Skip Navigation
Skip to contents

Journal of Microbiology : Journal of Microbiology

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
6 "fitness"
Filter
Filter
Article category
Keywords
Publication year
Reviews
Bacterial Crosstalk via Antimicrobial Peptides on the Human Skin: Therapeutics from a Sustainable Perspective
Seon Mi Lee , Hye Lim Keum , Woo Jun Sul
J. Microbiol. 2023;61(1):1-11.   Published online January 31, 2023
DOI: https://doi.org/10.1007/s12275-022-00002-8
  • 83 View
  • 0 Download
  • 3 Web of Science
  • 5 Crossref
AbstractAbstract
The skin’s epidermis is an essential barrier as the first guard against invading pathogens, and physical protector from external injury. The skin microbiome, which consists of numerous bacteria, fungi, viruses, and archaea on the epidermis, play a key role in skin homeostasis. Antibiotics are a fast-acting and effective treatment method, however, antibiotic use is a nuisance that can disrupt skin homeostasis by eradicating beneficial bacteria along with the intended pathogens and cause antibioticresistant bacteria spread. Increased numbers of antimicrobial peptides (AMPs) derived from humans and bacteria have been reported, and their roles have been well defined. Recently, modulation of the skin microbiome with AMPs rather than artificially synthesized antibiotics has attracted the attention of researchers as many antibiotic-resistant strains make treatment mediation difficult in the context of ecological problems. Herein, we discuss the overall insights into the skin microbiome, including its regulation by different AMPs, as well as their composition and role in health and disease.

Citations

Citations to this article as recorded by  
  • The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis
    Junchao Wu, Lisha Li, Tingrui Zhang, Jiaye Lu, Zongguang Tai, Quangang Zhu, Zhongjian Chen
    Journal of Advanced Research.2025; 68: 359.     CrossRef
  • Marine algal polysaccharides: Multifunctional bioactive ingredients for cosmetic formulations
    Si-Yuan Lu, Tao Zhou, Iqra Shabbir, Jaehwan Choi, Young Heui Kim, Myeongsam Park, Jude Juventus Aweya, Karsoon Tan, Saiyi Zhong, Kit-Leong Cheong
    Carbohydrate Polymers.2025; 353: 123276.     CrossRef
  • A review on pathogenicity of Aeromonas hydrophila and their mitigation through medicinal herbs in aquaculture
    Anurag Semwal, Avdhesh Kumar, Neelesh Kumar
    Heliyon.2023; 9(3): e14088.     CrossRef
  • Fırtına Deresindeki Gökkuşağı Alabalık Çiftliklerinde İzole Edilen Aeromonas spp. İzolatlarının Antimikrobiyel Hassasiyetin Belirlenmesi
    Fikri BALTA
    Journal of Anatolian Environmental and Animal Sciences.2020; 5(3): 397.     CrossRef
  • Monitoring microbial community structure and succession of an A/O SBR during start-up period using PCR-DGGE
    Xiuheng WANG, Kun ZHANG, Nanqi REN, Nan LI, Lijiao REN
    Journal of Environmental Sciences.2009; 21(2): 223.     CrossRef
Dissection of plant microbiota and plant-microbiome interactions
Kihyuck Choi , Raees Khan , Seon-Woo Lee
J. Microbiol. 2021;59(3):281-291.   Published online February 23, 2021
DOI: https://doi.org/10.1007/s12275-021-0619-5
  • 53 View
  • 0 Download
  • 42 Web of Science
  • 39 Crossref
AbstractAbstract
Plants rooted in soil have intimate associations with a diverse array of soil microorganisms. While the microbial diversity of soil is enormous, the predominant bacterial phyla associated with plants include Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, and Verrucomicrobia. Plants supply nutrient niches for microbes, and microbes support plant functions such as plant growth, development, and stress tolerance. The interdependent interaction between the host plant and its microbes sculpts the plant microbiota. Plant and microbiome interactions are a good model system for understanding the traits in eukaryotic organisms from a holobiont perspective. The holobiont concept of plants, as a consequence of co-evolution of plant host and microbiota, treats plants as a discrete ecological unit assembled with their microbiota. Dissection of plant-microbiome interactions is highly complicated; however, some reductionist approaches are useful, such as the synthetic community method in a gnotobiotic system. Deciphering the interactions between plant and microbiome by this reductionist approach could lead to better elucidation of the functions of microbiota in plants. In addition, analysis of microbial communities’ interactions would further enhance our understanding of coordinated plant microbiota functions. Ultimately, better understanding of plantmicrobiome interactions could be translated to improvements in plant productivity.

Citations

Citations to this article as recorded by  
  • The combined effects of tetracycline and glyphosate on growth and rhizosphere bacteria community in hulless barley over the whole growth period
    Wenxiu Xue, Shuhao Zhang, Fazila Younas, Ruwen Ma, Xingxu Yu, Jie Li, Xiaocui Wu, Wenhan Liu, Huitian Duan, Kang Wang, Xiaowei Cui, Xiufeng Cao, Zhaojie Cui
    Journal of Hazardous Materials.2025; 484: 136706.     CrossRef
  • Modeling Growth Kinetics of Escherichia coli and Background Microflora in Hydroponically Grown Lettuce
    Xiaoyan You, Dongqun Yang, Yang Qu, Mingming Guo, Yangping Zhang, Xiaoyan Zhao, Yujuan Suo
    Foods.2024; 13(9): 1359.     CrossRef
  • Influence and Role of Fungi, Bacteria, and Mixed Microbial Populations on Phosphorus Acquisition in Plants
    Yu Luo, Lige Ma, Qirui Feng, Huan Luo, Chen Chen, Shuqi Wang, Yue Yuan, Can Liu, Xulv Cao, Nannan Li
    Agriculture.2024; 14(3): 358.     CrossRef
  • Endophytic Pseudomonas fluorescens promotes changes in the phenotype and secondary metabolite profile of Houttuynia cordata Thunb.
    Kaifeng Wang, Zhannan Yang, Shiqiong Luo, Wenxuan Quan
    Scientific Reports.2024;[Epub]     CrossRef
  • Rhizosphere Microorganisms in Subsurface Flow Garden Constructed Wetland and their Influence on Nitrogen Removal Efficiency
    Baishi Wang, Liping Wu, Ruoqiao Wang, Jiangbo Huo, Zhou Yi, Zexin Wang, Hongzhou Zhang
    Water, Air, & Soil Pollution.2024;[Epub]     CrossRef
  • Developing stable, simplified, functional consortia from Brachypodium rhizosphere for microbial application in sustainable agriculture
    Mingfei Chen, Shwetha M. Acharya, Mon Oo Yee, Kristine Grace M. Cabugao, Romy Chakraborty
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • Using biochar for environmental recovery and boosting the yield of valuable non-food crops: The case of hemp in a soil contaminated by potentially toxic elements (PTEs)
    Matteo Garau, Mauro Lo Cascio, Sotirios Vasileiadis, Tom Sizmur, Maria Nieddu, Maria Vittoria Pinna, Costantino Sirca, Donatella Spano, Pier Paolo Roggero, Giovanni Garau, Paola Castaldi
    Heliyon.2024; 10(6): e28050.     CrossRef
  • Plant-Microbe Interactions: PGPM as Microbial Inoculants/Biofertilizers for Sustaining Crop Productivity and Soil Fertility
    Bibek Laishram, Okram Ricky Devi, Rinjumoni Dutta, T. Senthilkumar, Girish Goyal, Dinesh Kumar Paliwal, Narinder Panotra, Akhtar Rasool
    Current Research in Microbial Sciences.2024; : 100333.     CrossRef
  • Differences in autotoxic substances and microbial community in the root space of Panax notoginseng coinducing the occurrence of root rot
    Jinmiao Chen, Zhidan Liu, Yuyan Liu, Xiuling Ji, Xiaoran Li, Yunlin Wei, Futing Zi, Yong Tan, Arpita Bose
    Applied and Environmental Microbiology.2024;[Epub]     CrossRef
  • Root-associated microbial diversity and metabolomics in maize resistance to stalk rot
    Liming Wang, Jiao Jia, Qianfu Su, Hongzhe Cao, Shiqi Jia, Helong Si, Zhiyan Cao, Shujie Ma, Jihong Xing, Kang Zhang, Jingao Dong
    Frontiers in Microbiology.2024;[Epub]     CrossRef
  • Interplant communication increases aphid resistance and alters rhizospheric microbes in neighboring plants of aphid‐infested cucumbers
    Xingchen Liu, Changxia Du, Yinqing Tan, Cong Yue, Huaifu Fan
    Pest Management Science.2024; 80(10): 5005.     CrossRef
  • Phage-Dependent Alteration of Rhizosphere Microbiota in Tomato Plants
    Seung Yeup Lee, Roniya Thapa Magar, Kihyuck Choi, Hyo Jeong Kim, Insoo Park, Seon-Woo Lee
    Phytobiomes Journal.2024; 8(2): 223.     CrossRef
  • MAPK Cascades in Plant Microbiota Structure and Functioning
    Thijs Van Gerrewey, Hoo Sun Chung
    Journal of Microbiology.2024; 62(3): 231.     CrossRef
  • The structure and diversity of bacteria and fungi in the roots and rhizosphere soil of three different species of Geodorum
    Jianxiu Liu, Danjuan Zeng, Yang Huang, Lisha Zhong, Jialin Liao, Yuxing Shi, Haidu Jiang, Yajin Luo, Yu Liang, Shengfeng Chai
    BMC Genomics.2024;[Epub]     CrossRef
  • Irradiance level and elevation shape the soil microbiome communities of Coffea arabica L.
    Inocência da Piedade E. Tapaça, Chinedu C. Obieze, Gilberto V. de Melo Pereira, David Fangueiro, João Coutinho, Irene Fraga, Fábio L. Partelli, José C. Ramalho, Isabel Marques, Ana I. Ribeiro-Barros
    Environmental Microbiome.2024;[Epub]     CrossRef
  • Deciphering Molecular Mechanisms and Diversity of Plant Holobiont Bacteria: Microhabitats, Community Ecology, and Nutrient Acquisition
    Tomasz Grzyb, Justyna Szulc
    International Journal of Molecular Sciences.2024; 25(24): 13601.     CrossRef
  • Correlation of microbiomes in “plant-insect-soil” ecosystem
    Guomeng Li, Peng Liu, Jihan Zhao, Liangyinan Su, Mengyu Zhao, Zhengjie Jiang, Yang Zhao, Xiping Yang
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Distinctive Structure and Assembly of Phyllosphere Microbial Communities between Wild and Cultivated Rice
    Yue Yin, Yi-Fei Wang, Hui-Ling Cui, Rui Zhou, Lv Li, Gui-Lan Duan, Yong-Guan Zhu, Kristen M. DeAngelis
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Ecological Processes of Bacterial and Fungal Communities Associated with Typha orientalis Roots in Wetlands Were Distinct during Plant Development
    Lixiao Wang, Jinxian Liu, Meiting Zhang, Tiehang Wu, Baofeng Chai, Alison Sinclair
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • Existence of antibiotic pollutant in agricultural soil: Exploring the correlation between microbiome and pea yield
    Wangjing Zhai, Wenqi Jiang, Qiqi Guo, Zhixuan Wang, Donghui Liu, Zhiqiang Zhou, Peng Wang
    Science of The Total Environment.2023; 871: 162152.     CrossRef
  • Structural characteristics and diversity of the rhizosphere bacterial communities of wild Fritillaria przewalskii Maxim. in the northeastern Tibetan Plateau
    Zhijia Cui, Ran Li, Fan Li, Ling Jin, Haixu Wu, Chunya Cheng, Yi Ma, Zhenheng Wang, Yuanyuan Wang
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Integrated metagenomics and metabolomics analysis reveals changes in the microbiome and metabolites in the rhizosphere soil of Fritillaria unibracteata
    Chengcheng Liu, Jingsheng Yu, Jizhe Ying, Kai Zhang, Zhigang Hu, Zhixiang Liu, Shilin Chen
    Frontiers in Plant Science.2023;[Epub]     CrossRef
  • Transfer of antibiotic resistance genes from soil to wheat: Role of host bacteria, impact on seed-derived bacteria, and affecting factors
    Yanping Shen, Yibo Liu, Yutong Du, Xu Wang, Jiunian Guan, Xiaohui Jia, Fukai Xu, Ziwei Song, Hongjie Gao, Baiyu Zhang, Ping Guo
    Science of The Total Environment.2023; 905: 167279.     CrossRef
  • Effects of different fertilization conditions and different geographical locations on the diversity and composition of the rhizosphere microbiota of Qingke (Hordeum vulgare L.) plants in different growth stages
    Lei Wang, Handong Wang, Meijin Liu, Jinqing Xu, Haiyan Bian, Tongrui Chen, En You, Chao Deng, Youhai Wei, Tianyu Yang, Yuhu Shen
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Editorial: Women in plant pathogen interactions: 2022
    Špela Baebler, Anna Coll, Giulia Malacarne
    Frontiers in Plant Science.2023;[Epub]     CrossRef
  • The Co-Association of Enterobacteriaceae and Pseudomonas with Specific Resistant Cucumber against Fusarium Wilt Disease
    Yu-Lu Zhang, Xiao-Jing Guo, Xin Huang, Rong-Jun Guo, Xiao-Hong Lu, Shi-Dong Li, Hao Zhang
    Biology.2023; 12(2): 143.     CrossRef
  • Niche-dependent microbial assembly in salt-tolerant tall fescue and its contribution to plant biomass
    Tianqi Zhu, Liang Zhang, Zizheng Yan, Bowen Liu, Youyue Li, Xiangkai You, Mo-Xian Chen, Tie-Yuan Liu, Yuefei Xu, Jianhua Zhang
    Industrial Crops and Products.2023; 206: 117736.     CrossRef
  • Effects of time-space conversion on microflora structure, secondary metabolites composition and antioxidant capacity of Codonopsis pilosula root
    Lili Fan, Jiangqin Wang, Feifan Leng, Shaowei Li, Xiang Ma, Xiaoli Wang, Yonggang Wang
    Plant Physiology and Biochemistry.2023; 198: 107659.     CrossRef
  • The Root Microbiome: Techniques for Exploration and Agricultural Applications
    Ashling Cannon
    BioTechniques.2023; 75(1): 1.     CrossRef
  • Multi-omics approaches for deciphering the microbial modulation of plants' genetic potentials: What's known and what's next?
    Febri Doni, Mia Miranti, Muhamad Shakirin Mispan, Zulqarnain Mohamed, Norman Uphoff
    Rhizosphere.2022; 24: 100613.     CrossRef
  • Effects of Combined Abiotic Stresses Related to Climate Change on Root Growth in Crops
    Maria Sánchez-Bermúdez, Juan C. del Pozo, Mónica Pernas
    Frontiers in Plant Science.2022;[Epub]     CrossRef
  • Multi-genome metabolic modeling predicts functional inter-dependencies in the Arabidopsis root microbiome
    Victor Mataigne, Nathan Vannier, Philippe Vandenkoornhuyse, Stéphane Hacquard
    Microbiome.2022;[Epub]     CrossRef
  • Can moderate heavy metal soil contaminations due to cement production influence the surrounding soil bacterial communities?
    Thiago Augusto da Costa Silva, Marcos de Paula, Washington Santos Silva, Gustavo Augusto Lacorte
    Ecotoxicology.2022; 31(1): 134.     CrossRef
  • Mechanisms of plant cell wall surveillance in response to pathogens, cell wall-derived ligands and the effect of expansins to infection resistance or susceptibility
    Delia A. Narváez-Barragán, Omar E. Tovar-Herrera, Arturo Guevara-García, Mario Serrano, Claudia Martinez-Anaya
    Frontiers in Plant Science.2022;[Epub]     CrossRef
  • Fecal Microbiota Transplants for Inflammatory Bowel Disease Treatment: Synthetic- and Engineered Communities-Based Microbiota Transplants Are the Future
    Raees Khan, Nazish Roy, Hussain Ali, Muhammad Naeem, Eiji Sakai
    Gastroenterology Research and Practice.2022; 2022: 1.     CrossRef
  • The root microbiome: Community assembly and its contributions to plant fitness
    Bo Bai, Weidong Liu, Xingyu Qiu, Jie Zhang, Jingying Zhang, Yang Bai
    Journal of Integrative Plant Biology.2022; 64(2): 230.     CrossRef
  • The Role of Synthetic Microbial Communities (SynCom) in Sustainable Agriculture
    Ambihai Shayanthan, Patricia Ann C. Ordoñez, Ivan John Oresnik
    Frontiers in Agronomy.2022;[Epub]     CrossRef
  • Microbiome engineering and plant biostimulants for sustainable crop improvement and mitigation of biotic and abiotic stresses
    Su-Ee Lau, Wee Fei Aaron Teo, Ee Yang Teoh, Boon Chin Tan
    Discover Food.2022;[Epub]     CrossRef
  • Omics-based microbiome analysis in microbial ecology: from sequences to information
    Jang-Cheon Cho
    Journal of Microbiology.2021; 59(3): 229.     CrossRef
Journal Articles
GABA-producing Lactobacillus plantarum inhibits metastatic properties and induces apoptosis of 5-FU-resistant colorectal cancer cells via GABAB receptor signaling
JaeJin An , Heon Seok , Eun-Mi Ha
J. Microbiol. 2021;59(2):202-216.   Published online February 1, 2021
DOI: https://doi.org/10.1007/s12275-021-0562-5
  • 57 View
  • 0 Download
  • 34 Web of Science
  • 29 Crossref
AbstractAbstract
5-Fluorouracil (5-FU) is an essential drug in systemic chemotherapy treatments for colorectal cancer (CRC). Despite the development of several treatment strategies over the past decades, the patient benefits of 5-FU-based therapies have been compromised by the development of chemoresistance. Differences in treatment responses among CRC patients may be due to genetic and epigenetic factors unique to individuals. Therefore, important factors for realizing personalized medicine are to accurately understand the causes and mechanisms of drug resistance to 5-FU-based therapies and to identify and validate prognostic biomarkers. Gut microbes that interact directly with the host contribute to human health and cancer control. Lactobacillus plantarum, in particular, has the potential to be a therapeutic agent by producing bioactive compounds that may benefit the host. Here, we investigated the gamma-aminobutyric acid (GABA) and GABAB receptor (GABABR)-dependent signaling pathway as a treatment option for 5-FU-resistant HT-29 cells. GABA-producing L. plantarum activates anti-proliferative, anti-migration, and anti-invasion effects against 5-FU-resistant HT-29 cells. The inhibitory effects of GABA-producing L. plantarum are mediated via GABABR. Activated GABABR induces apoptosis through the inhibition of cAMP-dependent signaling pathways and cellular inhibitor of apoptosis protein 2 (cIAP2) expression. Thus, the GABAergic system has potential in 5- FU-resistant HT-29 cells as a predictive biomarker. In addition, GABA-producing L. plantarum is promising as an adjuvant treatment for 5-FU-resistant CRC, and its intervention in neurobiological signaling imply new possibilities for chemoprevention and the treatment of colon cancer-related diseases.

Citations

Citations to this article as recorded by  
  • Transcriptomic analysis and experiments revealed that remimazolam promotes proliferation and G1/S transition in HCT8 cells
    Runjia Wang, Shuai Li, Han Hu, Qi Hou, Huaqing Chu, Yu Hou, Cheng Ni, Yuliang Ran, Hui Zheng
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Enhanced antibacterial properties of enteric glial cells attenuate intestinal inflammation through the GABABR-mediated autophagy pathway
    Ziteng Deng, Jing Lan, Jiaqi Wang, Lu Wang, Zhihui Hao, Yunfei Ma
    One Health Advances.2024;[Epub]     CrossRef
  • Beneficial microbiome and diet interplay in early-onset colorectal cancer
    Zhengyuan Zhou, Linda Kleis, Ana Depetris-Chauvin, Stefanie Jaskulski, Victoria Damerell, Karin B Michels, Biljana Gigic, Ute Nöthlings, Gianni Panagiotou
    EMBO Molecular Medicine.2024;[Epub]     CrossRef
  • The Impact of the Gut Microbiome, Environment, and Diet in Early-Onset Colorectal Cancer Development
    Rui Dai, Bridget N. Kelly, Amarachi Ike, David Berger, Andrew Chan, David A. Drew, David Ljungman, David Mutiibwa, Rocco Ricciardi, Gerald Tumusiime, James C. Cusack
    Cancers.2024; 16(3): 676.     CrossRef
  • Epiberberine induced p53/p21-dependent G2/M cell cycle arrest and cell apoptosis in gastric cancer cells by activating γ-aminobutyric acid receptor- β3
    Mengmeng Li, Jiaye Yang, Juan Li, Yuan Zhou, Xiaoduo Li, Zhengcai Ma, Xuegang Li, Hang Ma, Xiaoli Ye
    Phytomedicine.2024; 123: 155198.     CrossRef
  • Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment
    Yifan Zhou, Yao Qin, Jingjing Ma, Zhiyuan Li, Weiwei Heng, Lei Zhang, Hong Liu, Ruowei Li, Miaomiao Zhang, Qiao Peng, Pei Ye, Ning Duan, Ting Liu, Wenmei Wang, Xiang Wang
    Experimental Hematology & Oncology.2024;[Epub]     CrossRef
  • Sodium Butyrate Inhibits the Malignant Proliferation of Colon Cancer Cells via the miR-183/DNAJB4 Axis
    Dingguo Pan, Jingchao Hao, Tao Wu, Tao Shen, Kun Yu, Qiang Li, Ruixi Hu, Zhaoyu Yang, Yunfeng Li
    Biochemical Genetics.2024; 62(5): 4174.     CrossRef
  • Intervention in gut microbiota increases intestinal γ-aminobutyric acid and alleviates anxiety behavior: a possible mechanism via the action on intestinal epithelial cells
    Mion Ikegami, Hikari Narabayashi, Kazuaki Nakata, Miyu Yamashita, Yutaka Sugi, Yushiro Fuji, Hiroshi Matsufuji, Gaku Harata, Kazutoyo Yoda, Kenji Miyazawa, Yusuke Nakanishi, Kyoko Takahashi
    Frontiers in Cellular and Infection Microbiology.2024;[Epub]     CrossRef
  • Targeting the gut and tumor microbiome in cancer treatment resistance
    Sona Ciernikova, Aneta Sevcikova, Michal Mego
    American Journal of Physiology-Cell Physiology.2024; 327(6): C1433.     CrossRef
  • GABAergic signaling as a potential therapeutic target in cancers
    Yihui Yang, Liwen Ren, Wan Li, Yizhi Zhang, Sen Zhang, Binbin Ge, Hong Yang, Guanhua Du, Bo Tang, Hongquan Wang, Jinhua Wang
    Biomedicine & Pharmacotherapy.2023; 161: 114410.     CrossRef
  • Nutritional value and health benefits of cashew apple
    Yaw Gyau Akyereko, Georgina Benewaa Yeboah, Faustina Dufie Wireko‐Manu, Francis Alemawor, F. C. Mills‐Robertson, William Odoom
    JSFA reports.2023; 3(3): 110.     CrossRef
  • Gut microbiota in colorectal cancer development and therapy
    Chi Chun Wong, Jun Yu
    Nature Reviews Clinical Oncology.2023; 20(7): 429.     CrossRef
  • Biosynthesis of Gamma-Aminobutyric Acid (GABA) by Lactiplantibacillus plantarum in Fermented Food Production
    Massimo Iorizzo, Gianluca Paventi, Catello Di Martino
    Current Issues in Molecular Biology.2023; 46(1): 200.     CrossRef
  • Lactobacillus plantarum Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses
    Sihyun Jeong, Yuju Kim, Soyeong Park, Doyeon Lee, Juho Lee, Shwe Phyu Hlaing, Jin-Wook Yoo, Sang Hoon Rhee, Eunok Im
    Molecules.2023; 28(4): 1890.     CrossRef
  • Various Effects of the GABAergic System on Cancer: The Conditions and Specificities of its use in the Treatment of Some Cancers
    Hossein Tahmasebi Dehkordi, Sorayya Ghasemi, Masoumeh Eliyasi Dashtaki
    Current Topics in Medicinal Chemistry.2023; 23(20): 1928.     CrossRef
  • The orchestra of human bacteriome by hormones
    Arif Luqman
    Microbial Pathogenesis.2023; 180: 106125.     CrossRef
  • Gamma‐aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABAA and GABAB receptors
    Veronika Kovaříková, Alexandra Špirková, Zuzana Šefčíková, Jozef Pisko, Laura Kalatová, Juraj Koppel, Dušan Fabian, Štefan Čikoš
    Reproductive Medicine and Biology.2023;[Epub]     CrossRef
  • Lactobacillus plantarum-derived metabolites sensitize the tumor-suppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells
    Hye-Ju Kim, JaeJin An, Eun-Mi Ha
    Journal of Microbiology.2022; 60(1): 100.     CrossRef
  • Engineered Bacteria-Based Living Materials for Biotherapeutic Applications
    Rabia Omer, Muhammad Zubair Mohsin, Ali Mohsin, Bilal Sajid Mushtaq, Xumeng Huang, Meijin Guo, Yingping Zhuang, Jiaofang Huang
    Frontiers in Bioengineering and Biotechnology.2022;[Epub]     CrossRef
  • Extracellular vesicles derived from Lactobacillus plantarum restore chemosensitivity through the PDK2-mediated glucose metabolic pathway in 5-FU-resistant colorectal cancer cells
    JaeJin An, Eun-Mi Ha
    Journal of Microbiology.2022; 60(7): 735.     CrossRef
  • Role of lactobacillus strains in the management of colorectal cancer: An overview of recent advances
    Elnaz Ghorbani, Amir Avan, Mikhail Ryzhikov, Gordon Ferns, Majid Khazaei, Saman Soleimanpour
    Nutrition.2022; 103-104: 111828.     CrossRef
  • Gut Microbiota Eubacterium callanderi Exerts Anti-Colorectal Cancer Activity
    Seoung Woo Ryu, Ji-Sun Kim, Byeong Seob Oh, Won Jung Choi, Seung Yeob Yu, Jeong Eun Bak, Seung-Hwan Park, Se Won Kang, Jiyoung Lee, Won Yong Jung, Jung-Sook Lee, Ju Huck Lee, Zhenjiang Zech Xu
    Microbiology Spectrum.2022;[Epub]     CrossRef
  • The intestinal microbiota in colorectal cancer metastasis – Passive observer or key player?
    Meera Patel, Milly McAllister, Raghavendar Nagaraju, Sara Samir Foad Al Badran, Joanne Edwards, Andrew J. McBain, Jorge Barriuso, Omer Aziz
    Critical Reviews in Oncology/Hematology.2022; 180: 103856.     CrossRef
  • A comprehensive analysis of the microbiota composition and host driver gene mutations in colorectal cancer
    Danping Yuan, Yong Tao, Haoyi Wang, Jiawei Wang, Yuepeng Cao, Wen Cao, Shou Pan, Zhaonan Yu
    Investigational New Drugs.2022; 40(5): 884.     CrossRef
  • Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment
    Francesca Battaglin, Priya Jayachandran, Carly Strelez, Annika Lenz, Sandra Algaze, Shivani Soni, Jae Ho Lo, Yan Yang, Joshua Millstein, Wu Zhang, Evanthia T. Roussos Torres, Jean C. Shih, Shannon M. Mumenthaler, Josh Neman, Heinz-Josef Lenz
    Oncogene.2022; 41(43): 4769.     CrossRef
  • Probiotics and live biotherapeutic products aiming at cancer mitigation and patient recover
    Zelinda Schemczssen-Graeff, Marcos Pileggi
    Frontiers in Genetics.2022;[Epub]     CrossRef
  • Gut microbiota: Linking nutrition and perinatal depression
    Jia Song, Bi Zhou, Juntao Kan, Guangya Liu, Sheng Zhang, Liang Si, Xianping Zhang, Xue Yang, Junhua Ma, Junrui Cheng, Xiaobo Liu, Yongde Yang
    Frontiers in Cellular and Infection Microbiology.2022;[Epub]     CrossRef
  • Exosome-Mediated Activation of Neuronal Cells Triggered by γ-Aminobutyric Acid (GABA)
    Ryo Inotsuka, Miyako Udono, Atsushi Yamatsu, Mujo Kim, Yoshinori Katakura
    Nutrients.2021; 13(8): 2544.     CrossRef
  • Restoring HOXD10 Exhibits Therapeutic Potential for Ameliorating Malignant Progression and 5-Fluorouracil Resistance in Colorectal Cancer
    Weijie Pan, Kaijing Wang, Jiayong Li, Hanhua Li, Yuchan Cai, Min Zhang, Aili Wang, Yazhou Wu, Wei Gao, Wenhao Weng
    Frontiers in Oncology.2021;[Epub]     CrossRef
Soft sweep development of resistance in Escherichia coli under fluoroquinolone stress
Xianxing Xie , Ruichen Lv , Chao Yang , Yajun Song , Yanfeng Yan , Yujun Cui , Ruifu Yang
J. Microbiol. 2019;57(12):1056-1064.   Published online September 25, 2019
DOI: https://doi.org/10.1007/s12275-019-9177-5
  • 61 View
  • 0 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract
We employed a stepwise selection model for investigating the dynamics of antibiotic-resistant variants in Escherichia coli K-12 treated with increasing concentrations of ciprofloxacin (CIP). Firstly, we used Sanger sequencing to screen the variations in the fluoquinolone target genes, then, employed Illumina NGS sequencing for amplicons targeted regions with variations. The results demonstrated that variations G81C in gyrA and K276N and K277L in parC are standing resistance variations (SRVs), while S83A and S83L in gyrA and G78C in parC were emerging resistance variations (ERVs). The variants containing SRVs and/or ERVs were selected successively based on their sensitivities to CIP. Variant strain 1, containing substitution G81C in gyrA, was immediately selected following ciprofloxacin exposure, with obvious increases in the parC SRV, and parC and gyrA ERV allele frequencies. Variant strain 2, containing the SRVs, then dominated the population following a 20× increase in ciprofloxacin concentration, with other associated allele frequencies also elevated. Variant strains 3 and 4, containing ERVs in gyrA and parC, respectively, were then selected at 40× and 160× antibiotic concentrations. Two variants, strains 5 and 6, generated in the selection procedure, were lost because of higher fitness costs or a lower level of resistance compared with variants 3 and 4. For the second induction, all variations/indels were already present as SRVs and selected out step by step at different passages. Whatever the first induction or second induction, our results confirmed the soft selective sweep hypothesis and provided critical information for guiding clinical treatment of pathogens containing SRVs.

Citations

Citations to this article as recorded by  
  • Could traces of fluoroquinolones in food induce ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae ? An in vivo study in Galleria mellonel
    Zina Gestels, Yuliia Baranchyk, Dorien Van den Bossche, Jolein Laumen, Said Abdellati, Basil Britto Xavier, Sheeba Santhini Manoharan-Basil, Chris Kenyon, Sadjia Bekal, Mustafa Sadek
    Microbiology Spectrum.2024;[Epub]     CrossRef
Review
REVIEW] The development of fluconazole resistance in Candida albicans – an example of microevolution of a fungal pathogen
Joachim Morschhäuser
J. Microbiol. 2016;54(3):192-201.   Published online February 27, 2016
DOI: https://doi.org/10.1007/s12275-016-5628-4
  • 59 View
  • 0 Download
  • 81 Crossref
AbstractAbstract
The yeast Candida albicans is a member of the microbiota in the gastrointestinal and urogenital tracts of most healthy persons, but it can also cause symptomatic infections, especially in immunocompromised patients. During the life-long association with its human host, C. albicans generates genetically altered variants that are better adapted to changes in their environment. A prime example of this microevolution is the development of resistance to the commonly used drug fluconazole, which inhibits ergosterol biosynthesis, during antimycotic therapy. Fluconazole resistance can be caused by mutations in the drug target, by changes in the sterol biosynthesis pathway, and by gain-of-function mutations in transcription factors that result in the constitutive upregulation of ergosterol biosynthesis genes and multidrug efflux pumps. Fluconazole also induces genomic rearrangements that result in gene amplification and loss of heterozygosity for resistance mutations, which further increases drug resistance. These genome alterations may affect extended chromosomal regions and have additional phenotypic consequences. A striking case is the loss of heterozygosity for the mating type locus MTL in many fluconazole-resistant clinical isolates, which allows the cells to switch to the mating-competent opaque phenotype. This, in turn, raises the possibility that sexual recombination between different variants of an originally clonal, drug-susceptible population may contribute to the generation of highly fluconazole-resistant strains with multiple resistance mechanisms. The gain-of-function mutations in transcription factors, which result in deregulated gene expression, also cause reduced fitness. In spite of this, many clinical isolates that contain such mutations do not exhibit fitness defects, indicating that they have overcome the costs of drug resistance with further evolution by still unknown mechanisms.

Citations

Citations to this article as recorded by  
  • Structural, physicochemical characterization and antimicrobial activities of a new tris(8-quinolinolato-κ2N,O)cobalt(III) ethanol solvate [Co(C9H6NO)3].(C2H6O)
    Salsabil Idoudi, Badiaa Essghaier, Mohamed Faouzi Zid, Saoussen Namouchi Cherni
    Journal of Molecular Structure.2024; 1296: 136848.     CrossRef
  • Adaptation of Candida albicans to specific host environments by gain-of-function mutations in transcription factors
    Joachim Morschhäuser, Aaron P. Mitchell
    PLOS Pathogens.2024; 20(11): e1012643.     CrossRef
  • The Neosartorya (Aspergillus) fischeri antifungal protein NFAP2 has low potential to trigger resistance development in Candida albicans in vitro
    Gábor Bende, Nóra Zsindely, Krisztián Laczi, Zsolt Kristóffy, Csaba Papp, Attila Farkas, Liliána Tóth, Szabolcs Sáringer, László Bodai, Gábor Rákhely, Florentine Marx, László Galgóczy, Gustavo H. Goldman, Norman van Rhijn
    Microbiology Spectrum.2024;[Epub]     CrossRef
  • Tackling multi-drug resistant fungi by efflux pump inhibitors
    Kritika Engle, Gautam Kumar
    Biochemical Pharmacology.2024; 226: 116400.     CrossRef
  • The TAC1 Gene in Candida albicans: Structure, Function, and Role in Azole Resistance: A Mini-Review
    Amir Hossein Mahdizade, Akbar Hoseinnejad, Mona Ghazanfari, Mohammad Javad Boozhmehrani, Seyed Sobhan Bahreiny, Mahdi Abastabar, Roberta Galbo, Letterio Giuffrè, Iman Haghani, Orazio Romeo
    Microbial Drug Resistance.2024; 30(7): 288.     CrossRef
  • Boric Acid for the Treatment of Vaginitis: New Possibilities Using an Old Anti‐Infective Agent: A Systematic Review
    Matilde Lærkeholm Müller, Christina Damsted Petersen, Ditte Marie L. Saunte, Althea East-Innis
    Dermatologic Therapy.2024;[Epub]     CrossRef
  • Anti-fungal peptides: an emerging category with enthralling therapeutic prospects in the treatment of candidiasis
    Jyoti Sankar Prusty, Ashwini Kumar, Awanish Kumar
    Critical Reviews in Microbiology.2024; : 1.     CrossRef
  • Microevolution during Chronic Infection May Lead T. asahii to Coexist with the Host
    Gen Ba, Xuelian Lv, Xin Yang, Wenling Wang, Junhong Ao, Rongya Yang, Ioannis D. Bassukas
    Dermatology Research and Practice.2024;[Epub]     CrossRef
  • Cluster analysis allowed to identify antifungal drugs that retain efficacy against Candida albicans isolated from patients with inflammatory diseases of the soft tissues of the maxillofacial area
    Mariia Faustova, Volodymyr Dobrovolskyi, Galina Loban’, Yevhenii Bereza, Aleksandra Kotelnikova, Oleksandr Dobrovolskyi
    Frontiers in Oral Health.2024;[Epub]     CrossRef
  • Two different types of tandem sequences mediate the overexpression of TinCYP51B in azole-resistant Trichophyton indotineae
    Tsuyoshi Yamada, Mari Maeda, Hiroaki Nagai, Karine Salamin, Yun-Tsan Chang, Emmanuella Guenova, Marc Feuermann, Michel Monod, Andreas H. Groll
    Antimicrobial Agents and Chemotherapy.2023;[Epub]     CrossRef
  • Anticandidal activity of nanocomposite based on nanochitosan, nanostarch and mycosynthesized copper oxide nanoparticles against multidrug-resistant Candida
    Mohamed Saied, Mohamed Hasanin, Tarek M. Abdelghany, Basma H. Amin, Amr H. Hashem
    International Journal of Biological Macromolecules.2023; 242: 124709.     CrossRef
  • Assessing the In Vitro Potential of Glatiramer Acetate (Copaxone®) as a Chemotherapeutic Candidate for the Treatment of Cryptococcus neoformans Infection
    Vinicius Alves, Pedro Henrique Martins, Bruna Miranda, Iara Bastos de Andrade, Luiza Pereira, Christina Takiya Maeda, Glauber Ribeiro de Sousa Araújo, Susana Frases
    Journal of Fungi.2023; 9(8): 783.     CrossRef
  • Detrimental consequences of tebuconazole on redox homeostasis and fatty acid profile of honeybee brain
    Máté Mackei, Csilla Sebők, Júlia Vöröházi, Patrik Tráj, Fruzsina Mackei, Barnabás Oláh, Hedvig Fébel, Zsuzsanna Neogrády, Gábor Mátis
    Insect Biochemistry and Molecular Biology.2023; 159: 103990.     CrossRef
  • Benzamidine Conjugation Converts Expelled Potential Active Agents into Antifungals against Drug-Resistant Fungi
    Xue Wang, Xueyang Jin, Zhiyu Xie, Hongyang Zhang, Tiantian Liu, Hongbo Zheng, Xiaoyi Luan, Yan Sun, Wenjie Fang, Wenqiang Chang, Hongxiang Lou
    Journal of Medicinal Chemistry.2023; 66(19): 13684.     CrossRef
  • Advances in efficacy enhancement of photosensitizer-mediated photodynamic antimicrobial chemotherapy
    Benard M. Isaiah, Edith K. Amuhaya, Clare I. Muhanji
    Journal of Porphyrins and Phthalocyanines.2023; 27(06): 819.     CrossRef
  • Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
    Martina Raschig, Bernardo Ramírez‐Zavala, Johannes Wiest, Marco Saedtler, Marcus Gutmann, Ulrike Holzgrabe, Joachim Morschhäuser, Lorenz Meinel
    Archiv der Pharmazie.2023;[Epub]     CrossRef
  • A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans
    Arome Solomon Odiba, Olanrewaju Ayodeji Durojaye, Ifeoma Maureen Ezeonu, Anthony Christian Mgbeahuruike, Bennett Chima Nwanguma
    Infection and Drug Resistance.2022; Volume 15: 3111.     CrossRef
  • Metabolite profiling, antifungal, biofilm formation prevention and disruption of mature biofilm activities of Erythrina senegalensis stem bark extract against Candida albicans and Candida glabrata
    Benjamin Kingsley Harley, Anthony Martin Quagraine, David Neglo, Mike Okweesi Aggrey, Emmanuel Orman, Nana Ama Mireku-Gyimah, Cedric Dzidzor Amengor, Jonathan Jato, Yussif Saaka, Theophilus Christian Fleischer, Umakanta Sarker
    PLOS ONE.2022; 17(11): e0278096.     CrossRef
  • Antifungal Exposure and Resistance Development: Defining Minimal Selective Antifungal Concentrations and Testing Methodologies
    Emily M. Stevenson, William H. Gaze, Neil A. R. Gow, Alwyn Hart, Wiebke Schmidt, Jane Usher, Adilia Warris, Helen Wilkinson, Aimee K. Murray
    Frontiers in Fungal Biology.2022;[Epub]     CrossRef
  • The Risk Factors and Mechanisms of Azole Resistance of Candida tropicalis Blood Isolates in Thailand: A Retrospective Cohort Study
    Teera Leepattarakit, Orawan Tulyaprawat, Popchai Ngamskulrungroj
    Journal of Fungi.2022; 8(10): 983.     CrossRef
  • Genomic Variation-Mediating Fluconazole Resistance in Yeast
    Wen-Yao Wang, Hong-Qing Cai, Si-Yuan Qu, Wei-Hao Lin, Cheng-Cheng Liang, Hao Liu, Ze-Xiong Xie, Ying-Jin Yuan
    Biomolecules.2022; 12(6): 845.     CrossRef
  • Antifungals and Drug Resistance
    Chowdhury Mobaswar Hossain, Lisa Kathleen Ryan, Meeta Gera, Sabyasachi Choudhuri, Nazmun Lyle, Kazi Asraf Ali, Gill Diamond
    Encyclopedia.2022; 2(4): 1722.     CrossRef
  • Synergistic Effect of the Combination of Deferoxamine and Fluconazole In Vitro and In Vivo against Fluconazole-Resistant Candida Spp.
    Lulu An, Jingwen Tan, Yuanyuan Wang, Siyu Liu, Yongyong Li, Lianjuan Yang
    Antimicrobial Agents and Chemotherapy.2022;[Epub]     CrossRef
  • Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis
    Wuqiang Wen, Hongxuan Cao, Yunyuan Huang, Jie Tu, Chen Wan, Jian Wan, Xinya Han, Han Chen, Jiaqi Liu, Li Rao, Chen Su, Chao Peng, Chunquan Sheng, Yanliang Ren
    Journal of Medicinal Chemistry.2022; 65(3): 2656.     CrossRef
  • Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survival
    Ifeanyi Elibe Mba, Emeka Innocent Nweze, Emmanuel Aniebonam Eze, Zikora Kizito Glory Anyaegbunam
    Infection, Genetics and Evolution.2022; 99: 105256.     CrossRef
  • Activity of poly(methacrylic acid)-silver nanoparticles on fluconazole-resistant Candida albicans strains: Synergistic and cytotoxic effects
    Cecília Maria Cruz Falcão, Audrey Andrade, Vanderlan Nogueira Holanda, Regina Celia Bressan Queiroz de Figueiredo, Eulália Azevedo Ximenes, Anderson Stevens Leonidas Gomes
    Journal of Applied Microbiology.2022; 132(6): 4300.     CrossRef
  • Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies
    Raphaëlle Youf, Max Müller, Ali Balasini, Franck Thétiot, Mareike Müller, Alizé Hascoët, Ulrich Jonas, Holger Schönherr, Gilles Lemercier, Tristan Montier, Tony Le Gall
    Pharmaceutics.2021; 13(12): 1995.     CrossRef
  • Etoposide and Camptothecin Reduce Growth, Viability, the Generation of Petite Mutants, and Recognize the Active Site of DNA Topoisomerase I and II Enzymes in Candida glabrata
    Dulce Andrade-Pavón, Omar Gómez-García
    Indian Journal of Microbiology.2021; 61(3): 306.     CrossRef
  • 8-hydroxyquinoline-5-(N-4-chlorophenyl) sulfonamide and fluconazole combination as a preventive strategy for Candida biofilm in haemodialysis devices
    Letícia Fernandes da Rocha, Bruna Pippi, Angélica Rocha Joaquim, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefria
    Journal of Medical Microbiology .2021;[Epub]     CrossRef
  • Genetic diversity and molecular epidemiology of Candida albicans from vulvovaginal candidiasis patients
    Ji-yun Tian, Yong-gang Yang, Shi Chen, Yong Teng, Xin-zheng Li
    Infection, Genetics and Evolution.2021; 92: 104893.     CrossRef
  • Chronic recurrent vulvovaginitis is not only due to Candida
    Alicia Arechavala, Ricardo Negroni, Gabriela Santiso, Roxana Depardo, Pablo Bonvehí
    Revista Iberoamericana de Micología.2021; 38(3): 132.     CrossRef
  • Systematic truncations of chromosome 4 and their responses to antifungals in Candida albicans
    Wasim Uddin, Darshan Dhabalia, S.M. Udaya Prakash, M. Anaul Kabir
    Journal of Genetic Engineering and Biotechnology.2021; 19(1): 92.     CrossRef
  • Hinokitiol chelates intracellular iron to retard fungal growth by disturbing mitochondrial respiration
    Xueyang Jin, Ming Zhang, Jinghui Lu, Ximeng Duan, Jinyao Chen, Yue Liu, Wenqiang Chang, Hongxiang Lou
    Journal of Advanced Research.2021; 34: 65.     CrossRef
  • Lysinibacillus Isolate MK212927: A Natural Producer of Allylamine Antifungal ‘Terbinafine’
    Sayed E. El-Sayed, Neveen A. Abdelaziz, Hosam-Eldin Hussein Osman, Ghadir S. El-Housseiny, Ahmed E. Aleissawy, Khaled M. Aboshanab
    Molecules.2021; 27(1): 201.     CrossRef
  • New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-l-Galacto-β-d-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation
    Justyna Rewak-Soroczynska, Paulina Sobierajska, Sara Targonska, Agata Piecuch, Lukasz Grosman, Jaroslaw Rachuna, Slawomir Wasik, Michal Arabski, Rafal Ogorek, Rafal J. Wiglusz
    International Journal of Molecular Sciences.2021; 22(6): 3112.     CrossRef
  • The phosphatome of opportunistic pathogen Candida species
    Krisztina Szabó, Márton Miskei, Ilona Farkas, Viktor Dombrádi
    Fungal Biology Reviews.2021; 35: 40.     CrossRef
  • Azole-triphenylphosphonium conjugates combat antifungal resistance and alleviate the development of drug-resistance
    Xin Wang, Jun Liu, Jinyao Chen, Ming Zhang, Chuan Tian, Xiaoping Peng, Gang Li, Wenqiang Chang, Hongxiang Lou
    Bioorganic Chemistry.2021; 110: 104771.     CrossRef
  • Activity of Compound Agrimony Enteritis Capsules against invasive candidiasis: Exploring the differences between traditional Chinese medicine prescriptions and its main components in the treatment of diseases
    Jun Li, Ze-Hua Jin, Jia-Sheng Li, Liu-Yan Su, Ying-Xian Wang, Yi Zhang, Ding-Mei Qin, Gao-Xiong Rao, Rui-Rui Wang
    Journal of Ethnopharmacology.2021; 277: 114201.     CrossRef
  • Identification and Characterization of Mediators of Fluconazole Tolerance in Candida albicans
    Eric Delarze, Ludivine Brandt, Emilie Trachsel, Marion Patxot, Claire Pralong, Fabio Maranzano, Murielle Chauvel, Mélanie Legrand, Sadri Znaidi, Marie-Elisabeth Bougnoux, Christophe d’Enfert, Dominique Sanglard
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • A Zinc Cluster Transcription Factor Contributes to the Intrinsic Fluconazole Resistance of Candida auris
    Eva-Maria Mayr, Bernardo Ramírez-Zavala, Ines Krüger, Joachim Morschhäuser, Aaron P. Mitchell
    mSphere.2020;[Epub]     CrossRef
  • Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design
    Brian C. Monk, Alia A. Sagatova, Parham Hosseini, Yasmeen N. Ruma, Rajni K. Wilson, Mikhail V. Keniya
    Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.2020; 1868(3): 140206.     CrossRef
  • Dispiropyrrolidine tethered piperidone heterocyclic hybrids with broad-spectrum antifungal activity against Candida albicans and Cryptococcus neoformans
    Sarah Lawson, Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, Shankar Thangamani
    Bioorganic Chemistry.2020; 100: 103865.     CrossRef
  • Lipid composition and cell surface hydrophobicity of Candida albicans influence the efficacy of fluconazole–gentamicin treatment
    Jakub Suchodolski, Jakub Muraszko, Aleksandra Korba, Przemysław Bernat, Anna Krasowska
    Yeast.2020; 37(1): 117.     CrossRef
  • Adaptive Laboratory Evolution of Native Torulaspora delbrueckii YCPUC10 With Enhanced Ethanol Resistance and Evaluation in Co-inoculated Fermentation
    Daniela Catrileo, Andrea Acuña-Fontecilla, Liliana Godoy
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • Genotype, biofilm formation ability and specific gene transcripts characteristics of endodontic Enterococcus faecalis under glucose deprivation condition
    Yawen Liu, Yifan Ping, Yuhua Xiong, Ruyu Zhou, Fulu Xu, Juan Wang, Jin Li
    Archives of Oral Biology.2020; 118: 104877.     CrossRef
  • Improved Methods of Extraction and In Vitro Evaluation of Antimicrobial Potential of Stem Bark of Terminalia arjuna
    Sarita Khatkar, Arun Nanda, Shahid Husain Ansari
    Current Biochemical Engineering.2019; 5(1): 50.     CrossRef
  • The small GTPase Rhb1 is involved in the cell response to fluconazole inCandida albicans
    Yu-Wen Chen, Ying-Chieh Yeh, Hsueh-Fen Chen, Ruei-Ching Chen, Guan-Yu Lin, Yu-Ting Chen, Chung-Yu Lan
    FEMS Yeast Research.2019;[Epub]     CrossRef
  • The Magnitude ofCandida albicansStress-Induced Genome Instability Results from an Interaction Between Ploidy and Antifungal Drugs
    Ognenka Avramovska, Meleah A Hickman
    G3 Genes|Genomes|Genetics.2019; 9(12): 4019.     CrossRef
  • Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans
    Wen-Xuan Wang, Xinxiang Lei, Hong-Lian Ai, Xue Bai, Jing Li, Juan He, Zheng-Hui Li, Yong-Sheng Zheng, Tao Feng, Ji-Kai Liu
    Organic Letters.2019; 21(4): 1108.     CrossRef
  • Antifungal Activity of a Hydroethanolic Extract From Astronium urundeuva Leaves Against Candida albicans and Candida glabrata
    Bruna Vidal Bonifácio, Taissa Vieira Machado Vila, Isadora Fantacini Masiero, Patrícia Bento da Silva, Isabel Cristiane da Silva, Érica de Oliveira Lopes, Matheus Aparecido dos Santos Ramos, Leonardo Perez de Souza, Wagner Vilegas, Fernando Rogério Pavan,
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • Dissection of the regulatory role for the N-terminal domain in Candida albicans protein phosphatase Z1
    Krisztina Szabó, Zoltán Kónya, Ferenc Erdődi, Ilona Farkas, Viktor Dombrádi, Joy Sturtevant
    PLOS ONE.2019; 14(2): e0211426.     CrossRef
  • The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicans
    Shen-Huan Liang, Richard J. Bennett
    Journal of Fungi.2019; 6(1): 10.     CrossRef
  • Evolution of Fluconazole-Resistant Candida albicans Strains by Drug-Induced Mating Competence and Parasexual Recombination
    Christina Popp, Bernardo Ramírez-Zavala, Sonja Schwanfelder, Ines Krüger, Joachim Morschhäuser, Judith Berman
    mBio.2019;[Epub]     CrossRef
  • Accelerated evolution at chaperone promoters among Antarctic notothenioid fishes
    Samuel N. Bogan, Sean P. Place
    BMC Evolutionary Biology.2019;[Epub]     CrossRef
  • Elevation of cell wall chitin via Ca2+–calcineurin‐mediated PKC signaling pathway maintains the viability of Candida albicans in the absence of β‐1,6‐glucan synthesis
    Qi Han, Na Wang, Chaoying Pan, Yue Wang, Jianli Sang
    Molecular Microbiology.2019; 112(3): 960.     CrossRef
  • Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161
    Brian C. Monk, Mikhail V. Keniya, Manya Sabherwal, Rajni K. Wilson, Danyon O. Graham, Harith F. Hassan, Danni Chen, Joel D. A. Tyndall
    Antimicrobial Agents and Chemotherapy.2019;[Epub]     CrossRef
  • The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors
    Jingxiang Zhang, Liping Li, Quanzhen Lv, Lan Yan, Yan Wang, Yuanying Jiang
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • Two New 1,3,4-Oxadiazoles With Effective Antifungal Activity Against Candida albicans
    Isis Regina Grenier Capoci, Karina Mayumi Sakita, Daniella Renata Faria, Franciele Abigail Vilugron Rodrigues-Vendramini, Glaucia Sayuri Arita, Admilton Gonçalves de Oliveira, Maria Sueli Felipe, Bernard Maigret, Patricia de Souza Bonfim-Mendonça, Erika S
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • Anti-candidal activity of selected analgesic drugs used alone and in combination with fluconazole, itraconazole, voriconazole, posaconazole and isavuconazole
    J. Król, U. Nawrot, M. Bartoszewicz
    Journal de Mycologie Médicale.2018; 28(2): 327.     CrossRef
  • Blad-containing oligomer: a novel fungicide used in crop protection as an alternative treatment for tinea pedis and tinea versicolor
    Alexandra Carreira, João Boavida Ferreira, Iliana Pereira, João Ferreira, Paulo Filipe, Ricardo Boavida Ferreira, Sara Monteiro
    Journal of Medical Microbiology.2018; 67(2): 198.     CrossRef
  • Varying susceptibility of clinical and environmental Scedosporium isolates to chemical oxidative stress in conidial germination
    Cindy Staerck, Charlotte Godon, Jean-Philippe Bouchara, Maxime J. J. Fleury
    Archives of Microbiology.2018; 200(3): 517.     CrossRef
  • Rice Defensin OsAFP1 is a New Drug Candidate against Human Pathogenic Fungi
    Akihito Ochiai, Kodai Ogawa, Minami Fukuda, Masahiro Ohori, Takumi Kanaoka, Takaaki Tanaka, Masayuki Taniguchi, Yoshiyuki Sagehashi
    Scientific Reports.2018;[Epub]     CrossRef
  • Thiobarbiturates as potential antifungal agents to control human infections caused by Candida and Cryptococcus species
    Muhammad Shabeer, Luiz C. A. Barbosa, Milandip Karak, Amanda C. S. Coelho, Jacqueline A. Takahashi
    Medicinal Chemistry Research.2018; 27(4): 1043.     CrossRef
  • A Case for Antifungal Stewardship
    Rachel A. Miller
    Current Fungal Infection Reports.2018; 12(1): 33.     CrossRef
  • A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes YOR1 Overexpression and Beauvericin Resistance in Candida albicans
    Bernardo Ramírez-Zavala, Hannah Manz, Frank Englert, P. David Rogers, Joachim Morschhäuser
    Antimicrobial Agents and Chemotherapy.2018;[Epub]     CrossRef
  • Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species
    J. D. Sobel, R. Sobel
    Expert Opinion on Pharmacotherapy.2018; 19(9): 971.     CrossRef
  • CYP51 as drug targets for fungi and protozoan parasites: past, present and future
    Galina I. Lepesheva, Laura Friggeri, Michael R. Waterman
    Parasitology.2018; 145(14): 1820.     CrossRef
  • TLS dependent and independent functions of DNA polymerase eta (Polη/Rad30) from Pathogenic Yeast Candida albicans
    Kodavati Manohar, Doureradjou Peroumal, Narottam Acharya
    Molecular Microbiology.2018; 110(5): 707.     CrossRef
  • Potential effect of 2-isopropyl-5-methylphenol (thymol) alone and in combination with fluconazole against clinical isolates of Candida albicans, C. glabrata and C. krusei
    A. Sharifzadeh, A.R. Khosravi, H. Shokri, H. Shirzadi
    Journal de Mycologie Médicale.2018; 28(2): 294.     CrossRef
  • Fluconazole-Pyridoxine Bis-Triazolium Compounds with Potent Activity against Pathogenic Bacteria and Fungi Including Their Biofilm-Embedded Forms
    Marsel R. Garipov, Roman S. Pavelyev, Svetlana A. Lisovskaya, Elena V. Nikitina, Airat R. Kayumov, Alina E. Sabirova, Oksana V. Bondar, Albina G. Malanyeva, Alexander M. Aimaletdinov, Alfia G. Iksanova, Konstantin V. Balakin, Yurii G. Shtyrlin
    Journal of Chemistry.2017; 2017: 1.     CrossRef
  • Bridging the Gap to Non-toxic Fungal Control: Lupinus-Derived Blad-Containing Oligomer as a Novel Candidate to Combat Human Pathogenic Fungi
    Ana M. Pinheiro, Alexandra Carreira, Thomas A. K. Prescott, Ricardo B. Ferreira, Sara A. Monteiro
    Frontiers in Microbiology.2017;[Epub]     CrossRef
  • An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses
    Irene A. I. Hampe, Justin Friedman, Mira Edgerton, Joachim Morschhäuser, Julia Ruth Koehler
    PLOS Pathogens.2017; 13(9): e1006655.     CrossRef
  • Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions
    José Robson Neves Cavalcanti Filho, Tiago Fonseca Silva, Woah Queiroz Nobre, Larissa Isabela Oliveira de Souza, Cristiane Santos Silva e Silva Figueiredo, Regina Celia Bressan Queiroz de Figueiredo, Norma Buarque de Gusmão, Márcia Vanusa Silva, Luís Cláud
    Pharmaceutical Biology.2017; 55(1): 1521.     CrossRef
  • Antifungal Resistance: An Emerging Reality and A Global Challenge
    Dimitrios P Kontoyiannis
    The Journal of Infectious Diseases.2017; 216(suppl_3): S431.     CrossRef
  • Candida albicans Swi/Snf and Mediator Complexes Differentially Regulate Mrr1-Induced MDR1 Expression and Fluconazole Resistance
    Zhongle Liu, Lawrence C. Myers
    Antimicrobial Agents and Chemotherapy.2017;[Epub]     CrossRef
  • Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis
    Tatiana Y. Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Aidong Qi, William J. Hoekstra, Robert J. Schotzinger, John D. York, F. Peter Guengerich, Galina I. Lepesheva
    Journal of Biological Chemistry.2017; 292(16): 6728.     CrossRef
  • The natural compound magnolol affects growth, biofilm formation, and ultrastructure of oral Candida isolates
    Jawad Behbehani, Sheikh Shreaz, Mohammad Irshad, Maribassapa Karched
    Microbial Pathogenesis.2017; 113: 209.     CrossRef
  • The Structure of Thymidylate Kinase from Candida albicans Reveals a Unique Structural Element
    Kaustubh Sinha, Gordon S. Rule
    Biochemistry.2017; 56(33): 4360.     CrossRef
  • Histone Acetyltransferase Encoded by NGG1 is Required for Morphological Conversion and Virulence of Candida Albicans
    De-Dong Li, Beth Burgwyn Fuchs, Yan Wang, Xiao-Wen Huang, Dan-Dan Hu, Yan Sun, Dong Chai, Yuan-Ying Jiang, Eleftherios Mylonakis
    Future Microbiology.2017; 12(16): 1497.     CrossRef
  • Human fungal pathogens: Why should we learn?
    Jeong-Yoon Kim
    Journal of Microbiology.2016; 54(3): 145.     CrossRef
  • Candidaspecies isolated from different body sites and their antifungal susceptibility pattern: Cross-analysis ofCandida albicansandCandida glabratabiofilms
    Valentina Cataldi, Emanuela Di Campli, Paolo Fazii, Tonino Traini, Luigina Cellini, Mara Di Giulio
    Medical Mycology.2016; : myw126.     CrossRef
Effects of Genetically Different 2.4-D-degradative Plasmids on Degradation Phenotype and Competitiveness of Soil Microorganisms
Hong, Seok Myeong , Ahn, Young Joon , Park, Yong Keun , Min, Kyung Hee , Kim, Chi Kyung , Ka, Jong Ok
J. Microbiol. 1995;33(3):208-214.
  • 36 View
  • 0 Download
AbstractAbstract
The effects of various 2, 4-D-degradative plasmids on the axenic growth patterns, the degradation phenotypes, and the competitiveness of different host bacteria were evaluated in liquid cultures; the organisms and plasmids used were Alcaligenes eutrophus JMP134/pJP4, Alcaligenes paradoxus/p2811, Pseudomonas pickettii/p712, pJP4, and p712 or p 2811 exhibited very different restriction fragment profiles in restriction endonuclease digests. These plasmids were transferred to the recipients (P. cepacia and Alcaligenes JMP228) at relatively high frequencies ranging from 8.9 × 10^-3 to 1.6 × 10^-5 per donor cell. In the axenic liquid cultures the fast-growing strains, such as P. pseudomallei/p745 and P. cepacia/pJP4, exhibited short lag periods, high specific growth rates, and high relative fitness coefficients, while the slow-growing strains, such as P. pickettii/p712 and A. paradoxus/p2811, had long lag periods, low specific growth rates, and low relative fitness coefficients. Depending on the type of plasmid containing the genes for the 2, 4-D pathway, some transconjugants exhibited intermediate growth patterns between the fast-growing strains and the slow-growing strains. The plasmid and plasmid-host interactions determined specific growth rate and lag time, respectively, which were shown to be principal determinants of competitiveness among the strains, but relative fitness coefficient derived from the axenic culture was not always predictive for the mixed culture condition.

Journal of Microbiology : Journal of Microbiology
TOP