, Sidharth J. Lalla
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Escherichia coli virulence inhibition by cell-free supernatants from mangrove forest bacteria producing quorum sensing inhibitor
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LWT.2023; 185: 115182. CrossRef
Bacillus subtilis BS-15 Effectively Improves Plantaricin Production and the Regulatory Biosynthesis in Lactiplantibacillus plantarum RX-8
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Frontiers in Microbiology.2022;[Epub] CrossRef
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Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
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Life.2022; 12(12): 2006. CrossRef
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Frontiers in Nutrition.2022;[Epub] CrossRef
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Andrea Muras, Natalia Mallo, Paz Otero‐Casal, José M. Pose‐Rodríguez, Ana Otero
Oral Diseases.2022; 28(2): 307. CrossRef
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Microbial Pathogenesis.2022; 169: 105673. CrossRef
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Molecules.2022; 27(15): 4887. CrossRef
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Pharmaceutics.2022; 14(12): 2740. CrossRef
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Jianyao Lu, Xuechao Hu, Lujing Ren
Trends in Food Science & Technology.2022; 123: 103. CrossRef
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Microorganisms.2022; 10(9): 1783. CrossRef
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Zongmin Liu, Haitao Li, Lingzhi Li, QingQing Ma, ZhiFeng Fang, Hongchao Wang, Yuankun Lee, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu
Gene.2022; 826: 146449. CrossRef
Enriched autoinducer-2 (AI-2)-based quorum quenching consortium in a ceramic anaerobic membrane bioreactor (AnMBR) for biofouling retardation
Boyan Xu, Qi An Celine Cho, Tze Chiang Albert Ng, Shujuan Huang, How Yong Ng
Water Research.2022; 214: 118203. CrossRef
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Food Chemistry.2021; 338: 128134. CrossRef
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Allan Radaic, Yvonne L. Kapila
Computational and Structural Biotechnology Journal.2021; 19: 1335. CrossRef
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Journal of Microbiology.2021; 59(12): 1142. CrossRef
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Haseena, Adnan Khan, Iqra Ghaffar, Roua S. Baty, Mohamed M. Abdel-Daim, Shahida M. Habib, Tasmina Kanwal, Muhammad Raza Shah
Antibiotics.2021; 10(12): 1469. CrossRef
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Microorganisms.2021; 9(2): 385. CrossRef
LuxS quorum sensing system and biofilm formation of oral microflora: A short review article
Abdurahman A. Niazy
The Saudi Dental Journal.2021; 33(3): 116. CrossRef
Modulation of quorum sensing-associated virulence in bacteria: carbohydrate as a key factor
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Archives of Microbiology.2021; 203(5): 1881. CrossRef
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Ok‐Jin Park, Solmin Jung, Taehwan Park, A Reum Kim, Dongwook Lee, Hyun Jung Ji, Ho Seong Seo, Cheol‐Heui Yun, Seung Hyun Han
Molecular Oral Microbiology.2020; 35(6): 271. CrossRef
Tannic acid-modified silver nanoparticles for enhancing anti-biofilm activities and modulating biofilm formation
Lulu Liu, Chuang Ge, Yu Zhang, Wenrui Ma, Xi Su, Li Chen, Shunbo Li, Li Wang, Xiaojing Mu, Yi Xu
Biomaterials Science.2020; 8(17): 4852. CrossRef
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Marina Papaianni, Debora Paris, Sheridan L. Woo, Andrea Fulgione, Maria Manuela Rigano, Ermenegilda Parrilli, Maria L. Tutino, Roberta Marra, Gelsomina Manganiello, Angela Casillo, Antonio Limone, Astolfo Zoina, Andrea Motta, Matteo Lorito, Rosanna Cappar
Frontiers in Microbiology.2020;[Epub] CrossRef
Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria
Xihong Zhao, Zixuan Yu, Tian Ding
Microorganisms.2020; 8(3): 425. CrossRef
Acyl homoserine lactone-mediated quorum sensing in the oral cavity: a paradigm revisited
Andrea Muras, Paz Otero-Casal, Vanessa Blanc, Ana Otero
Scientific Reports.2020;[Epub] CrossRef
Use of d-galactose to regulate biofilm growth of oral streptococci
Eun-Ju Ryu, Sun-Jin An, Jaehyun Sim, Jun Sim, Julian Lee, Bong-Kyu Choi
Archives of Oral Biology.2020; 111: 104666. CrossRef
Decreased metabolism and increased tolerance to extreme environments in Staphylococcus warneri during long‐term spaceflight
Po Bai, Bin Zhang, Xian Zhao, Diangeng Li, Yi Yu, Xuelin Zhang, Bing Huang, Changting Liu
MicrobiologyOpen.2019;[Epub] CrossRef
Time-Dependent Toxicities of Quorum Sensing Inhibitors to Aliivibrio fischeri and Bacillus subtilis
Yueheng Zhang, Jinyuan Song, Ting Wang, Haoyu Sun, Zhifen Lin, Yinjiang Zhang
Dose-Response.2019;[Epub] CrossRef
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Periodontology 2000.2017; 75(1): 52. CrossRef

Amino acid residues in the Ler protein critical for derepression of the LEE5 promoter in enteropathogenic E. coli: Su-Mi Choi , Jae-Ho Jeong , Hyon E. Choy , Minsang Shin; J. Microbiol. 2016;54(8):559-564. Published online August 2, 2016; DOI: https://doi.org/10.1007/s12275-016-6027-6

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Enteropathogenic E. coli causes attaching and effacing (A/E) intestinal lesions. The genes involved in the formation of A/E lesions are encoded within a chromosomal island comprising of five major operons, LEE1-5. The global regulator H-NS represses the expression of these operons. Ler, a H-NS homologue, counteracts the H-NS–mediated repression. Using a novel genetic approach, we identified the amino acid residues in Ler that are involved in the interaction with H-NS: I20 and L23 in the C-terminal portion of α-helix 3, and I42 in the following unstructured linker region.

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Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens
R. Christopher D. Furniss, Abigail Clements, William Margolin
Journal of Bacteriology.2018;[Epub] CrossRef

Review

MINIREVIEW] Transcriptional control of sexual development in Cryptococcus neoformans: Matthew E. Mead , Christina M. Hull; J. Microbiol. 2016;54(5):339-346. Published online April 20, 2016; DOI: https://doi.org/10.1007/s12275-016-6080-1

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Abstract PDF

Developmental processes are essential for the normal life cycles of many pathogenic fungi, and they can facilitate survival in challenging environments, including the human host. Sexual development of the human fungal pathogen Cryptococcus neoformans not only produces infectious particles (spores) but has also enabled the evolution of new disease-related traits such as drug resistance. Transcription factor networks are essential to the development and pathogenesis of C. neoformans, and a variety of sequence-specific DNA-binding proteins control both key developmental transitions and virulence by regulating the expression of their target genes. In this review we discuss the roles of known transcription factors that harbor important connections to both development and virulence. Recent studies of these transcription factors have identified a common theme in which metabolic, stress, and other responses that are required for sexual development appear to have been co-opted for survival in the human host, thus facilitating pathogenesis. Future work elucidating the connection between development and pathogenesis will provide vital insights into the evolution of complex traits in eukaryotes as well as mechanisms that may be used to combat fungal pathogens.

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Effect of a Mating Type Gene Editing in Lentinula edodes Using RNP/Nanoparticle Complex
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Sinil Kim, Byeongsuk Ha, Minseek Kim, Hyeon-Su Ro
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The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Cryptococcus Human Pathogenic Fungi
Sheng Sun, Marco A. Coelho, Márcia David-Palma, Shelby J. Priest, Joseph Heitman
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Research Support, Non-U.S. Gov't

Antibacterial effects of N-acetylcysteine against endodontic pathogens: Ji-Hoi Moon , Young-Suk Choi , Hyeon-Woo Lee , Jung Sun Heo , Seok Woo Chang , Jin-Yong Lee; J. Microbiol. 2016;54(4):322-329. Published online April 1, 2016; DOI: https://doi.org/10.1007/s12275-016-5534-9

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Abstract PDF

The success of endodontic treatment depends on the eradication of microorganisms from the root canal system and the prevention of reinfection. The purpose of this investigation was to evaluate the antibacterial and antibiofilm efficacy of N-acetylcysteine (NAC), an antioxidant mucolytic agent, as an intracanal medicament against selected endodontic pathogens. Minimum inhibitory concentrations (MICs) of NAC for Actinomyces naeslundii, Lactobacillus salivarius, Streptococcus mutans, and Enterococcus faecalis were determined using the broth microdilution method. NAC showed antibacterial activity, with MIC values of 0.78–1.56 mg/ml. The effect of NAC on biofilm formation of each bacterium and a multispecies culture consisting of the four bacterial species was assessed by crystal violet staining. NAC significantly inhibited biofilm formation by all the monospecies and multispecies bacteria at minimum concentrations of 0.78–3.13 mg/ml. The efficacy of NAC for biofilm disruption was evaluated by scanning electron microscopy and ATP-bioluminescence quantification using mature multispecies biofilms. Preformed mature multispecies biofilms on saliva-coated hydroxyapatite disks were disrupted within 10 min by treatment with NAC at concentrations of 25 mg/ml or higher. After 24 h of treatment, the viability of mature biofilms was reduced by > 99% compared with the control. Moreover, the biofilm disrupting activity of NAC was significantly higher than that of saturated calcium hydroxide or 2% chlorhexidine solution. Within the limitations of this in vitro study, we conclude that NAC has excellent antibacterial and antibiofilm efficacy against endodontic pathogens and may be used as an alternative intracanal medicament in root canal therapies.

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Reviews

REVIEW] Innate host defenses against Cryptococcus neoformans: Camaron Hole , Floyd L. Wormley Jr.; J. Microbiol. 2016;54(3):202-211. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5625-7

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Abstract PDF

Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, can cause life-threatening infections of the central nervous system in immunocompromised and immunocompetent individuals. Cryptococcal meningoencephalitis is the most common disseminated fungal infection in AIDS patients, and remains the third most common invasive fungal infection among organ transplant recipients. The administration of highly active antiretroviral therapy (HAART) has
result
ed in a decrease in the number of cases of AIDS-related cryptococcosis in developed countries, but in developing countries where HAART is not readily available, Cryptococcus is still a major concern. Therefore, there is an urgent need for the development of novel therapies and/or vaccines to combat cryptococcosis. Understanding the protective immune responses against Cryptococcus is critical for development of vaccines and immunotherapies to combat cryptococcosis. Consequently, this review focuses on our current knowledge of protective immune responses to C. neoformans, with an emphasis on innate immune responses.

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mBio.2025;[Epub] CrossRef
Global trends in Cryptococcus and its interactions with the host immune system: a bibliometric analysis
Shiqin Tang, Ruiying Hao, Xin Liu, Huina He, Yanan Tian, Tingting Jing, Zhao Liu, Yanyan Xu, Xiaojing Li
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Chinese Medical Journal.2018; 131(18): 2210. CrossRef
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The Journal of Infectious Diseases.2018; 218(10): 1631. CrossRef
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Bilge Aldemir Kocabaş, Mehmet Emin Parlak, Betil Özhak Baysan, Kamil Karaali, Ayşen Bingöl, Şenay Haspolat
Pediatric Infectious Disease Journal.2018; 37(4): 373. CrossRef
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Mitra Shourian, Ben Ralph, Isabelle Angers, Donald C. Sheppard, Salman T. Qureshi
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Irina Vlasova-St. Louis, Christina C Chang, Samar Shahid, Martyn A French, Paul R Bohjanen
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Jintao Xu, Adam Flaczyk, Lori M Neal, Zhenzong Fa, Alison J Eastman, Antoni N Malachowski, Daphne Cheng, Bethany B Moore, Jeffrey L Curtis, John J Osterholzer, Michal A Olszewski
The Journal of Immunology.2017; 198(9): 3548. CrossRef
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PLOS ONE.2017; 12(1): e0169347. CrossRef
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Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef
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Journal of Microbiology.2016; 54(3): 145. CrossRef
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Immunogenetics.2016; 68(8): 649. CrossRef

REVIEW] Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans: Lois M. Douglas , James B. Konopka; J. Microbiol. 2016;54(3):178-191. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5621-y

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Abstract PDF

Candida albicans is a human fungal pathogen capable of causing lethal systemic infections. The plasma membrane plays key roles in virulence because it not only functions as a protective barrier, it also mediates dynamic functions including secretion of virulence factors, cell wall synthesis, invasive hyphal morphogenesis, endocytosis, and nutrient uptake. Consistent with this functional complexity, the plasma membrane is composed of a wide array of lipids and proteins. These components are organized into distinct domains that will be the topic of this review. Some of the plasma membrane domains that will be described are known to act as scaffolds or barriers to diffusion, such as MCC/eisosomes, septins, and sites of contact with the endoplasmic reticulum. Other zones mediate dynamic processes, including secretion, endocytosis, and a special region at hyphal tips that facilitates rapid growth. The highly organized architecture of the plasma membrane facilitates the coordination of diverse functions and promotes the pathogenesis of C. albicans.

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Infection and Immunity.2017;[Epub] CrossRef
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Journal of Fungi.2017; 3(4): 61. CrossRef
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D.G. Sant, S.G. Tupe, C.V. Ramana, M.V. Deshpande
Journal of Applied Microbiology.2016; 121(6): 1498. CrossRef

Research Support, Non-U.S. Gov't

The hrp pathogenicity island of Pseudomonas syringae pv. tomato DC3000 is induced by plant phenolic acids: Jun Seung Lee , Hye Ryun Ryu , Ji Young Cha , Hyung Suk Baik; J. Microbiol. 2015;53(10):725-731. Published online October 2, 2015; DOI: https://doi.org/10.1007/s12275-015-5256-4

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Abstract

Plants produce a wide array of antimicrobial compounds, such as phenolic compounds, to combat microbial pathogens. The hrp PAI is one of the major virulence factors in the plant pathogen, Pseudomonas syringae. A major role of hrp PAI is to disable the plant defense system during bacterial invasion. We examined the influence of phenolic compounds on hrp PAI gene expression at low and high concentrations. There was approximately 2.5 times more hrpA and hrpZ mRNA in PtoDC3000 that was grown in minimal media (MM) supplemented with 10 μM of ortho-coumaric acid than in PtoDC3000 grown in MM alone. On the other hand, a significantly lower amount of hrpA mRNA was observed in bacteria grown in MM supplemented with a high concentration of phenolic compounds. To determine the regulation pathway for hrp PAI gene expression, we performed qRTPCR using gacS, gacA, and hrpS deletion mutants.

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Review

MINIREVIEW] The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis: Jaehyuk Choi , Won Hee Jung , James W. Kronstad; J. Microbiol. 2015;53(9):579-587. Published online August 1, 2015; DOI: https://doi.org/10.1007/s12275-015-5247-5

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Abstract PDF

A number of pathogenic species of basidiomycete fungi are either life-threatening pathogens of humans or major economic pests for crop production. Sensing the host is a key aspect of pathogen proliferation during disease, and signal transduction pathways are critically important for detecting environmental conditions and facilitating adaptation. This review focuses on the contributions of the cAMP/protein kinase A (PKA) signaling pathway in Cryptococcus neoformans, a species that causes meningitis in humans, and Ustilago maydis, a model phytopathogen that causes a smut disease on maize. Environmental sensing by the cAMP/PKA pathway regulates the production of key virulence traits in C. neoformans including the polysaccharide capsule and melanin. For U. maydis, the pathway controls the dimorphic transition from budding growth to the filamentous cell type required for proliferation in plant tissue. We discuss recent advances in identifying new components of the cAMP/PKA pathway in these pathogens and highlight an emerging theme that pathway signaling influences iron acquisition.

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Xiaoning Fan, Xiaoqin Zhou, Junliang He, Hongyun Xie, Nianwu Tang, Ming Tang, Xianan Xie
New Phytologist.2025;[Epub] CrossRef
Signaling Pathways Regulating Dimorphism in Medically Relevant Fungal Species
Uriel Ramírez-Sotelo, Manuela Gómez-Gaviria, Héctor M. Mora-Montes
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Hyunjin Cha, Doyeon Won, Yong-Sun Bahn, Marcio Rodrigues
mBio.2025;[Epub] CrossRef
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Veronica Teresa Ober, George Boniface Githure, Yuri Volpato Santos, Sidney Becker, Gabriel Moya Munoz, Jérôme Basquin, Frank Schwede, Esben Lorentzen, Michael Boshart
eLife.2024;[Epub] CrossRef
Disruption of the pkac2 gene in Pleurotus ostreatus alters cell wall structures and enables mycelial dispersion in liquid culture
Yuitsu Otsuka, Moriyuki Kawauchi, Kai Yoshizawa, Saori Endo, Kim Schiphof, Kenya Tsuji, Akira Yoshimi, Chihiro Tanaka, Shigekazu Yano, Vladimir Elisashvili, Takehito Nakazawa, Toshikazu Irie, Yoichi Honda
FEMS Microbiology Letters.2024;[Epub] CrossRef
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Veronica Teresa Ober, George Boniface Githure, Yuri Volpato Santos, Sidney Becker, Gabriel Moya Munoz, Jérôme Basquin, Frank Schwede, Esben Lorentzen, Michael Boshart
eLife.2024;[Epub] CrossRef
How temperature modulates the expression of pathogenesis-related molecules of the cross-kingdom pathogen Lasiodiplodia hormozganensis
Carina Félix, Rodrigo Meneses, Micael F.M. Gonçalves, Ana S. Duarte, Jesus V. Jorrín-Novo, Yves van de Peer, Dieter Deforce, Filip Van Nieuwerburgh, Artur Alves, Ana C. Esteves
Science of The Total Environment.2024; 927: 171917. CrossRef
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Yi Zhang, Yongding He, Meixin Yan, Shilong Zhang, Sisi Zhou, Wankuan Shen, Michael Klutstein
Microbiology Spectrum.2024;[Epub] CrossRef
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Ni Li, Zhouyuan Qiu, Wanchuan Cai, Yaling Shen, Dongzhi Wei, Yumeng Chen, Wei Wang
Biotechnology for Biofuels and Bioproducts.2023;[Epub] CrossRef
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Yuanyuan Zong, Xuemei Zhang, Di Gong, Feng Zhang, Lirong Yu, Yang Bi, Edward Sionov, Dov Prusky
Postharvest Biology and Technology.2023; 197: 112192. CrossRef
A Novel FYVE Domain-Containing Protein Kinase, PsZFPK1, Plays a Critical Role in Vegetative Growth, Sporangium Formation, Oospore Production, and Virulence in Phytophthora sojae
Binglu Ru, Xinchang Hao, Wenhao Li, Qin Peng, Jianqiang Miao, Xili Liu
Journal of Fungi.2023; 9(7): 709. CrossRef
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Yuanyuan Ma, Liang Yang, Mengna Jiang, Xinyuan Zhao, Peng Xue
International Journal of Molecular Sciences.2023; 24(17): 13515. CrossRef
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Rongtao Fu, Jian Wang, Cheng Chen, Yao Liu, Liyu Zhao, Daihua Lu
International Journal of Molecular Sciences.2023; 24(13): 10805. CrossRef
Squalene Monooxygenase Gene SsCI80130 Regulates Sporisorium scitamineum Mating/Filamentation and Pathogenicity
Yichang Cai, Yi Zhang, Han Bao, Jiaoyun Chen, Jianwen Chen, Wankuan Shen
Journal of Fungi.2022; 8(5): 470. CrossRef
Iron Deprivation Modulates the Exoproteome in Paracoccidioides brasiliensis
Aparecido Ferreira de Souza, Laurine Lacerda Pigosso, Lana O’Hara Souza Silva, Italo Dany Cavalcante Galo, Juliano Domiraci Paccez, Kleber Santiago Freitas e Silva, Milton Adriano Pelli de Oliveira, Maristela Pereira, Célia Maria de Almeida Soares
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Secretion of the siderophore rhizoferrin is regulated by the cAMP-PKA pathway and is involved in the virulence of Mucor lusitanicus
Viridiana Alejandre-Castañeda, J. Alberto Patiño-Medina, Marco I. Valle-Maldonado, Rosa E. Nuñez-Anita, Gustavo Santoyo, Karla V. Castro-Cerritos, Rafael Ortiz-Alvarado, Alma R. Corrales-Escobosa, Martha I. Ramírez-Díaz, J. Felix Gutiérrez-Corona, Adolfo
Scientific Reports.2022;[Epub] CrossRef
Adenylyl Cyclase and Protein Kinase A Play Redundant and Distinct Roles in Growth, Differentiation, Antifungal Drug Resistance, and Pathogenicity of Candida auris
Ji-Seok Kim, Kyung-Tae Lee, Myung Ha Lee, Eunji Cheong, Yong-Sun Bahn, James W. Kronstad
mBio.2021;[Epub] CrossRef
Signaling pathways involved in virulence and stress response of plant-pathogenic Fusarium species
Łukasz Stępień, Justyna Lalak-Kańczugowska
Fungal Biology Reviews.2021; 35: 27. CrossRef
Comparative Proteomic Analysis within the Developmental Stages of the Mushroom White Hypsizygus marmoreus
Xiuqing Yang, Rongmei Lin, Kang Xu, Lizhong Guo, Hao Yu
Journal of Fungi.2021; 7(12): 1064. CrossRef
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Xiaoqin Zhou, Jiangyong Li, Nianwu Tang, Hongyun Xie, Xiaoning Fan, Hui Chen, Ming Tang, Xianan Xie
Microorganisms.2021; 9(8): 1557. CrossRef
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Enping Cai, Shuquan Sun, Yizhen Deng, Peishen Huang, Xian Sun, Yuting Wang, Changqing Chang, Zide Jiang
Journal of Fungi.2021; 7(8): 610. CrossRef
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Sahar Nahle, André El Khoury, Ali Atoui
European Journal of Plant Pathology.2021; 159(2): 247. CrossRef
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Cellular Microbiology.2020;[Epub] CrossRef
Defects in the Ferroxidase That Participates in the Reductive Iron Assimilation System Results in Hypervirulence in Botrytis Cinerea
Esteban Vasquez-Montaño, Gustavo Hoppe, Andrea Vega, Consuelo Olivares-Yañez, Paulo Canessa, B. Gillian Turgeon
mBio.2020;[Epub] CrossRef
Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans
Yuan-Hong Li, Tong-Bao Liu
International Journal of Molecular Sciences.2020; 21(4): 1361. CrossRef
Life Cycle ofCryptococcus neoformans
Youbao Zhao, Jianfeng Lin, Yumeng Fan, Xiaorong Lin
Annual Review of Microbiology.2019; 73(1): 17. CrossRef
The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans
Mélissa Caza, James W. Kronstad
Frontiers in Cellular and Infection Microbiology.2019;[Epub] CrossRef
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Yixu Wang, Yi Zhen Deng, Guobing Cui, Chengwei Huang, Bin Zhang, Changqing Chang, Zide Jiang, Lian-Hui Zhang, Aaron P. Mitchell
mSphere.2019;[Epub] CrossRef
Induction of signal transduction pathways related to the pathogenicity of Cryptococcus neoformans in the host environment
Yasuhiko Matsumoto, Saki Azami, Haruka Shiga, Tae Nagamachi, Hikari Moriyama, Yuki Yamashita, Asami Yoshikawa, Takashi Sugita
Drug Discoveries & Therapeutics.2019; 13(4): 177. CrossRef
A multi-omics analysis of the grapevine pathogen Lasiodiplodia theobromae reveals that temperature affects the expression of virulence- and pathogenicity-related genes
Carina Félix, Rodrigo Meneses, Micael F. M. Gonçalves, Laurentijn Tilleman, Ana S. Duarte, Jesus V. Jorrín-Novo, Yves Van de Peer, Dieter Deforce, Filip Van Nieuwerburgh, Ana C. Esteves, Artur Alves
Scientific Reports.2019;[Epub] CrossRef
cAMP/PKA signalling pathway regulates redox homeostasis essential for Sporisorium scitamineum mating/filamentation and virulence
Changqing Chang, Enping Cai, Yi Zhen Deng, Dan Mei, Shanxu Qiu, Baoshan Chen, Lian‐Hui Zhang, Zide Jiang
Environmental Microbiology.2019; 21(3): 959. CrossRef
Cloning and disruption of the UeArginase in Ustilago esculenta: evidence for a role of arginine in its dimorphic transition
Yafen Zhang, Min Wu, Qianwen Ge, Mengfei Yang, Wenqiang Xia, Haifeng Cui, Xiaoping Yu, Shangfa Zhang, Zihong Ye
BMC Microbiology.2019;[Epub] CrossRef
Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus
Jing Wang, Yabing Chen, Zhangpeng Chen, Zou Xiang, Jie Ding, Xiaodong Han
Ecotoxicology and Environmental Safety.2018; 163: 391. CrossRef
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eLife.2018;[Epub] CrossRef
Signaling pathways governing iron homeostasis in budding yeast
Telma S. Martins, Vítor Costa, Clara Pereira
Molecular Microbiology.2018; 109(4): 422. CrossRef
The PKR regulatory subunit of protein kinase A (PKA) is involved in the regulation of growth, sexual and asexual development, and pathogenesis in Fusarium graminearum
Chaoqun Li, Yonghui Zhang, Huan Wang, Lingfeng Chen, Ju Zhang, Manli Sun, Jin‐Rong Xu, Chenfang Wang
Molecular Plant Pathology.2018; 19(4): 909. CrossRef
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JSM Mycotoxins.2018; 68(1): 1. CrossRef
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Cellular Microbiology.2018; 20(10): e12863. CrossRef
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Process Biochemistry.2018; 69: 22. CrossRef
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Guanggan Hu, Mélissa Caza, Erik Bakkeren, Matthias Kretschmer, Gaurav Bairwa, Ethan Reiner, James Kronstad
Cellular Microbiology.2017; 19(6): e12718. CrossRef
mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans
Amanda L. M. Bloom, Jay Leipheimer, John C. Panepinto
WIREs RNA.2017;[Epub] CrossRef
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Gaurav Bairwa, Won Hee Jung, James W. Kronstad
Metallomics.2017; 9(3): 215. CrossRef
When green and red mycology meet: Impressions from an interdisciplinary forum on virulence mechanisms of phyto- and human-pathogenic fungi
Yidong Yu, Bernhard Hube, Jörg Kämper, Vera Meyer, Sven Krappmann
Virulence.2017; 8(7): 1435. CrossRef
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Frontiers in Cellular and Infection Microbiology.2017;[Epub] CrossRef
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Dithi Banerjee, Amanda L. M. Bloom, John C. Panepinto
Molecular Microbiology.2016; 102(2): 306. CrossRef
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Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef
Roles of Rack1 Proteins in Fungal Pathogenesis
Xue Zhang, Rashmi Jain, Guotian Li
BioMed Research International.2016; 2016: 1. CrossRef

Research Support, Non-U.S. Gov'ts

Antibacterial potential of a small peptide from Bacillus sp. RPT-0001 and its capping for green synthesis of silver nanoparticles: Supriya Deepak Patil , Rajnikant Sharma , Tapas Bhattacharyya , Piyush Kumar , Manasi Gupta , Bhupinder Singh Chaddha , Naveen Kumar Navani , Ranjana Pathania; J. Microbiol. 2015;53(9):643-652. Published online August 1, 2015; DOI: https://doi.org/10.1007/s12275-015-4686-3

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Abstract PDF

Infirmity and death from diseases caused by unsafe food are a continual hazard to communal health safety and socio-economic growth throughout the world. Chemical preservatives are associated with health hazards and toxicity issues. In the study reported here, 200 soil isolates from Western Himalayan region in India were screened for potential antibacterial activity against food-borne pathogens. This study led to the isolation of a bacterial strain belonging to the Genus Bacillus and was designated as RPT-0001. The associated antibacterial activity was sensitive to pronase E treatment. Bioassay-guided fractionation using reverse phase high performance liquid chromatography (RP-HPLC) led to isolation of the antibacterial peptide designated as RPT-0001. The molecular weight of RPT-0001 was determined by electro- spray ionization mass spectroscopy (ESI-MS) as 276.9 Da. RPT-0001 was inhibitory to both Gram-negative and Grampositive food-borne bacteria tested. The characteristics of RPT-0001 do not match with that of any other known antibacterial peptides produced by Bacillus sp. or related genera. Purified RPT-0001 was successfully used in synthesis of silver nanoparticles effective against food-borne pathogenic bacteria. The antibacterial peptide and silver nanoparticles synthesized utilizing it as a capping and reducing agent hold promising potential in food preservation, in packaging material and as a therapeutic agent in the treatment of foodborne infections.

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Scientific Reports.2020;[Epub] CrossRef
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Functional properties of the major outer membrane protein in Stenotrophomonas maltophilia: Yih-Yuan Chen , Han-Chiang Wu , Juey-Wen Lin , Shu-Fen Weng; J. Microbiol. 2015;53(8):535-543. Published online July 31, 2015; DOI: https://doi.org/10.1007/s12275-015-5202-5

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Abstract

Stenotrophomonas maltophilia is an opportunistic pathogen that is closely associated with high morbidity and mortality in debilitated and immunocompromised individuals. Therefore, to investigate the pathogenesis mechanism is urgently required. However, there are very few studies to evaluate the functional properties of outer membrane protein, which may contribute to the pathogenesis in S. maltophilia. In this study, three abundant proteins in the outer membrane fraction of S. maltophilia were identified by liquid chromatography- tandem mass spectrometry as OmpW1, MopB, and a hypothetical protein. MopB, a member of the OmpA family, was firstly chosen for functional investigation in this study because many OmpA-family proteins are known to be involved in pathogenesis and offer potential as vaccines. Membrane fractionation analyses demonstrated that MopB was indeed the most abundant outer membrane protein (OMP) in S. maltophilia. For functional studies, the mopB mutant of S. maltophilia (SmMopB) was constructed by insertional mutation. MopB deficiency resulted in a change in the protein composition of OMPs and altered the architecture of the outer membrane. The SmMopB strain exhibited reduced cytotoxicity toward L929 fibroblasts and was more sensitive to numerous stresses, including human serum, sodium dodecyl sulfate, and hydrogen peroxide compared with wildtype S. maltophilia. These results suggest that MopB may be a good candidate for the design of vaccines or anti-MopB drugs for controlling serious nosocomial infections of multidrug- resistant S. maltophilia, especially in immunosuppressed patients.

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σ P -NagA-L1/L2 Regulatory Circuit Involved in ΔompA 299-356 -Mediated Increase in β-Lactam Susceptibility in Stenotrophomonas maltophilia
Li-Hua Li, Cheng-Mu Wu, Chia-Lun Chang, Hsin-Hui Huang, Chao-Jung Wu, Tsuey-Ching Yang, Silvia T. Cardona
Microbiology Spectrum.2022;[Epub] CrossRef
Advances in the Microbiology of Stenotrophomonas maltophilia
Joanna S. Brooke
Clinical Microbiology Reviews.2021;[Epub] CrossRef
Recombinant Ax21 protein is a promising subunit vaccine candidate against Stenotrophomonas maltophilia in a murine infection model
Amal Tarek Sarhan, Mohammed Bahey-El-Din, Taha Ibrahim Zaghloul
Vaccine.2021; 39(32): 4471. CrossRef
Intranasal immunization with recombinant outer membrane protein A induces protective immune response against Stenotrophomonas maltophilia infection
Yan Li, Xueping Tang, Zunquan Zhao, Hui Wang, Xin Wang, Xueyi Shang, Peng Liu, Zhihua Kou, Yongqiang Jiang, Yan Li, Daniela Flavia Hozbor
PLOS ONE.2019; 14(4): e0214596. CrossRef
The Major Outer Membrane Protein MopB Is Required for Twitching Movement and Affects Biofilm Formation and Virulence in Two Xylella fastidiosa strains
Hongyu Chen, Prem P. Kandel, Luisa F. Cruz, Paul A. Cobine, Leonardo De La Fuente
Molecular Plant-Microbe Interactions®.2017; 30(11): 896. CrossRef

Morphological changes in human gastric epithelial cells induced by nuclear targeting of Helicobacter pylori urease subunit A: Jung Hwa Lee , So Hyun Jun , Jung-Min Kim , Seung Chul Baik , Je Chul Lee; J. Microbiol. 2015;53(6):406-414. Published online May 30, 2015; DOI: https://doi.org/10.1007/s12275-015-5085-5

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Abstract

Nuclear targeting of bacterial proteins and their pathological effects on host cells are an emerging pathogenic mechanism in bacteria. We have previously reported that urease subunit A (UreA) of Helicobacter pylori targets the nuclei of COS-7 cells through nuclear localization signals (NLSs). This study further investigated whether UreA of H. pylori targets the nuclei of gastric epithelial cells and then induces molecular and cellular changes in the host cells. H. pylori 26695 strain produced and secreted outer membrane vesicles (OMVs). UreA was translocated into gastric epithelial AGS cells through outer membrane vesicles (OMVs) and then targeted the nuclei of AGS cells. Nuclear targeting of rUreA did not induce host cell death, but resulted in morphological changes, such as cellular elongation, in AGS cells. In contrast, AGS cells treated with rUreAΔNLS proteins did not show this morphological change. Next generation sequencing revealed that nuclear targeting of UreA differentially regulated 102 morphogenesis- related genes, of which 67 and 35 were up-regulated and down-regulated, respectively. Our results suggest that nuclear targeting of H. pylori UreA induces both molecular and cellular changes in gastric epithelial cells.

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Microbial Trojan Horses: Virulence Factors as Key Players in Neurodegenerative Diseases
Matheus V. C. Grahl, Kelvin Siqueira Hohl, Thiago Smaniotto, Célia R. Carlini
Molecules.2025; 30(3): 687. CrossRef
Extracellular vesicles in Helicobacter pylori-mediated diseases: mechanisms and therapeutic potential
Jianjun Wang, Xiuping Wang, Hao Luo, Yiping Xie, Hui Cao, Lingxiang Mao, Tingting Liu, Yushan Yue, Hui Qian
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Nucleomodulins from gut bacteria: diverse mechanisms of translocation and interaction with host nuclear processes
Sania Korgaonkar, Chandrani Bose, Swadha Anand, Issac Cann
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Effects of Exosomes Derived From Helicobacter pylori Outer Membrane Vesicle-Infected Hepatocytes on Hepatic Stellate Cell Activation and Liver Fibrosis Induction
Masoumeh Ebadi Zahmatkesh, Mariyeh Jahanbakhsh, Negin Hoseini, Saina Shegefti, Amir Peymani, Hossein Dabin, Rasoul Samimi, Shahin Bolori
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Significance of Helicobacter pylori and Its Serological Typing in Gastric Cancer
碧玉张
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Rational Development of Bacterial Ureases Inhibitors
Saurabh Loharch, Łukasz Berlicki
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Emerging therapeutic targets for gastric cancer from a host-Helicobacter pylori interaction perspective
Esmat Abdi, Saeid Latifi-Navid, Fatemeh Abedi Sarvestani, Mohammad Hassan Esmailnejad
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Non-enzymatic properties of Proteus mirabilis urease subunits
Valquiria Broll, Ana Paula A. Perin, Fernanda C. Lopes, Anne Helene S. Martinelli, Natalia R. Moyetta, Leonardo L. Fruttero, Matheus V.C. Grahl, Augusto F. Uberti, Diogo R. Demartini, Rodrigo Ligabue-Braun, Celia R. Carlini
Process Biochemistry.2021; 110: 263. CrossRef
Nuclear trafficking of bacterial effector proteins
Lena Hoang My Le, Le Ying, Richard L. Ferrero
Cellular Microbiology.2021;[Epub] CrossRef
Proteus mirabilis Urease: Unsuspected Non-Enzymatic Properties Relevant to Pathogenicity
Matheus V. C. Grahl, Augusto F. Uberti, Valquiria Broll, Paula Bacaicoa-Caruso, Evelin F. Meirelles, Celia R. Carlini
International Journal of Molecular Sciences.2021; 22(13): 7205. CrossRef
Helicobacter pylori Outer Membrane Vesicles and Extracellular Vesicles from Helicobacter pylori-Infected Cells in Gastric Disease Development
María Fernanda González, Paula Díaz, Alejandra Sandoval-Bórquez, Daniela Herrera, Andrew F. G. Quest
International Journal of Molecular Sciences.2021; 22(9): 4823. CrossRef
Tracking the cargo of extracellular symbionts into host tissues with correlated electron microscopy and nanoscale secondary ion mass spectrometry imaging
Stephanie K. Cohen, Marie‐Stéphanie Aschtgen, Jonathan B. Lynch, Sabrina Koehler, Fangmin Chen, Stéphane Escrig, Jean Daraspe, Edward G. Ruby, Anders Meibom, Margaret McFall‐Ngai
Cellular Microbiology.2020;[Epub] CrossRef
Role of Probiotics in Prophylaxis of Helicobacter pylori Infection
Kashyapi Chakravarty, Smriti Gaur
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Helicobacter pylori: molecular basis for colonization and survival in gastric environment and resistance to antibiotics. A short review
Sharmila Fagoonee, Rinaldo Pellicano
Infectious Diseases.2019; 51(6): 399. CrossRef
Cross‐Reactivity of Polyclonal Antibodies against Canavalia ensiformis (Jack Bean) Urease and Helicobacter pylori Urease Subunit A Fragments
Zbigniew Jerzy Kaminski, Inga Relich, Iwona Konieczna, Wieslaw Kaca, Beata Kolesinska
Chemistry & Biodiversity.2018;[Epub] CrossRef
Ureases: Historical aspects, catalytic, and non-catalytic properties – A review
Karine Kappaun, Angela Regina Piovesan, Celia Regina Carlini, Rodrigo Ligabue-Braun
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The Impact of Helicobacter pylori Urease upon Platelets and Consequent Contributions to Inflammation
Adriele Scopel-Guerra, Deiber Olivera-Severo, Fernanda Staniscuaski, Augusto F. Uberti, Natália Callai-Silva, Natália Jaeger, Bárbara N. Porto, Celia R. Carlini
Frontiers in Microbiology.2017;[Epub] CrossRef
A New Role for Helicobacter pylori Urease: Contributions to Angiogenesis
Deiber Olivera-Severo, Augusto F. Uberti, Miguel S. Marques, Marta T. Pinto, Maria Gomez-Lazaro, Céu Figueiredo, Marina Leite, Célia R. Carlini
Frontiers in Microbiology.2017;[Epub] CrossRef

In vitro effects of N-acetyl cysteine alone and in combination with antibiotics on Prevotella intermedia: Ji-Hoi Moon , Eun-Young Jang , Kyu Sang Shim , Jin-Yong Lee; J. Microbiol. 2015;53(5):321-329. Published online May 3, 2015; DOI: https://doi.org/10.1007/s12275-015-4500-2

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Abstract

N-acetyl cysteine (NAC) is an antioxidant that possesses anti-inflammatory activities in tissues. In the field of dentistry, NAC was demonstrated to prevent the expression of LPS-induced inflammatory mediators in phagocytic cells and gingival fibroblasts during the inflammatory process, but the effect of NAC on oral pathogens has been rarely studied. Here, we examined the effect of NAC against planktonic and biofilm cells of Prevotella intermedia, a major oral pathogen. NAC showed antibacterial activity against the planktonic P. intermedia with MIC value of 3 mg/ml and significantly decreased biofilm formation by the bacterium even at sub MIC. NAC did not affect the antibiotic susceptibility of planktonic P. intermedia, showing indifference (fractional inhibitory concentration index of 0.5?) results against the bacterium in combination with ampicillin, ciprofloxacin, tetracycline or metronidazole. On the other hand, viability of the pre-established bacterial biofilm exposed to the antibiotics except metronidazole was increased in the presence of NAC. Collectively, NAC may be used for prevention of the biofilm formation by P. intermedia rather than eradication of the pre-established bacterial biofilm. Further studies are required to explore antibacterial and anti-biofilm activity of NAC against mixed population of oral bacteria and its modulatory effect on antibiotics used for oral infectious diseases.

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Reviews

Against friend and foe: Type 6 effectors in plant-associated bacteria: Choong-Min Ryu; J. Microbiol. 2015;53(3):201-208. Published online March 3, 2015; DOI: https://doi.org/10.1007/s12275-015-5055-y

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Abstract PDF

Bacterial secretion systems play critical roles in communication with neighboring bacteria and in the modulation of host immune responses via the secretion of small proteins called effectors. Several secretion systems have been identified and these are denoted types I-II. Of these, the type VI secretion system (T6SS) and its effectors were only recently elucidated. Most studies on the role and significance of the T6SS and its effectors have focused on human pathogens. In this review, type 6 effectors from plant-associated beneficial and pathogenic bacteria are discussed, including effectors from Agrobacterium tumefaciens, Dickeya dadanti, Rhizobium leguminosarum, Pectobacterium atroseptium, Ralstonia solanacearum, Pseudomonas syringae, Pseudomonas fluorescens, and Pseudomonas protegens. Type 6 effectors act in symbiosis, biofilm formation, virulence, and interbacterial competition. Understanding the impact of type 6 effectors on pathogenesis will contribute to the management of bacterial pathogens in crop plants by allowing the manipulation of intra and inter-specific interactions.

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Minireview] The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back: Xiaolei Wei , Yuanwei Zhang Zhang , Ling Lu; J. Microbiol. 2015;53(2):91-99. Published online January 28, 2015; DOI: https://doi.org/10.1007/s12275-015-5014-7

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Abstract

The growing use of immunosuppressive therapies has resulted in a dramatic increased incidence of invasive fungal infections (IFIs) caused by Aspergillus fumigatus, a common pathogen, and is also associated with a high mortality rate. Azoles are the primary guideline-recommended therapy agents for first-line treatment and prevention of IFIs. However, increased azole usage in medicinal and agricultural settings has caused azole-resistant isolates to repeatedly emerge in the environment, resulting in a significant threat to human health. In this review, we present and summarize current research on the resistance mechanisms of azoles in A. fumigatus as well as efficient susceptibility testing methods. Moreover, we analyze and discuss the putative clinical (bedside) indication of these findings from bench work.

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The mitochondrial protein Bcs1A regulates antifungal drug tolerance by affecting efflux pump expression in the filamentous pathogenic fungus Aspergillus fumigatus
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A Putative Mitochondrial Iron Transporter MrsA in Aspergillus fumigatus Plays Important Roles in Azole-, Oxidative Stress Responses and Virulence
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Highly efficient CRISPR mutagenesis by microhomology-mediated end joining in Aspergillus fumigatus
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Research Support, Non-U.S. Gov't

Pneumococcal wall teichoic acid is required for the pathogenesis of Streptococcus pneumoniae in murine models: Hongmei Xu , Libin Wang , Jian Huang , Yanqing Zhang , Feng Ma , Jianmin Wang , Wenchun Xu , Xuemei Zhang , Yibing Yin , Kaifeng Wu; J. Microbiol. 2015;53(2):147-154. Published online January 28, 2015; DOI: https://doi.org/10.1007/s12275-015-4616-4

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Abstract

Pneumococcal asymptomatic colonization of the respiratory tracts is a major risk for invasive pneumococcal disease. We have previously shown that pneumococcal wall teichoic acid (WTA) was involved in pneumococcal infection of sepsis and adherence to epithelial and endothelial cells. In this study, we investigated the contribution of pneumococcal WTA to bacterial colonization and dissemination in murine models. The result showed that nasopharynx colonizing D39 bacterial cells have a distinct phenotype showing an increased exposure of teichoic acids relative to medium-grown bacteria. The WTA-deficient mutants were impaired in their colonization to the nasopharynx and lungs, and led to a mild inflammation in the lungs at 36 h post-inoculation. Pretreatment of the murine nares with WTA reduced the ability of wild type D39 bacteria to colonize the nasopharynx. In addition, the WTA-deficient strain was impaired in its ability to invade the blood and brain following intranasal administration. WTA-deficient D39 strain was reduced in C3 deposition but was more susceptible to the killing by the neutrophils as compared with its parent strain. Our results also demonstrated that the WTA enhanced pneumococcal colonization and dissemination independently of the host strains. These results indicate that WTA plays an important role in pneumococcal pathogenesis, both in colonization and dissemination processes.

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Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
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Robert T Gale, Eric D Brown
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Review

Minireivew] Protective Role of Gut Commensal Microbes against Intestinal Infections: My Young Yoon , Keehoon Lee , Sang Sun Yoon; J. Microbiol. 2014;52(12):983-989. Published online November 29, 2014; DOI: https://doi.org/10.1007/s12275-014-4655-2

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Abstract PDF

The human gastrointestinal tract is colonized by multitudes of microorganisms that exert beneficial effects on human health. Mounting evidence suggests that intestinal microbiota contributes to host resistance against enteropathogenic bacterial infection. However, molecular details that account for such an important role has just begun to be understood. The commensal microbes in the intestine regulate gut homeostasis through activating the development of host innate immunity and producing molecules with antimicrobial activities that directly inhibit propagation of pathogenic bacteria. Understanding the protective roles of gut microbiota will provide a better insight into the molecular basis that underlies complicated interaction among host-pathogen-symbiont. In this review, we highlighted recent findings that help us broaden our knowledge of the intestinal ecosystem and thereby come up with a better strategy for combating enteropathogenic infection.

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Journal Article

Note] Antifungal Chitinase against Human Pathogenic Yeasts from Coprinellus congregatus: Yeeun Yoo Hyoung T. Choi; J. Microbiol. 2014;52(5):441-443. Published online February 17, 2014; DOI: https://doi.org/10.1007/s12275-014-3257-3

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Abstract PDF

The inky cap, Coprinellus congregatus, produces mushrooms which become autolyzed rapidly to generate black liquid droplets, in which no cell wall is detected by microscopy. A chitinase (Chi2) which is synthesized during the autolytic phase of C. congregatus inhibits the growths of Candida al-bicans and Cryptococcus neoformans up to 10% at the con-centration of 10 μg/ml, about 50% at concentration of 20 μg/ml, and up to 95% at the concentration of 70 μg/ml. Upon treatment these yeast cells are observed to be severely de-formed, with the formation of large holes in the cell wall. The two yeast species show no growth inhibition at the concen-tration of 5 μg/ml, which means the minimum inhibitory concentrations for both yeast species are 10 μg/ml under these experimental conditions.

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Analysis of the Antifungal Potential of Macrocybe Titans Extract Against Candida Albicans
Fernanda CBN Pereira, Gabrielle C Peiter, Vivian EMS Justo, Gabrieli M Huff, Pollyanna CV Conrado, Mauro AP da Silva, Patrícia S Bonfim-Mendonça, Terezinha IE Svidzinski, Fabio R Rosado, Adriana Fiorini
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Disarming Fungal Pathogens: Bacillus safensis Inhibits Virulence Factor Production and Biofilm Formation by Cryptococcus neoformans and Candida albicans
François L. Mayer, James W. Kronstad, Yong-Sun Bahn, J. Andrew Alspaugh, Deborah Hogan
mBio.2017;[Epub] CrossRef

Research Support, Non-U.S. Gov't

A Novel Retron of Vibrio parahaemolyticus Is Closely Related to Retron-Vc95 of Vibrio cholerae: Toshi Shimamoto , Ashraf M. Ahmed , Tadashi Shimamoto; J. Microbiol. 2013;51(3):323-328. Published online June 28, 2013; DOI: https://doi.org/10.1007/s12275-013-2715-7

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Abstract PDF

Some bacteria produce a satellite RNA-DNA complex termed msDNA, multicopy single-stranded DNA. In this report, msDNA from Vibrio parahaemolyticus, a cause of acute gastroenteritis, was identified and named msDNA-Vp96. The retron element containing the ret gene, encoding the reverse transcriptase (RT) that is responsible for msDNA production, was cloned and characterized. Comparison of msDNAVp96 and msDNA-Vc95, from Vibrio cholerae, showed a high level of sequence similarity. We exchanged the two ret genes to examine whether msDNA was produced by the RT from different sources. We found that RT-Vp96 of V. parahaemolyticus was able to synthesize msDNA-Vc95 of V. cholerae and vice versa. To the best of our knowledge, this is the first report that RT from different bacterial species can synthesize msDNA.

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Retrons and their applications in genome engineering
Anna J Simon, Andrew D Ellington, Ilya J Finkelstein
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