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- Comprehensive Analysis of Gut Microbiota Alteration in the Patients and Animal Models with Polycystic Ovary Syndrome
- Jing Zhou , Xuemei Qiu , Xuejing Chen , Sihan Ma , Zhaoyang Chen , Ruzhe Wang , Ying Tian , Yufan Jiang , Li Fan , Jingjie Wang
- J. Microbiol. 2023;61(9):821-836. Published online October 12, 2023
- DOI: https://doi.org/10.1007/s12275-023-00079-9
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- 3 Web of Science
- 3 Crossref
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Abstract
- Polycystic ovary syndrome (PCOS) is a common disease of endocrine–metabolic disorder, and its etiology remains largely unknown. The gut microbiota is possibly involved in PCOS, while the association remains unclear. The comprehensive analysis combining gut microbiota with PCOS typical symptoms was performed to analyze the role of gut microbiota in PCOS in this study. The clinical patients and letrozole-induced animal models were determined on PCOS indexes and gut microbiota, and fecal microbiota transplantation (FMT) was conducted. Results indicated that the animal models displayed typical PCOS symptoms, including disordered estrous cycles, elevated testosterone levels, and ovarian morphological change; meanwhile, the symptoms were improved after FMT. Furthermore, the microbial diversity exhibited disordered, and the abundance of the genus Ruminococcus and Lactobacillus showed a consistent trend in PCOS rats and patients. The microbiota diversity and several key genera were restored subjected to FMT, and correlation analysis also supported relevant conclusions. Moreover, LEfSe analysis showed that Gemmiger, Flexispira, and Eubacterium were overrepresented in PCOS groups. Overall, the results indicate the involvement of gut microbiota in PCOS and its possible alleviation of endocrinal and reproductive dysfunctions through several special bacteria taxa, which can function as the biomarker or potential target for diagnosis and treatment. These results can provide the new insights for treatment and prevention strategies of PCOS.
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Citations
Citations to this article as recorded by
- Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics
Vineet Singh, Kanika Mahra, DaRyung Jung, Jae-Ho Shin
Probiotics and Antimicrobial Proteins.2024; 16(5): 1744. CrossRef - Potential therapeutic application and mechanism of gut microbiota-derived extracellular vesicles in polycystic ovary syndrome
Liangliang Yang, Tingxiu Liu, Yan Liao, Yuehan Ren, Zheng Zheng, Mingyue Zhang, Yue Yu, Chang Liu, Chaoying Wang, Tong Chen, Lili Zhang, Dongxue Zheng, Haidan Zhao, Zhexin Ni, Xinmin Liu
Biomedicine & Pharmacotherapy.2024; 180: 117504. CrossRef - Research Advance on the Prevention and Treatment of Polycystic Ovary Syndrome Based on Dysbiosis of Gut Microbiota
钰炜 王
Advances in Clinical Medicine.2024; 14(08): 895. CrossRef
- Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics
- Lactobacillus plantarum-derived metabolites sensitize the tumorsuppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells
- Hye-Ju Kim , JaeJin An , Eun-Mi Ha
- J. Microbiol. 2022;60(1):100-117. Published online December 29, 2021
- DOI: https://doi.org/10.1007/s12275-022-1533-1
- 80 View
- 0 Download
- 29 Web of Science
- 23 Crossref
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Abstract
- A critical obstacle to the successful treatment of colorectal cancer (CRC) is chemoresistance. Chemoresistant CRC cells contribute to treatment failure by providing a mechanism of drug lethargy and modifying chemoresistance-associated molecules. The gut microbiota provide prophylactic and therapeutic effects by targeting CRC through anticancer mechanisms. Among them, Lactobacillus plantarum contributes to the health of the host and is clinically effective in treating CRC. This study confirmed that 5-fluorouracil (5-FU)-resistant CRC HCT116 (HCT116/5FUR) cells acquired butyrateinsensitive properties. To date, the relationship between 5- FU-resistant CRC and butyrate resistance has not been elucidated. Here, we demonstrated that the acquisition of butyrate resistance in HCT116/5FUR cells was strongly correlated with the inhibition of the expression and function of SMCT1, a major transporter of butyrate in colonocytes. L. plantarum-cultured cell-free supernatant (LP) restored the functional expression of SMCT1 in HCT116/5FUR cells, leading to butyrate-induced antiproliferative effect and apoptosis. These results suggest that LP has a synergistic effect on the SMCT1/butyrate-mediated tumor suppressor function and is a potential chemosensitizer to overcome dual 5-FU and butyrate resistance in HCT116 cells.
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Citations
Citations to this article as recorded by- The role of gut microbiota and metabolites in cancer chemotherapy
Shiyu Li, Shuangli Zhu, Jun Yu
Journal of Advanced Research.2024; 64: 223. CrossRef - Sodium Butyrate Inhibits the Expression of Thymidylate Synthase and Induces Cell Death in Colorectal Cancer Cells
Nayeon Kim, Changwon Yang
International Journal of Molecular Sciences.2024; 25(3): 1572. CrossRef - Anticancer Properties of Saccharomyces boulardii Metabolite Against Colon Cancer Cells
Babak Pakbin, Samaneh Allahyari, Shaghayegh Pishkhan Dibazar, Amir Peymani, Mozhdeh Khajeh Haghverdi, Khadijeh Taherkhani, Maryam Javadi, Razzagh Mahmoudi
Probiotics and Antimicrobial Proteins.2024; 16(1): 224. CrossRef - The effect of oral butyrate on colonic short-chain fatty acid transporters and receptors depends on microbial status
Karla Vagnerová, Tomáš Hudcovic, Martin Vodička, Peter Ergang, Petra Klusoňová, Petra Petr Hermanová, Dagmar Šrůtková, Jiří Pácha
Frontiers in Pharmacology.2024;[Epub] CrossRef - Exploiting lactic acid bacteria for colorectal cancer: a recent update
Yang Chen, Bo Yang, Jianxin Zhao, R. Paul Ross, Catherine Stanton, Hao Zhang, Wei Chen
Critical Reviews in Food Science and Nutrition.2024; 64(16): 5433. CrossRef - Gut microbial metabolites: Shaping future diagnosis and treatment against gastrointestinal cancer
Hongyan Gou, Ruijie Zeng, Harry Cheuk Hay Lau, Jun Yu
Pharmacological Research.2024; 208: 107373. CrossRef - Probiotics intervention in colorectal cancer: From traditional approaches to novel strategies
Suki Ha, Xiang Zhang, Jun Yu
Chinese Medical Journal.2024; 137(1): 8. CrossRef - A Narrative Review on the Advance of Probiotics to Metabiotics
Hye Ji Jang, Na-Kyoung Lee, Hyun-Dong Paik
Journal of Microbiology and Biotechnology.2024; 34(3): 487. CrossRef - Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs – is it a new perspective for personalized treatment of cancer patients?
Karolina Kaźmierczak-Siedlecka, Nikola Bulman, Paweł Ulasiński, Bartosz Kamil Sobocki, Karol Połom, Luigi Marano, Leszek Kalinowski, Karolina Skonieczna-Żydecka
Gut Microbes.2023;[Epub] CrossRef - Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer
Dalong Liu, Yun Wang, Xiaojiang Li, Yan Wang, Zhiqiang Zhang, Zhifeng Wang, Xudong Zhang
Amino Acids.2023; 55(10): 1223. CrossRef - Microbial metabolites in colorectal tumorigenesis and cancer therapy
Yali Liu, Harry Cheuk-Hay Lau, Jun Yu
Gut Microbes.2023;[Epub] CrossRef - Lactobacillus plantarum Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses
Sihyun Jeong, Yuju Kim, Soyeong Park, Doyeon Lee, Juho Lee, Shwe Phyu Hlaing, Jin-Wook Yoo, Sang Hoon Rhee, Eunok Im
Molecules.2023; 28(4): 1890. CrossRef - Lactobacillus plantarum modulate gut microbiota and intestinal immunity in cyclophosphamide-treated mice model
Zhibo Zeng, Zonghao Huang, Wen Yue, Shah Nawaz, Xinzhu Chen, Jing Liu
Biomedicine & Pharmacotherapy.2023; 169: 115812. CrossRef - Gut Microbiome in Colorectal Cancer: Clinical Diagnosis and Treatment
Yali Liu, Harry Cheuk-Hay Lau, Wing Yin Cheng, Jun Yu
Genomics, Proteomics & Bioinformatics.2023; 21(1): 84. CrossRef - Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer
Xiang Lin, Xinyu Yang, Yushang Yang, Hangbin Zhang, Xuan Huang
Frontiers in Oncology.2023;[Epub] CrossRef - Characterization of Wnt signaling pathway under treatment of Lactobacillus acidophilus postbiotic in colorectal cancer using an integrated in silico and in vitro analysis
Nafiseh Erfanian, Saeed Nasseri, Adib Miraki Feriz, Hossein Safarpour, Mohammad Hassan Namaei
Scientific Reports.2023;[Epub] CrossRef - A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy
Qiqing Yang, Bin Wang, Qinghui Zheng, Heyu Li, Xuli Meng, Fangfang Zhou, Long Zhang
Advanced Science.2023;[Epub] CrossRef - Anti-tumour effect of Huangqin Decoction on colorectal cancer mice through microbial butyrate mediated PI3K/Akt pathway suppression
Jia-Jie Zhu, Hai-Yan Liu, Liang-Jun Yang, Zheng Fang, Rui Fu, Jia-Bin Chen, Shan Liu, Bao-Ying Fei
Journal of Medical Microbiology .2023;[Epub] CrossRef - Fecal levels of SCFA and BCFA during capecitabine in patients with metastatic or unresectable colorectal cancer
Janine Ziemons, Romy Aarnoutse, Anne Heuft, Lars Hillege, Janneke Waelen, Judith de Vos-Geelen, Liselot Valkenburg-van Iersel, Irene E. G. van Hellemond, Geert-Jan M. Creemers, Arnold Baars, Johanna H. M. J. Vestjens, John Penders, Koen Venema, Marjolein
Clinical and Experimental Medicine.2023; 23(7): 3919. CrossRef - Probiotic-Derived Bioactive Compounds in Colorectal Cancer Treatment
Christina Thoda, Maria Touraki
Microorganisms.2023; 11(8): 1898. CrossRef - Gut microbiota and microbiota-derived metabolites in colorectal cancer: enemy or friend
Xinyi Wang, Xicai Sun, Jinjin Chu, Wenchang Sun, Shushan Yan, Yaowen Wang
World Journal of Microbiology and Biotechnology.2023;[Epub] CrossRef - Determination of the effect of L. plantarum AB6-25, L. plantarum MK55 and S. boulardii T8-3C microorganisms on colon, cervix, and breast cancer cell lines: Molecular docking, and molecular dynamics study
Seda Yalçınkaya, Serap Yalçın Azarkan, Aynur Gül Karahan Çakmakçı
Journal of Molecular Structure.2022; 1261: 132939. CrossRef - Extracellular vesicles derived from Lactobacillus plantarum restore chemosensitivity through the PDK2-mediated glucose metabolic pathway in 5-FU-resistant colorectal cancer cells
JaeJin An, Eun-Mi Ha
Journal of Microbiology.2022; 60(7): 735. CrossRef
- The role of gut microbiota and metabolites in cancer chemotherapy
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