Journal of Microbiology

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Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model: Woon-ki Kim , You Jin Jang , SungJun Park , Sung-gyu Min , Heeun Kwon , Min Jung Jo , GwangPyo Ko; J. Microbiol. 2024;62(2):91-99. Published online February 22, 2024; DOI: https://doi.org/10.1007/s12275-024-00104-5

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Atopic dermatitis (AD) is a chronic inflammatory skin disease with repeated exacerbations of eczema and pruritus. Probiotics can prevent or treat AD appropriately via modulation of immune responses and gut microbiota. In this study, we evaluated effects of Lactobacillus acidophilus (L. acidophilus) KBL409 using a house dust mite (Dermatophagoides farinae)-induced in vivo AD model. Oral administration of L. acidophilus KBL409 significantly reduced dermatitis scores and decreased infiltration of immune cells in skin tissues. L. acidophilus KBL409 reduced in serum immunoglobulin E and mRNA levels of T helper (Th)1 (Interferon-γ), Th2 (Interleukin [IL]-4, IL-5, IL-13, and IL-31), and Th17 (IL-17A) cytokines in skin tissues. The anti-inflammatory cytokine IL-10 was increased and Foxp3 expression was up-regulated in AD-induced mice with L. acidophilus KBL409. Furthermore, L. acidophilus KBL409 significantly modulated gut microbiota and concentrations of short-chain fatty acids and amino acids, which could explain its effects on AD. Our results suggest that L. acidophilus KBL409 is the potential probiotic for AD treatment by modulating of immune responses and gut microbiota of host.

Citations

Citations to this article as recorded by

Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis
Sung Jae Jang, Eun Jung Jo, Cheonghoon Lee, Bo-Ram Cho, Yun Jeong Shin, Jun Soo Song, Woon-Ki Kim, Nanhee Lee, Hyungjin Lee, SungJun Park, GwangPyo Ko
Probiotics and Antimicrobial Proteins.2025; 17(6): 4580. CrossRef
The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential
Maira Jimenez-Sanchez, Larissa S. Celiberto, Hyungjun Yang, Ho Pan Sham, Bruce A. Vallance
Gut Microbes.2025;[Epub] CrossRef
Probiotics ameliorate atopic dermatitis by modulating the dysbiosis of the gut microbiota in dogs
Hyokeun Song, Seung-Hyun Mun, Dae-Woong Han, Jung-Hun Kang, Jae-Uk An, Cheol-Yong Hwang, Seongbeom Cho
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Letitia Grant, Manijeh Mohammadi Dehcheshmeh, Esmaeil Ebrahimie, Aliakbar Khabiri, Tania Veltman, Michael Shipstone, Darren J. Trott
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Journal of Functional Foods.2025; 131: 106950. CrossRef
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Matthew H. Foley, Arthur S. McMillan, Sarah O'Flaherty, Rajani Thanissery, Molly E. Vanhoy, Mary Gracen Fuller, Rodolphe Barrangou, Casey M. Theriot, Jacques Ravel
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Jingtai Ma, Yiting Fang, Jinxing Hu, Shiqi Li, Lilian Zeng, Siyi Chen, Zhifeng Li, Ruiling Meng, Xingfen Yang, Fenglin Zhang, Guiyuan Ji, Peihua Liao, Liang Chen, Wei Wu
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Tânia Lagoa, Luís Martins, Maria Cristina Queiroga
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Lactobacillus crispatus KBL693 alleviates atopic dermatitis symptoms through immune modulation
Seokcheon Song, Jun-Hyeong Kim, Sung Jae Jang, Eun Jung Jo, Sang Kyun Lim, GwangPyo Ko
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Oral Administration of Lactiplantibacillus plantarum KBL396 Regulates Serum 5-Hydroxytryptamine and Gut Microbiota: Evidence from a Preclinical Mouse Model and a Randomized Controlled Human Trial
Woojae Myung, Sung Jae Jang, Giljae Lee, Cheonghoon Lee, Kiuk Lee, Sung Hyun Moon, Yunsun Jeong, Woon-Ki Kim, SungJun Park, Hyungjin Lee, Yun Seong Park, Sangah Shin, Tae-Wook Nam, Hong Jin Jeon, GwangPyo Ko
Probiotics and Antimicrobial Proteins.2025;[Epub] CrossRef
The Skin Histopathology of Pro- and Parabiotics in a Mouse Model of Atopic Dermatitis
Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Jeong Doo Heo, Hyun Wook Kim, Je Kyung Seong, Tae Yang Kim, Jeong Woo Park, Byeong Soo Kim, Gon Sup Kim
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Effective mucosal live attenuated Salmonella vaccine by deleting phosphotransferase system component genes ptsI and crr: Yong Zhi , Shun Mei Lin , A-Yeung Jang , Ki Bum Ahn , Hyun Jung Ji , Hui-Chen Guo , Sangyong Lim , Ho Seong Seo; J. Microbiol. 2019;57(1):64-73. Published online October 2, 2018; DOI: https://doi.org/10.1007/s12275-019-8416-0

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Abstract PDF

Salmonella enterica is a major human pathogen that causes invasive non-typhoidal Salmonellosis (iNTS), resulting in significant morbidity and mortality. Although a number of pre-clinical and clinical studies have reported on the feasibility of developing a safe and effective vaccine against iNTS, there have been no licensed Salmonella vaccines available to protect against NTS strains. Vaccine formulations of highest priority for NTS are live attenuated vaccines, which can elicit effective induction of intestinal mucosal and intracellular bacteria-specific cell mediated immune responses. Since glucose is crucial for intracellular survival and replication in host cells, we constructed strains with mutations in components of the glucose uptake system, called the phosphotransferase system (PTS), and compared the relative virulence and immune responses in mice. In this study, we found that the strain with mutations in both ptsI and crr (KST0556) was the most attenuated strain among the tested strains, and proved to be highly effective in inducing a mucosal immune response that can protect against NTS infections in mice. Thus, we suggest here that KST0556 (ΔptsIΔcrr) is a potential live vaccine candidate for NTS, and may also be a candidate for a live delivery vector for heterologous antigens. Moreover, since PTS is a well-conserved glucose transporter system in both Gramnegative and Gram-positive bacteria, the ptsI and crr genes may be potential targets for creating live bacterial vectors or vaccine strains.

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Scientific Reports.2020;[Epub] CrossRef
Transporters of glucose and other carbohydrates in bacteria
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Pflügers Archiv - European Journal of Physiology.2020; 472(9): 1129. CrossRef
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International Journal of Molecular Medicine.2020;[Epub] CrossRef

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