Journal of Microbiology

Skip Navigation: Skip to contents

OPEN ACCESS

SEARCH: Search

Advanced Search

mobile menu button

Search

Page Path: HOME > Search

Reviews

Targeting innate immune sensors for therapeutic strategies in infectious diseases: Seyun Shin, Young Ki Choi, SangJoon Lee; J. Microbiol. 2025;63(6):e2503009. Published online June 30, 2025; DOI: https://doi.org/10.71150/jm.2503009

3,535 View
94 Download
3 Web of Science
3 Crossref

Abstract PDF

The innate immune system relies on innate immune sensors, such as pattern recognition receptors (PRRs), to detect pathogens and initiate immune responses, crucial for controlling infections but also implicated in inflammatory diseases. These innate immune sensors, including Toll-like receptors (TLRs), nod-like receptors (NLRs), RIG-I-like receptors (RLRs), absent in melanoma 2 (AIM2), and Z-DNA binding protein 1 (ZBP1) trigger signaling pathways that produce cytokines, modulating inflammation and cell death. Traditional therapies focus on directly targeting pathogens; however, host-targeting therapeutic strategies have emerged as innovative approaches to modulate innate immune sensor activity. These strategies aim to fine-tune the immune response, either enhancing antiviral defenses or mitigating hyperinflammation to prevent tissue damage. This review explores innate immune sensor-based therapeutic approaches, including inhibitors, agonists, and antagonists, that enhance antiviral defense or suppress harmful inflammation, highlighting innate immune sensors as promising targets in infectious and inflammatory disease treatment.

Citations

Citations to this article as recorded by

A new fucosylated glucuronoxylomannan from the fruit bodies of Tremella aurantia: structural characterization and immunoenhancing activity on seasonal influenza mRNA vaccine
Jing Chen, Yuan Ma, Zhi-Min Rao, Song-Lin Jiang, Ying-Jun Lou, Karim Malik, Arman Chowdhury, Hua-Zhong Ying, Chen-Huan Yu
Carbohydrate Polymers.2026; 373: 124660. CrossRef
Z-DNA interaction proteins - insights from ChIP-seq data
Michaela Dobrovolná, Václav Brázda
Biochemical and Biophysical Research Communications.2025; 790: 152910. CrossRef
AIM2 drives inflammatory cell death and monkeypox pathogenesis
Jueun Oh, Yun-Ho Hwang, Jihye Lee, Cheong Seok, SuHyeon Oh, Hye Yoon Kim, Nabukenya Mariam, Jaeyoung Ahn, GyeongJu Yu, Jaewoo Park, Hayeon Kim, Suhyun Kim, Seyun Shin, Min-Chul Jung, Jinwoo Gil, Joo Sang Lee, Young Ki Choi, Dokeun Kim, Daesik Kim, You-Jin
Cellular & Molecular Immunology.2025; 22(12): 1615. CrossRef

Microbiome-Mucosal Immunity Nexus: Driving Forces in Respiratory Disease Progression: Young Chae Park, Soo Yeon Choi, Yunah Cha, Hyeong Won Yoon, Young Min Son; J. Microbiol. 2024;62(9):709-725. Published online September 6, 2024; DOI: https://doi.org/10.1007/s12275-024-00167-4

533 View
6 Download
4 Web of Science
5 Crossref

Abstract PDF

The importance of the complex interplay between the microbiome and mucosal immunity, particularly within the respiratory tract, has gained significant attention due to its potential implications for the severity and progression of lung diseases. Therefore, this review summarizes the specific interactions through which the respiratory tract-specific microbiome influences mucosal immunity and ultimately impacts respiratory health. Furthermore, we discuss how the microbiome affects mucosal immunity, considering tissue-specific variations, and its capacity in respiratory diseases containing asthma, chronic obstructive pulmonary disease, and lung cancer. Additionally, we investigate the external factors which affect the relationship between respiratory microbiome and mucosal immune responses. By exploring these intricate interactions, this review provides valuable insights into the potential for microbiome-based interventions to modulate mucosal immunity and alleviate the severity of respiratory diseases.

Citations

Citations to this article as recorded by

The impact of environmental factors on respiratory tract microbiome and respiratory system diseases
Yutao Ge, Guo Tang, Yawen Fu, Peng Deng, Rong Yao
European Journal of Medical Research.2025;[Epub] CrossRef
Meta-transcriptomics Reveals Dysbiosis of the Respiratory Microbiome in Older Adults with Long COVID
Meng’en Liao, Jianpeng Cai, Feng Zhu, Yuanbo Lan, Tianqi Xu, Jingxin Guo, Quanlin Xue, Yilong Wen, Fan Zou, Yu Zhang, Shiliang Zhang, Yan Yan, Jingwen Ai, Jie Cui, Wenhong Zhang
Research.2025;[Epub] CrossRef
Lactobacillus salivarius HHuMin-U attenuates vulvovaginal candidiasis via vaginal epithelial immune enhancement mediated by NF-κB activation
Juwon Choi, Jay-Young Jo, Ji Su Lee, Joe Eun Son, Sun Young Kim, Hye Eun Lee, Yeong-Je Seong, Keon Heo, Yongbaek Kim, Myeong Soo Park, Sanguine Byun
New Biotechnology.2025; 90: 36. CrossRef
Immune system - can it be boosted/influenced?
Jiřina Bartůňková
Medicína pro praxi.2025; 22(5): 319. CrossRef
Bacteria and fungi of the lung: allies or enemies?
Enrico Garaci, Marilena Pariano, Emilia Nunzi, Claudio Costantini, Marina Maria Bellet, Cinzia Antognelli, Matteo Antonio Russo, Luigina Romani
Frontiers in Pharmacology.2024;[Epub] CrossRef

Balancing Act of the Intestinal Antimicrobial Proteins on Gut Microbiota and Health: Ye Eun Ra, Ye‑Ji Bang; J. Microbiol. 2024;62(3):167-179. Published online April 17, 2024; DOI: https://doi.org/10.1007/s12275-024-00122-3

657 View
23 Download
15 Web of Science
17 Crossref

Abstract PDF

The human gut houses a diverse and dynamic microbiome critical for digestion, metabolism, and immune development, exerting profound efects on human health. However, these microorganisms pose a potential threat by breaching the gut barrier, entering host tissues, and triggering infections, uncontrolled infammation, and even sepsis. The intestinal epithelial cells form the primary defense, acting as a frontline barrier against microbial invasion. Antimicrobial proteins (AMPs), produced by these cells, serve as innate immune efectors that regulate the gut microbiome by directly killing or inhibiting microbes. Abnormal AMP production, whether insufcient or excessive, can disturb the microbiome equilibrium, contributing to various intestinal diseases. This review delves into the complex interactions between AMPs and the gut microbiota and sheds light on the role of AMPs in governing host-microbiota interactions. We discuss the function and mechanisms of action of AMPs, their regulation by the gut microbiota, microbial evasion strategies, and the consequences of AMP dysregulation in disease. Understanding these complex interactions between AMPs and the gut microbiota is crucial for developing strategies to enhance immune responses and combat infections within the gut microbiota. Ongoing research continues to uncover novel aspects of this intricate relationship, deepening our understanding of the factors shaping gut health. This knowledge has the potential to revolutionize therapeutic interventions, ofering enhanced treatments for a wide range of gut-related diseases.

Citations

Citations to this article as recorded by

Microbiota-derived D-amino acids in intestinal homeostasis and inflammatory bowel disease
Kentaro Miyamoto, Tomohisa Sujino
Inflammation and Regeneration.2026;[Epub] CrossRef
Host-directed therapies modulating innate immunity against infection in hematologic malignancies
Qiong Wang, Kristján Hermannsson, Egill Másson, Peter Bergman, Guðmundur Hrafn Guðmundsson
Blood Reviews.2025; 70: 101255. CrossRef
Progress in the Identification and Design of Novel Antimicrobial Peptides Against Pathogenic Microorganisms
Shengwei Sun
Probiotics and Antimicrobial Proteins.2025; 17(2): 918. CrossRef
Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience
Henriette Arnesen, Signe Birkeland, Harriet Stendahl, Klaus Neuhaus, David Masopust, Preben Boysen, Harald Carlsen
Discovery Immunology.2025;[Epub] CrossRef
Oral administration of LEAP2 enhances immunity against Edwardsiella tarda through regulation of gut bacterial community and metabolite in mudskipper
Ting-Fang Zhu, Hai-Peng Guo, Li Nie, Jiong Chen
Fish & Shellfish Immunology.2025; 158: 110128. CrossRef
Pharmacology of Intestinal Inflammation and Repair
Céline Deraison, Nathalie Vergnolle
Annual Review of Pharmacology and Toxicology .2025; 65(1): 301. CrossRef
Microbiome dysbiosis in SARS-CoV-2 infection: implication for pathophysiology and management strategies of COVID-19
Shukur Wasman Smail, Niaz Albarzinji, Rebaz Hamza Salih, Kalthum Othman Taha, Sarah Mousa Hirmiz, Hero M. Ismael, Marwa Fateh Noori, Sarkar Sardar Azeez, Christer Janson
Frontiers in Cellular and Infection Microbiology.2025;[Epub] CrossRef
Harnessing the Microbiome: CRISPR-Based Gene Editing and Antimicrobial Peptides in Combating Antibiotic Resistance and Cancer
Radwa A. Amen, Yaser M. Hassan, Rawan A. Essmat, Rana H. Ahmed, Marwan M. Azab, Nadia R. Shehata, Mariam M. Elgazzar, Wael M. El-Sayed
Probiotics and Antimicrobial Proteins.2025; 17(4): 1938. CrossRef
The Role of Functional Feed in Modulating Fish Gut Microbiome to Enhance Resistance Against Aquaculture Pathogens
Eswar Marcharla, A Vishnuprasadh, Lalitha Gnanasekaran, Saranya Vinayagam, Thanigaivel Sundaram, Swamynathan Ganesan
Probiotics and Antimicrobial Proteins.2025;[Epub] CrossRef
Metabolic profiling and genetic tool development in the mucosal bacterium Selenomonas sputigena
Trinh Thi Nguyen, Yu-Kyung Kim, Trang Vu Thien Nguyen, Junbeom Kwon, Ye-Ji Bang
Genes & Genomics.2025; 47(10): 997. CrossRef
Impact of the COVID-19 pandemic on vancomycin-resistant Enterococcus bloodstream infections: a 6-year study in Western Greece
Maria Lagadinou, Christos Michailides, Christodoulos Chatzigrigoriadis, Ioannis Erginousakis, Prodromos Avramidis, Marina Amerali, Fotini Tasouli, Anna Chondroleou, Katerina Skintzi, Anastasia Spiliopoulou, Fevronia Kolonitsiou, Leonidia Leonidou, Stelios
Frontiers in Microbiology.2025;[Epub] CrossRef
Modeling gut inflammation using intestinal organoids: Advances, challenges, and future perspectives
Justina Guzauskiene, Deimante Valentelyte, Goda Butaite, Ugne Kulokiene, Viltaute Laukaitiene, Ruta Inciuraite, Jurgita Skieceviciene
Best Practice & Research Clinical Gastroenterology.2025; 78: 102048. CrossRef
Rational bioengineering of polysaccharide in designing of microbiome modulation
Jeong Hyun Moon, Kidong Kim, Yubin Kim, Sejin Son
Trends in Biotechnology.2025;[Epub] CrossRef
Swine-Derived Probiotics and Their Metabolites as an Alternative to Veterinary Antibiotics
Mengshi Zhao, Bihong Chen, Song Peng, Guiheng Mei, Meiqin Li, Fengqiang Lin, Tiecheng Sun, Zhaolong Li
Veterinary Sciences.2025; 12(11): 1100. CrossRef
Macrophages and Gut Barrier Function: Guardians of Gastrointestinal Health in Post-Inflammatory and Post-Infection Responses
Edward Xiangtai Meng, George Nicholas Verne, Qiqi Zhou
International Journal of Molecular Sciences.2024; 25(17): 9422. CrossRef
Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef
Gut Microbiota as Emerging Players in the Development of Alcohol-Related Liver Disease
Wei Li, Wenkang Gao, Shengqi Yan, Ling Yang, Qingjing Zhu, Huikuan Chu
Biomedicines.2024; 13(1): 74. CrossRef

MAPK Cascades in Plant Microbiota Structure and Functioning: Thijs Van Gerrewey, Hoo Sun Chung; J. Microbiol. 2024;62(3):231-248. Published online April 8, 2024; DOI: https://doi.org/10.1007/s12275-024-00114-3

664 View
7 Download
14 Web of Science
14 Crossref

Abstract PDF

Mitogen-activated protein kinase (MAPK) cascades are highly conserved signaling modules that coordinate diverse biological processes such as plant innate immunity and development. Recently, MAPK cascades have emerged as pivotal regulators of the plant holobiont, infuencing the assembly of normal plant microbiota, essential for maintaining optimal plant growth and health. In this review, we provide an overview of current knowledge on MAPK cascades, from upstream perception of microbial stimuli to downstream host responses. Synthesizing recent fndings, we explore the intricate connections between MAPK signaling and the assembly and functioning of plant microbiota. Additionally, the role of MAPK activation in orchestrating dynamic changes in root exudation to shape microbiota composition is discussed. Finally, our review concludes by emphasizing the necessity for more sophisticated techniques to accurately decipher the role of MAPK signaling in establishing the plant holobiont relationship.

Citations

Citations to this article as recorded by

The microbiome orchestrates contaminant low-dose phytostimulation
Evgenios Agathokleous, Edward J. Calabrese, Stavros D. Veresoglou
Trends in Plant Science.2025; 30(5): 515. CrossRef
Lipid transfer protein VAS inhibits the hypersensitive response via reactive oxygen species signaling in Nicotiana benthamiana
Rina Koyama, Akira Suzuki, Kouhei Ohnishi, Yasufumi Hikichi, Akinori Kiba, Stefanie Ranf
Journal of Experimental Botany.2025; 76(4): 1285. CrossRef
Short-Term Fertilization with the Nitrogen-Fixing Bacterium (NFB) Kosakonia radicincitans GXGL-4A Agent Can Modify the Transcriptome Expression Profiling of Cucumber (Cucumis sativus L.) Root
Baoyun Feng, Erxing Wang, Yating Zhang, Lurong Xu, Yanwen Xue, Yunpeng Chen
Microorganisms.2025; 13(3): 506. CrossRef
Genome-wide identification and unveiling the role of MAP kinase cascade genes involved in sugarcane response to abiotic stressors
Ahmad Ali, Xue-Ting Zhao, Ji-Shan Lin, Ting-Ting Zhao, Cui-Lian Feng, Ling Li, Rui-Jie Wu, Qi-Xing Huang, Hong-Bo Liu, Jun-Gang Wang
BMC Plant Biology.2025;[Epub] CrossRef
Comparative transcriptome and co-expression network reveals key genes associated with mesocotyl elongation in foxtail millet (Setaria italica)
Meiqiang Yin, Mengyao An, Yuxin Gao, Jianjun Guo, Chongyue Wang, Yanjie Wen, Mingjing Huang, Juan Zhao, Yinyuan Wen
Environmental and Experimental Botany.2025; 234: 106144. CrossRef
Comparative transcriptomic analysis and genome-wide identification provide insights into the potential role of fungal-responsive MAPK cascade genes in tanshinone accumulation in Salvia miltiorrohiza
Ann Abozeid, Xinru Du, Lan Zhang, Furui Yang, Jianxiong Wu, Lin Zhang, Qi Cui, Zongqi Yang, Dongfeng Yang
Frontiers in Plant Science.2025;[Epub] CrossRef
Characteristics of the MAPK gene family in Zizania latifolia and MAPK3 role in response to fungal pathogen infection
Lijun Xu, Pengfei Guo, Yong Kuang, Ke Su, Keling Hu, Defang Gan
Journal of Genetics.2025;[Epub] CrossRef
Chitosan oligosaccharide regulates host defense in pepper plants against cucumber mosaic virus
Jing Shi, Lele Li, Hao Zhou, Jialian Su, Song Bai, Miao Li, Jianta Wang, Lei Tang
Pesticide Biochemistry and Physiology.2025; 215: 106654. CrossRef
Unlocking the leaf microcosm: Ecological dynamics, functional roles, and implications for sustainable agriculture
Hassan Etesami, Umarov Otabek, Bafayeva Zahro, To'rayeva Nargiza, Ochilova Muyassar
Physiological and Molecular Plant Pathology.2025; 139: 102841. CrossRef
MAP kinases and stomatal regulation: current updates and future perspectives
Ming Ding, Houqing Zeng, Yohei Takahashi, Toshinori Kinoshita, Haidong Ding
Trends in Plant Science.2025;[Epub] CrossRef
Rice blast pathogen effector AvrPib compromises disease resistance by targeting Raf‐like protein kinase OsMAPKKK72 to inhibit MAPK signaling
Zhanchun Wang, Guitao Zhong, Beibei Zhang, Yilin Xie, Yufan Gan, Dingzhong Tang, Wei Wang
Journal of Integrative Plant Biology.2025;[Epub] CrossRef
Pharmacological effects and the related mechanism of scutellarin on inflammation-related diseases: a review
Yang Zhou, Chenlin Gu, Yan Zhu, Yuting Zhu, Yutong Chen, Li Shi, Yang Yang, Xin Lu, Hanqing Pang
Frontiers in Pharmacology.2024;[Epub] CrossRef
Rice E3 ubiquitin ligases: From key modulators of host immunity to potential breeding applications
Yuqing Yan, Hui Wang, Yan Bi, Fengming Song
Plant Communications.2024; 5(12): 101128. CrossRef
Host-Associated Microbiome
Woo Jun Sul
Journal of Microbiology.2024; 62(3): 135. CrossRef

Journal Articles

Evaluation of Cyc1 protein stability in Acidithiobacillus ferrooxidans bacterium after E121D mutation by molecular dynamics simulation to improve electron transfer: Mahnaz Shojapour , Somayeh Farahmand , Faezeh Fatemi , Marzieh Dehghan Shasaltaneh; J. Microbiol. 2022;60(5):526-532. Published online March 14, 2022; DOI: https://doi.org/10.1007/s12275-022-1645-7

374 View
0 Download
2 Web of Science
1 Crossref

Abstract PDF

Cyc1 (Cytochrome c552) is a protein in the electron transport chain of the Acidithiobacillus ferrooxidans (Af) bacteria which obtain their energy from oxidation Fe2+ to Fe3+. The electrons are directed through Cyc2, RCY (rusticyanin), Cyc1, and Cox aa3 proteins to O2. Cyc1 protein consists of two chains, A and B. In the present study, a novel mutation (E121D) in the A chain of Cyc1 protein was selected due to electron receiving from Histidine 143 of RCY. Then, the changes performed in the E121D mutant were evaluated by MD simulations analyzes. Cyc1 and RCY proteins were docked by a Patchdock server. By E121D mutation, the connection between Zn 1388 of chain B and aspartate 121 of chain A weaken. Asp 121 gets farther from Zn 1388. Therefore, the aspartate gets closer to Cu 1156 of the RCY leading to the higher stability of the RCY/ Cyc1 complex. Further, an acidic residue (Glu121) becomes a more acidic residue (Asp121) and improves the electron transfer to Cyc1 protein. The results of RMSF analysis showed further ligand flexibility in mutation. This leads to fluctuation of the active site and increases redox potential at the mutation point and the speed of electron transfer. This study also predicts that in all respiratory chain proteins, electrons probably enter the first active site via glutamate and exit histidine in the second active site of each respiratory chain protein.

Citations

Citations to this article as recorded by

Point mutation consideration in CcO protein of the electron transfer chain by MD simulation
Mahnaz Shojapour, Somayeh Farahmand
Journal of Molecular Graphics and Modelling.2022; 117: 108309. CrossRef

Vibrio vulnificus PlpA facilitates necrotic host cell death induced by the pore forming MARTX toxin: Changyi Cho , Sanghyeon Choi , Myung Hee Kim , Byoung Sik Kim; J. Microbiol. 2022;60(2):224-233. Published online February 1, 2022; DOI: https://doi.org/10.1007/s12275-022-1448-x

479 View
3 Download
14 Web of Science
13 Crossref

Abstract PDF

Opportunistic pathogen Vibrio vulnificus causes severe systemic infection in humans with high mortality. Although multiple exotoxins have been characterized in V. vulnificus, their interactions and potential synergistic roles in pathogen-induced host cell death have not been investigated previously. By employing a series of multiple exotoxin deletion mutants, we investigated whether specific exotoxins of the pathogen functioned together to achieve severe and rapid necrotic cell death. Human epithelial cells treated with V. vulnificus with a plpA deletion background exhibited an unusually prolonged cell blebbing, suggesting the importance of PlpA, a phospholipase A2, in rapid necrotic cell death by this pathogen. Additional deletion of the rtxA gene encoding the multifunctional autoprocessing repeats-in-toxin (MARTX) toxin did not result in necrotic cell blebs. However, if the rtxA gene was engineered to produce an effector-free MARTX toxin, the cell blebbing was observed, indicating that the pore forming activity of the MARTX toxin is sufficient, but the MARTX toxin effector domains are not necessary, for the blebbing. When a recombinant PlpA was treated on the blebbed cells, the blebs were completely disrupted. Consistent with this, MARTX toxin-pendent rapid release of cytosolic lactate dehydrogenase was significantly delayed in the plpA deletion background. Mutations in other exotoxins such as elastase, cytolysin/hemolysin, and/or extracellular metalloprotease did not affect the bleb formation or disruption. Together, these findings indicate that the pore forming MARTX toxin and the phospholipase A2, PlpA, cooperate sequentially to achieve rapid necrotic cell death by inducing cell blebbing and disrupting the blebs, respectively.

Citations

Citations to this article as recorded by

Immunogenicity and protective efficacy of Vibrio vulnificus outer membrane vesicles in zebrafish: Implications for fish immunization
Duo Chen, Chengyang Zheng, Jiapeng Wang, Zhenlu Li, Chenhuan Dong, Yuanxin Liang, Yilin Huang, Youqiang Chen, Ting Xue, Chentao Lin
Fish & Shellfish Immunology.2026; 168: 110981. CrossRef
Genome-wide phenotypic profiling of transcription factors and identification of novel targets to control the virulence of Vibrio vulnificus
Dayoung Sung, Garam Choi, Minji Ahn, Hokyung Byun, Tae Young Kim, Hojun Lee, Zee-Won Lee, Ji Yong Park, Young Hyun Jung, Ho Jae Han, Sang Ho Choi
Nucleic Acids Research.2025;[Epub] CrossRef
Differential expressed genes (DEGs) and differential alternative splicing genes (DASs) revealed the common pathologic mechanism of three bacterial pathogens to American eels (Anguilla rostrata)
Zihao Chen, Guanghua Sun, Songlin Guo
Aquaculture Reports.2025; 40: 102632. CrossRef
Implication of environmental factors on the pathogenicity of Vibrio vulnificus: Insights into gene activation and disease outbreak
Aswathi Bharathan, Yaser Arafath, Aifa Fathima, Saqib Hassan, Prabhakar Singh, George Seghal Kiran, Joseph Selvin
Microbial Pathogenesis.2025; 204: 107591. CrossRef
Non-Repeat Segment 1 in Vibrio vulnificus MARTX toxin, which binds to biantennary N-glycans, is essential for host cell blebbing but dispensable for effector translocation
Jieun Lee, Yunjeong Kim, Byoung Sik Kim
Microbiological Research.2025; 295: 128108. CrossRef
The clinical characteristics and diagnostic and treatment protocol for 14 acute Vibrio vulnificus infections caused by aquatic products
Donghua Ma, Jinjun Wang, Baoying Fan, Jianji Liang, Qing Liu, Zhiyong He
Medicine.2025; 104(34): e43942. CrossRef
It’s time to act: Understanding and combating Vibrio vulnificus
Chao Li, Gang Li, Ming Li
Virulence.2025;[Epub] CrossRef
Comparative Transcriptomic Analysis Underlies the Differential Virulence of Vibrio harveyi and Vibrio vulnificus in American Eels (Anguilla rostrata)
Qiuhua Yang, Guanghua Sun, Sijia Hong, Qi Lin, Jinjin Yang, Songlin Guo
International Journal of Molecular Sciences.2025; 26(24): 11763. CrossRef
Vibrio-infecting bacteriophages and their potential to control biofilm
Ana Cevallos-Urena, Jeong Yeon Kim, Byoung Sik Kim
Food Science and Biotechnology.2023; 32(12): 1719. CrossRef
Pathogenic Mechanism of Vibrio Vulnificus Infection
Kun Lu, Yang Li, Rui Chen, Hua Yang, Yong Wang, Wei Xiong, Fang Xu, Qijun Yuan, Haihui Liang, Xian Xiao, Renqiang Huang, Zhipeng Chen, Chunou Tian, Songqing Wang
Future Microbiology.2023; 18(6): 373. CrossRef
Functional conservation of specialized ribosomes bearing genome-encoded variant rRNAs in Vibrio species
Younkyung Choi, Eunkyoung Shin, Minho Lee, Ji-Hyun Yeom, Kangseok Lee, Bashir Sajo Mienda
PLOS ONE.2023; 18(12): e0289072. CrossRef
Complex regulatory networks of virulence factors in Vibrio vulnificus
Garam Choi, Sang Ho Choi
Trends in Microbiology.2022; 30(12): 1205. CrossRef
MARTX toxin of Vibrio vulnificus induces RBC phosphatidylserine exposure that can contribute to thrombosis
Han Young Chung, Yiying Bian, Kyung-Min Lim, Byoung Sik Kim, Sang Ho Choi
Nature Communications.2022;[Epub] CrossRef

Description of Vagococcus coleopterorum sp. nov., isolated from the intestine of the diving beetle, Cybister lewisianus, and Vagococcus hydrophili sp. nov., isolated from the intestine of the dark diving beetle, Hydrophilus acuminatus, and emended description of the genus Vagococcus: Dong-Wook Hyun , Euon Jung Tak , Pil Soo Kim , Jin-Woo Bae; J. Microbiol. 2021;59(2):132-141. Published online December 23, 2020; DOI: https://doi.org/10.1007/s12275-021-0485-1

480 View
0 Download
6 Web of Science
6 Crossref

Abstract PDF

A polyphasic taxonomic approach was used to characterize two novel bacterial strains, HDW17AT and HDW17BT, isolated from the intestine of the diving beetle Cybister lewisianus, and the dark diving beetle Hydrophilus acuminatus, respectively. Both strains were Gram-positive and facultative anaerobic cocci forming cream-colored colonies. The isolates grew optimally at 25°C, pH 7, in the presence of 0.3% (wt/vol) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences and genome sequences showed that the isolates were members of the genus Vagococcus, and strain HDW17AT was closely related to Vagococcus fessus CCUG 41755T (98.9% of 16S rRNA gene sequence similarity and 74.3% of average nucleotide identity [ANI]), whereas strain HDW17BT was closely related to Vagococcus fluvialis NCFB 2497T (98.9% of 16S rRNA gene sequence similarity and 76.6% of ANI). Both strains contained C16:0, and C18:1 ω9c as the major cellular fatty acids, but C16:1 ω9c was also observed only in strain HDW17BT as the major cellular fatty acid. The respiratory quinone of the isolates was MK-7. The major polar lipid components were phosphatidylglycerol, phosphatidylethanolamine, and diphosphatidylglycerol. The genomic DNA G + C content of strains HDW17AT and HDW17BT were 36.6 and 34.4%, respectively. Both strains had cell wall peptidoglycan composed of the amino acids L-alanine, glycine, D-glutamic acid, L-tryptophan, L-lysine, and L-aspartic acid, and the sugars ribose, glucose, and galactose. Based on phylogenetic, phenotypic, chemotaxonomic, and genotypic analyses, strains HDW17AT and HDW17BT represent two novel species in the genus Vagococcus. We propose the name Vagococcus coleopterorum sp. nov. for strain HDW17AT (= KACC 21348T = KCTC 49324T = JCM 33674T) and the name Vagococcus hydrophili sp. nov. for strain HDW17BT (= KACC 21349T = KCTC 49325T = JCM 33675T).

Citations

Citations to this article as recorded by

Vagococcus proximus sp. nov. and Vagococcus intermedius sp. nov., originating from modified atmosphere packaged broiler meat
Per Johansson, Elina Jääskeläinen, Elina Säde, Johanna Björkroth
International Journal of Systematic and Evolutionary Microbiology .2023;[Epub] CrossRef
A case of Vagococcus fluvialis isolated from the bile of a patient with calculous cholecystitis
Dan Zhang, Xiaosu Wang, Jingdan Yu, Zheng Dai, Qichao Li, Litao Zhang
BMC Infectious Diseases.2023;[Epub] CrossRef
Vagococcus luciliae sp. nov., isolated from the common green bottle fly Lucilia sericata
Juan Guzman, Anja Poehlein, Rolf Daniel, Peter Kämpfer, Andreas Vilcinskas
International Journal of Systematic and Evolutionary Microbiology .2023;[Epub] CrossRef
Valid publication of new names and new combinations effectively published outside the IJSEM. Validation List no. 203
Aharon Oren, George M. Garrity
International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
Effects of different doses of electron beam irradiation on bacterial community of Portunus trituberculatus
Huijuan Pan, Qi Yu, Chenru Qian, Haitao Shao, Jiajun Han, Yongyong Li, Yongjiang Lou
Food Bioscience.2021; 42: 101198. CrossRef
Description of Nocardioides piscis sp. nov., Sphingomonas piscis sp. nov. and Sphingomonas sinipercae sp. nov., isolated from the intestine of fish species Odontobutis interrupta (Korean spotted sleeper) and Siniperca scherzeri (leopard mandarin fish)
Dong-Wook Hyun, Yun-Seok Jeong, Jae-Yun Lee, Hojun Sung, So-Yeon Lee, Jee-Won Choi, Hyun Sik Kim, Pil Soo Kim, Jin-Woo Bae
Journal of Microbiology.2021; 59(6): 552. CrossRef

Vagococcus zengguangii sp. nov., isolated from yak faeces: Yajun Ge , Dong Jin , Xin-He Lai , Jing Yang , Shan Lu , Ying Huang , Han Zheng , Xiaoyan Zhang , Jianguo Xu; J. Microbiol. 2021;59(1):1-9. Published online December 23, 2020; DOI: https://doi.org/10.1007/s12275-021-0406-3

360 View
1 Download
3 Web of Science
2 Crossref

Abstract PDF

Two unknown Gram-stain-positive, catalase- and oxidasenegative, non-motile, and coccus-shaped bacteria, designated MN-17T and MN-09, were isolated from yaks faeces (Bos grunniens) in the Qinghai-Tibet Plateau of China. 16S rRNA gene sequence-based comparative analyses revealed that the two strains were grouped within the genus Vagococcus, displaying the highest similarity with Vagococcus xieshaowenii CGMCC 1.16436T (98.6%) and Vagococcus elongatus CCUG 51432T (96.4%). Both strains grew optimally at 37°C and pH 7.0 in the presence of 0.5% (w/v) NaCl. The complete genome of MN-17T comprises 2,085 putative genes with a total of 2,190,262 bp and an average G + C content of 36.7 mol%. The major fatty acids were C16:0 (31.2%), C14:0 (28.5%), and C18:1ω9c (13.0%); the predominant respiratory quinone was MK-7 (68.8%); the peptidoglycan type was A4α(L-Lys-DAsp); and the major polar lipid was diphosphatidylglycerol. Together, these supported the affiliation of strain MN-17T to the genus Vagococcus. In silico DNA-DNA hybridization and the average nucleotide identity values between MN-17T and all recognized species in the genus were 21.6–26.1% and 70.7–83.0%, respectively. MN-17T produced acid from D-cellobiose, D-fructose, glycerol, D-glucose, N-acetyl-glucosamine, gentiobiose, D-mannose, D-maltose, D-ribose, Dsaccharose, salicin, D-trehalose, and D-xylose. These results distinguished MN-17T and MN-09 from closely related species in Vagococcus. Thus, we propose that strains MN-17T and MN-09 represent a novel species in the genus Vagococcus, with the name Vagococcus zengguangii sp. The type strain is MN-17T (= CGMCC 1.16726T = GDMCC 1.1589T = JCM 33478T).

Citations

Citations to this article as recorded by

Vagococcus proximus sp. nov. and Vagococcus intermedius sp. nov., originating from modified atmosphere packaged broiler meat
Per Johansson, Elina Jääskeläinen, Elina Säde, Johanna Björkroth
International Journal of Systematic and Evolutionary Microbiology .2023;[Epub] CrossRef
Phenotypic and genomic characteristics of Brevibacterium zhoupengii sp. nov., a novel halotolerant actinomycete isolated from bat feces
Yuyuan Huang, Lingzhi Dong, Jian Gong, Jing Yang, Shan Lu, Xin-He Lai, Dong Jin, Qianni Huang, Ji Pu, Liyun Liu, Jianguo Xu
Journal of Microbiology.2022; 60(10): 977. CrossRef

Review

Regulation of the AcrAB efflux system by the quorum-sensing regulator AnoR in Acinetobacter nosocomialis: Bindu Subhadra , Surya Surendran , Bo Ra Lim , Jong Sung Yim , Dong Ho Kim , Kyungho Woo , Hwa-Jung Kim , Man Hwan Oh , Chul Hee Choi; J. Microbiol. 2020;58(6):507-518. Published online May 27, 2020; DOI: https://doi.org/10.1007/s12275-020-0185-2

406 View
0 Download
13 Web of Science
11 Crossref

Abstract PDF

Multidrug efflux pumps play an important role in antimicrobial resistance and pathogenicity in bacteria. Here, we report the functional characterization of the RND (resistance-nodulation- division) efflux pump, AcrAB, in Acinetobacter nosocomialis. An in silico analysis revealed that homologues of the AcrAB efflux pump, comprising AcrA and AcrB, are widely distributed among different bacterial species. Deletion of acrA and/or acrB genes led to decreased biofilm/pellicle formation and reduced antimicrobial resistance in A. nosocomialis. RNA sequencing and mRNA expression analyses showed that expression of acrA/B was downregulated in a quorum sensing (QS) regulator (anoR)-deletion mutant, indicating transcriptional activation of the acrAB operon by AnoR in A. nosocomialis. Bioassays showed that secretion of N-acyl homoserine lactones (AHLs) was unaffected in acrA and acrB deletion mutants; however, AHL secretion was limited in a deletion mutant of acrR, encoding the acrAB regulator, AcrR. An in silico analysis indicated the presence of AcrR-binding motifs in promoter regions of anoI (encoding AHL synthase) and anoR. Specific binding of AcrR was confirmed by electrophoretic mobility shift assays, which revealed that AcrR binds to positions -214 and -217 bp upstream of the translational start sites of anoI and anoR, respectively, demonstrating transcriptional regulation of these QS genes by AcrR. The current study further addresses the possibility that AcrAB is controlled by the osmotic stress regulator, OmpR, in A. nosocomialis. Our data demonstrate that the AcrAB efflux pump plays a crucial role in biofilm/pellicle formation and antimicrobial resistance in A. nosocomialis, and is under the transcriptional control of a number of regulators. In addition, the study emphasizes the interrelationship of QS and AcrAB efflux systems in A. nosocomialis.

Citations

Citations to this article as recorded by

Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to Acinetobacter baumannii
Kira M. Zack, Trent Sorenson, Suresh G. Joshi
Pathogens.2024; 13(3): 197. CrossRef
Lysine Trimethylation in Planktonic and Pellicle Modes of Growth in Acinetobacter baumannii
Nicolas Nalpas, Takfarinas Kentache, Emmanuelle Dé, Julie Hardouin
Journal of Proteome Research.2023; 22(7): 2339. CrossRef
The Mechanism of Tigecycline Resistance in Acinetobacter baumannii Revealed by Proteomic and Genomic Analysis
Cunwei Liu, Lei Wang, Ping Wang, Di Xiao, Qinghua Zou
International Journal of Molecular Sciences.2023; 24(10): 8652. CrossRef
Antimicrobial photodynamic therapy against oral biofilm: influencing factors, mechanisms, and combined actions with other strategies
Yijun Li, Guanwen Sun, Jingchan Xie, Suli Xiao, Chen Lin
Frontiers in Microbiology.2023;[Epub] CrossRef
The multifaceted genusAcinetobacter: from infection to bioremediation
Ujwal Dahal, Karan Paul, Shelly Gupta
Journal of Applied Microbiology.2023;[Epub] CrossRef
Efflux pumps and microbial biofilm formation
Mahdyeh Neghabi Hajiagha, Hossein Samadi Kafil
Infection, Genetics and Evolution.2023; 112: 105459. CrossRef
Targeting the Holy Triangle of Quorum Sensing, Biofilm Formation, and Antibiotic Resistance in Pathogenic Bacteria
Ronit Vogt Sionov, Doron Steinberg
Microorganisms.2022; 10(6): 1239. CrossRef
Evidence for Complex Interplay between Quorum Sensing and Antibiotic Resistance in Pseudomonas aeruginosa
Rakesh Sikdar, Mikael H. Elias, Giordano Rampioni
Microbiology Spectrum.2022;[Epub] CrossRef
Update on Multidrug Resistance Efflux Pumps in Acinetobacter spp.
Vanessa Kornelsen, Ayush Kumar
Antimicrobial Agents and Chemotherapy.2021;[Epub] CrossRef
Orthopedic Implant-Related Biofilm Pathophysiology: A Review of the Literature
Meletis Rozis, Dimitrios S Evangelopoulos, Spyros G Pneumaticos
Cureus.2021;[Epub] CrossRef
The impact of cell structure, metabolism and group behavior for the survival of bacteria under stress conditions
Xinyi Zhang, Zhendong Li, Shengmei Pang, Boyu Jiang, Yang Yang, Qiangde Duan, Guoqiang Zhu
Archives of Microbiology.2021; 203(2): 431. CrossRef

Journal Articles

Development of a real-time loop-mediated isothermal amplification method for the detection of severe fever with thrombocytopenia syndrome virus: Jae Woong Lee , Yu-Jung Won , Lae Hyung Kang , Sung-Geun Lee , Seung-Won Park , Soon-Young Paik; J. Microbiol. 2020;58(8):711-715. Published online May 18, 2020; DOI: https://doi.org/10.1007/s12275-020-0109-1

393 View
0 Download
12 Web of Science
11 Crossref

Abstract PDF

Severe fever with thrombocytopenia syndrome (SFTS) is being reported annually in South Korea since its first detection there in 2010. The causal agent is a negative-strand RNA virus 80–100 nm in diameter. It causes fever, thrombocytopenia, leukocytopenia, gastrointestinal symptoms, and neural symptoms. The mortality rate of SFTS was 32.6% among 172
case
s reported from 2012 to 2015 in South Korea. Thus, is necessary to develop an effective diagnostic method that selectively identifies the isolates circulating in South Korea. The real-time reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay is a simple, rapid, and sensitive approach for molecular diagnosis. Here, we designed novel primers for this assay and found that the technique had very high specificity, sensitivity, and efficiency. This real-time RTLAMP approach using the novel primers developed herein can be applied for early diagnosis of SFTSV strains in South Korea to reduce the mortality rate of SFTS.

Citations

Citations to this article as recorded by

Reverse Transcription Loop-Mediated Isothermal Amplification Assay Using Samples Directly: Point-of-Care Detection of Severe Fever with Thrombocytopenia Syndrome Virus
Marla Anggita, Kyoko Hayashida, Miyuka Nishizato, Hiroshi Shimoda, Daisuke Hayasaka
Zoonotic Diseases.2025; 5(3): 19. CrossRef
One-pot one-step detection platform for severe fever with thrombocytopenia syndrome virus via the CRISPR/Cas12a detection system
Jiwei Shu, Qilong Tan, Zhe Huang, Tongjie Zhang, Ling Ye, Shuqin Fu, Zhilei Mao
Virology Journal.2025;[Epub] CrossRef
Long-Term Detection and Isolation of Severe Fever with Thrombocytopenia Syndrome (SFTS) Virus in Dog Urine
Yumiko Saga, Toshikazu Yoshida, Rieko Yoshida, Shunsuke Yazawa, Takahisa Shimada, Noriko Inasaki, Masae Itamochi, Emiko Yamazaki, Kazunori Oishi, Hideki Tani
Viruses.2023; 15(11): 2228. CrossRef
Advancements in the Worldwide Detection of Severe Fever with Thrombocytopenia Syndrome Virus Infection from 2009 to 2023
Lin Ai, Wei Wang, Zheng Teng
China CDC Weekly.2023; 5(31): 687. CrossRef
Molecular detection of “Candidatus Rickettsia tarasevichiae” by Loop-mediated Isothermal Amplification (LAMP) of the ompA gene
Jing Xue, Qing Ren, Rui Jian, Guang-Cheng Xie, Yongliang Chen, Jiangli Wang, Luanying Du, Wen-Ping Guo
Journal of Microbiological Methods.2022; 202: 106601. CrossRef
Dual-gene detection in a single-tube system based on CRISPR-Cas12a/Cas13a for severe fever thrombocytopenia syndrome virus
Yating Zhu, Chen Xing, Li Yang, Qian Li, Xiaofeng Wang, Jing Zhou, Cong Zhang, Cuiping Ren, Fahu Liu, Jun He, Bing Shen, Yinan Du, Yan Liu
Frontiers in Microbiology.2022;[Epub] CrossRef
CRISPR/Cas12a Technology Combined With RPA for Rapid and Portable SFTSV Detection
Mengqian Huang, Sihua Liu, Yanan Xu, Aqian Li, Wei Wu, Mifang Liang, Guoyu Niu, Zhiyun Wang, Tao Wang
Frontiers in Microbiology.2022;[Epub] CrossRef
Development of monoclonal antibody based IgG and IgM ELISA for diagnosis of severe fever with thrombocytopenia syndrome virus infection
Mei Zhang, Yanhua Du, Li Yang, Lin Zhan, Bin Yang, Xueyong Huang, Bianli Xu, Koichi Morita, Fuxun Yu
The Brazilian Journal of Infectious Diseases.2022; 26(4): 102386. CrossRef
Development of an RT-LAMP Assay for the Rapid Detection of SFTS Virus
Shiori Sano, Shuetsu Fukushi, Souichi Yamada, Shizuko Harada, Hitomi Kinoshita, Satoko Sugimoto, Tomoki Yoshikawa, Takeshi Kurosu, Yuki Takamatsu, Masayuki Shimojima, Shoichi Toda, Yuka Hamada, Naoki Fujisawa, Takayuki Sugimoto, Masayuki Saijo
Viruses.2021; 13(4): 693. CrossRef
A Real-Time Loop-Mediated Isothermal Amplification for Detection of the Wheat Dwarf Virus in Wheat and the Insect VectorPsammotettix alienus
Xingan Hao, Licheng Wang, Xudong Zhang, Qinrong Zhong, Jamal-U-Ddin Hajano, Liangsheng Xu, Yunfeng Wu
Plant Disease.2021; 105(12): 4113. CrossRef
Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
Nathen E. Bopp, Jaclyn A. Kaiser, Ashley E. Strother, Alan D. T. Barrett, David W. C. Beasley, Virginia Benassi, Gregg N. Milligan, Marie-Pierre Preziosi, Lisa M. Reece
npj Vaccines.2020;[Epub] CrossRef

Streptococcus pneumoniae aminopeptidase N contributes to bacterial virulence and elicits a strong innate immune response through MAPK and PI3K/AKT signaling: Ling Wang , Xuemei Zhang , Guangying Wu , Yuhong Qi , Jinghui Zhang , Jing Yang , Hong Wang , Wenchun Xu; J. Microbiol. 2020;58(4):330-339. Published online February 27, 2020; DOI: https://doi.org/10.1007/s12275-020-9538-0

369 View
0 Download
11 Web of Science
10 Crossref

Abstract PDF

Streptococcus pneumoniae is a Gram-positive pathogen with high morbidity and mortality globally but some of its pathogenesis remains unknown. Previous research has provided evidence that aminopeptidase N (PepN) is most likely a virulence factor of S. pneumoniae. However, its role in S. pneumoniae virulence and its interaction with the host remains to be confirmed. We generated a pepN gene deficient mutant strain and found that its virulence for mice was significantly attenuated as were in vitro adhesion and invasion of host cells. The PepN protein could induce a strong innate immune response in vivo and in vitro and induced secretion of IL-6 and TNF-α by primary peritoneal macrophages via the rapid phosphorylation of MAPK and PI3K/AKT signaling pathways and this was confirmed using specific pathway inhibitors. In conclusion, PepN is a novel virulence factor that is essential for the virulence of S. pneumoniae and induces host innate immunity via MAPK and PI3K/AKT signaling.

Citations

Citations to this article as recorded by

The role of oral microbiota in lung carcinogenesis through the oral-lung axis: a comprehensive review of mechanisms and therapeutic potential
Mingzhu Zhou, Yan Liu, Xin Yin, Jiannan Gong, Jianqiang Li
Discover Oncology.2025;[Epub] CrossRef
Integrative network pharmacology and experimental validation of multi-target synergy against multidrug-resistant klebsiella pneumoniae via PI3K/AKT-MAPK pathway disruption
Tian Man, Huiyong Yu, Lei Li, Weicheng Nie, Chengxiang Wang
Naunyn-Schmiedeberg's Archives of Pharmacology.2025;[Epub] CrossRef
Maternal immune activation mediated prenatal chronic stress induces Th17/Treg cell imbalance may relate to the PI3K/Akt/NF-κB signaling pathway in offspring rats
Ye Li, Guixiang Yao, Rui Wang, Jiashu Zhu, Hongyu Li, Deguang Yang, Shuqin Ma, Youjuan Fu, Can Liu, Suzhen Guan
International Immunopharmacology.2024; 126: 111308. CrossRef
Secreted protein NFA47630 from Nocardia farcinica IFM10152 induces immunoprotective effects in mice
Lichao Han, Xingzhao Ji, Shihong Fan, Jirao Shen, Bin Liang, Zhenjun Li
Tropical Diseases, Travel Medicine and Vaccines.2024;[Epub] CrossRef
Human microbiomes in cancer development and therapy
Chenglai Xia, Jiyan Su, Can Liu, Zhikai Mai, Shuanghong Yin, Chuansheng Yang, Liwu Fu
MedComm.2023;[Epub] CrossRef
Identification and Analysis of Potential Immune-Related Biomarkers in Endometriosis
Yanan He, Jixin Li, Yanjun Qu, Liyuan Sun, Xibo Zhao, Han Wu, Guangmei Zhang, Amar Singh
Journal of Immunology Research.2023; 2023: 1. CrossRef
The identification of two M20B family peptidases required for full virulence in Staphylococcus aureus
Nathanial J. Torres, Devon N. Rizzo, Maria A. Reinberg, Mary-Elizabeth Jobson, Brendan C. Totzke, Jessica K. Jackson, Wenqi Yu, Lindsey N. Shaw
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef
Exploration of immune response mechanisms in cadmium and copper co-exposed juvenile golden cuttlefish (Sepia esculenta) based on transcriptome profiling
Xiaokai Bao, Weijun Wang, Xipan Chen, Yanwei Feng, Xiaohui Xu, Guohua Sun, Bin Li, Xiumei Liu, Zan Li, Jianmin Yang
Frontiers in Immunology.2022;[Epub] CrossRef
Pathogenicity and virulence ofStreptococcus pneumoniae: Cutting to the chase on proteases
Mary E. Marquart
Virulence.2021; 12(1): 766. CrossRef
Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics
Chang Yi Shi, Chen Huan Yu, Wen Ying Yu, Hua Zhong Ying, Hua Zhang
Canadian Journal of Infectious Diseases and Medical Microbiology.2021; 2021: 1. CrossRef

The discovery of potent immunostimulatory CpG-ODNs widely distributed in bacterial genomes: Juan Liu , Yan Wei , Yongling Lu , Yangyuling Li , Qian Chen , Yan Li; J. Microbiol. 2020;58(2):153-162. Published online December 23, 2019; DOI: https://doi.org/10.1007/s12275-020-9289-y

363 View
0 Download
4 Web of Science
2 Crossref

Abstract PDF

Oligodeoxynucleotides containing unmethylated CpG dinucleotides (CpG-ODN) can be specifically recognized by Toll-like receptor 9 (TLR9), provoking innate immune responses. Designed according to this structural feature, many synthetic phosphorothioate CpG-ODNs successfully activate macrophages. However, it is difficult to find potent stimulatory CpG-DNA fragments in microbial genomes. Therefore, whether microbial CpG-DNA substantially contributes to infectious and immune diseases remains controversial. In this study, high-throughput scanning was carried out for thousands of bacterial genomes with bioinformatics tools to comprehensively evaluate the distribution of CpG-DNA fragments. A random sampling test was then performed to verify their immunostimulatory properties by experiments in vitro and in vivo. Natural TLR9-dependent and potent stimulatory CpG-DNA fragments were found in microbial genomes. Interestingly, highly conserved stimulatory CpG-DNA fragments were found in 16S and 23S rDNA sequences with multiple copies, while others were species-specific. Additionally, we found that the reported active motifs were mostly nonstimulatory in natural CpG fragments. This evidence indicates that the previous structural descriptions of functional CpG-ODNs are incomplete. Our study has assessed the distribution of microbial CpG-DNA fragments, and identified natural stimulatory CpG-DNA fragments. These findings provide a deeper understanding of CpG-ODN structures and new evidence for microbial DNA inflammatory function and pathogenicity.

Citations

Citations to this article as recorded by

Advances in protein subunit vaccines against H1N1/09 influenza
Yu Zhang, Jingyao Gao, Wenqi Xu, Xingyu Huo, Jingyan Wang, Yirui Xu, Wenting Ding, Zeliang Guo, Rongzeng Liu
Frontiers in Immunology.2024;[Epub] CrossRef
Cell-free DNA beyond a biomarker for rejection: Biological trigger of tissue injury and potential therapeutics
Naoko Tsuji, Sean Agbor-Enoh
The Journal of Heart and Lung Transplantation.2021; 40(6): 405. CrossRef

Reviews

[MINIREVIEW] Interdependence between iron acquisition and biofilm formation in Pseudomonas aeruginosa: Donghoon Kang , Natalia V. Kirienko; J. Microbiol. 2018;56(7):449-457. Published online June 14, 2018; DOI: https://doi.org/10.1007/s12275-018-8114-3

437 View
1 Download
95 Crossref

Abstract PDF

Bacterial biofilms remain a persistent threat to human healthcare due to their role in the development of antimicrobial resistance. To combat multi-drug resistant pathogens, it is crucial to enhance our understanding of not only the regulation of biofilm formation, but also its contribution to bacterial virulence. Iron acquisition lies at the crux of these two subjects. In this review, we discuss the role of iron acquisition in biofilm formation and how hosts impede this mechanism to defend against pathogens. We also discuss recent findings that suggest that biofilm formation can also have the reciprocal effect, influencing siderophore production and iron sequestration.

Citations

Citations to this article as recorded by

Understanding gallium oxyhydroxide surface for improving titanium-based biomaterial applications
Harigovind Nandhakumar, Adithyakrishnan Kapparath, Ansheed Raheem, Praveenkumar Kesavan, Arunima Rajan, Kateřina Skotnicová, Geetha Manivasagam, Balakrishnan Shankar, Jithin Vishnu
Colloids and Surfaces A: Physicochemical and Engineering Aspects.2026; 728: 138689. CrossRef
A gallium-integrated nanoplatform for synergistic therapy of Pseudomonas aeruginosa wound infections
Jing Qiao, Lingling Cao, Ben Fan, Huan Gao, Ying-Shi Guan
Journal of Materials Chemistry B.2026;[Epub] CrossRef
The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance
Naveenraj Rajasekar, Vijaya Bharathi Srinivasan, Karthikeyan Krishnan, Chankit Giri, Mahesh Kumar, Balvinder Singh, Govindan Rajamohan
Archives of Microbiology.2026;[Epub] CrossRef
Anti-motilities and anti-biofilm effects of Ageratum conyzoides L. methanol extract
Eli Compaoré, Moussa Compaoré, Vincent Ouédraogo, Ablassé Rouamba, Alimata Bancé, Mignini R. Dofini, Martin Kiendrebeogo
Journal of Medicinal Plants for Economic Development.2025;[Epub] CrossRef
γ Irradiation Alters the Staphylococcus aureus Proteome and Enhances Pathogenicity
Jingjing Liu, Xinghua Jin, Jingxin Zhu, Jundong Feng, Jian Zhao, Yixuan Wang, Quan Wang, Xiaofeng Song
Journal of Proteome Research.2025; 24(3): 1373. CrossRef
An astrobiological perspective on microbial biofilms: their importance for habitability and production of detectable and lasting biosignatures
Sarah Gonzalez-Henao, Matthew O. Schrenk, Betül Kaçar
Applied and Environmental Microbiology.2025;[Epub] CrossRef
Inhibitory Effects of Nisin and Gallium (III) Nitrate Hydrate on Planktonic and Adhered Cells and Implications for the Viable but Non-Culturable State
Valeria Poscente, Luciana Di Gregorio, Roberta Bernini, Annamaria Bevivino
Microorganisms.2025; 13(2): 276. CrossRef
Hemolytic Streptococcus agalactiae isolation and identification from the Southern Mediterranean Sea and effect on growth- and biofilm-forming ability under stressful environment
Imen Laadouze, Noussaiha Salhi, Ibtissem Khouja, Emna Grami, Kathleen Sullivan Sealey, Neila Saidi
Euro-Mediterranean Journal for Environmental Integration.2025; 10(5): 4133. CrossRef
Feature-Based Molecular Networking Guided Characterization of Clonocoprogen Siderophores with Anti-Pseudomonas aeruginosa Activity in Nematodes through Immune Up-Regulating Effects
Guoliang Zhu, Weize Yuan, Kun Wang, Huimin Wu, Kangjie Lv, Xinye Wang, Alex Tuffour, Biao Ren, Jingyu Zhang, Chenglin Jiang, Yi Jiang, Tom Hsiang, Peter Shen Yu, Frederick M Ausubel, Lixin Zhang, Huanqin Dai, Xueting Liu
ACS Chemical Biology.2025; 20(7): 1450. CrossRef
Modern approaches to the treatment of infections caused by Pseudomonas aeruginosa with multiple antimicrobial resistance. What a practicing physician should know
Natalia Yu. Epifanova
Supportive Therapy in Oncology.2025; 2(2): 44. CrossRef
Neutrophil membrane-encapsulated nanosonosensitizer with ultrasound-reinforced ferroptosis in Pseudomonas aeruginosa pneumonia
Chunhong Du, Shuai Wang, Yijie Cheng, Jie Li, Yufei Zhang, Zhuohao Li, Baolin Zhu, Zhongming Wu, Xinge Zhang, Lingyi Zhou
Journal of Nanobiotechnology.2025;[Epub] CrossRef
Corrosion of AISI 1030 mild steel is influenced by bacteria type, oxygen availability, and biofilm formation under controlled laboratory conditions
Phuong Nguyen Tran, Agnes A Michalczyk, Rainier A Catubig, Jess Glasson, Jhonatan Soto Puelles, Mahdi Ghorbani, Anthony E Somers, Maria Forsyth, Margaret Leigh Ackland
Journal of Applied Microbiology.2025;[Epub] CrossRef
The DOPA scaffold: Tracing catechol chemistry from prebiotic earth to cognitive agency
Amal Alachkar
Progress in Biophysics and Molecular Biology.2025; 198: 71. CrossRef
Metal chelation as an antibacterial strategy for Pseudomonas aeruginosa and Acinetobacter baumannii
Martina M. Golden, Amelia C. Heppe, Cassandra L. Zaremba, William M. Wuest
RSC Chemical Biology.2024; 5(11): 1083. CrossRef
Iron transport pathways in the human malaria parasite Plasmodium falciparum revealed by RNA-sequencing
Juliane Wunderlich, Vadim Kotov, Lasse Votborg-Novél, Christina Ntalla, Maria Geffken, Sven Peine, Silvia Portugal, Jan Strauss
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Taxonomic and functional characterization of biofilms from a photovoltaic panel reveals high genetic and metabolic complexity of the communities
Viviane Faria Morais Jotta, Glen Jasper Yupanqui García, Paula Luize Camargos Fonseca, Angela de Mello Ferreira, Vasco Azevedo, Bertram Brenig, Aristóteles Góes-Neto, Fernanda Badotti
Journal of Applied Microbiology.2024;[Epub] CrossRef
Global transcriptome analysis of Pseudomonas aeruginosa NT06 response to potassium chloride, sodium lactate, sodium citrate, and microaerophilic conditions in a fish ecosystem
Natalia Tomaś, Kamila Myszka, Łukasz Wolko, Wojciech Juzwa
FEMS Microbiology Letters.2024;[Epub] CrossRef
Compassionate use of cefiderocol in a complex case of extensively drug-resistant Acinetobacter baumannii fracture-related infection: a comprehensive approach and multidisciplinary management
Flavia Petrucci, Beatrice Perciballi, Marco Rivano Capparuccia, Giancarlo Iaiani, Federico Lo Torto, Diego Ribuffo, Stefano Gumina, Daniele De Meo
Infection.2024; 52(6): 2487. CrossRef
Ultrafiltration (UF) and biological oxygen-dosed activated carbon (BODAC) filtration to prevent fouling of reversed osmosis (RO) membranes: A mass balance analysis
Sara Ribeiro Pinela, Amanda Larasati, Roel J.W. Meulepas, Maria Cristina Gagliano, Robbert Kleerebezem, Harry Bruning, Huub H.M. Rijnaarts
Journal of Water Process Engineering.2024; 57: 104648. CrossRef
Deferiprone-Gallium-Protoporphyrin Chitogel Decreases Pseudomonas aeruginosa Biofilm Infection without Impairing Wound Healing
Tahlia L. Kennewell, Hanif Haidari, Suzanne Mashtoub, Gordon S. Howarth, Catherine Bennett, Clare M. Cooksley, Peter John Wormald, Allison J. Cowin, Sarah Vreugde, Zlatko Kopecki
Materials.2024; 17(4): 793. CrossRef
Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens
Vera Vollenweider, Karoline Rehm, Clara Chepkirui, Manuela Pérez-Berlanga, Magdalini Polymenidou, Jörn Piel, Laurent Bigler, Rolf Kümmerli
eLife.2024;[Epub] CrossRef
Influence of carbonyl cyanide m-chlorophenyl hydrazone on biofilm dynamics, protease, and siderophore production by Burkholderia pseudomallei
Glaucia Morgana de Melo Guedes, Crister José Ocadaque, Bruno Rocha Amando, Alyne Soares Freitas, Vinicius Carvalho Pereira, Rossana de Aguiar Cordeiro, Silviane Praciano Bandeira, Pedro Filho Noronha Souza, Marcos Fábio Gadelha Rocha, José Júlio Costa Sid
Biofouling.2024; 40(8): 514. CrossRef
Siderophores: A Case Study in Translational Chemical Biology
Andrew R. LeBlanc, William M. Wuest
Biochemistry.2024; 63(15): 1877. CrossRef
Pseudomonas aeruginosa kills Staphylococcus aureus in a polyphosphate-dependent manner
Ritika Shah, Julius Kwesi Narh, Magdalena Urlaub, Olivia Jankiewicz, Colton Johnson, Barry Livingston, Jan-Ulrik Dahl, Craig D. Ellermeier
mSphere.2024;[Epub] CrossRef
Deferiprone and Gallium-Protoporphyrin Chitogel as an antimicrobial treatment: Preclinical studies demonstrating antimicrobial activity for S. aureus infected cutaneous wounds
T.L. Kennewell, H. Haidari, S. Mashtoub, G.S. Howarth, P.J. Wormald, A.J. Cowin, S. Vreugde, Z. Kopecki
International Journal of Biological Macromolecules.2024; 276: 133874. CrossRef
In vitro lung epithelial cell model reveals novel roles for Pseudomonas aeruginosa siderophores
Donghoon Kang, Qi Xu, Natalia V. Kirienko, Giordano Rampioni
Microbiology Spectrum.2024;[Epub] CrossRef
In vitro effect of the iron chelator deferiprone on the antimicrobial susceptibility and biofilms of Burkholderia pseudomallei
Glaucia Morgana de Melo Guedes, Késia Veras Costa Ribeiro, Emanuela Silva de Araújo, Vinícius Carvalho Pereira, Ana Carla de Castro Freitas Soares, Alyne Soares Freitas, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha, Débo
Biofouling.2023; 39(2): 135. CrossRef
Gallium-enabled bactericidal medicine
Yong Liu, Fei Yang, Zixin Pan, Zhenzhen Fu, Xiaoli Jiang, Zhenping Cao, Juanjuan Li, Hao Wang
Materials Today.2023; 67: 548. CrossRef
Study on the inhibitory effect of quercetin combined with gentamicin on the formation of Pseudomonas aeruginosa and its bioenvelope
Shuangyan Luo, Xinyun Kang, Xiaofeng Luo, Caixia Li, Guiqin Wang
Microbial Pathogenesis.2023; 182: 106274. CrossRef
Antibiofilm activity of promethazine, deferiprone, and Manuka honey in an ex vivo wound model
Gláucia Morgana de Melo Guedes, Alyne Soares Freitas, Rodrigo Machado Pinheiro, Vinicius Carvalho Pereira, Carliane Melo Alves Melgarejo, Emanuela Silva de Araujo, Késia Veras Costa Ribeiro, Silviane Praciano Bandeira, Rossana de Aguiar Cordeiro, Marcos F
Letters in Applied Microbiology.2023;[Epub] CrossRef
Absence of proline-peptide transporter YjiY in Salmonella Typhimurium leads to secretion of factors which inhibits intra-species biofilm formation
Kasturi Chandra, Abhilash Vijay Nair, Ritika Chatterjee, Prerana Muralidhara, Anmol Singh, Sathisha Kamanna, Utpal S. Tatu, Dipshikha Chakravortty
Microbiological Research.2023; 273: 127411. CrossRef
Study on pyoverdine and biofilm production with detection of LasR gene in MDR Pseudomonas aeruginosa
Esraa H. Hamza, Ashraf M. El-Shawadfy, Ayman A. Allam, Wesam A. Hassanein
Saudi Journal of Biological Sciences.2023; 30(1): 103492. CrossRef
Mobilization of iron stored in bacterioferritin, a new target for perturbing iron homeostasis and developing antibacterial and antibiofilm molecules
Mario Rivera
Journal of Inorganic Biochemistry.2023; 247: 112306. CrossRef
Novel marine metalloprotease—new approaches for inhibition of biofilm formation of Stenotrophomonas maltophilia
Marie Kristin Peters, Yekaterina Astafyeva, Yuchen Han, Jascha F. H. Macdonald, Daniela Indenbirken, Jacqueline Nakel, Sanamjeet Virdi, Guido Westhoff, Wolfgang R. Streit, Ines Krohn
Applied Microbiology and Biotechnology.2023; 107(23): 7119. CrossRef
Legionella pneumophila Rhizoferrin Promotes Bacterial Biofilm Formation and Growth within Amoebae and Macrophages
Alberto E. Lopez, Lubov S. Grigoryeva, Armando Barajas, Nicholas P. Cianciotto, Craig R. Roy
Infection and Immunity.2023;[Epub] CrossRef
The action of phytochemicals in biofilm control
Ariana S. C. Gonçalves, Miguel M. Leitão, Manuel Simões, Anabela Borges
Natural Product Reports.2023; 40(3): 595. CrossRef
Virulence-associated genes and antimicrobial resistance patterns in bacteria isolated from pregnant and nonpregnant women with urinary tract infections: the risk of neonatal sepsis
Uriel A. Angulo-Zamudio, Hector Flores-Villaseñor, Nidia Leon-Sicairos, Dina Zazueta-Armenta, Francisco A. Martínez-Villa, Gabriela Tapia-Pastrana, Jorge Angulo-Rocha, Joel Murillo-Llanes, Mario Francisco Barajas-Olivas, Adrian Canizalez-Roman
Canadian Journal of Microbiology.2023; 69(12): 488. CrossRef
Insight into the Global Negative Regulation of Iron Scavenger 7-HT Biosynthesis by the SigW/RsiW System in Pseudomonas donghuensis HYS
Shiyu Teng, Tingting Wu, Donghao Gao, Siyi Wu, Yaqian Xiao, Yan Long, Zhixiong Xie
International Journal of Molecular Sciences.2023; 24(2): 1184. CrossRef
Host-microbe interactions in chronic rhinosinusitis biofilms and models for investigation
Emily J. Vanderpool, Kendra P. Rumbaugh
Biofilm.2023; 6: 100160. CrossRef
Mechanisms of iron homeostasis in Pseudomonas aeruginosa and emerging therapeutics directed to disrupt this vital process
Ana Sánchez‐Jiménez, Francisco J. Marcos‐Torres, María A. Llamas
Microbial Biotechnology.2023; 16(7): 1475. CrossRef
Host cell responses against the pseudomonal biofilm: A continued tale of host-pathogen interactions
Sathish Sankar, Pitchaipillai Sankar Ganesh, Suganya Subramaniam, Esaki M Shankar, Monal Yuwanati, Rajakumar Govindasamy, Muthu Thiruvengadam
Microbial Pathogenesis.2023; 174: 105940. CrossRef
Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens
Zachary W. Scott, Seoung-ryoung Choi, Bradley E. Britigan, Prabagaran Narayanasamy
ACS Infectious Diseases.2023; 9(4): 716. CrossRef
Functionalized Amphiphilic Block Copolymers and Complex Emulsions for Selective Sensing of Dissolved Metals at Liquid–Liquid Interfaces
Tyler J. Durkin, Baishali Barua, Jamie J. Holmstrom, Vasiliki Karanikola, Suchol Savagatrup
Langmuir.2023; 39(36): 12845. CrossRef
Characterisation of Ferritin–Lymphocyte Ratio in COVID-19
Alexander Liu, Robert Hammond, Kenneth Chan, Chukwugozie Chukwuenweniwe, Rebecca Johnson, Duaa Khair, Eleanor Duck, Oluwaseun Olubodun, Kristian Barwick, Winston Banya, James Stirrup, Peter D. Donnelly, Juan Carlos Kaski, Anthony R. M. Coates
Biomedicines.2023; 11(10): 2819. CrossRef
Pseudomonas aeruginosa responds to altered membrane phospholipid composition by adjusting the production of two-component systems, proteases and iron uptake proteins
Muttalip Caliskan, Gereon Poschmann, Mirja Gudzuhn, Daniel Waldera-Lupa, Rebecka Molitor, Christoph Heinrich Strunk, Wolfgang R. Streit, Karl-Erich Jaeger, Kai Stühler, Filip Kovacic
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2023; 1868(6): 159317. CrossRef
Biofilm formation in xenobiotic-degrading microorganisms
Pankaj Bhatt, Kalpana Bhatt, Yaohua Huang, Jiayi Li, Siyi Wu, Shaohua Chen
Critical Reviews in Biotechnology.2023; 43(8): 1129. CrossRef
Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review
Felipe Francisco Tuon, Leticia Ramos Dantas, Paula Hansen Suss, Victoria Stadler Tasca Ribeiro
Pathogens.2022; 11(3): 300. CrossRef
Molecular Technology for the Detection of Pyoviridine Gene in Pseudomonas aeruginosa Isolated from Burn Cases
Eman Nassir Hussan AL-Jesmany, Oruba Khalid Abbas, Basima QASIM Hasan AlSaadi
Mustansiriya Medical Journal.2022; 21(1): 23. CrossRef
Heme cross-feeding can augment Staphylococcus aureus and Enterococcus faecalis dual species biofilms
Jun-Hong Ch’ng, Mugil Muthu, Kelvin K L Chong, Jun Jie Wong, Casandra A Z Tan, Zachary J S Koh, Daniel Lopez, Artur Matysik, Zeus J Nair, Timothy Barkham, Yulan Wang, Kimberly A Kline
The ISME Journal.2022; 16(8): 2015. CrossRef
Human lactoferrin from breast milk: characterization by HPLC and its in vitro antibiofilm performance
Karina Jeanette Parra-Saavedra, Adriana Macaria Macias-Lamas, Jorge Manuel Silva-Jara, Josué Raymundo Solís-Pacheco, Pablo César Ortiz-Lazareno, Blanca Rosa Aguilar-Uscanga
Journal of Food Science and Technology.2022; 59(12): 4907. CrossRef
Elucidation of Iron(III) Bioleaching Properties of Gram-Positive Bacteria
Hao Jing, Zhao Liu, Jun Chen, Chun Loong Ho
ACS Omega.2022; 7(42): 37212. CrossRef
Proteomic and Transcriptomic Analyses Indicate Reduced Biofilm-Forming Abilities in Cefiderocol-Resistant Klebsiella pneumoniae
Jinfeng Bao, Lu Xie, Yating Ma, Ran An, Bing Gu, Chengbin Wang
Frontiers in Microbiology.2022;[Epub] CrossRef
Zeolite-supported biofilms as inoculants for the treatment of MCPA-polluted soil and sand by bioaugmentation: A microcosm study
Nataliia Gorodylova, Alain Seron, Karine Michel, Catherine Joulian, Fabian Delorme, Coralie Soulier, Sophie Bresch, Catherine Garreau, Fabien Giovannelli, Caroline Michel
Applied Soil Ecology.2022; 180: 104614. CrossRef
Bacterial Siderophores: Structure, Functions, and Role in the Pathogenesis of Infections
D. A. Kuznetsova, V. A. Rykova, O. N. Podladchikova
Problems of Particularly Dangerous Infections.2022; (3): 14. CrossRef
Harnessing microbial iron chelators to develop innovative therapeutic agents
Marta Ribeiro, Cátia A. Sousa, Manuel Simões
Journal of Advanced Research.2022; 39: 89. CrossRef
Understanding the Potential and Risk of Bacterial Siderophores in Cancer
Valentina Pita-Grisanti, Kaylin Chasser, Trevor Sobol, Zobeida Cruz-Monserrate
Frontiers in Oncology.2022;[Epub] CrossRef
Overexpression of pdeR promotes biofilm formation of Paracoccus denitrificans by promoting ATP production and iron acquisition
Na Wang, Jie Gao, Shujie Xiao, Guoqiang Zhuang
Frontiers in Microbiology.2022;[Epub] CrossRef
Impact of Fe2+ and Shear Stress on the Development and Mesoscopic Structure of Biofilms—A Bacillus subtilis Case Study
Luisa Gierl, Harald Horn, Michael Wagner
Microorganisms.2022; 10(11): 2234. CrossRef
Clinical Efficacy and In Vitro Drug Sensitivity Test Results of Azithromycin Combined With Other Antimicrobial Therapies in the Treatment of MDR P. aeruginosa Ventilator-Associated Pneumonia
Yuqin Huang, Wenguo Wang, Qiang Huang, Zhengyan Wang, Zhuanzhuan Xu, Chaochao Tu, Dongli Wan, Miaobo He, Xiaoyi Yang, Huaqiang Xu, Hanqin Wang, Ying Zhao, Mingli Tu, Quan Zhou
Frontiers in Pharmacology.2022;[Epub] CrossRef
Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents
Fupeng Li, Fengxiang Liu, Kai Huang, Shengbing Yang
Frontiers in Bioengineering and Biotechnology.2022;[Epub] CrossRef
Genomic characterization of denitrifying methylotrophic Pseudomonas aeruginosa strain AAK/M5 isolated from municipal solid waste landfill soil
Ashish Kumar Singh, Rakesh Kumar Gupta, Hemant J. Purohit, Anshuman Arun Khardenavis
World Journal of Microbiology and Biotechnology.2022;[Epub] CrossRef
Pyoverdine Inhibitors and Gallium Nitrate Synergistically Affect Pseudomonas aeruginosa
Donghoon Kang, Alexey V. Revtovich, Alexander E. Deyanov, Natalia V. Kirienko, Patricia A. Bradford
mSphere.2021;[Epub] CrossRef
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors
Irene Jurado-Martín, Maite Sainz-Mejías, Siobhán McClean
International Journal of Molecular Sciences.2021; 22(6): 3128. CrossRef
Role of Tris-CaEDTA as an adjuvant with nebulised tobramycin in cystic fibrosis patients with Pseudomonas aeruginosa lung infections: A randomised controlled trial
Ramaa Puvvadi, Helga Mikkelsen, Lucy McCahon, Samantha Grogan, William Ditcham, David W. Reid, Iain Lamont, Stephen M. Stick, Barry Clements
Journal of Cystic Fibrosis.2021; 20(2): 316. CrossRef
Transcriptional profiling of Pseudomonas aeruginosa PAO1 in response to anti‐biofilm and anti‐infection agent exopolysaccharide EPS273
Z. Wu, R. Zheng, J. Zhang, S. Wu
Journal of Applied Microbiology.2021; 130(1): 265. CrossRef
Wolf in Sheep’s Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections
Jazmin Meza-Torres, Emile Auria, Bruno Dupuy, Yannick D. N. Tremblay
Microorganisms.2021; 9(9): 1922. CrossRef
Variability of the structure of winter microbial communities in Chelyabinsk lakes
S. V. Andreeva, Y. Y. Filippova, E. V. Devyatova, D. Y. Nokhrin
Biosystems Diversity.2021; 29(4): 311. CrossRef
The cystic fibrosis lung microenvironment alters antibiotic activity: causes and effects
Sara Van den Bossche, Emma De Broe, Tom Coenye, Eva Van Braeckel, Aurélie Crabbé
European Respiratory Review.2021; 30(161): 210055. CrossRef
Virulent and multidrug‐resistant Klebsiella pneumoniae from clinical samples in Balochistan
Sareeen Fatima, Faiza Liaqat, Ali Akbar, Muhammad Sahfee, Abdul Samad, Muhammad Anwar, Shazia Iqbal, Shabir Ahmad Khan, Haleema Sadia, Gul Makai, Anila Bahadur, Wajeeha Naeem, Adnan Khan
International Wound Journal.2021; 18(4): 510. CrossRef
Cefiderocol Retains Antibiofilm Activity in Multidrug-Resistant Gram-Negative Pathogens
Christine A. Pybus, Christina Felder-Scott, Victor Obuekwe, David E. Greenberg
Antimicrobial Agents and Chemotherapy.2021;[Epub] CrossRef
Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa
Katja Koeppen, Amanda Nymon, Roxanna Barnaby, Laura Bashor, Zhongyou Li, Thomas H. Hampton, Amanda E. Liefeld, Fred W. Kolling, Ian S. LaCroix, Scott A. Gerber, Deborah A. Hogan, Swetha Kasetty, Carey D. Nadell, Bruce A. Stanton
Proceedings of the National Academy of Sciences.2021;[Epub] CrossRef
High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents
Donghoon Kang, Liyang Zhang, Natalia V. Kirienko, Danielle A. Garsin
mBio.2021;[Epub] CrossRef
Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius
Anna De Filippis, Francesca Paola Nocera, Simona Tafuri, Francesca Ciani, Alessia Staropoli, Ernesto Comite, Assunta Bottiglieri, Laura Gioia, Matteo Lorito, Sheridan Lois Woo, Francesco Vinale, Luisa De Martino
Natural Product Research.2021; 35(23): 5440. CrossRef
Ex situ model of biofilm‐associated wounds: providing a host‐like environment for the study of Staphylococcus aureus and Pseudomonas aeruginosa biofilms
G.M.M. Guedes, A.S.P. Santos‐Filho, W.F.M. Regis, C.J. Ocadaque, B.R. Amando, J.J.C. Sidrim, R.S.N. Brilhante, R.A. Cordeiro, S.P. Bandeira, M.F.G. Rocha, D.S.C.M. Castelo‐Branco
Journal of Applied Microbiology.2021; 131(3): 1487. CrossRef
Iron Chelation in Local Infection
Cassidy Scott, Gaurav Arora, Kayle Dickson, Christian Lehmann
Molecules.2021; 26(1): 189. CrossRef
The Adc regulon mediates zinc homeostasis in Streptococcus mutans
Yangyang Pan, Yang Chen, Jiamin Chen, Qizhao Ma, Tao Gong, Shuxing Yu, Qiong Zhang, Jing Zou, Yuqing Li
Molecular Oral Microbiology.2021; 36(5): 278. CrossRef
Small Molecule Inhibitors of the Bacterioferritin (BfrB)–Ferredoxin (Bfd) Complex Kill Biofilm-Embedded Pseudomonas aeruginosa Cells
Anabel Soldano, Huili Yao, Achala N. D. Punchi Hewage, Kevin Meraz, Joel K. Annor-Gyamfi, Richard A. Bunce, Kevin P. Battaile, Scott Lovell, Mario Rivera
ACS Infectious Diseases.2021; 7(1): 123. CrossRef
Recent Evidence for Multifactorial Biofilm Regulation by Heme Sensor Proteins NosP and H-NOX
Jiayuan Fu, Steven Hall, Elizabeth M. Boon
Chemistry Letters.2021; 50(5): 1095. CrossRef
New Perspectives on Antimicrobial Agents: Cefiderocol
Erin K. McCreary, Emily L. Heil, Pranita D. Tamma
Antimicrobial Agents and Chemotherapy.2021;[Epub] CrossRef
Design of Polymeric Thin Films to Direct Microbial Biofilm Growth, Virulence, and Metabolism
Trevor Franklin, Yinan Wu, Jiayan Lang, Sijin Li, Rong Yang
Biomacromolecules.2021; 22(12): 4933. CrossRef
Aspergillus fumigatus biofilms: Toward understanding how growth as a multicellular network increases antifungal resistance and disease progression
Kaesi A. Morelli, Joshua D. Kerkaert, Robert A. Cramer, Chaoyang Xue
PLOS Pathogens.2021; 17(8): e1009794. CrossRef
Variability of the structure of winter microbial communities in Chelyabinsk lakes
S. V. Andreeva, Y. Y. Filippova, E. V. Devyatova, D. Y. Nokhrin
Biosystems Diversity.2021; 29(4): 311. CrossRef
Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol
Michael Dagher, Felicia Ruffin, Steven Marshall, Magdalena Taracila, Robert A Bonomo, Rachel Reilly, Vance G Fowler, Joshua T Thaden
Open Forum Infectious Diseases.2020;[Epub] CrossRef
Identification and validation of a novel anti-virulent that binds to pyoverdine and inhibits its function
Xu Wang, Quinn Kleerekoper, Alexey V. Revtovich, Donghoon Kang, Natalia V. Kirienko
Virulence.2020; 11(1): 1293. CrossRef
Inhibiting Iron Mobilization from Bacterioferritin in Pseudomonas aeruginosa Impairs Biofilm Formation Irrespective of Environmental Iron Availability
Anabel Soldano, Huili Yao, Josephine R. Chandler, Mario Rivera
ACS Infectious Diseases.2020; 6(3): 447. CrossRef
Mobilization of Iron Stored in Bacterioferritin Is Required for Metabolic Homeostasis in Pseudomonas aeruginosa
Achala N. D. Punchi Hewage, Leo Fontenot, Jessie Guidry, Thomas Weldeghiorghis, Anil K. Mehta, Fabrizio Donnarumma, Mario Rivera
Pathogens.2020; 9(12): 980. CrossRef
Role of aspartate ammonia-lyase in Pasteurella multocida
Zui Wang, Li Li, Peng Liu, Chen Wang, Qin Lu, Lina Liu, Xiaozhong Wang, Qingping Luo, Huabin Shao
BMC Microbiology.2020;[Epub] CrossRef
An In Vitro Cell Culture Model for Pyoverdine-Mediated Virulence
Donghoon Kang, Natalia V. Kirienko
Pathogens.2020; 10(1): 9. CrossRef
Vertebrate mucus stimulates biofilm development and upregulates iron acquisition genes in Flavobacterium columnare
Miles D. Lange, Bradley D. Farmer, Jason Abernathy
Journal of Fish Diseases.2020; 43(1): 101. CrossRef
Rhamnolipid Enhances Burkholderia Pseudomallei Biofilm Susceptibility, Disassembly and Production of Virulence Factors
José JC Sidrim, Crister J Ocadaque, Bruno R Amando, Glaucia M de M Guedes, Cecília L Costa, Raimunda SN Brilhante, Rossana de A Cordeiro, Marcos FG Rocha, Débora SCM Castelo-Branco
Future Microbiology.2020; 15(12): 1109. CrossRef
An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1
Adithi R. Varadarajan, Raymond N. Allan, Jules D. P. Valentin, Olga E. Castañeda Ocampo, Vincent Somerville, Franziska Pietsch, Matthias T. Buhmann, Jonathan West, Paul J. Skipp, Henny C. van der Mei, Qun Ren, Frank Schreiber, Jeremy S. Webb, Christian H.
npj Biofilms and Microbiomes.2020;[Epub] CrossRef
Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance
Savannah J. Post, Justin A. Shapiro, William M. Wuest
MedChemComm.2019; 10(4): 505. CrossRef
Novel Pyoverdine Inhibitors Mitigate Pseudomonas aeruginosa Pathogenesis
Daniel R. Kirienko, Donghoon Kang, Natalia V. Kirienko
Frontiers in Microbiology.2019;[Epub] CrossRef
Bioaccumulation of potentially toxic elements by submerged plants and biofilms: A critical review
Nan Geng, Yichao Wu, Ming Zhang, Daniel C.W. Tsang, Jörg Rinklebe, Yinfeng Xia, Debao Lu, Lifang Zhu, Kumuduni Niroshika Palansooriya, Ki-Hyun Kim, Yong Sik Ok
Environment International.2019; 131: 105015. CrossRef
Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients
Donghoon Kang, Alexey V. Revtovich, Qingquan Chen, Kush N. Shah, Carolyn L. Cannon, Natalia V. Kirienko
Frontiers in Microbiology.2019;[Epub] CrossRef

REVIEW] Type 3 regulatory T cells at the interface of symbiosis: Joo-Hong Park , Gérard Eberl; J. Microbiol. 2018;56(3):163-171. Published online February 28, 2018; DOI: https://doi.org/10.1007/s12275-018-7565-x

454 View
0 Download
22 Crossref

Abstract PDF

The mammalian gastrointestinal tract accommodates trillions of bacteria, many of which provide beneficial effects to the host, including protection from pathogenic microorganisms and essential metabolites. However, the intestinal immune system needs to adapt to the constantly fluctuating microbial environment at mucosal surfaces in order to maintain homeostasis. In particular, the gut microbiota induces the differentiation of effector Th17 cells and regulatory T cells (Tregs) that express RORγt, the master regulator of antimicrobial type 3 immunity. RORγt+ Tregs constitute a major population of colonic Tregs that is distinct from thymusderived Tregs and require bacterial antigens for differentiation. The balance between Th17 cells and RORγt+ Tregs, that is, the tone of the local type 3 immune response, is regulated by the vitamin A metabolite retinoic acid produced by the host. Furthermore, Th17 cells and RORγt+ Tregs regulate intestinal type 2 immune responses, explaining how bacteria block allergic reactions. Here, we review the cellular and molecular mechanisms involved in the differentiation, regulation and function of RORγt+ (type 3) Tregs, and discuss the multiple equilibria that exist between effector T cells and Tregs, as well as between different types of immune responses, which are necessary to maintain homeostasis and health.

Citations

Citations to this article as recorded by

Maternal consumption of urbanized diet compromises early-life health in association with gut microbiota
Rong Huang, Guicheng Zhou, Jie Cai, Cha Cao, Zhenjun Zhu, Qingping Wu, Fen Zhang, Yu Ding
Gut Microbes.2025;[Epub] CrossRef
Independent and temporally separated dynamics for RORγt and Foxp3 during Th17 differentiation
Stav Miller, Inbal Eizenberg-Magar, Shlomit Reich-Zeliger, Jacob Rimer, Irina Zaretsky, Dan Reshef, Ekaterina Kopitman, Nir Friedman, Yaron E Antebi
Frontiers in Immunology.2025;[Epub] CrossRef
Viral Liver Disease and Intestinal Gut–Liver Axis
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki
Gastrointestinal Disorders.2024; 6(1): 64. CrossRef
Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease: Mechanism, clinical evidence, and prospect
Xiao-Xia Qiu, Sheng-Li Cheng, Yan-Hui Liu, Yu Li, Rui Zhang, Nan-Nan Li, Zheng Li
World Journal of Gastroenterology.2024; 30(8): 833. CrossRef
Endotoxin Inflammatory Action on Cells by Dysregulated-Immunological-Barrier-Linked ROS-Apoptosis Mechanisms in Gut–Liver Axis
Andrei Dumitru, Elena Matei, Georgeta Camelia Cozaru, Anca Chisoi, Luana Alexandrescu, Răzvan Cătălin Popescu, Mihaela Pundiche Butcaru, Eugen Dumitru, Sorin Rugină, Cristina Tocia
International Journal of Molecular Sciences.2024; 25(5): 2472. CrossRef
MAFLD and Celiac Disease in Children
Serena Scapaticci, Annamaria Venanzi, Francesco Chiarelli, Cosimo Giannini
International Journal of Molecular Sciences.2023; 24(2): 1764. CrossRef
Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta
Aleksi Husso, Tiina Pessa-Morikawa, Ville Mikael Koistinen, Olli Kärkkäinen, Hyuk Nam Kwon, Leo Lahti, Antti Iivanainen, Kati Hanhineva, Mikael Niku
BMC Biology.2023;[Epub] CrossRef
Gut microbiome as a therapeutic target for liver diseases
Tejinder Pal Singh, Saurabh Kadyan, Harisha Devi, Gwoncheol Park, Ravinder Nagpal
Life Sciences.2023; 322: 121685. CrossRef
Contribution of the microbiome for better phenotyping of people living with obesity
Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Gabriella Garruti, Piero Portincasa
Reviews in Endocrine and Metabolic Disorders.2023; 24(5): 839. CrossRef
The Role of the Gastrointestinal Microbiome in Liver Disease
Nicholas Shalaby, Dorit Samocha-Bonet, Nadeem O. Kaakoush, Mark Danta
Pathogens.2023; 12(9): 1087. CrossRef
The role of microbiota in nonalcoholic fatty liver disease
Agostino Di Ciaula, Leonilde Bonfrate, Piero Portincasa
European Journal of Clinical Investigation.2022;[Epub] CrossRef
Intestinal Barrier and Permeability in Health, Obesity and NAFLD
Piero Portincasa, Leonilde Bonfrate, Mohamad Khalil, Maria De Angelis, Francesco Maria Calabrese, Mauro D’Amato, David Q.-H. Wang, Agostino Di Ciaula
Biomedicines.2021; 10(1): 83. CrossRef
A Pulmonary Lactobacillus murinus Strain Induces Th17 and RORγt+ Regulatory T Cells and Reduces Lung Inflammation in Tuberculosis
Lucie Bernard-Raichon, André Colom, Sarah C Monard, Amine Namouchi, Margaux Cescato, Hugo Garnier, Stephen A Leon-Icaza, Arnaud Métais, Alexia Dumas, Dan Corral, Natsinet Ghebrendrias, Pauline Guilloton, Christel Vérollet, Denis Hudrisier, Aude Remot, Phi
The Journal of Immunology.2021; 207(7): 1857. CrossRef
Microbiota-mediated protection against antibiotic-resistant pathogens
Rekha B. Panwar, Richard P. Sequeira, Thomas B. Clarke
Genes & Immunity.2021; 22(5-6): 255. CrossRef
Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells
Mari Tenno, Alicia Yoke Wei Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo, Peter See, Tamotsu Kato, Takashi Taida, Michiko Oishi-Ohno, Hiroshi Ohno, Hideyuki Yoshida, Florent Ginhoux, Ichiro Taniuchi
Life Science Alliance.2020; 3(1): e201900441. CrossRef
Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection
Slater L. Clay, Alberto Bravo-Blas, Daniel M. Wall, Megan K.L. MacLeod, Simon W.F. Milling
Mucosal Immunology.2020; 13(6): 946. CrossRef
The gut-liver axis in liver disease: Pathophysiological basis for therapy
Agustín Albillos, Andrea de Gottardi, María Rescigno
Journal of Hepatology.2020; 72(3): 558. CrossRef
Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A Never-Ending Bidirectional Cross-Talk
Agostino Di Ciaula, Jacek Baj, Gabriella Garruti, Giuseppe Celano, Maria De Angelis, Helen H. Wang, Domenica Maria Di Palo, Leonilde Bonfrate, David Q-H Wang, Piero Portincasa
Journal of Clinical Medicine.2020; 9(8): 2648. CrossRef
Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis
Margherita T. Cantorna, Lindsay Snyder, Juhi Arora
Critical Reviews in Biochemistry and Molecular Biology.2019; 54(2): 184. CrossRef
Gut microbiomes and their metabolites shape human and animal health
Woojun Park
Journal of Microbiology.2018; 56(3): 151. CrossRef
Regulatory B and T lymphocytes in multiple sclerosis: friends or foes?
Georgios K. Vasileiadis, Efthymios Dardiotis, Athanasios Mavropoulos, Zisis Tsouris, Vana Tsimourtou, Dimitrios P. Bogdanos, Lazaros I. Sakkas, Georgios M. Hadjigeorgiou
Autoimmunity Highlights.2018;[Epub] CrossRef
Classic Models for New Perspectives: Delving into Helminth–Microbiota–Immune System Interactions
Alba Cortés, Rafael Toledo, Cinzia Cantacessi
Trends in Parasitology.2018; 34(8): 640. CrossRef

REVIEW] Innate host defenses against Cryptococcus neoformans: Camaron Hole , Floyd L. Wormley Jr.; J. Microbiol. 2016;54(3):202-211. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5625-7

390 View
0 Download
18 Crossref

Abstract PDF

Cryptococcus neoformans, the predominant etiological agent of cryptococcosis, can cause life-threatening infections of the central nervous system in immunocompromised and immunocompetent individuals. Cryptococcal meningoencephalitis is the most common disseminated fungal infection in AIDS patients, and remains the third most common invasive fungal infection among organ transplant recipients. The administration of highly active antiretroviral therapy (HAART) has
result
ed in a decrease in the number of cases of AIDS-related cryptococcosis in developed countries, but in developing countries where HAART is not readily available, Cryptococcus is still a major concern. Therefore, there is an urgent need for the development of novel therapies and/or vaccines to combat cryptococcosis. Understanding the protective immune responses against Cryptococcus is critical for development of vaccines and immunotherapies to combat cryptococcosis. Consequently, this review focuses on our current knowledge of protective immune responses to C. neoformans, with an emphasis on innate immune responses.

Citations

Citations to this article as recorded by

Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs
Christopher J. Winski, Peter V. Stuckey, Armando M. Marrufo, Georgina Agyei, Robbi L. Ross, Tamanna Urmi, Sarah Chapman, Felipe H. Santiago-Tirado, Luis R. Martinez
mBio.2025;[Epub] CrossRef
Global trends in Cryptococcus and its interactions with the host immune system: a bibliometric analysis
Shiqin Tang, Ruiying Hao, Xin Liu, Huina He, Yanan Tian, Tingting Jing, Zhao Liu, Yanyan Xu, Xiaojing Li
Frontiers in Immunology.2024;[Epub] CrossRef
The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways
Jennifer L. O'Connor, Jillian C. Nissen
International Journal of Molecular Sciences.2023; 24(5): 4739. CrossRef
Microglia are not protective against cryptococcal meningitis
Sally H. Mohamed, Man Shun Fu, Sofia Hain, Alanoud Alselami, Eliane Vanhoffelen, Yanjian Li, Ebrima Bojang, Robert Lukande, Elizabeth R. Ballou, Robin C. May, Chen Ding, Greetje Vande Velde, Rebecca A. Drummond
Nature Communications.2023;[Epub] CrossRef
Pathogen-Host Interaction Repertoire at Proteome and Posttranslational Modification Levels During Fungal Infections
Yanjian Li, Hailong Li, Tianshu Sun, Chen Ding
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis
Tao Zhu, Wan-Ting Luo, Gui-Hua Chen, Yue-Sheng Tu, Shuo Tang, Huo-Jin Deng, Wei Xu, Wei Zhang, Di Qi, Dao-Xin Wang, Chang-Yi Li, He Li, Yan-Qiao Wu, Shen-Jin Li
Chinese Medical Journal.2018; 131(18): 2210. CrossRef
A case report of fatal disseminated Mycobacterium colombiense infection in a renal transplant recipient
Jasmine Gosal, B. Craig Lee
Transplant Infectious Disease.2018;[Epub] CrossRef
The Major Surface Glycoprotein of Pneumocystis murina Does Not Activate Dendritic Cells
Monica Sassi, Geetha Kutty, Gabriela A Ferreyra, Lisa R Bishop, Yueqin Liu, Ju Qiu, Da Wei Huang, Joseph A Kovacs
The Journal of Infectious Diseases.2018; 218(10): 1631. CrossRef
Disseminated Cryptococcosis With Severe Increased Intracranial Pressure Complicated With Cranial Nerve Palsy in a Child
Bilge Aldemir Kocabaş, Mehmet Emin Parlak, Betil Özhak Baysan, Kamil Karaali, Ayşen Bingöl, Şenay Haspolat
Pediatric Infectious Disease Journal.2018; 37(4): 373. CrossRef
Contribution of IL-1RI Signaling to Protection against Cryptococcus neoformans 52D in a Mouse Model of Infection
Mitra Shourian, Ben Ralph, Isabelle Angers, Donald C. Sheppard, Salman T. Qureshi
Frontiers in Immunology.2018;[Epub] CrossRef
Transcriptomic Predictors of Paradoxical Cryptococcosis-Associated Immune Reconstitution Inflammatory Syndrome
Irina Vlasova-St. Louis, Christina C Chang, Samar Shahid, Martyn A French, Paul R Bohjanen
Open Forum Infectious Diseases.2018;[Epub] CrossRef
Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection
Jintao Xu, Adam Flaczyk, Lori M Neal, Zhenzong Fa, Alison J Eastman, Antoni N Malachowski, Daphne Cheng, Bethany B Moore, Jeffrey L Curtis, John J Osterholzer, Michal A Olszewski
The Journal of Immunology.2017; 198(9): 3548. CrossRef
Neuro-Immune Mechanisms of Anti-Cryptococcal Protection
Rebecca Drummond
Journal of Fungi.2017; 4(1): 4. CrossRef
Role of microglia in fungal infections of the central nervous system
George W. Koutsouras, Raddy L. Ramos, Luis R. Martinez
Virulence.2017; 8(6): 705. CrossRef
Dectin-3 Is Not Required for Protection against Cryptococcus neoformans Infection
Althea Campuzano, Natalia Castro-Lopez, Karen L. Wozniak, Chrissy M. Leopold Wager, Floyd L. Wormley, Kirsten Nielsen
PLOS ONE.2017; 12(1): e0169347. CrossRef
Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison
Pedro Pais, Catarina Costa, Mafalda Cavalheiro, Daniela Romão, Miguel C. Teixeira
Frontiers in Cellular and Infection Microbiology.2016;[Epub] CrossRef
Human fungal pathogens: Why should we learn?
Jeong-Yoon Kim
Journal of Microbiology.2016; 54(3): 145. CrossRef
Activation strategies for invariant natural killer T cells
Ayano C. Kohlgruber, Carlos A. Donado, Nelson M. LaMarche, Michael B. Brenner, Patrick J. Brennan
Immunogenetics.2016; 68(8): 649. CrossRef

Research Support, Non-U.S. Gov't

Therapeutic potential of an AcHERV-HPV L1 DNA vaccine: Hee-Jung Lee , Jong Kwang Yoon , Yoonki Heo , Hansam Cho , Yeondong Cho , Yongdae Gwon , Kang Chang Kim , Jiwon Choi , Jae Sung Lee , Yu-Kyoung Oh , Young Bong Kim; J. Microbiol. 2015;53(6):415-420. Published online May 30, 2015; DOI: https://doi.org/10.1007/s12275-015-5150-0

353 View
0 Download
6 Crossref

Cervical cancer is strongly associated with chronic human papillomavirus infections, among which HPV16 is the most common. Two commercial HPV vaccines, Gardasil and Cervarix are effective for preventing HPV infection, but cannot be used to treat existing HPV infections. Previously, we developed a human endogenous retrovirus (HERV)-enveloped recombinant baculovirus capable of delivering the L1 genes of HPV types 16, 18, and 58 (AcHERV-HP16/18/58L1, AcHERV-HPV). Intramuscular administration of AcHERVHPV vaccines induced a strong cellular immune response as well as a humoral immune response. In this study, to examine the therapeutic effect of AcHERV-HPV in a mouse model, we established an HPV16 L1 expressing tumor cell line. Compared to Cervarix, immunization with AcHERVHPV greatly enhanced HPV16 L1-specific cytotoxic T lymphocytes (CTL) in C57BL/6 mice. Although vaccination could not remove preexisting tumors, strong CTL activity retarded the growth of inoculated tumor cells. These results indicate that AcHERV-HPV could serve as a potential therapeutic DNA vaccine against concurrent infection with HPV 16, 18, and 58.

Citations

Citations to this article as recorded by

Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia
Chichao Xia, Sile Li, Teng Long, Zigui Chen, Paul K. S. Chan, Siaw Shi Boon
Cancers.2021; 13(11): 2691. CrossRef
In Silico Design and Immunological Studies of Two Novel Multiepitope DNA-Based Vaccine Candidates Against High-Risk Human Papillomaviruses
Matin Kayyal, Azam Bolhassani, Zahra Noormohammadi, Majid Sadeghizadeh
Molecular Biotechnology.2021; 63(12): 1192. CrossRef
Unraveling the Genome-Wide Impact of Recombinant Baculovirus Infection in Mammalian Cells for Gene Delivery
Ha Youn Shin, Hanul Choi, Nahyun Kim, Nayoung Park, Heesun Kim, Jaebum Kim, Young Bong Kim
Genes.2020; 11(11): 1306. CrossRef
Treatment with Radix Euphorbiae Ebracteolatae Significantly Decreases the Expression of E6 and L1, and Increases the Expression of p53 and Rb in HPV18-infected Human Foreskin Keratinocytes
Xiang He, Xufeng He, Ping Xu, Lili Yang, Xin Ma, Wen Li, Huimin Zhang
Current Molecular Medicine.2019; 19(1): 20. CrossRef
Trial watch: DNA-based vaccines for oncological indications
Stefano Pierini, Renzo Perales-Linares, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvogel, Guido Kroemer, Andrea Facciabene, Lorenzo Galluzzi
OncoImmunology.2017; 6(12): e1398878. CrossRef
Broad-spectrum antiviral properties of andrographolide
Swati Gupta, K. P. Mishra, Lilly Ganju
Archives of Virology.2017; 162(3): 611. CrossRef

Reviews

Microbial ecology in Hydra: Why viruses matter: Thomas C.G. Bosch , Juris A. Grasis , Tim Lachnit; J. Microbiol. 2015;53(3):193-200. Published online March 3, 2015; DOI: https://doi.org/10.1007/s12275-015-4695-2

435 View
0 Download
13 Crossref

Abstract PDF

While largely studied because of their harmful effects on human health, there is growing appreciation that viruses are also important members of the animal holobiont. This review highlights recent findings on viruses associated with Hydra and related Cnidaria. These early evolutionary diverging animals not only select their bacterial communities but also select for viral communities in a species-specific manner. The majority of the viruses associating with these animals are bacteriophages. We demonstrate that the animal host and its virome have evolved into a homeostatic, symbiotic relationship and propose that viruses are an important part of the Hydra holobiont by controlling the species-specific microbiome. We conclude that beneficial virus-bacterial-host interactions should be considered as an integral part of animal development and evolution.

Citations

Citations to this article as recorded by

Hydra for 21st Century—A Fine Model in Freshwater Research
Goran Kovačević, Petra Korać, Davor Želježić, Mirela Sertić Perić, Petra Peharec Štefanić, Damir Sirovina, Maja Novosel, Sanja Gottstein
Water.2024; 16(15): 2114. CrossRef
Four Novel Caudoviricetes Bacteriophages Isolated from Baltic Sea Water Infect Colonizers of Aurelia aurita
Melissa Stante, Nancy Weiland-Bräuer, Urska Repnik, Almut Werner, Marc Bramkamp, Cynthia M. Chibani, Ruth A. Schmitz
Viruses.2023; 15(7): 1525. CrossRef
Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease
Caijiao Dai, Xin Chen, Shiyu Qian, Yihui Fan, Lijuan Li, Junfa Yuan
Microbial Biotechnology.2023; 16(10): 1940. CrossRef
First evidence of virus-like particles in the bacterial symbionts of Bryozoa
A. E. Vishnyakov, N. P. Karagodina, G. Lim-Fong, P. A. Ivanov, T. F. Schwaha, A. V. Letarov, A. N. Ostrovsky
Scientific Reports.2021;[Epub] CrossRef
Interactions of host‐associated multispecies bacterial communities
Heidi Goodrich‐Blair
Periodontology 2000.2021; 86(1): 14. CrossRef
Oyster hemolymph is a complex and dynamic ecosystem hosting bacteria, protists and viruses
S. Dupont, A. Lokmer, E. Corre, J.-C. Auguet, B. Petton, E. Toulza, C. Montagnani, G. Tanguy, D. Pecqueur, C. Salmeron, L. Guillou, C. Desnues, B. La Scola, J. Bou Khalil, J. de Lorgeril, G. Mitta, Y. Gueguen, J.-M. Escoubas
Animal Microbiome.2020;[Epub] CrossRef
Upside-Down but Headed in the Right Direction: Review of the Highly Versatile Cassiopea xamachana System
Aki H. Ohdera, Michael J. Abrams, Cheryl L. Ames, David M. Baker, Luis P. Suescún-Bolívar, Allen G. Collins, Christopher J. Freeman, Edgar Gamero-Mora, Tamar L. Goulet, Dietrich K. Hofmann, Adrian Jaimes-Becerra, Paul F. Long, Antonio C. Marques, Laura A.
Frontiers in Ecology and Evolution.2018;[Epub] CrossRef
Temperate phages as self-replicating weapons in bacterial competition
Xiang-Yi Li, Tim Lachnit, Sebastian Fraune, Thomas C. G. Bosch, Arne Traulsen, Michael Sieber
Journal of The Royal Society Interface.2017; 14(137): 20170563. CrossRef
Grazing of Nuclearia thermophila and Nuclearia delicatula (Nucleariidae, Opisthokonta) on the toxic cyanobacterium Planktothrix rubescens
Sebastian Dirren, Gianna Pitsch, Marisa O.D. Silva, Thomas Posch
European Journal of Protistology.2017; 60: 87. CrossRef
The Intra-Dependence of Viruses and the Holobiont
Juris A. Grasis
Frontiers in Immunology.2017;[Epub] CrossRef
Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model
Peter Deines, Thomas C. G. Bosch
Frontiers in Microbiology.2016;[Epub] CrossRef
Bacterial associations with the hydromedusaNemopsis bacheiand scyphomedusaAurelia auritafrom the North Atlantic Ocean
Meaghan C. Daley, Juanita Urban-Rich, Pia H. Moisander
Marine Biology Research.2016; 12(10): 1088. CrossRef
Promiscuous and specific bacterial symbiont acquisition in the amoeboid genusNuclearia(Opisthokonta)
Sebastian Dirren, Thomas Posch, Julie Olson
FEMS Microbiology Ecology.2016; 92(8): fiw105. CrossRef

REVIEW] Chronic Obstructive Pulmonary Disease (COPD): Evaluation From Clinical, Immunological and Bacterial Pathogenesis Perspectives: Daniel J. Hassett , Michael T. Borchers , Ralph J. Panos; J. Microbiol. 2014;52(3):211-226. Published online March 1, 2014; DOI: https://doi.org/10.1007/s12275-014-4068-2

361 View
0 Download
50 Crossref

Abstract PDF

Chronic obstructive pulmonary disease (COPD), a disease manifested by significantly impaired airflow, afflicts ~14.2 million cases in the United States alone with an estimated 63 million people world-wide. Although there are a number of causes, the predominant cause is excessive tobacco smoke. In fact, in China, there have been estimates of 315,000,000 people that smoke. Other less frequent causes are associated with indirect cigarette smoke, air pollutants, biomass fuels, and genetic mutations. COPD is often associated with heart disease, lung cancer, osteoporosis and conditions can worsen in patients with sudden falls. COPD also affects both innate and adaptive immune processes. Cigarette smoke increases the expression of matrix metalloproteases and proinflammatory chemokines and increases lung titers of natural killer cells and neutrophils. Yet, neutrophil reactive oxygen species (ROS) mediated by the phagocytic respiratory burst and phagocytosis is impaired by nicotine. In contrast to innate immunity in COPD, dendritic cells represent leukocytes recruited to the lung that link the innate immune responses to adaptive immune responses by activating naïve T cells through antigen presentation. The autoimmune process that is also a significant part of inflammation associated with COPD. Moreover, coupled with restricted FEV1 values, are the prevalence of patients with single or multiple infections by bacteria, viruses and fungi. Finally, we focus on one of the more problematic infectious agents, the Gram-negative opportunistic pathogenic bacterium, Pseudomonas aeruginosa. Specifically, we delve into the development of highly problematic biofilm infections that are highly refractory to conventional antibiotic therapies in COPD. We offer a nonconventional, biocidal treatment that may be effective for COPD airway infections as well as with combinations of current antibiotic regimens for more effective treatment outcomes and relief for patients with COPD.

Citations

Citations to this article as recorded by

Comparative Effects of Cigarette Smoke and Heated Tobacco Product Aerosols on Biofilm Production by Respiratory Pathogens
Pavel Schiopu, Dan Alexandru Toc, Ioana Alina Colosi, Carmen Costache, Paul-Ștefan Panaitescu, Vlad Sever Neculicioiu, Codrina Mihaela Gorcea, Tudor-Ioan Zăgărin, Andreea Roxana Murarasu, Doina Adina Todea
Microorganisms.2025; 13(11): 2459. CrossRef
Immune system dynamics in response to Pseudomonas aeruginosa biofilms
Abhijeet Sahu, Rohit Ruhal
npj Biofilms and Microbiomes.2025;[Epub] CrossRef
A biocompatible β-cyclodextrin inclusion complex containing natural extracts: a promising antibiofilm agent
Obaydah Abd Alkader Alabrahim, Mostafa Fytory, Ahmed M. Abou-Shanab, Jude Lababidi, Wolfgang Fritzsche, Nagwa El-Badri, Hassan Mohamed El-Said Azzazy
Nanoscale Advances.2025; 7(5): 1405. CrossRef
In vitro lung epithelial cell model reveals novel roles for Pseudomonas aeruginosa siderophores
Donghoon Kang, Qi Xu, Natalia V. Kirienko, Giordano Rampioni
Microbiology Spectrum.2024;[Epub] CrossRef
A metaplasia escamosa em dpoc: uma revisão sistemática
Daniela Sasso Pasquini, Isabella Vieira Laporte Ambrozewicz, Sofia Garcia Santana
Journal Archives of Health.2024; 5(1): 399. CrossRef
Pseudomonas aeruginosa in chronic lung disease: untangling the dysregulated host immune response
Rhea Nickerson, Christina S. Thornton, Brent Johnston, Amy H. Y. Lee, Zhenyu Cheng
Frontiers in Immunology.2024;[Epub] CrossRef
Unlocking the potential of lactic acid bacteria mature biofilm extracts as antibiofilm agents
Pamela Hindieh, Joseph Yaghi, Jean Claude Assaf, Ali Chokr, Ali Atoui, Nicolas Louka, André El Khoury
AMB Express.2024;[Epub] CrossRef
Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective
Pierachille Santus, Juan Camilo Signorello, Fiammetta Danzo, Giada Lazzaroni, Marina Saad, Dejan Radovanovic
Journal of Clinical Medicine.2024; 13(14): 4127. CrossRef
Biofilms as Battlefield Armor for Bacteria against Antibiotics: Challenges and Combating Strategies
Sara Bano, Noor Hassan, Muhammad Rafiq, Farwa Hassan, Maliha Rehman, Naveed Iqbal, Hazrat Ali, Fariha Hasan, Ying-Qian Kang
Microorganisms.2023; 11(10): 2595. CrossRef
Antibiofilm agents with therapeutic potential against enteroaggregative Escherichia coli
David A. Kwasi, Chinedum P. Babalola, Olujide O. Olubiyi, Jennifer Hoffmann, Ikemefuna C. Uzochukwu, Iruka N. Okeke, Luther A. Bartelt
PLOS Neglected Tropical Diseases.2022; 16(10): e0010809. CrossRef
Resistance Is Not Futile: The Role of Quorum Sensing Plasticity in Pseudomonas aeruginosa Infections and Its Link to Intrinsic Mechanisms of Antibiotic Resistance
Kayla A. Simanek, Jon E. Paczkowski
Microorganisms.2022; 10(6): 1247. CrossRef
Early COPD Risk Decision for Adults Aged From 40 to 79 Years Based on Lung Radiomics Features
Yingjian Yang, Wei Li, Yingwei Guo, Yang Liu, Qiang Li, Kai Yang, Shicong Wang, Nanrong Zeng, Wenxin Duan, Ziran Chen, Huai Chen, Xian Li, Wei Zhao, Rongchang Chen, Yan Kang
Frontiers in Medicine.2022;[Epub] CrossRef
The effect of N-acetylcysteine in patients with non-cystic fibrosis bronchiectasis (NINCFB): study protocol for a multicentre, double-blind, randomised, placebo-controlled trial
Yue Liao, Yanqiu Wu, Kai Zi, Yongchun Shen, Tao Wang, Jiangyue Qin, Lei Chen, Mei Chen, Lin Liu, Weiming Li, Hui Zhou, Shuguan Xiong, Fuqiang Wen, Jun Chen
BMC Pulmonary Medicine.2022;[Epub] CrossRef
Small-Angle Neutron Scattering Reveals the Nanostructure of Liposomes with Embedded OprF Porins of Pseudomonas aeruginosa
Francesco Spinozzi, Jean-Pierre Alcaraz, Maria Grazia Ortore, Landry Gayet, Aurel Radulescu, Donald K. Martin, Marco Maccarini
Langmuir.2022; 38(49): 15026. CrossRef
Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
Ze-Guang Zheng, Wu-Zhuang Sun, Jie-Ying Hu, Zhi-Jun Jie, Jin-Fu Xu, Jie Cao, Yuan-Lin Song, Chang-Hui Wang, Jing Wang, Hui Zhao, Zhong-Liang Guo, Nan-Shan Zhong
Respiratory Research.2021;[Epub] CrossRef
Health economics matters in the nanomaterial world: Cost-effectiveness of utilizing an inhalable antibacterial nanomaterial for the treatment of multidrug-resistant pneumonia
Vuk Uskoković
Technology in Society.2021; 66: 101641. CrossRef
Microbial biofilm: A matter of grave concern for human health and food industry
Muzamil A. Rather, Kuldeep Gupta, Pritam Bardhan, Munmi Borah, Anupama Sarkar, Khalifa S. H. Eldiehy, Shuvam Bhuyan, Manabendra Mandal
Journal of Basic Microbiology.2021; 61(5): 380. CrossRef
Plant-derived nanotherapeutic systems to counter the overgrowing threat of resistant microbes and biofilms
Sajid Asghar, Ikram Ullah Khan, Saad Salman, Syed Haroon Khalid, Rabia Ashfaq, Thierry F. Vandamme
Advanced Drug Delivery Reviews.2021; 179: 114019. CrossRef
The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies
R. Frèdi Langendonk, Daniel R. Neill, Joanne L. Fothergill
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Tissue-Specific Ultra-Short Telomeres in Chronic Obstructive Pulmonary Disease

Huseyin Cagsin, Ali Uzan, Ozgur Tosun, Finn Rasmussen, Nedime Serakinci
International Journal of Chronic Obstructive Pulmonary Disease.2020; Volume 15: 2751. CrossRef
Host responses to mucosal biofilms in the lung and gut
Jada C. Domingue, Julia L. Drewes, Christian A. Merlo, Franck Housseau, Cynthia L. Sears
Mucosal Immunology.2020; 13(3): 413. CrossRef
Overexpression of phzM contributes to much more production of pyocyanin converted from phenazine-1-carboxylic acid in the absence of RpoS in Pseudomonas aeruginosa
Kewen Wang, Le Kai, Kailu Zhang, Mengyue Hao, Yanjie Yu, Xinyu Xu, Zhifen Yu, Lijuan Chen, Xiaoyan Chi, Yihe Ge
Archives of Microbiology.2020; 202(6): 1507. CrossRef
Haemophilus influenzaepersists in biofilm communities in a smoke-exposed ferret model of COPD
Benjamin C. Hunt, Denise Stanford, Xin Xu, Jindong Li, Amit Gaggar, Steven M. Rowe, S. Vamsee Raju, W. Edward Swords
ERJ Open Research.2020; 6(3): 00200-2020. CrossRef
Airway Natural Killer Cells and Bacteria in Health and Disease
Maud Theresine, Neha D. Patil, Jacques Zimmer
Frontiers in Immunology.2020;[Epub] CrossRef
Clinical Significance of Carbapenem-Tolerant Pseudomonas aeruginosa Isolated in the Respiratory Tract
Momoyo Azuma, Keiji Murakami, Rina Murata, Keiko Kataoka, Hideki Fujii, Yoichiro Miyake, Yasuhiko Nishioka
Antibiotics.2020; 9(9): 626. CrossRef
Biofilm dispersion
Kendra P. Rumbaugh, Karin Sauer
Nature Reviews Microbiology.2020; 18(10): 571. CrossRef
Clinical significance of BPI‐ANCA detecting in COPD patients with Pseudomonas aeruginosa colonization
Yongjian Tian, Tingting Zeng, Liming Tan, Yang Wu, Jianlin Yu, Jiayi Huang, Zihuang Pei
Journal of Clinical Laboratory Analysis.2019;[Epub] CrossRef
Signal Sensing and Transduction Are Conserved between the Periplasmic Sensory Domains of BifA and SagS
Jozef Dingemans, Rebecca E. Al-Feghali, Holger Sondermann, Karin Sauer, Bryan Krantz
mSphere.2019;[Epub] CrossRef
Wearable Cardiopulmonary Function Evaluation System for Six-Minute Walking Test
Bor-Shing Lin, Ruei-Jie Jhang, Bor-Shyh Lin
Sensors.2019; 19(21): 4656. CrossRef
Synthesized Heparan Sulfate Competitors Attenuate Pseudomonas aeruginosa Lung Infection
Nicola Lorè, Noemi Veraldi, Camilla Riva, Barbara Sipione, Lorenza Spagnuolo, Ida De Fino, Medede Melessike, Elisa Calzi, Alessandra Bragonzi, Annamaria Naggi, Cristina Cigana
International Journal of Molecular Sciences.2018; 19(1): 207. CrossRef
Mechanisms and Targeted Therapies forPseudomonas aeruginosaLung Infection
Colleen S. Curran, Thomas Bolig, Parizad Torabi-Parizi
American Journal of Respiratory and Critical Care Medicine.2018; 197(6): 708. CrossRef
Establishment and Evaluation of a Rat Model of Sidestream Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease
Genfa Wang, Nabijan Mohammadtursun, Jing Sun, Yubao Lv, Hualiang Jin, Jinpei Lin, Lingwen Kong, Zhengxiao Zhao, Hongying Zhang, Jingcheng Dong
Frontiers in Physiology.2018;[Epub] CrossRef
Baicalin Exerts Anti‐Airway Inflammation and Anti‐Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease
Genfa Wang, Nabijan Mohammadtursun, Yubao Lv, Hongying Zhang, Jing Sun, Jingcheng Dong, Antonella Di Sotto
Evidence-Based Complementary and Alternative Medicine.2018;[Epub] CrossRef
Multifaceted activity ofN-acetyl-l-cysteine in chronic obstructive pulmonary disease
Luigino Calzetta, Maria Gabriella Matera, Paola Rogliani, Mario Cazzola
Expert Review of Respiratory Medicine.2018; 12(8): 693. CrossRef
MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: An in vivo and in vitro study
Wen Shen, Jia Liu, Minjuan Fan, Shukun Wang, Yang Zhang, Linqiao Wen, Ruili Wang, Wei Wei, Na Li, You Zhang, Guohou Zhao
Experimental Cell Research.2018; 362(2): 370. CrossRef
Functional Characterization of Cell-Free Expressed OprF Porin from Pseudomonas aeruginosa Stably Incorporated in Tethered Lipid Bilayers
Marco Maccarini, Landry Gayet, Jean-Pierre Alcaraz, Lavinia Liguori, Barry Stidder, Erik B. Watkins, Jean-Luc Lenormand, Donald K. Martin
Langmuir.2017; 33(38): 9988. CrossRef
Respiratory Microbiome of Endangered Southern Resident Killer Whales and Microbiota of Surrounding Sea Surface Microlayer in the Eastern North Pacific
Stephen A. Raverty, Linda D. Rhodes, Erin Zabek, Azad Eshghi, Caroline E. Cameron, M. Bradley Hanson, J. Pete Schroeder
Scientific Reports.2017;[Epub] CrossRef
The OxyR-regulated phnW gene encoding 2-aminoethylphosphonate:pyruvate aminotransferase helps protect Pseudomonas aeruginosa from tert-butyl hydroperoxide
Warunya Panmanee, Nisanart Charoenlap, Sopapan Atichartpongkul, Aekkapol Mahavihakanont, Matthew D. Whiteside, Geoff Winsor, Fiona S. L. Brinkman, Skorn Mongkolsuk, Daniel J. Hassett, Michael R. Volkert
PLOS ONE.2017; 12(12): e0189066. CrossRef
Master Autophagy Regulator Transcription Factor EB Regulates Cigarette Smoke-Induced Autophagy Impairment and Chronic Obstructive Pulmonary Disease–Emphysema Pathogenesis
Manish Bodas, Neel Patel, David Silverberg, Kyla Walworth, Neeraj Vij
Antioxidants & Redox Signaling.2017; 27(3): 150. CrossRef
Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease
Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki, Péter Engelmann
Respiratory Research.2017;[Epub] CrossRef
Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae
Begoña Euba, Nahikari López-López, Irene Rodríguez-Arce, Ariadna Fernández-Calvet, Montserrat Barberán, Nuria Caturla, Sara Martí, Roberto Díez-Martínez, Junkal Garmendia
Scientific Reports.2017;[Epub] CrossRef
Human Lung Mononuclear Phagocytes in Health and Disease
Faezzah Baharom, Gregory Rankin, Anders Blomberg, Anna Smed-Sörensen
Frontiers in Immunology.2017;[Epub] CrossRef
IL-17A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa
Nicola Ivan Lorè, Cristina Cigana, Camilla Riva, Ida De Fino, Alessandro Nonis, Lorenza Spagnuolo, Barbara Sipione, Lisa Cariani, Daniela Girelli, Giacomo Rossi, Veronica Basso, Carla Colombo, Anna Mondino, Alessandra Bragonzi
Scientific Reports.2016;[Epub] CrossRef
A Putative ABC Transporter Permease Is Necessary for Resistance to Acidified Nitrite and EDTA in Pseudomonas aeruginosa under Aerobic and Anaerobic Planktonic and Biofilm Conditions
Cameron McDaniel, Shengchang Su, Warunya Panmanee, Gee W. Lau, Tristan Browne, Kevin Cox, Andrew T. Paul, Seung-Hyun B. Ko, Joel E. Mortensen, Joseph S. Lam, Daniel A. Muruve, Daniel J. Hassett
Frontiers in Microbiology.2016;[Epub] CrossRef
Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo
Laura A. Novotny, Joseph A. Jurcisek, Steven D. Goodman, Lauren O. Bakaletz
eBioMedicine.2016; 10: 33. CrossRef
‘”Why me, why now?” Using clinical immunology and epidemiology to explain who gets nontuberculous mycobacterial infection
M. Alexandra Lake, Lyn R. Ambrose, Marc C. I. Lipman, David M. Lowe
BMC Medicine.2016;[Epub] CrossRef
Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases
Emily V.S. Ha, Duncan F. Rogers
Pharmacology.2016; 97(1-2): 84. CrossRef
Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short
Carla S. Andrews, Shingo Matsuyama, Byung-Cheol Lee, Jian-Dong Li
Scientific Reports.2016;[Epub] CrossRef
Population pharmacokinetics of fluticasone propionate/salmeterol using two different dry powder inhalers
K. Soulele, P. Macheras, L. Silvestro, S. Rizea Savu, V. Karalis
European Journal of Pharmaceutical Sciences.2015; 80: 33. CrossRef
Molecular microbiology in antibacterial research
You-Hee Cho
Journal of Microbiology.2014; 52(3): 185. CrossRef

REVIEW] Enterococcus Infection Biology: Lessons from Invertebrate Host Models: Grace J. Yuen , Frederick M. Ausubel; J. Microbiol. 2014;52(3):200-210. Published online March 1, 2014; DOI: https://doi.org/10.1007/s12275-014-4011-6

392 View
1 Download
43 Crossref

Abstract PDF

The enterococci are commensals of the gastrointestinal tract of many metazoans, from insects to humans. While they normally do not cause disease in the intestine, they can become pathogenic when they infect sites outside of the gut. Recently, the enterococci have become important nosocomial pathogens, with the majority of human enterococcal infections caused by two species, Enterococcus faecalis and Enterococcus faecium. Studies using invertebrate infection models have revealed insights into the biology of enterococcal infections, as well as general principles underlying host innate immune defense. This review highlights recent findings on Enterococcus infection biology from two invertebrate infection models, the greater wax moth Galleria mellonella and the free-living bacteriovorous nematode Caenorhabditis elegans.

Citations

Citations to this article as recorded by

Galleria mellonella (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens
Stefania Villani, Matteo Calcagnile, Christian Demitri, Pietro Alifano
Nanomaterials.2025; 15(1): 67. CrossRef
Investigating the gut bacteria structure and function of hibernating bats through 16S rRNA high-throughput sequencing and culturomics
Jian Zhou, Ying Liu, Tao Gu, Jingzhu Zhou, Fengming Chen, Shijun Li, Guan-Hong Wang
mSystems.2025;[Epub] CrossRef
Patterns of Insect Distribution in Fruit Trees of South Romania and Their Role as Bacterial Vectors
Dana S. Copoiu, Paris Lavin, Corina Itcus, Cristina Purcarea
Diversity.2025; 17(4): 295. CrossRef
Role of gut microbiota in predicting chemotherapy-induced neutropenia duration in leukemia patients
Yezi Huang, Lihong Liao, Yanjun Jiang, Si Tao, Duozhuang Tang
Frontiers in Microbiology.2025;[Epub] CrossRef
Midgut microorganisms transformed into hemolymph pathogens: Mediating DUOX-ROS immune response to regulate the insecticidal activity of Bacillus thuringiensis against Spodoptera exigua
Yujie Ji, Bo Gao, Dan Zhao, Lu Zhang, Han Wu, Yifan Xie, Qiuyu Shi, Wei Guo
Pesticide Biochemistry and Physiology.2025; 213: 106477. CrossRef
Enhancing Resistance to Enterococcus faecalis: Immunobiotic Lactiplantibacillus plantarum Strains as a Strategy for Malnourished Hosts
María Daniela Vera, Lorena Paola Arce, Melisa Florencia Müller, Fernanda Raya Tonetti, Ramiro Ortiz Moyano, Héctor Luis Blanco, Haruki Kitazawa, María Guadalupe Vizoso-Pinto, Julio Villena
Nutrients.2025; 17(11): 1770. CrossRef
Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms
Hina Singh, Sri Renukadevi Balusamy, Johan Sukweenadhi, Muthupandian Saravanan, Mohanprasanth Aruchamy, Ivan Mijakovic, Priyanka Singh
Journal of Nanobiotechnology.2025;[Epub] CrossRef
Microbiological profiles and clinical outcomes of critically ill surgical patients with lower gastrointestinal perforation in Japan: a single-center retrospective observational study
Takashi Nishikawa, Jiro Ito, Ryutaro Seo, Koichi Ariyoshi, Hiroyuki Mima
BMC Anesthesiology.2024;[Epub] CrossRef
Navigating ESKAPE Pathogens: Considerations and Caveats for Animal Infection Models Development
Haojie Yu, Yongchang Xu, Saber Imani, Zhuo Zhao, Saif Ullah, Qingjing Wang
ACS Infectious Diseases.2024; 10(7): 2336. CrossRef
Unveiling MurM inhibitors in Enterococcus faecalis V583: a promising approach to tackle antibiotic resistance
Km.Rakhi, Rittik Bhati, Monika Jain, Amit Kumar Singh, Jayaraman Muthukumaran
Journal of Biomolecular Structure and Dynamics.2024; : 1. CrossRef
Multi-omics reveals the ecological and biological functions of Enterococcus mundtii in the intestine of lepidopteran insects
Guannan Li, Meihong Wu, Yi Xiao, Yujie Tong, Sheng Li, Heying Qian, Tianfu Zhao
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics.2024; 52: 101309. CrossRef
Caenorhabditis elegansfor research on cancer hallmarks
Julián Cerón
Disease Models & Mechanisms.2023;[Epub] CrossRef
Enterococcus casseliflavus Infection: A Review of Clinical Features and Treatment
Yusuke Yoshino
Infection and Drug Resistance.2023; Volume 16: 363. CrossRef
It's all relative: analyzing microbiome compositions, its significance, pathogenesis and microbiota derived biofilms: Challenges and opportunities for disease intervention
Sahar Zaidi, Khursheed Ali, Asad U. Khan
Archives of Microbiology.2023;[Epub] CrossRef
Antimicrobial Activity of Ceragenins against Vancomycin-Susceptible and -Resistant Enterococcus spp.
Mayram Hacioglu, Fatima Nur Yilmaz, Ozlem Oyardi, Cagla Bozkurt Guzel, Nese Inan, Paul B. Savage, Sibel Dosler
Pharmaceuticals.2023; 16(12): 1643. CrossRef
Assessing Clinical Outcomes of Vancomycin Treatment in Adult Patients with Vancomycin-Susceptible Enterococcus faecium Bacteremia
Hiroshi Sasano, Kazuhiko Hanada
Antibiotics.2023; 12(11): 1577. CrossRef
The transmittable through stinging microbiota differs between honeybees and wasps: a potentially greater microbial risk of the wasp sting for humans
Ioanna Gkitsaki, Alexandros Papachristoforou, Sofia Michailidou, Nikolaos Karamvalis, Ioannis Iliadis, Dimitra Graikini, Christina Sakarikou, Evangelos Tsoukis, Anagnostis Argyriou, Efstathios Giaouris
International Microbiology.2023; 26(3): 663. CrossRef
Analysis of Virulence Genes, Drug Resistance Detection, and Pathogenicity in Enterococcus from Diverse Animal Populations
Kang Xinyun, Yanqin Wei, Xiaofei Fan, Shuangyan Luo, Xiaofeng Luo, Sijun Zhao, Guiqin Wang
SSRN Electronic Journal .2022;[Epub] CrossRef
Enterococcal symbionts of caterpillars facilitate the utilization of a suboptimal diet
Bosheng Chen, Charles J. Mason, Michelle Peiffer, Dayu Zhang, Yongqi Shao, Gary W. Felton
Journal of Insect Physiology.2022; 138: 104369. CrossRef
Analysis of virulence genes, drug resistance detection, and pathogenicity in Enterococcus from farm animals
Xinyun Kang, Yanqin Wei, Xiaofei Fan, Shuangyan Luo, Xiaofeng Luo, Sijun Zhao, Guiqin Wang
Microbial Pathogenesis.2022; 171: 105745. CrossRef
The Prevalence of Virulent and Multidrug-Resistant Enterococci in River Water and in Treated and Untreated Municipal and Hospital Wastewater
Anna Gotkowska-Płachta
International Journal of Environmental Research and Public Health.2021; 18(2): 563. CrossRef
First Report of the Local Spread of Vancomycin-Resistant Enterococci Ascribed to the Interspecies Transmission of a vanA Gene Cluster-Carrying Linear Plasmid
Yusuke Hashimoto, Izumi Kita, Masato Suzuki, Hidetada Hirakawa, Hirofumi Ohtaki, Haruyoshi Tomita, Paul D. Fey
mSphere.2020;[Epub] CrossRef
The red flour beetle Tribolium castaneum: A model for host-microbiome interactions
Aparna Agarwal, Deepa Agashe, Jeffrey P. Demuth
PLOS ONE.2020; 15(10): e0239051. CrossRef
RNA-Seq comparative analysis reveals the response of Enterococcus faecalis TV4 under fluoride exposure
Guannan Li, Min Shi, Shan Zhao, Dan Li, Yaohang Long, Chengfei Yang, Yong Zhu
Gene.2020; 726: 144197. CrossRef
Determination of vancomicin- resistant strains (VRE) with VanA and VanB enzymes among field isolates of Enterococcus spp., obtained from drinking water samples
T.A. Garkavenko, O.I. Gorbatiuk, T.G. Kozitska, V.O. Andriyashchuk, S.M. Dibkova
Bulletin "Veterinary biotechnology".2020; 36: 21. CrossRef
Galleria mellonella as an experimental model to study human oral pathogens
Rodnei Dennis Rossoni, Felipe de Camargo Ribeiro, Hanna Flávia Santana dos Santos, Jéssica Diane dos Santos, Nicássia de Sousa Oliveira, Marignês Theotonio dos Santos Dutra, Simone Aparecida Biazzi de Lapena, Juliana Campos Junqueira
Archives of Oral Biology.2019; 101: 13. CrossRef
Association between vancomycin pharmacokinetic/pharmacodynamic parameters, patient characteristics, and mortality in patients with bacteremia caused by vancomycin-susceptible Enterococcus faecium: a single-center retrospective study
Ichiro Nakakura, Kota Sakakura, Kaori Imanishi, Rumi Sako, Kunio Yamazaki
Journal of Pharmaceutical Health Care and Sciences.2019;[Epub] CrossRef
Interplay between mitochondria and diet mediates pathogen and stress resistance in Caenorhabditis elegans
Alexey V. Revtovich, Ryan Lee, Natalia V. Kirienko, Danielle A. Garsin
PLOS Genetics.2019; 15(3): e1008011. CrossRef
Pathogenicity of Enterococci
Elizabeth Fiore, Daria Van Tyne, Michael S. Gilmore, Vincent A. Fischetti, Richard P. Novick, Joseph J. Ferretti, Daniel A. Portnoy, Miriam Braunstein, Julian I. Rood
Microbiology Spectrum.2019;[Epub] CrossRef
Detection of transferable oxazolidinone resistance determinants in Enterococcus faecalis and Enterococcus faecium of swine origin in Sichuan Province, China
Zhuang-Zhuang Kang, Chang-Wei Lei, Ling-Han Kong, Yu-Long Wang, Xiao-Lan Ye, Bo-Heng Ma, Xue-Chun Wang, Cui Li, Yu Zhang, Hong-Ning Wang
Journal of Global Antimicrobial Resistance.2019; 19: 333. CrossRef
Sortase-Dependent Proteins Promote Gastrointestinal Colonization by Enterococci
Leou Ismael Banla, Adam M. Pickrum, Michael Hayward, Christopher J. Kristich, Nita H. Salzman, Manuela Raffatellu
Infection and Immunity.2019;[Epub] CrossRef
Quantitative Proteomics Analysis of Membrane Proteins in Enterococcus faecalis With Low-Level Linezolid-Resistance
Jia Yan, Yun Xia, Mi Yang, Jiaqi Zou, Yingzhu Chen, Dawei Zhang, Liang Ma
Frontiers in Microbiology.2018;[Epub] CrossRef
The activation of the oxidative stress response transcription factor SKN-1 in Caenorhabditis elegans by mitis group streptococci
Ali Naji, John Houston IV, Caroline Skalley Rog, Ali Al Hatem, Saba Rizvi, Ransome van der Hoeven, David J. Reiner
PLOS ONE.2018; 13(8): e0202233. CrossRef
Orally Administered Chitooligosaccharides Modulate Colon Microbiota in Normal and Colitis Mice
Ting Long, Zhi-Jun Yu, Jun Wang, Jia Liu, Bing-Shu He
International Journal of Pharmacology.2018; 14(2): 291. CrossRef
Implications of the expression of Enterococcus faecalis citrate fermentation genes during infection
Gabriela P. Martino, Cristian E. Perez, Christian Magni, Víctor S. Blancato, Alex V. Chaves
PLOS ONE.2018; 13(10): e0205787. CrossRef
Probiotics in human gut microbiota can degrade host glycosaminoglycans
Keigo Kawai, Reiko Kamochi, Sayoko Oiki, Kousaku Murata, Wataru Hashimoto
Scientific Reports.2018;[Epub] CrossRef
The Influence of Host Stress on the Mechanism of Infection: Lost Microbiomes, Emergent Pathobiomes, and the Role of Interkingdom Signaling
John C. Alverdy, James N. Luo
Frontiers in Microbiology.2017;[Epub] CrossRef
Transferrin and Lactoferrin – Human Iron Sources for Enterococci
PAWEŁ LISIECKI
Polish Journal of Microbiology.2017; 66(4): 419. CrossRef
Capacity of blood plasma is higher in birds breeding in radioactively contaminated areas
Magdalena Ruiz-Rodríguez, Anders P. Møller, Timothy A. Mousseau, Juan J. Soler, Roberto Ambrosini
PLOS ONE.2017; 12(6): e0179209. CrossRef
Animals devoid of pulmonary system as infection models in the study of lung bacterial pathogens
YamilÃ© LÃ³pez HernÃ¡ndez, Daniel Yero, Juan M. Pinos-RodrÃguez, Isidre Gibert
Frontiers in Microbiology.2015;[Epub] CrossRef
Rapidly Progressive Gas-containing Lumbar Spinal Epidural Abscess
Jin Hyuk Bang, Keun-Tae Cho
Korean Journal of Spine.2015; 12(3): 139. CrossRef
Enterococcus faecalis 6-Phosphogluconolactonase Is Required for Both Commensal and Pathogenic Interactions with Manduca sexta
Jonathan F. Holt, Megan R. Kiedrowski, Kristi L. Frank, Jing Du, Changhui Guan, Nichole A. Broderick, Gary M. Dunny, Jo Handelsman, A. Camilli
Infection and Immunity.2015; 83(1): 396. CrossRef
Molecular microbiology in antibacterial research
You-Hee Cho
Journal of Microbiology.2014; 52(3): 185. CrossRef

Research Support, Non-U.S. Gov't

Nucleotide-Binding Oligomerization Domain 2 (Nod2) Is Dispensable for the Innate Immune Responses of Macrophages against Yersinia enterocolitica: Yu-Jin Jeong , Chang-Hwan Kim , Eun-Jung Song , Min-Jung Kang , Jee-Cheon Kim , Sang-Muk Oh , Kyung-Bok Lee , Jong-Hwan Park; J. Microbiol. 2012;50(3):489-495. Published online June 30, 2012; DOI: https://doi.org/10.1007/s12275-012-1534-6

231 View
0 Download
8 Scopus

Abstract PDF: Nucleotide-binding oligomerization domain 2 (Nod2) is a cytosolic sensor for muramyl dipeptide, a component of bacterial peptidoglycan. In this study, we have examined whether Nod2 mediates the immune response of macrophages against Yersinia enterocolitica. Bone-marrow-derived macrophages (BMDMs) were isolated from WT and Nod2-deficient mice and were infected with various strains of Y. enterocolitica. ELISA showed that the production of IL-6 and TNF-α in BMDMs infected with Y. enterocolitica was not affected by the Nod2 deficiency. iNOS mRNA expression was induced in both WT and Nod2-deficienct BMDMs in response to Y. enterocolitica, beginning 2 h after infection. Nitric oxide (NO) production by Y. enterocolitica did not differ between WT and Nod2-deficient BMDMs. Western blot analysis revealed that Y. enterocolitica induces activation of NF-κB, p38, and ERK MAPK through a Nod2-independent pathway. Neither LDH release by Y. enterocolitica nor the phagocytic activity of the macrophages was altered by Nod2 deficiency. An in vivo experiment showed that bacterial clearance ability and production of IL-6 and KC in serum were comparable in WT and Nod2-deficient mice infected with Y. enterocolitica. These findings suggest that Nod2 may not be critical for initiating the innate immune response of macrophages against Yersinia infection.

Editorial

EDITORIAL] Gut microbiomes and their metabolites shape human and animal health: Woojun Park; J. Microbiol. 2018;56(3):151-153.; DOI: https://doi.org/10.1007/s12275-018-0577-8

454 View
0 Download
45 Crossref

Abstract PDF

The host genetic background, complex surrounding environments, and gut microbiome are very closely linked to human and animal health and disease. Although significant correlations between gut microbiota and human and animal health have been revealed, the specific roles of each gut bacterium in shaping human and animal health and disease remain unclear. However, recent omics-based studies using experimental animals and surveys of gut microbiota from unhealthy humans have provided insights into the relationships among microbial community, their metabolites, and human and animal health. This editorial introduces six review papers that provide new discoveries of disease-associated microbiomes and suggest possible microbiome-based therapeutic approaches to human disease.

Citations

Citations to this article as recorded by

Microbial Enrichments Contribute to Characterization Of Desert Tortoise Gut Microbiota
Elaina M. Blair, Noa J. Margalith, Michelle A. O’Malley
Microbial Ecology.2025;[Epub] CrossRef
Dietary Habits and Their Influence on the Microbiome and Mental Health in Adolescents
Andreea Sălcudean, Dora-Mihaela Cîmpian, Ramona-Amina Popovici, Norina Forna, Diana-Mihaela Corodan-Comiati, Andreea-Bianca Sasu, Melania-Maria Cozma, Cristina-Raluca Bodo, Eduard-Cristian Enache, Mariana Păcurar, Ramona-Elena Crăciun, Alexandru Blidaru,
Nutrients.2025; 17(9): 1496. CrossRef
Unraveling the Gut–Liver–Brain Axis: Microbiome, Inflammation, and Emerging Therapeutic Approaches
Hiral Aghara, Manali Patel, Prashsti Chadha, Kirti Parwani, Ruchi Chaturvedi, Palash Mandal, Mirella Giovarelli
Mediators of Inflammation.2025;[Epub] CrossRef
Lactobacillus reuteri attenuates methotrexate-induced liver injury via modulation of oxidative stress and inflammation through HO-1/GPX4 and NF-κB/NLRP3 pathways
Wen-Ru Li, Yi-Ke Li, Huan Ren, Zhen Guo, Chen-Lin Xiao, Jian-Quan Luo
European Journal of Pharmacology.2025; : 178185. CrossRef
Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickens
Fangren Lan, Xiqiong Wang, Qianqian Zhou, Xiaochang Li, Jiaming Jin, Wenxin Zhang, Chaoliang Wen, Guiqin Wu, Guangqi Li, Yiyuan Yan, Ning Yang, Congjiao Sun
Microbiome.2025;[Epub] CrossRef
Mental Health and the Microbiome: A Review of Psychological Impacts of Gut Microflora
Ananya Gupt, Sonal Naudiyal, Anju Rani, Sunil Kumar
Current Pharmacology Reports.2024; 10(4): 223. CrossRef
Effects of microalgae, with or without xylanase supplementation, on serum immunoglobulins, cecal short-chain fatty acids, microbial diversity, and metabolic pathways of broiler chickens
Pravin Mishra, Razib Das, Ajay Chaudhary, Birendra Mishra, Rajesh Jha
Poultry Science.2024; 103(2): 103325. CrossRef
The Influence of Microbiota on Wild Birds’ Parental Coprophagy Behavior: Current Advances and Future Research Directions
Saba Gul, Yurou Shi, Jie Hu, Sen Song
Microorganisms.2024; 12(12): 2468. CrossRef
Bacillus spp. as potential probiotics: promoting piglet growth by improving intestinal health
Xiaopeng Tang, Yan Zeng, Kangning Xiong, Jinfeng Zhong
Frontiers in Veterinary Science.2024;[Epub] CrossRef
Changes in the Human Gut Microbiome Caused by the Short-Term Impact of Lactic Acid Bacteria Consumption in Healthy People
Mariya Gryaznova, Yuliya Smirnova, Inna Burakova, Mikhail Syromyatnikov, Pavel Chizhkov, Evgeny Popov, Vasily Popov
Probiotics and Antimicrobial Proteins.2024; 16(4): 1240. CrossRef
Characterization of the Effects of a Novel Probiotic on Salmonella Colonization of a Piglet-Derived Intestinal Microbiota Using Improved Bioreactor
Amely Grandmont, Mohamed Rhouma, Marie-Pierre Létourneau-Montminy, William Thériault, Isabelle Mainville, Yves Arcand, Roland Leduc, Bruno Demers, Alexandre Thibodeau
Animals.2024; 14(5): 787. CrossRef
State of the art in research on the gut-liver and gut-brain axis in poultry
Aleksandra Beldowska, Marcin Barszcz, Aleksandra Dunislawska
Journal of Animal Science and Biotechnology.2023;[Epub] CrossRef
Phage Interactions with the Nervous System in Health and Disease
Adam Jędrusiak, Wojciech Fortuna, Joanna Majewska, Andrzej Górski, Ewa Jończyk-Matysiak
Cells.2023; 12(13): 1720. CrossRef
IgA-Biome Profiles Correlate with Clinical Parkinson’s Disease Subtypes
Eric L. Brown, Heather T. Essigmann, Kristi L. Hoffman, Ashley S. Alexander, Michael Newmark, Zhi-Dong Jiang, Jessika Suescun, Mya C. Schiess, Craig L. Hanis, Herbert L. DuPont
Journal of Parkinson’s Disease.2023; 13(4): 501. CrossRef
The impact of cefuroxime prophylaxis on human intestinal microbiota in surgical oncological patients
Irina Cezara Văcărean-Trandafir, Roxana-Maria Amărandi, Iuliu Cristian Ivanov, Ştefan Iacob, Ana-Maria Muşină, Elena-Roxana Bărgăoanu, Mihail-Gabriel Dimofte
Frontiers in Microbiomes.2023;[Epub] CrossRef
Selection methods for probiotic microorganisms with high adhesive properties
Marya S. Kanochkina, Ivan A. Fomenko, Irina M. Chernukha, Natalia G. Mashentseva
Clinical nutrition and metabolism.2023; 4(1): 19. CrossRef
Disentangling relationships between physiology, morphology, diet, and gut microbial diversity in American kestrel nestlings
Jennifer L. Houtz, Mercy Melo, Jean‐François Therrien, Allison Cornell
Journal of Avian Biology.2023;[Epub] CrossRef
Nasal Microbiota, Olfactory Health, Neurological Disorders and Aging—A Review
Subramanian Thangaleela, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Muruganantham Bharathi, Chaiyavat Chaiyasut
Microorganisms.2022; 10(7): 1405. CrossRef
Emerging frontiers of antibiotics use and their impacts on the human gut microbiome
Rekha Kumari, Yasha Yadav, Richa Misra, Utpal Das, Upasana Das Adhikari, Pushkar Malakar, Gyanendra P. Dubey
Microbiological Research.2022; 263: 127127. CrossRef
Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema
John M. Pezzuto, Asim Dave, Eun-Jung Park, Diren Beyoğlu, Jeffrey R. Idle
Antioxidants.2022; 11(12): 2372. CrossRef
Nocardioides palaemonis sp. nov. and Tessaracoccus palaemonis sp. nov., isolated from the gastrointestinal tract of lake prawn
Do-Yeon Kim, In-Chul Jeong, So-Yeon Lee, Yun-Seok Jeong, Jeong Eun Han, Euon Jung Tak, June-Young Lee, Pil Soo Kim, Dong-Wook Hyun, Jin-Woo Bae
International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
Gut Microbiome Studies in Livestock: Achievements, Challenges, and Perspectives
Giovanni Forcina, Lucía Pérez-Pardal, Júlio Carvalheira, Albano Beja-Pereira
Animals.2022; 12(23): 3375. CrossRef
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Shokufeh Ghasemian Sorboni, Hanieh Shakeri Moghaddam, Reza Jafarzadeh-Esfehani, Saman Soleimanpour
Clinical Microbiology Reviews.2022;[Epub] CrossRef
Investigation of memory-enhancing effects of Streptococcus thermophilus EG007 in mice and elucidating molecular and metagenomic characteristics using nanopore sequencing
Hyaekang Kim, Soomin Jeon, Jina Kim, Donghyeok Seol, JinChul Jo, Seoae Cho, Heebal Kim
Scientific Reports.2022;[Epub] CrossRef
Exposure to Bisphenol A Caused Hepatoxicity and Intestinal Flora Disorder in Rats
Ruijing Liu, Boping Liu, Lingmin Tian, Xinwei Jiang, Xusheng Li, Dongbao Cai, Jianxia Sun, Weibin Bai, Yulong Jin
International Journal of Molecular Sciences.2022; 23(14): 8042. CrossRef
Short-Term Tomato Consumption Alters the Pig Gut Microbiome toward a More Favorable Profile
Mallory L. Goggans, Emma A. Bilbrey, Cristian D. Quiroz-Moreno, David M. Francis, Sheila K. Jacobi, Jasna Kovac, Jessica L. Cooperstone, Simon Daniels
Microbiology Spectrum.2022;[Epub] CrossRef
A unique gut microbiota signature in pulmonary arterial hypertension: A pilot study
Arun Jose, Senu Apewokin, Walaa E. Hussein, Nicholas J. Ollberding, Jean M. Elwing, David B. Haslam
Pulmonary Circulation.2022;[Epub] CrossRef
Pathogenomics of Streptococcus ilei sp. nov., a newly identified pathogen ubiquitous in human microbiome
Dong-Wook Hyun, Jae-Yun Lee, Min-Soo Kim, Na-Ri Shin, Tae Woong Whon, Kyung Hyun Kim, Pil Soo Kim, Euon Jung Tak, Mi-Ja Jung, June Young Lee, Hyun Sik Kim, Woorim Kang, Hojun Sung, Che Ok Jeon, Jin-Woo Bae
Journal of Microbiology.2021; 59(8): 792. CrossRef
Comparative Studies on Phospholipase A2 as a Marker for Gut Microbiota- liver-brain Axis in a rodent Model of Autism
Abeer Al-Dbass, Abir Ben Bacha, Nadine M.S. Moubayed, Ramesa Shafi Bhat, Manar Al-Mutairi, Osima M. Alnakhli, Majidh Al-Mrshoud, Hanan Alfawaz, Maha Daghestani, Afaf El-Ansary
Current Proteomics.2021; 18(2): 169. CrossRef
Individual and Site-Specific Variation in a Biogeographical Profile of the Coyote Gastrointestinal Microbiota
Scott Sugden, Colleen Cassady St. Clair, Lisa Y. Stein
Microbial Ecology.2021; 81(1): 240. CrossRef
Characterization of the gut microbiome in wild rocky mountainsnails (Oreohelix strigosa)
Bridget Chalifour, Jingchun Li
Animal Microbiome.2021;[Epub] CrossRef
Description of Ornithinimicrobium ciconiae sp. nov., and Ornithinimicrobium avium sp. nov., isolated from the faeces of the endangered and near-threatened birds
So-Yeon Lee, Hojun Sung, Pil Soo Kim, Hyun Sik Kim, Jae-Yun Lee, June-Young Lee, Yun-Seok Jeong, Euon Jung Tak, Jeong Eun Han, Dong-Wook Hyun, Jin-Woo Bae
Journal of Microbiology.2021; 59(11): 978. CrossRef
Dynamic Changes in Fecal Microbial Communities of Neonatal Dairy Calves by Aging and Diarrhea
Eun-Tae Kim, Sang-Jin Lee, Tae-Yong Kim, Hyo-Gun Lee, Rahman M. Atikur, Bon-Hee Gu, Dong-Hyeon Kim, Beom-Young Park, Jun-Kyu Son, Myung-Hoo Kim
Animals.2021; 11(4): 1113. CrossRef
Impact of oral galenic formulations of Lactobacillus salivarius on probiotic survival and interactions with microbiota in human in vitro gut models
M.E. Arnal, S. Denis, O. Uriot, C. Lambert, S. Holowacz, F. Paul, S. Kuylle, B. Pereira, M. Alric, S. Blanquet-Diot
Beneficial Microbes.2021; 12(4): 381. CrossRef
Fatty acid metabolism and acyl-CoA synthetases in the liver-gut axis
Yunxia Ma, Miljana Nenkov, Yuan Chen, Adrian T Press, Elke Kaemmerer, Nikolaus Gassler
World Journal of Hepatology.2021; 13(11): 1512. CrossRef
Host phylogeny and host ecology structure the mammalian gut microbiota at different taxonomic scales
Connie A. Rojas, Santiago Ramírez-Barahona, Kay E. Holekamp, Kevin R. Theis
Animal Microbiome.2021;[Epub] CrossRef
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Kirsten Berding, Klara Vlckova, Wolfgang Marx, Harriet Schellekens, Catherine Stanton, Gerard Clarke, Felice Jacka, Timothy G Dinan, John F Cryan
Advances in Nutrition.2021; 12(4): 1239. CrossRef
MAP, Johne’s disease and the microbiome; current knowledge and future considerations
Chloe Matthews, Paul D. Cotter, Jim O’ Mahony
Animal Microbiome.2021;[Epub] CrossRef
Effects of alkaline protease on the production performance, egg quality, and cecal microbiota of hens during late laying period
Xiaochen Chen, Wenfeng Ma, Naizhi Hu, Yan Yan, Yipu Zhu, Zhanbin Wang, Guobao Jiao, Xiaoyu Chen
Animal Science Journal.2021;[Epub] CrossRef
Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein
Hui-wen Xiao, Ming Cui, Yuan Li, Jia-li Dong, Shu-qin Zhang, Chang-chun Zhu, Mian Jiang, Tong Zhu, Bin Wang, Hai-Chao Wang, Sai-jun Fan
Microbiome.2020;[Epub] CrossRef
Body site-specific microbiota reflect sex and age-class among wild spotted hyenas
Connie A Rojas, Kay E Holekamp, Andrew D Winters, Kevin R Theis
FEMS Microbiology Ecology.2020;[Epub] CrossRef
Diet Control More Intensively Disturbs Gut Microbiota Than Genetic Background in Wild Type and ob/ob Mice
Jing-Hua Wang, Na Rae Shin, Soo-Kyoung Lim, Ungjin Im, Eun-Ji Song, Young-Do Nam, Hojun Kim
Frontiers in Microbiology.2019;[Epub] CrossRef
Indoles: metabolites produced by intestinal bacteria capable of controlling liver disease manifestation
T. Hendrikx, B. Schnabl
Journal of Internal Medicine.2019; 286(1): 32. CrossRef
Beneficial effects of a selected probiotic mixture administered to high fat-fed mice before and after the development of obesity
Marianna Roselli, Alberto Finamore, Elisa Brasili, Rita Rami, Fabio Nobili, Carla Orsi, Angelo Vittorio Zambrini, Elena Mengheri
Journal of Functional Foods.2018; 45: 321. CrossRef
Dietary Nutrients, Proteomes, and Adhesion of Probiotic Lactobacilli to Mucin and Host Epithelial Cells
Hasan Ufuk Celebioglu, Birte Svensson
Microorganisms.2018; 6(3): 90. CrossRef

Protective Immune Reponses Induced by Non-infectious L-particles of Equine Herpesvirus Type-1: Implication of Cellular Immunity: Mohd Lila Mohd Azmi , Hugh John Field , Frazer Rixon , John McLauchlan; J. Microbiol. 2002;40(1):11-19.

240 View
0 Download

Abstract PDF: Mice immunized with equine herpesvirus type-1 (EHV-1) L-particles showed a significant increase (p<0.05) in serum antibody titers. Upon a booster dose four weeks later, antibody titers increased significantly. Interestingly, immunization via intravenous or intramuscular route induced significantly higher (p<0.05) antibody titers. However, mice iummunized with UV-treated L-particles, virions or immunization via intranasal route induced lower antibody titers. Upon challenge inoculation with wild-type EHV-1, our data showed there was a poor correlation between antibody titers and protection against virus replication. Therefore, the role of cell-mediated immunity towards protection was investigated. As predicted, the strongest cell-mediated immunity, as measured by delayed-hypersensitivity test, was detected in mice immunized with live virus particles. The magnitude of cell-mediated immune response correlated with the efficacy of L-particles as immunizing agent. The highest efficacy, as indicated in mice immunized via intranasal route, was highly correlated with cell-mediated immunity. A similar phenomenon was also demonstrated in mice immunized intranasally with UV-treated L-particles. However, the degree of protection was reduced when mice immunized intravenously or intramuscularly with UV-treated L-particles. In conclusion, protection conferred in these animals was highly implicated by immune cells and the least by antibodies. The route of immunization and the nature of the antigen also contributed to the efficacy of L-particles as immunizing agent. In contrast to that of herpes simplex virus type 1, our data showed EHV-1 non-infectious L-particles are highly suitable for immunization of the host against EHV-1 disease.

Histological Alterations and Immune Response Induced by Pet Toxin During Colonization with Enteroaggregative Escherichia coli (EAEC) in a Mouse Model: Teresita Sainz , Julia Perez , Ma. Cristina Fresan , Veronica Flores , Luis Jimenez , Ulises Hernandez , Ismael Herrera , Carlos Eslava; J. Microbiol. 2002;40(2):91-97.

242 View
0 Download

Abstract PDF: Enteroaggregative E. coli (EAEC) is an important aethiological causal agent of diarrhea in people of developed and undeveloped countries. Different in vitro and in vivo models have been proposed to study the pathogenic and immune mechanisms of EAEC infection. The aim of this study was to analyze whether BALB/c mice could be used as an animal model to study EAEC pathogenesis. Six-week-old BALB/c mice were inoculated with EAEC strain 042 (O44:H18) nalidixic acid resistant, and re-inoculated ten days after. Mice feces were monitored for the presence of the EAEC strain over a period of 20 days. Bacteria were enumerated on MacConkey agar containing 100 ug of nalidixic acid per ml. Results showed that 35% of the animals were colonized for 3 days, 15% for 5 and 10% for more than 7 days. After re-inoculation only 16% of the animals remained colonized for more than 3 days. During the necropsy, the intestinal fluid of some of the infected animals presented mucus and blood. Six of these fluids showed the presence of IgA antibodies against Pet toxin and IgG antibodies raised against the toxin were also detected in the animal serum. Histopathologic evidence confirms the stimulation of mucus hypersecretion, an increased amount of goblet cells and the presence of bacterial aggregates in the apical surfaces of intestinal epithelial cells. Edema was present in the submucosa. These results suggest that BALB/c mice could be used as an animal model for the in vivo study of EAEC infection.

Protection of Specific-pathogen-free (Spf) Foals from Severe Equine Herpesvirus Type-1 (Ehv-1) Infection Following Immunization with Non-infectious L-particles: Mohd Lila Mohd-Azmi , John Gibson , Frazer Rixon , John McLauchlan , Hugh John Field; J. Microbiol. 2002;40(3):183-192.

227 View
0 Download

Abstract PDF: Cells infected with equine herpesvirus type-1 (EHV-1) produced both infectious and non-infectious virus-related particles. Compared to the whole virion, non-infectious particles termed L-particles were determined to lack 150 kDa protein, commonly known as nucleocapsid protein. The potential of L-particles to induce immune responses was studied in mice and foals. Intranasal immunization with L-particles or whole virions induced poor IgG antibody responses in mice. Interestingly, despite the poor antibody response, the conferred immunity protected the host from challenge infections. This was indicated by a significant reduction in virus titers in line with recovery towards normal body weight. Subsequently, the test on the usefulness of L-particles as immunizing agents was extended to foals. Immunization of specific-pathogen-free (SPF) foals resulted in similar results. As determined by a complement-fixing-antibody test (CFT), foals seroconverted when they were immunized either with inactivated L-particles or whole virions via intramuscular (i.m.) injections. The presence of the antibody correlated with the degree of protection. Beyond day 1 post challenge infection (p.i.), there was no virus shedding in the nasal mucus of foals immunized with whole EHV-1 virions. Virus shedding was observed in foals immunized with L-particles but limited to days 6 to 8 p.i. only. In contrast, extended virus shedding was observed in non-immunized foals and it was well beyond day 14 p.i. Viremia was not detected for more than four days except in non-immunized foals. Immunization in mice via intranasal (i.n.) conferred good protection. However, compared to the i.n. route, a greater degree of protection was obtained in foals following immunization via i.m. route. Despite variation in the degree of protection due to different routes of immunization in the two animal species, our results have established significant evidence that immunization with L-particles confers protection in the natural host. It is suggested that non-infectious L-particles should be used as immunizing agents for vaccination of horses against EHV-1 infection.

First
Prev
Page of 1
Next
Last

TOP