Journal of Microbiology

Journal Articles

Antiviral effects of human placenta hydrolysate (Laennec) against SARS-CoV-2 in vitro and in the ferret model: Eun-Ha Kim , Young-il Kim , Seung-Gyu Jang , Minju Im , Kyeongsoo Jeong , Young Ki Choi , Hae-Jung Han; J. Microbiol. 2021;59(11):1056-1062. Published online October 6, 2021; DOI: https://doi.org/10.1007/s12275-021-1367-2

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The COVID-19 pandemic has caused unprecedented health, social, and economic crises worldwide. However, to date, there is an only a limited effective treatment for this disease. Human placenta hydrolysate (hPH) has previously been shown to be safe and to improve the health condition in patients with hyperferritinemia and COVID-19. In this study, we aimed to determine the antiviral effects of hPH against SARS-CoV-2 in vitro and in vivo models and compared with Remdesivir, an FDA-approved drug for COVID-19 treatment. To assess whether hPH inhibited SARS-CoV-2 replication, we determined the CC50, EC50, and selective index (SI) in Vero cells by infection with a SARS-CoV-2 at an MOI of 0.01. Further, groups of ferrets infected with 105.8 TCID50/ml of SARS-CoV-2 and treated with hPH at 2, 4, 6 dpi, and compared their clinical manifestation and virus titers in respiratory tracts with PBS control-treated group. The mRNA expression of immunerelated cytokines was determined by qRT-PCR. hPH treatment attenuated virus replication in a dose-dependent manner in vitro. In a ferret infection study, treatment with hPH resulted in minimal bodyweight loss and attenuated virus replication in the nasal wash, turbinates, and lungs of infected ferrets. In addition, qRT-PCR results revealed that the hPH treatment remarkably upregulated the gene expression of type I (IFN-α and IFN-β) and II (IFN-γ) IFNs in SARS-CoV-2 infected ferrets. Our data collectively suggest that hPH has antiviral efficacy against SARS-CoV-2 and might be a promising therapeutic agent for the treatment of SARS-CoV-2 infection.

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Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic
I Kawikova, K Hakenova, M Lebedeva, L Kleteckova, L Jakob, V Spicka, L Wen, F Spaniel, K Vales
Physiological Research.2024; : S615. CrossRef
Human Placenta Extract (HPH) Suppresses Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model
Jung Ok Lee, Youna Jang, A Yeon Park, Jung Min Lee, Kyeongsoo Jeong, So-Hyun Jeon, Hui Jin, Minju Im, Jae-Won Kim, Beom Joon Kim
Journal of Microbiology and Biotechnology.2024; 34(10): 1969. CrossRef
Systematic analysis of the pharmacology of standardized extracts of human placenta
T. E. Bogacheva, I. Yu. Torshin, O. A. Gromova
Pharmacokinetics and Pharmacodynamics.2024; (4): 3. CrossRef
Distinctive Combinations of RBD Mutations Contribute to Antibody Evasion in the Case of the SARS-CoV-2 Beta Variant
Tae-Hun Kim, Sojung Bae, Sunggeun Goo, Jinjong Myoung
Journal of Microbiology and Biotechnology.2023; 33(12): 1587. CrossRef
Current state-of-the-art and potential future therapeutic drugs against COVID-19
Ailong Sha, Yi Liu, Haiyan Hao
Frontiers in Cell and Developmental Biology.2023;[Epub] CrossRef
SARS-CoV-2 Aerosol and Intranasal Exposure Models in Ferrets
Elizabeth E. Zumbrun, Samantha E. Zak, Eric D. Lee, Philip A. Bowling, Sara I. Ruiz, Xiankun Zeng, Jeffrey W. Koehler, Korey L. Delp, Russel R. Bakken, Shannon S. Hentschel, Holly A. Bloomfield, Keersten M. Ricks, Tamara L. Clements, April M. Babka, John
Viruses.2023; 15(12): 2341. CrossRef
Human placenta hydrolysates: from V.P. Filatov to the present day: Review
Olga A. Gromova, Ivan Yu. Torshin, Alexander G. Chuchalin, Valeriy А. Maximov
Terapevticheskii arkhiv.2022; 94(3): 434. CrossRef

Characterization of the velvet regulators in Aspergillus flavus: Tae-Jin Eom , Heungyun Moon , Jae-Hyuk Yu , Hee-Soo Park; J. Microbiol. 2018;56(12):893-901. Published online October 25, 2018; DOI: https://doi.org/10.1007/s12275-018-8417-4

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Abstract

Fungal development and secondary metabolism are closely associated via the activities of the fungal NK-kB-type velvet regulators that are highly conserved in filamentous fungi. Here, we investigated the roles of the velvet genes in the aflatoxigenic fungus Aspergillus flavus. Distinct from other Aspergillus species, the A. flavus genome contains five velvet genes, veA, velB, velC, velD, and vosA. The deletion of velD blocks the production of aflatoxin B1, but does not affect the formation of sclerotia. Expression analyses revealed that vosA and velB mRNAs accumulated at high levels during the late phase of asexual development and in conidia. The absence of vosA or velB decreased the content of conidial trehalose and the tolerance of conidia to the thermal and UV stresses. In addition, double mutant analyses demonstrated that VosA and VelB play an inter-dependent role in trehalose biosynthesis and conidial stress tolerance. Together with the findings of previous studies, the results of the present study suggest that the velvet regulators play the conserved and vital role in sporogenesis, conidial trehalose biogenesis, stress tolerance, and aflatoxin biosynthesis in A. flavus.

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Xinyue Zhang, Wenjing Peng, Mumin Zheng, Bolei Yang, Bowen Tai, Xu Li, Fuguo Xing
Journal of Agricultural and Food Chemistry.2024;[Epub] CrossRef
Rhein Inhibits Cell Development and Aflatoxin Biosynthesis via Energy Supply Disruption and ROS Accumulation in Aspergillus flavus
Xiaoyan Wang, Kashif Iqbal Sahibzada, Ruibo Du, Yang Lei, Shan Wei, Na Li, Yuansen Hu, Yangyong Lv
Toxins.2024; 16(7): 285. CrossRef
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Xuwen Hou, Liyao Liu, Dan Xu, Daowan Lai, Ligang Zhou
Journal of Fungi.2024; 10(8): 561. CrossRef
SscA is required for fungal development, aflatoxin production, and pathogenicity in Aspergillus flavus
Ye-Eun Son, Hee-Soo Park
International Journal of Food Microbiology.2024; 413: 110607. CrossRef
HacA, a key transcription factor for the unfolded protein response, is required for fungal development, aflatoxin biosynthesis and pathogenicity of Aspergillus flavus
Min Yu, Xiaoling Zhou, Dongyue Chen, Yuan Jiao, Guomin Han, Fang Tao
International Journal of Food Microbiology.2024; 417: 110693. CrossRef
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Shota Morikawa, Callum Verdonk, Evan John, Leon Lenzo, Nicolau Sbaraini, Chala Turo, Hang Li, David Jiang, Yit-Heng Chooi, Kar-Chun Tan
BMC Microbiology.2024;[Epub] CrossRef
Beyond morphogenesis and secondary metabolism: function of Velvet proteins and LaeA in fungal pathogenesis
Ana M. Calvo, Apoorva Dabholkar, Elizabeth M. Wyman, Jessica M. Lohmar, Jeffrey W. Cary, Yvonne Nygård
Applied and Environmental Microbiology.2024;[Epub] CrossRef
UvVelC is important for conidiation and pathogenicity in the rice false smut pathogen Ustilaginoidea virens
Mina Yu, Tianqiao Song, Junjie Yu, Huijuan Cao, Xiayan Pan, Zhongqiang Qi, Yan Du, Wende Liu, Yongfeng Liu
Virulence.2024;[Epub] CrossRef
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Martina Loi, Antonio F. Logrieco, Tünde Pusztahelyi, Éva Leiter, László Hornok, István Pócsi
Frontiers in Microbiology.2023;[Epub] CrossRef
Estragole Inhibits Growth and Aflatoxin Biosynthesis of Aspergillus flavus by Affecting Reactive Oxygen Species Homeostasis
Liuke Liang, Wei Zhang, Jing Hao, Yanyu Wang, Shan Wei, Shuaibing Zhang, Yuansen Hu, Yangyong Lv, Xiaohui Zhou
Microbiology Spectrum.2023;[Epub] CrossRef
The novel spore-specific regulator SscA controls Aspergillus conidiogenesis
Ye-Eun Son, Jae-Hyuk Yu, Hee-Soo Park, Gustavo H. Goldman
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Light regulation of secondary metabolism in fungi
Wenbin Yu, Rongqiang Pei, Yufei Zhang, Yayi Tu, Bin He
Journal of Biological Engineering.2023;[Epub] CrossRef
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Zongting Huang, Dandan Wu, Sile Yang, Wangzhuo Fu, Dongmei Ma, Yanfang Yao, Hong Lin, Jun Yuan, Yanling Yang, Zhenhong Zhuang
Journal of Fungi.2023; 9(11): 1077. CrossRef
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Postharvest Biology and Technology.2023; 195: 112121. CrossRef
Histone 2-Hydroxyisobutyryltransferase Encoded by Afngg1 Is Involved in Pathogenicity and Aflatoxin Biosynthesis in Aspergillus flavus
Jing Wang, Liuke Liang, Shan Wei, Shuaibing Zhang, Yuansen Hu, Yangyong Lv
Toxins.2022; 15(1): 7. CrossRef
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Liuqing Wang, Meng Wang, Jian Jiao, Hongmei Liu
Frontiers in Microbiology.2022;[Epub] CrossRef
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He-Jin Cho, Sung-Hun Son, Wanping Chen, Ye-Eun Son, Inhyung Lee, Jae-Hyuk Yu, Hee-Soo Park
Cells.2022; 11(18): 2796. CrossRef
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Microbiology Spectrum.2022;[Epub] CrossRef
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Heungyun Moon, Kap-Hoon Han, Jae-Hyuk Yu
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Hao-Nan Wang, Xia Ke, Jun-Ping Zhou, Zhi-Qiang Liu, Yu-Guo Zheng
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P. Chang, B. Tai, M. Zheng, Q. Yang, F. Xing
World Mycotoxin Journal.2022; 15(3): 269. CrossRef
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JSM Mycotoxins.2022; 72(1): 39. CrossRef
The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
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Jing Gao, Xinge Xu, Kunlun Huang, Zhihong Liang
Frontiers in Microbiology.2021;[Epub] CrossRef
Transcriptomic, Protein-DNA Interaction, and Metabolomic Studies of VosA, VelB, and WetA in Aspergillus nidulans Asexual Spores
Ming-Yueh Wu, Matthew E. Mead, Mi-Kyung Lee, George F. Neuhaus, Donovon A. Adpressa, Julia I. Martien, Ye-Eun Son, Heungyun Moon, Daniel Amador-Noguez, Kap-Hoon Han, Antonis Rokas, Sandra Loesgen, Jae-Hyuk Yu, Hee-Soo Park, Xiaorong Lin
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Molecular Mechanisms of Conidial Germination in Aspergillus spp
Tim J. H. Baltussen, Jan Zoll, Paul E. Verweij, Willem J. G. Melchers
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The role of the VosA-repressed dnjA gene in development and metabolism in Aspergillus species
Ye-Eun Son, He-Jin Cho, Wanping Chen, Sung-Hun Son, Mi-Kyung Lee, Jae-Hyuk Yu, Hee-Soo Park
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The velvet Regulator VosA Governs Survival and Secondary Metabolism of Sexual Spores in Aspergillus nidulans
Min-Ju Kim, Mi-Kyung Lee, Huy Quang Pham, Myeong Ju Gu, Bohan Zhu, Sung-Hun Son, Dongyup Hahn, Jae-Ho Shin, Jae-Hyuk Yu, Hee-Soo Park, Kap-Hoon Han
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Ye-Eun Son, He-Jin Cho, Mi-Kyung Lee, Hee-Soo Park, Kap-Hoon Han
PLOS ONE.2020; 15(2): e0228643. CrossRef
Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Su-Yeon Lim, Ye-Eun Son, Dong-Hyun Lee, Tae-Jin Eom, Min-Ju Kim, Hee-Soo Park
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Conserved Roles of MonA in Fungal Growth and Development inAspergillusSpecies
Ye-Eun Son, Hee-Soo Park
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The Velvet Proteins VosA and VelB Play Different Roles in Conidiation, Trap Formation, and Pathogenicity in the Nematode-Trapping Fungus Arthrobotrys oligospora
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Frontiers in Microbiology.2019;[Epub] CrossRef

Review

REVIEW] Developmental regulators in Aspergillus fumigatus: Hee-Soo Park , Jae-Hyuk Yu; J. Microbiol. 2016;54(3):223-231. Published online February 27, 2016; DOI: https://doi.org/10.1007/s12275-016-5619-5

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Abstract

The filamentous fungus Aspergillus fumigatus is the most prevalent airborne fungal pathogen causing severe and usually fatal invasive aspergillosis in immunocompromised patients. This fungus produces a large number of small hydrophobic asexual spores called conidia as the primary means of reproduction, cell survival, propagation, and infectivity. The initiation, progression, and completion of asexual development (conidiation) is controlled by various regulators that govern expression of thousands of genes associated with formation of the asexual developmental structure conidiophore, and biogenesis of conidia. In this review, we summarize key regulators that directly or indirectly govern conidiation in this important pathogenic fungus. Better understanding these developmental regulators may provide insights into the improvement in controlling both beneficial and detrimental aspects of various Aspergillus species.

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Ye-Eun Son, Jiwoo Han, Kyung-Tae Lee, Hee-Soo Park
Mycology.2024; 15(2): 238. CrossRef
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Kunzhi Jia, Yipu Jia, Qianhua Zeng, Zhaoqi Yan, Shihua Wang
Journal of Fungi.2024; 10(9): 650. CrossRef
Comprehensive Insights into the Remarkable Function and Regulatory Mechanism of FluG during Asexual Development in Beauveria bassiana
Fang Li, Juefeng Zhang, Haiying Zhong, Kaili Yu, Jianming Chen
International Journal of Molecular Sciences.2024; 25(11): 6261. CrossRef
Genome-wide patterns of noncoding and protein-coding sequence variation in the major fungal pathogen Aspergillus fumigatus
Alec Brown, Jacob L Steenwyk, Antonis Rokas, J Comeron
G3: Genes, Genomes, Genetics.2024;[Epub] CrossRef
Cellular communication and fusion regulate cell fusion, trap morphogenesis, conidiation, and secondary metabolism in Arthrobotrys oligospora
Wenjie Wang, Yankun Liu, Shipeng Duan, Na Bai, Meichen Zhu, Jinkui Yang
Microbiological Research.2024; 278: 127516. CrossRef
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Yanmei Shen, Xuewei Yang, Meichen Zhu, Shipeng Duan, Qianqian Liu, Jinkui Yang
Journal of Fungi.2024; 10(9): 626. CrossRef
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Jun Zi Zhu, Ping Li, Zhuo Zhang, Xiao Gang Li, Jie Zhong
International Journal of Biological Macromolecules.2024; 271: 132437. CrossRef
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Fidel Diego-Nava, Carlos Granados-Echegoyen, Jaime Ruíz-Vega, Teodulfo Aquino-Bolaños, Rafael Pérez-Pacheco, Alejo Díaz-Ramos, Nancy Alonso-Hernández, Fabián Arroyo-Balán, Mónica Beatriz López-Hernández
AgriEngineering.2023; 5(2): 801. CrossRef
Verticillium dahliae Asp1 regulates the transition from vegetative growth to asexual reproduction by modulating microtubule dynamic organization
Juan Tian, Mengli Pu, Bin Chen, Guangda Wang, Chunli Li, Xiaxia Zhang, Yanjun Yu, Zhi Wang, Zhaosheng Kong
Environmental Microbiology.2023; 25(3): 738. CrossRef
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Andleeb Khan, Sivakumar Sivagurunathan Moni, M. Ali, Syam Mohan, Huma Jan, Saiema Rasool, Mohammad A Kamal, Saeed Alshahrani, Maryam Halawi, Hassan A Alhazmi
Current Molecular Pharmacology.2023; 16(1): 15. CrossRef
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Veronica S. Brauer, André M. Pessoni, Mateus S. Freitas, Marinaldo P. Cavalcanti-Neto, Laure N. A. Ries, Fausto Almeida
Journal of Fungi.2023; 9(1): 89. CrossRef
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Shuai Liu, Xiaoyan Lu, Mengyao Dai, Shizhu Zhang
Molecular Microbiology.2023; 120(6): 830. CrossRef
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Ya-Mei Wu, Xue-Qiong Yang, Jing-Xin Chen, Ting Wang, Tai-Ran Li, Fan-Rong Liao, Run-Tong Liu, Ya-Bin Yang, Zhong-Tao Ding
Natural Product Research.2023; 37(13): 2243. CrossRef
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Songmao Lu, Huobing Deng, Yaqi Lin, Meimei Huang, Haixia You, Yan Zhang, Weijian Zhuang, Guodong Lu, Yingzi Yun
Journal of Fungi.2023; 10(1): 1. CrossRef
Light regulates the degradation of the regulatory protein VE-1 in the fungus Neurospora crassa
María del Mar Gil-Sánchez, Sara Cea-Sánchez, Eva M. Luque, David Cánovas, Luis M. Corrochano
BMC Biology.2022;[Epub] CrossRef
The C-22 sterol desaturase Erg5 is responsible for ergosterol biosynthesis and conidiation in Aspergillus fumigatus
Nanbiao Long, Guowei Zhong
Journal of Microbiology.2022; 60(6): 620. CrossRef
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Huaxiang Li, Dan Ji, Zhishan Luo, Yilin Ren, Zhenming Lu, Zhenquan Yang, Zhenghong Xu
Foods.2022; 11(17): 2715. CrossRef
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Sofia Marisel Rivelli Zea, Takahito Toyotome
Microbiology and Immunology.2022; 66(3): 135. CrossRef
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Sara Cea-Sánchez, María Corrochano-Luque, Gabriel Gutiérrez, N. Louise Glass, David Cánovas, Luis M. Corrochano, Reinhard Fischer
mBio.2022;[Epub] CrossRef
The secondary metabolite regulator, BbSmr1, is a central regulator of conidiation via the BrlA‐AbaA‐WetA pathway in Beauveria bassiana
Jin‐Feng Chen, Yu Liu, Gui‐Rong Tang, Dan Jin, Xi Chen, Yan Pei, Yan‐Hua Fan
Environmental Microbiology.2021; 23(2): 810. CrossRef
BbWor1, a Regulator of Morphological Transition, Is Involved in Conidium-Hypha Switching, Blastospore Propagation, and Virulence in Beauveria bassiana
Lei Qiu, Tong-Sheng Zhang, Ji-Zheng Song, Jing Zhang, Ze Li, Juan-Juan Wang, Christina A. Cuomo
Microbiology Spectrum.2021;[Epub] CrossRef
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Yanxia Zhao, Mi-Kyung Lee, Jieyin Lim, Heungyun Moon, Hee-Soo Park, Weifa Zheng, Jae-Hyuk Yu
Journal of Microbiology.2021; 59(8): 746. CrossRef
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Patrícia Alves de Castro, Clara Valero, Jéssica Chiaratto, Ana Cristina Colabardini, Lakhansing Pardeshi, Lilian Pereira Silva, Fausto Almeida, Marina Campos Rocha, Roberto Nascimento Silva, Iran Malavazi, Wenyue Du, Paul S. Dyer, Matthias Brock, Flávio V
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Molecular Microbiology.2021; 115(6): 1191. CrossRef
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Journal of Microbiology.2021; 59(6): 563. CrossRef
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Yuxin Ma, Xuewei Yang, Meihua Xie, Guosheng Zhang, Le Yang, Na Bai, Yining Zhao, Dongni Li, Ke-Qin Zhang, Jinkui Yang
Fungal Genetics and Biology.2020; 138: 103352. CrossRef
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Duanxu Zhou, Meihua Xie, Na Bai, Le Yang, Ke-Qin Zhang, Jinkui Yang
Frontiers in Microbiology.2020;[Epub] CrossRef
Molecular Mechanisms of Conidial Germination in Aspergillus spp
Tim J. H. Baltussen, Jan Zoll, Paul E. Verweij, Willem J. G. Melchers
Microbiology and Molecular Biology Reviews.2020;[Epub] CrossRef
Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway
James I. P. Stewart, Vinicius M. Fava, Joshua D. Kerkaert, Adithya S. Subramanian, Fabrice N. Gravelat, Melanie Lehoux, P. Lynne Howell, Robert A. Cramer, Donald C. Sheppard, James W. Kronstad
mBio.2020;[Epub] CrossRef
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Mi-Kyung Lee, Ye-Eun Son, Hee-Soo Park, Ahmad Alshannaq, Kap-Hoon Han, Jae-Hyuk Yu
Scientific Reports.2020;[Epub] CrossRef
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Timothy Satterlee, Binita Nepal, Sophie Lorber, Olivier Puel, Ana M. Calvo, Irina S. Druzhinina
Applied and Environmental Microbiology.2020;[Epub] CrossRef
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Marina Campos Rocha, João Henrique Tadini Marilhano Fabri, Isabelle Taira Simões, Rafael Silva-Rocha, Daisuke Hagiwara, Anderson Ferreira da Cunha, Gustavo Henrique Goldman, David Cánovas, Iran Malavazi, Irina S. Druzhinina
Applied and Environmental Microbiology.2020;[Epub] CrossRef
In vitro and in vivo characterization of two nonsporulating Aspergillus fumigatus clinical isolates from immunocompetent patients
Zheng Zhang, Yuan Jiang, Jun Chen, Peiying Chen, Qingtao Kong, Ling Lu, Hong Sang
Medical Mycology.2020; 58(4): 543. CrossRef
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Chrystian Zetina-Serrano, Ophélie Rocher, Claire Naylies, Yannick Lippi, Isabelle P. Oswald, Sophie Lorber, Olivier Puel
International Journal of Molecular Sciences.2020; 21(18): 6660. CrossRef
Recurrent Loss of abaA, a Master Regulator of Asexual Development in Filamentous Fungi, Correlates with Changes in Genomic and Morphological Traits
Matthew E Mead, Alexander T Borowsky, Bastian Joehnk, Jacob L Steenwyk, Xing-Xing Shen, Anita Sil, Antonis Rokas, Jason E Stajich
Genome Biology and Evolution.2020; 12(7): 1119. CrossRef
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Chi-Jan Lin, Yi-Hsuan Hou, Ying-Lien Chen
Medical Mycology.2019;[Epub] CrossRef
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Haomiao Ouyang, Ting Du, Hui Zhou, Iain B. H. Wilson, Jinghua Yang, Jean-Paul Latgé, Cheng Jin
Scientific Reports.2019;[Epub] CrossRef
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Ting Zhang, Lu-Sheng Liao, Cheng-Xi Li, Gui-Yan Liao, Xiong Lin, Xue-Mei Luo, Shuai Zhao, Jia-Xun Feng
Frontiers in Microbiology.2019;[Epub] CrossRef
The Velvet Proteins VosA and VelB Play Different Roles in Conidiation, Trap Formation, and Pathogenicity in the Nematode-Trapping Fungus Arthrobotrys oligospora
Guosheng Zhang, Yaqing Zheng, Yuxin Ma, Le Yang, Meihua Xie, Duanxu Zhou, Xuemei Niu, Ke-Qin Zhang, Jinkui Yang
Frontiers in Microbiology.2019;[Epub] CrossRef
An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus
Abigail L. Lind, Fang Yun Lim, Alexandra A. Soukup, Nancy P. Keller, Antonis Rokas, Aaron P. Mitchell
mSphere.2018;[Epub] CrossRef
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Özlem Sarikaya Bayram, Jean Paul Latgé, Özgür Bayram
Current Genetics.2018; 64(1): 141. CrossRef
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Putative methyltransferase LaeA and transcription factor CreA are necessary for proper asexual development and controlling secondary metabolic gene cluster expression
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Research Support, Non-U.S. Gov'ts

Multiple roles of a putative vacuolar protein sorting associated protein 74, FgVPS74, in the cereal pathogen Fusarium graminearum: Hee-Kyoung Kim , Ki Woo Kim , Sung-Hwan Yun; J. Microbiol. 2015;53(4):243-249. Published online April 8, 2015; DOI: https://doi.org/10.1007/s12275-015-5067-7

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Abstract

Fusarium graminearum, a member of the F. graminearum species complex, is a filamentous ascomycetous group that causes serious diseases in cereal crops. A screen of insertional mutants of F. graminearum, generated using a restriction enzyme-mediated integration method, identified a mutant designated R7048 showing pleiotropic phenotypes in several mycological traits. The vector insertion site in the R7048 genome was identified as the KpnI site within an ORF annotated as FGSG_06346 (designated FgVPS74), which showed similarity to vacuolar protein sorting-associated protein 74 in the baker yeast. Both targeted gene deletion and complementation analyses confirmed that FgVPS74 was involved in hyphal growth, conidiation, sexual development, mycotoxin production, and virulence towards host plants in F. graminearum. Electron microscopy analysis revealed no significant changes in morphology of the vacuole or other organelles, but a greater number of mitochondria were produced in the ΔFgVPS74 strain compared to the wild-type progenitor. Expression of a GFP-tagged FgVPS74 construct under its native promoter in the ΔFgVPS74 strain exhibited localization of GFP signal to putative vesicle structures, but not to the vacuolar membrane. Taken together, these findings demonstrated that a functional vacuolar protein-sorting pathway mediated by FgVPS74 is crucial for fungal growth and development in F. graminearum.

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Trichoderma reesei Sch9 and Yak1 regulate vegetative growth, conidiation, and stress response and induced cellulase production: Xinxing Lv† , Weixin Zhang† , Guanjun Chen , Weifeng Liu; J. Microbiol. 2015;53(4):236-242. Published online January 31, 2015; DOI: https://doi.org/10.1007/s12275-015-4639-x

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Abstract

Protein kinases are key players in controlling many basic cellular processes in almost all the organisms via mediating signal transduction processes. In the present study, we characterized the cellulolytic Trichoderma reesei orthologs of Saccharomyces cerevisiae Sch9 and Yak1 by sequence alignment and functional analysis. The T. reesei Trsch9Δ and Tryak1Δ mutant strains displayed a decreased growth rate on different carbon sources and produced less conidia. The absence of these two kinases also resulted in different but abnormal polarized apical growth as well as sensitivity to various stresses. In addition, disruption of the genes Trsch9 or Tryak1 resulted in perturbation of cell wall integrity. Interestingly, while the induced production of cellulases was slightly compromised in the Trsch9Δ strain, the extracellular production of cellulases was significantly improved in the absence of Yak1. The results indicate that TrSch9 and TrYak1 play an important role in filamentous growth, stress response and induced production of cellulases in T. reesei.

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Journal Articles

The Observation of PlcA Mutation and Localization in Aspergillus nidulans: Chun-Seob Ahn , Young Taek Oh , Jeong-Geun Kim , Kap-Hoon Han , Chang-Won Lee , Jae Won Kim; J. Microbiol. 2014;52(7):590-596. Published online June 28, 2014; DOI: https://doi.org/10.1007/s12275-014-3651-x

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Abstract

To know the function of the plcA gene, which encodes a putative phosphoinositide-specific phospholipase C, in a model filamentous fungus Aspergillus nidulans, it was disrupted thorough homologous recombination and examined. The germination rate of ΔplcA was reduced by approximately 65% and germination of ΔplcA at a lower temperature (25°C) was much slower than germination under normal conditions (37°C), suggesting the plcA is responsible for cold-sensitivity. The hyphal growth of ΔplcA was slightly reduced at 37°C and conspicuously reduced at 25°C. While germinating ΔplcA formed giant swollen spores, and generated short and thick hyphae. The results of the nuclear examination of ΔplcA showed nuclear division with missegregation, and the rate of nuclear division was lower than that of wild type at both 25°C and 37°C. The results of this study showed that plcA is localized to the nucleus through intracellular calcium signaling in A. nidulans. The abnormal nuclear division, resulting from plcA gene deletion, affects conidiation in asexual development. Taken together, these results suggested that plcA is required for normal vegetative growth, morphogenesis, conidiation, and nuclear division
in A. nidulans.

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NOTE] Sawadaea koelreuteriae comb. nov., a Powdery Mildew of Koelreuteria paniculata: Hyeon-Dong Shin , Mi-Jeong Park; J. Microbiol. 2011;49(5):862-866. Published online November 9, 2011; DOI: https://doi.org/10.1007/s12275-011-1479-1

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Abstract: A powdery mildew parasitizing Koelreuteria spp. was first described under the name Uncinula koelreuteriae Miyake and later transferred to the genus Typhulochaeta. Based on morphological and molecular data of several herbarium specimens collected from Korea, the generic placement of Typhulochaeta is discussed and T. koelreuteriae is combined in the genus Sawadaea. Redescription and epitypification of this species is provided hereby.

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