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Research Support, Non-U.S. Gov't
- Anti-HIV-1 Efficacy of Extracts from Medicinal Plants
- Su-A Lee , Seong-Karp Hong , Chang-Il Suh , Mi-Hwa Oh , Jeong-Ho Park , Byoung-Wook Choi , Seung-Won Park , Soon-Young Paik
- J. Microbiol. 2010;48(2):249-252. Published online May 1, 2010
- DOI: https://doi.org/10.1007/s12275-009-0176-9
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- 13 Crossref
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Abstract
PDF - The anti-HIV-1 activities of butanol, hexane, chloroform and water extracts from four widely used folk medicinal plants (Sophora flavescens, Tulipa edulis, Herba ephedra, and Pachyma hoelen Rumph) were evaluated in this study. The hexane extract of Pachyma hoelen Rumph, PH-4, showed effective inhibition against HIV-1. The 50% effective concentration (EC50) of PH-4 was 37.3 μg/ml in the p24 antigen assay and 36.8% in the HIV-1 recombinant RT activity test (at 200 μg/ml). In addition, the PH-4 showed the protective effect on the infected MT-4 cells, with a 58.2% rate of protection. The 50% cytotoxic concentration (CC50) of PH-4 was 100.6 μg/ml. These results suggest that PH-4 from Pachyma hoelen Rumph might be the candidate for the chemotherapy agent against HIV-1 infection with further study.
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Citations
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Molecules.2020; 25(14): 3283. CrossRef - Immune stimulatory and anti-HIV-1 potential of extracts derived from marine brown algae Padina tetrastromatica
Dinesh Subramaniam, Luke Elizabeth Hanna, Kuppusamy Maheshkumar, Karuppiah Ponmurugan, Naif Abdullah Al-Dhabi, P. Murugan
Journal of Complementary and Integrative Medicine.2020;[Epub] CrossRef - Physicochemical and antioxidant potential of polysaccharides sequentially extracted from Amana edulis
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International Journal of Biological Macromolecules.2019; 131: 453. CrossRef - Role of medicinal plants in HIV/AIDS therapy
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International Journal of Molecular Sciences.2018; 19(5): 1459. CrossRef - Identification of miRNAs Involved in Stolon Formation in Tulipa edulis by High-Throughput Sequencing
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Frontiers in Plant Science.2016;[Epub] CrossRef - Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences
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European Journal of Drug Metabolism and Pharmacokinetics.2016; 41(2): 93. CrossRef - A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency
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Journal of Ethnopharmacology.2015; 175: 528. CrossRef - Lead Screening for HIV-1 Integrase (IN) Inhibited by Traditional Chinese Medicine
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BioMed Research International.2014; 2014: 1. CrossRef - Anti-HIV-1 activity of phlorotannin derivative 8,4‴-dieckol from Korean brown alga Ecklonia cava
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Bioscience, Biotechnology, and Biochemistry.2014; 78(7): 1151. CrossRef - Virological efficacy and immunological recovery among Ethiopian HIV-1 infected adults and children
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BMC Infectious Diseases.2014;[Epub] CrossRef - Potential Anti-HIV Agents from Marine Resources: An Overview
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Marine Drugs.2010; 8(12): 2871. CrossRef
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